Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Caloric Intake”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,423 records · Page 79Linked to original sources

Total parenteral nutrition in pregnancy complicated by Crohn's disease.

Despite the widespread use of total parenteral nutrition (TPN) in nonpregnant patients, the literature reflects limited experience with TPN in pregnancy. However, since maternal nutritional deprivation may cause adverse fetal effects, its use appears warranted. We present a case of a pregnant patient with a poor reproductive history and recently diagnosed Crohn's disease who required TPN. We discuss the use of TPN with fat emulsions in this patient who was unable to tolerate enteral feedings during pregnancy. The patient underwent a 4-week period without oral intake. Total parenteral nutrition enabled continued fetal growth, resulting in a good outcome for the patient and her infant. This report supports the early use of TPN in pregnancy complicated by inadequate caloric intake.

Adult↗

Dietary guidelines for chronic disease prevention.

In developed nations, diet is related directly or indirectly to the most prevalent chronic diseases. Research has helped clarify diet-disease relationships and enabled the promulgation of dietary recommendations for chronic disease prevention. We reviewed epidemiologic study results, clinical trial data, and general dietary recommendations from various agencies to develop a set of overall dietary guidelines for the prevention of the most common chronic diseases in the United States, including coronary heart disease, hypertension, cancer, and osteoporosis. Intake of monounsaturated fats, fiber, calcium, vegetables and fruits, and whole grains should be promoted. Consumption of saturated and trans fats, sodium, and refined grains should be minimized. Moderation in alcohol and caloric intake should be encouraged. Although research into associations between diet and disease is constantly in flux, our guidelines are based on replicated findings and provide a starting point for assisting patients in improving their diets.

Adult↗

Macronutrient intakes of elderly in the Lipid Research Clinics Program Prevalence Study.

As part of the Lipid Research Clinics (LRC) Program Prevalence Study of coronary heart disease risk factors, nutrient intakes of two US populations over 59 years of age were determined by 24-hour recalls in the 1970s. Characteristics of the populations were (1) California: suburban, upper-middle class, 95% high school graduates, 10% blue collar occupations; (2) Oklahoma: rural lower-middle class, 75% high school graduates, and 40% blue-collar occupations. Macronutrients consumed by both populations were similar, except for alcohol. For both men and women, energy intake was approximately 25 kcal/kg/day (body weight) sources of energy were approximately 40% from carbohydrate, 16% from protein, 37% from fat, and 4% from alcohol. The Oklahoma population, however, consumed significantly less alcohol than did Californians. Percentages of calories from fatty acids were approximately 14% from saturated and 6% from polyunsaturated, which yielded a polyunsaturated: saturated ratio of 0.48. The intake of cholesterol for women was 190 mg/1000 kcal and for men, 210 mg/1000 kcal. Between the ages of 60 and 69, the Oklahoma men consumed more energy than did the California men. Both sexes demonstrated lower energy intakes with advancing age and with increasing body mass index. The higher energy intake of the Oklahoma cohort aged 60-69 was attributed to the greater physical demands of their occupations, but this difference disappeared after age 70. The California and Oklahoma women had similar caloric intakes beyond age 60. In summary, the LRC findings suggest that geographically diverse American populations consumed in the late 1970s remarkably similar intakes of macronutients and cholesterol, with the only major exception being energy from alcoholic beverages.

Aged↗

Leptin: an essential regulator of lipid metabolism.

This paper reviews the general mechanisms by which leptin acts as a regulator of lipid reserves through changes in food intake, energy expenditure and fuel selection, with an emphasis on its direct effects on cellular lipid metabolism. Briefly, when leptin levels increase, food consumption decreases via modulation of hypothalamic neuropeptides. As well, normal decreases in energy expenditures (e.g. with diurnal cycles or reduced caloric intake) do not occur. This is probably caused by an increase in mitochondrial proton leak mediated by leptin via increases in sympathetic nervous system stimulation and thyroid hormone release. The decrease in caloric input coupled with relatively higher energy expenditure, therefore, leads to negative energy balance. Leptin also changes the fuel source from which ATP is generated. Fuel preference switches from carbohydrate (glucose) to lipid (fatty acids). This effect arises through stimulation of triacylglycerol catabolism by leptin. In vitro studies show that leptin is a potent stimulator of lipolysis and fatty acid oxidation in adipocytes and other cell types. Consequently, leptin is also a regulator of cellular triacylglycerol content. Hormonal regulation of leptin, as well as its role in fasting and seasonal weight gain and energy expenditure are also briefly discussed.

Adipocytes↗

Inverse relationship between brown fat thermogenesis and meal size: the thermostatic control of food intake revisited.

This study examines a new hypothesis whereby heat production from brown fat in response to eating may serve as a feedback signal for satiety. To test this hypothesis, in vitro respiration rate of brown adipose tissue (BAT) was determined in relation to the voluntary caloric intake of the preceding test meal. This relationship was examined as a function of meal composition and of obesity. It was found that in rats fed a high fat diet, as well as in two types of obese rats (VMH and Zucker), respiration rate per 100 mg tissue was significantly reduced, and energy intake of the preceding test meal increased compared to rats receiving a low fat diet or to respective lean rats. These data lend support to a brown fat mediated thermostatic hypothesis for the control of food intake.

Adipose Tissue, Brown↗

Saturated fat intake and insulin resistance in men with coronary artery disease. The Stanford Coronary Risk Intervention Project Investigators and Staff.

BACKGROUND: To determine whether there is an association between diet and plasma insulin concentration that is independent of obesity, we studied the relation of dietary composition and caloric intake to obesity and plasma insulin concentrations in 215 nondiabetic men aged 32-74 years with angiographically proven coronary artery disease. METHODS AND RESULTS: After adjusting for age, the intake of saturated fatty acids and cholesterol were positively correlated (p less than 0.05) with body mass index (r = 0.18, r = 0.16), waist-to-hip circumference ratio (r = 0.21, r = 0.22), and fasting insulin (r = 0.26, r = 0.23). Carbohydrate intake was negatively correlated with body mass index (r = -0.21), waist-to-hip ratio (r = -0.21), and fasting insulin (r = -0.16). Intake of monounsaturated fatty acids did not correlate significantly with body mass index or waist-to-hip circumference ratio but did correlate positively with fasting insulin (r = 0.24). Intake of dietary calories was negatively correlated with body mass index (r = -0.15). In multivariate analysis, intake of saturated fatty acids was significantly related to elevated fasting insulin concentration independently of body mass index. CONCLUSIONS: These cross-sectional findings in nondiabetic men with coronary artery disease suggest that increased consumption of saturated fatty acids is associated independently with higher fasting insulin concentrations.

Adult↗

Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions.

The incidence and severity of obesity and type 2 diabetes are increasing in Western societies. The progression of obesity to type 2 diabetes is gradual with overlapping symptoms of insulin resistance, hyperinsulinemia, hyperglycemia, dyslipidemias, ion imbalance, and inflammation; this complex syndrome has been called diabesity. We describe here comparisons of gene expression in livers of A/a (agouti) vs. A(vy)/A (obese yellow) segregants (i.e., littermates) from BALB/cStCrlfC3H/Nctr x VYWffC3Hf/Nctr-A(vy)/a matings in response to 70% and 100% of ad libitum caloric intakes of a reproducible diet. Twenty-eight (28) genes regulated by diet, genotype, or diet x genotype interactions mapped to diabesity quantitative trait loci. A subset of the identified genes is linked to abnormal physiological signs observed in obesity and diabetes.

Animals↗

Effect of ovariohysterectomy on maintenance energy requirement in cats.

OBJECTIVE: To determine whether maintenance energy requirement (MER) to maintain stable body weight (BW) is substantially lower for spayed female cats than for sexually intact female cats and to assess whether an equation commonly used to estimate MER would accurately predict caloric need in spayed cats. DESIGN: Prospective study. ANIMALS: 10 spayed and 5 sham-operated young adult female cats. PROCEDURE: During an acclimatization period, initial daily food allowance was determined by estimating MER as 1.4 x (30 x BW + 70), then adjusted weekly to maintain BW within 200 g of baseline. Ovariohysterectomy (OHE) or sham laparotomy was performed at week 7, and the study was continued for 15 additional weeks (period 1). To correct for a presumptive effect of continued musculoskeletal growth that resulted in some cats becoming unacceptably thin during period 1, the study was repeated over an additional 10 weeks (period 2), using a new estimate of MER calculated from BW measured after reestablishing normal body condition. RESULTS: Substantial restriction in food allowance was necessary to prevent BW gain in the OHE group during both periods. Caloric intake of spayed cats in dietary balance was significantly lower than that of control cats at the end of each study period. Sexually intact cats appeared to self-regulate food intake, whereas spayed cats tended to eat all food available to them. Significant differences were not detected between OHE and control groups in observations of physical activity before or after surgery. The equation used to predict caloric needs overestimated the apparent MER for spayed and sexually intact cats. CLINICAL IMPLICATIONS: Ad libitum feeding of spayed cats may be inadvisable, and careful monitoring of food allowance, relative to body condition, is suggested to prevent excessive weight gain.

Animal Feed↗

The gut and food intake: an update for surgeons.

Food intake is the simplest and most obvious measure of gastrointestinal function, yet it rarely receives more than cursory attention from surgeons. In this review we cover recent findings on relationships between gut function and appetite regulation mediated via neuropeptides influenced by afferent and efferent vagal activity. Evidence from the new discipline known as neurogastroenterology elucidates gastric and intestinal signals involved in the elicitation of hunger, satiety, and aversion. Discovery of the adipose-tissue-derived hormone, leptin, has energized the field of metabolism spawning increasing numbers of publications related to interactions between leptin and insulin release and glucose disposal, as well as appetitive behavior. Peptides such as cholecystokinin (CCK), the proglucagon-derived peptides, glucagon-like peptides 1 and 2 (GLP-1 and GLP-2), and the recently identified powerful intake-stimulating molecule, orexin, are examples of potential targets for drug development and studies of surgical pathophysiology. A major conclusion of this work is that the considerable redundancy and overlap between mediators of caloric intake subserving survival of the species, while beneficial after foregut surgery, contribute to the complexity of treating the global epidemic of obesity. Possibly knowledge derived from basic research in neurogastroenterology can translate into advances in surgical treatment of obesity.

Appetite Regulation↗

Dietary vitamin C intake and lung function in rural China.

The relation between dietary vitamin C intake and pulmonary function was investigated in a cross-sectional study carried out in 69 counties in rural China in 1989. Within each of the 69 counties, 120 subjects aged 35-64 years were identified using a three-stage random clustering procedure. Each subject underwent pulmonary function testing, completed a detailed questionnaire, and provided a blood sample. Dietary vitamin C intakes were estimated among half of the subjects using a 3-day weighed record of household food intake. Plasma vitamin C was measured in sex-specific blood pools created from individual samples in each geographic area. Among the 3,085 subjects for whom there were complete data, dietary intake of vitamin C (151 mg/day (standard deviation, 111)) was significantly related to forced expiratory volume in the first second (FEV1) and forced vital capacity after adjustment for sex, age, height, weight, total caloric intake, tobacco smoking, and education. An increase of 100 mg/day in vitamin C intake was associated with an increase of 21.6 ml (95% confidence interval -0.4 to 43.5) in FEV1 and an increase of 24.9 ml (95% confidence interval 0.2 to 49.6) in forced vital capacity. No significant interaction with smoking status was observed. A significant positive association was also observed at the geographic level, between county-pooled plasma vitamin C and mean FEV1. These data support the hypothesis that dietary vitamin C may protect against the loss of pulmonary function.

Adult↗

Can food intake be reduced with peptide YY3-36?

Obesity shortens life expectancy. The peripheral administration of peptide YY3-36 (PYY3-36) inhibits food intake in mice and rats. The effects of PYY3-36 on food intake have been assessed in obese and lean subjects in a double-blind, placebo-controlled, cross-over study. In fasting obese and lean subjects, infusion of PYY3-36 reduced the caloric intake in 24 h by 17 and 24%, respectively. Long-term studies to determine whether PYY3-36 reduces food intake in freely fed humans are now required.

Adult↗

Contemporary diet and body weight of Navajo women receiving food assistance: an ethnographic and nutritional investigation.

Preceded by 6 months of ethnographic research, a survey of 107 Navajo women, primarily food assistance participants, was conducted to describe and evaluate the contemporary Navajo diet. On the basis of results of 1-day dietary recalls, mean nutrient intakes were found to be below the RDA for calcium, phosphorus, iron, vitamin A, and energy. Sixty-three percent of the women in the sample were overweight or obese. The overall percentages of energy from fat, carbohydrate, and protein were closer to those recommended in the Dietary Goals than those in the current U.S. diet. The fat in the diet appeared to be primarily saturated, however, and fiber intake was lower than the U.S. average. Traditional foods were infrequently consumed. Women with higher incomes tended to have better diets. Commodity foods supplied by USDA's Food Distribution Program provided 43% of caloric intake and 37% to 57% of the intakes of all other nutrients except fat and vitamin C for the 72% of the sample participating in that program. It is concluded that the Food Distribution Program provides an important nutritional contribution to the contemporary Navajo diet.

Adult↗

Comparison of nutrient intake in middle-aged men and women runners and controls.

Runners and other active individuals typically have plasma lipoprotein patterns different than their more sedentary peers. In an attempt to determine if these patterns could be explained by dietary differences, we studied nutrient intake in middle-aged (35-59 yr) men and women runners averaging 55-65 km/wk, and inactive controls. The runners were leaner (P less than or equal to 0.0001) and had higher caloric intakes (40-60% higher on a weight-adjusted basis); they also ate more fat and carbohydrate (P less than or equal to 0.01), and were more likely to consume alcoholic beverages. When nutrient intake was expressed as a percent of total calories, the runners ate less protein (P less than or equal to 0.001). The runners obtained a smaller percentage of calories from starch and a greater percentage from other carbohydrates. Differences in nutrient intake seemed unlikely to account for observed differences in plasma lipids and lipoproteins between the runners and controls.

Adult↗

Feeding response of rats to no-fat and high-fat cakes.

The nutritional effects of high-fat diets have been extensively studied in laboratory animals, but as yet few experiments have examined the feeding response of animals to newly developed fat substitutes. The present study used commercially available no-fat (0% fat, 92% carbohydrate) and high-fat (41% fat, 54% carbohydrate) cake to determine the effects of fat substitutes on food preference and caloric intake in rats. The first experiment showed that nondeprived rats found the high-fat and no-fat cakes equally palatable and highly preferred to lab chow. Food deprived rats, however, preferred the high-fat cake to the no-fat cake, which may be related to its higher caloric density. In the second experiment, rats fed high-fat cake, in addition to chow, for 30 days consumed more calories and gained more weight than did rats fed no-fat cake and chow. The no-fat cake group, however, overate and gained more weight than chow-only controls. The hyperphagic response to the no-fat cake can be attributed to its carbohydrate content, moisture, and high palatability. Thus, removing fat from the cake reduced, but did not eliminate, its obesity-promoting effect. Obviously, low-fat foods must be consumed in moderation if used for weight control.

Animal Feed↗

Effects of estrogen on food intake, body weight, and temperature of male and female obese mice.

Estradiol benzoate (EB) treatment of male and female C57BL/6J ob/ob mice for 32 days led to decreased body weight (20%), percentage body fat (8%) and carcass protein content (12%) when compared with non-EB-treated obese control mice. Estradiol reduced the caloric intakes of both genders by 25-35%, but did not affect body temperature regulation. Circulating glucose and insulin concentrations were also lowered by estrogens, although hyperinsulinemia persisted. Since post-treatment body weight changes correlated with daily food intakes (r = 0.81) rather than to rectal temperatures (r = -0.19), it appears that hypophagia provided a greater contribution to the estrogen-mediated reductions of growth and carcass fat than did altered energy expenditure for thermoregulation. While these data show that EB treatment does reduce the severity of some metabolic disturbances in a genetic model of type II diabetes, long-term estrogens do not appear to offer substantial advantages in the treatment of obesity or diabetes when compared with the effects of caloric restriction alone.

Adipose Tissue↗

Dietary patterns in patients with advanced cancer: implications for anorexia-cachexia therapy.

BACKGROUND: Severe malnutrition and wasting are considered hallmarks of advanced malignant disease, and clinical research into anorexia-cachexia therapy and nutritional support for cancer patients is ongoing. However, information on typical dietary intakes and food choices for this population is notably lacking; proposed therapies for anorexia and wasting are not framed within the context of current intake. OBJECTIVE: The objective of the study was to characterize the food intake patterns of patients with advanced cancer. DESIGN: Patients with advanced cancer (n = 151) recruited from a regional cancer center and palliative-care program completed a 3-d dietary record a mean (+/-SD) 8 +/- 7 mo before death. Food items were categorized according to macronutrient content and dietary use and subsequently entered into cluster analysis. RESULTS: Wide variations in intakes of energy (range: 4-53 kcal . kg body wt(-1) . d(-1); x +/- SD: 25.1 +/- 10.0 kcal . kg body wt(-1) . d(-1)) and protein (range: 0.2-2.7 g . kg body wt(-1) . d(-1); x +/- SD: 1.0 +/- 0.4 g . kg body wt(-1) . d(-1)) were observed. Even the subjects with the highest intakes had a recent history of weight loss, which suggests that the diets of those persons were consistently inadequate for weight maintenance. Cluster analysis found 3 dietary patterns that differed in food choice and caloric intake. Low intakes and a high risk of weight loss were associated with decreased frequency of eating and dietary profiles with little variety and unusually high proportions of liquids. CONCLUSION: These data provide a glimpse into dietary habits toward the end of life. Unique dietary patterns were found in this nutritionally vulnerable patient population.

Aged↗

The management of enzymatic therapy in cystic fibrosis patients by an individualized approach.

We evaluated nutritional status, pulmonary impairment, nutritional intake, and fat absorption in 73 cystic fibrosis (CF) patients to identify the primary factor(s) influencing growth. In general, the growth pattern in our patients was satisfactory since 60/73 were not underweight. When caloric intake is greater than or equal to 95% of RDA, wasting does not occur regardless of the degree of malabsorption, dietary fat content, or lung involvement. In the group of patients who consume less than the RDA, underweight is related to the severity of pulmonary disease; indeed, 11/13 underweight patients have a chest x-ray score over 15. Steatorrhea is well controlled in most patients; only 11 of 73 show a fat excretion greater than 25% of fat intake. The daily number of capsules of Pancrease varies from 4 to 57. The amount of Pancrease to be given was individualized to meet each patient's requirements using fat balance studies to determine the necessary daily Pancrease dose, then distributing the total dose in proportion to the fat content of each meal.

Adolescent↗

Divergent effect of dehydroepiandrosterone on energy intakes of Zucker rats.

Oral dehydroepiandrosterone (DHEA) causes weight loss in the obese Zucker rat. To study this process, we fed lean and obese female Zucker rats either control chow diets alone or diets containing 0.6% DHEA for 4 weeks. DHEA treatment led to a significant increase in the caloric intake of lean-treatment rats and a significant decrease in obese-treatment rats compared to their respective controls. These phenotype-specific divergent effects began acutely and were sustained. The energy intake changes with DHEA treatment were significant after correcting for body weight. Divergent effects of DHEA were also observed in body weight changes and in the food efficiency ratios of the animals; DHEA affected obese rats but not lean ones. The results of the present study suggest that the appetite component of DHEA's antiobesity effect in the Zucker fatty rat cannot be discounted.

Animals↗