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PubMed1988

[Effect of chronic alcoholism on the state of the microcirculatory bed of the myocardium].

Ultrastructure of myocardial capillaries of rats was studied in cases of chronic alcohol intoxication, experimental alcoholic cardiomyopathy (ACM) and its correction with antioxidants (vitamin E, dibunol). Alterations in the microcirculatory bed were similar in all groups of animals irrespective of disturbances in cardiomyocytes. Cardiomyocyte ultrastructure was improved after treatment with antioxidants, but capillary bed was the same as in untreated animals. High dibunol doses caused the onset of perivascular sclerosis. Disturbances in the microcirculatory bed are, probably, the first step in the determination of ACM pathogenesis and therapy of ACM must be directed at the correction of both alterations of cardiomyocytes and capillary bed.

Animals↗
PubMedDate not supplied

[Simulation of attempted homicide by dog bite in unconscious state].

It is reported on the unusual event of dog scavenging in an unconscious and intoxicated (alcohol) person. Due to the particular circumstances a case of attempted homicide was primarily suspected. Peculiarities of the case were a small dog (dachshund) as the responsible cause and the survival of the injured woman. Intensive and partly deep wounds due to scavenging were found on both shoulders/upper arms in nearly symmetrical order. Vomit from the dog could be assigned to the unconscious person by DNA typing. The typical morphological features of dog bites and injuries due to scavenging, respectively, and the possible motivation of the animal are discussed.

Aged↗
PubMed1996

[Drunkenness in traffic in Geneva: occasional abuse or alcoholism?].

The main aim of the study is to measure the importance of alcoholism amongst alcohol intoxication (up to the Swiss legal BAC: 0.8 gr/kg) in traffic. The method used describes the characteristics of all cases of inebriety (amongst pedestrians and drivers) recorded by the police during one year and relates this with complementary data such as the determination of a biological marker of alcohol consumption (Gamma Glutamyl Transferase), or DWI recidivism. Results of general interest are: 22% of recorded cases of alcohol intoxication are recidivists; about one third of the cases of alcohol intoxication registered are due to alcoholism rather than to social drinking. A preventive policy in road traffic safety must integrate the problems, caused by alcoholism, on Public Health.

Accidents, Traffic↗
PubMed2006

Predictors of future anabolic androgenic steroid use.

PURPOSE: To prospectively study the stability of anabolic androgenic steroid (AAS) use and predictors of AAS use, and to investigate whether AAS use alters the risk of later emotional and behavioral problems. METHODS: Survey of a national sample of Norwegian high school students (age 15-19) in 1994 followed up in 1999 (N = 2924). Measures of frequent alcohol intoxication (50+ times per 12 months), cannabis use (12 months), hard drug use (12 months), being offered cannabis, eating problems, conduct problems, sexual debut before age 15, BMI, involvement in power sports, perceived physical appearance, and satisfaction with body parts were obtained. RESULTS: Life-time prevalence of AAS use were 1.9 and 0.8% in the follow-up period. Multivariate logistic regression revealed that future AAS use was predicted by young age, male gender, previous AAS use, involvement in power sports, and frequent alcohol intoxication. AAS use did not predict future emotional or behavioral problems other than reducing the risk of future frequent alcohol intoxication. CONCLUSION: Frequent alcohol intoxication and involvement in power sports appear to predict future AAS use. At the population level there was little stability in individual AAS use from adolescence to early adulthood. No detrimental effects of AAS use could be detected in this study, but low statistical power limits this conclusion.

Adolescent↗
PubMed1985

The effect of naloxone on the hepatocellular redox state and serum ethanol concentrations following acute ethanol administration.

Naloxone hydrochloride (2.0 mg/kg) has been found to reverse the significant decreases in the hepatic cytosolic and mitochondrial [NAD+]/[NADH] ratios observed after acute ethanol administration in rats. This correction of the ethanol-induced changes in the hepatocellular redox state by naloxone was, however, not associated with any lowering of serum ethanol concentrations or an observable reduction in the extent of intoxication. This lack of antagonism of alcohol intoxication by naloxone was not affected by the feeding status of the animals, the time point after naloxone administration at which serum ethanol concentration was determined or the method used for ethanol analysis. Thus this study has failed to confirm that naloxone antagonises acute alcohol intoxication, in spite of its potent ability to reverse the ethanol-induced changes in the hepatic redox state.

Alcoholic Intoxication↗
PubMed1994

The effect of enforcement upon service of alcohol to intoxicated patrons of bars and restaurants.

Laws prohibiting the service of alcohol to already intoxicated patrons of bars and restaurants are seldom enforced. Following introduction of an enforcement effort in Washtenaw County, Michigan, observed refusals of service to "pseudopatrons" simulating intoxication rose from 17.5% to 54.3%, declining eventually to 41.0%. At the same time, the percentage of those arrested drunk drivers coming from bars and restaurants declined from 31.7% to 23.3%. In a comparison county, refusals of service rose to a significantly smaller extent, from 11.5% to 32.7%, while the percentage of DWIs coming from bars and restaurants showed no significant changes. Service refusals were related to volume of business and numbers of intoxicated patrons in an establishment at the time of observation, while numbers of arrested DWIs was related to the nature of the establishment's clientele, policies, and practices. While enforcement of alcohol service laws offers a potentially cost beneficial means of reducing highway crashes, replication across additional jurisdictions is needed.

Accidents, Traffic↗
PubMed1988

Recognition of intoxication by alcohol counselors.

Recent studies have found that police officers, bartenders, social drinkers, and trained interviewers are often unable to recognize when others are intoxicated. The present two studies were conducted to evaluate: (a) the recognition ability of alcohol counselors compared to mental health counselors, and (b) the recognition ability of less-experienced versus more-experienced alcohol counselors. Subjects viewed four videotapes of a 21-year-old male engaged in simulated counseling interviews after he was given drinks containing alcohol to achieve one of four target Blood Alcohol Level (BAL) goals: .00%, .05%, .10%, .15%. Results indicated that alcohol counselors were not uniformly more accurate than mental health therapists, nor were more-experienced alcohol counselors uniformly more accurate than less-experienced alcohol counselors at recognizing intoxication or estimating BAL. In addition, subjects generally underestimated the target's sober-intoxicated status and BAL when he was given alcohol, but almost every subject recognized that the target was at least moderately intoxicated when his BAL was .15%.

Adult↗
PubMed1998

Differential sensitivity to alcohol reinforcement in groups of men at risk for distinct alcoholism subtypes.

The present study examines the relationship of familial and personality risk factors for alcoholism to individual differences in sensitivity to the positively and negatively reinforcing properties of alcohol. Sixteen sons of male alcoholics with multigenerational family histories of alcoholism (MFH) and 11 men who self-report heightened sensitivity to anxiety (HAS) were compared with 13 age-matched family history negative, low anxiety sensitive men (FH-LAS) on sober and alcohol-intoxicated response patterns. We were interested in the effects of alcohol on specific psychophysiological indices of "stimulus reactivity," anxiety, and incentive reward. Alcohol significantly dampened heart rate reactivity to aversive stimulation for the MFH and HAS men equally, yet did not for the FH-LAS group. HAS men evidenced idiosyncrasies with respect to alcohol-induced changes in electrodermal reactivity to aversive stimulation (an index of anxiety/fear-dampening), and MFH men demonstrated elevated alcohol-intoxicated resting heart rates (an index of psychostimulation) relative to the FH-LAS men. The results are interpreted as reflecting a sensitivity to the "stimulus reactivity-dampening" effects of alcohol in both high-risk groups, yet population-specific sensitivities to the fear-dampening and psychostimulant properties of alcohol in the HAS and MFH groups, respectively.

Adaptation, Psychological↗
PubMed2006

Electrocardiographic findings after acute absinthe intoxication.

A 29-year-old comatose patient was brought to Emergency Department with severe alcohol intoxication. No risk factors or cardiac abnormalities were documented. The analysis was negative for other drugs. Plasma electrolyte and cardiac enzymes were normal. The electrocardiogram showed Mobitz type-I atrioventricular block that developed to a rapid junctional rhythm. The patient was stabilized and recovered completely, electrocardiogram then showed sinus rhythm. He admitted important absinthe consumption. Although tachyarrhythmias are frequently developed in acute alcohol intoxication, bradyarrhythmias are exceptional in this context. We present a Wenckebach-type atrioventricular-block in severe alcohol intoxication with absinthe that developed to a rapid junctional rhythm, never described before.

Absinthe↗
PubMedDate not supplied

Alcohol dependence among patients admitted to psychiatric emergency services.

We assessed the prevalence of alcohol dependence among patients examined in the psychiatric emergency service of a general hospital. We compared socio-demographic data and psychiatric status of patients with and without alcohol dependence. One-hundred and four consecutive patients received by the psychiatric emergency service of Bichat-Claude Bernard Hospital (Paris, France) were assessed. Diagnosis of alcohol dependence, acute alcohol intoxication, and antisocial personality was determined according to DSM-IV criteria. Other psychiatric disorders were identified using a structured psychiatric interview, the Mini International Neuropsychiatric Interview (MINI). Prevalency rate of alcohol dependence was 37.5% among patients examined by the psychiatric emergency service. Alcohol-dependent patients were more often men than women and more often unemployed than non-alcohol-dependent psychiatric emergencies. They presented more dysthymia, acute alcohol intoxication, and antisocial personality than non-alcoholic patients followed by the psychiatric emergency service. Attempted suicide was as frequent in alcohol-dependent patients (23%) as in other patients (29%). Alcohol-dependent patients consumed alcohol more often when alone, and their alcohol consumption began more frequently in the morning. Patients seen in a psychiatric emergency service must be identified as a population at risk for alcohol dependence (37.5%). Alcohol-dependent patients are more often men and have a higher rate of unemployment. They present significantly more often dysthymia and acute alcohol intoxication associated to alcohol dependence.

Adult↗
PubMed1978

An analytic comparison of persons arrested for driving while intoxicated and alcohol detoxification patients.

This article presents findings on an analytic comparison of two groups of persons for whom alcohol is an identical clinical or social problem--247 patients currently under treatment in a detoxification unit in a general hospital and 118 individuals who had been arrested for driving while intoxicated (DWI) and were attending a DWI school. A systematic comparison of these two groups yielded several important, statistically significant differences and it becomes increasingly apparent that distinctions can be made that permit the identification of high-risk segments of the DWI population, facilitating early diagnosis and differential treatment modes.

Adult↗
PubMed1996

No loss of somatostatin-immunoreactive neurons in the hippocampal dentate hilus of alcohol-withdrawal-kindled rats.

The neuropeptide somatostatin has been suggested to play a role in seizure genesis, electrical kindling and the neurotoxic effects of alcohol. The purpose of the present experiment was to study somatostatin-immunoreactive (SS-IR) neurons in hippocampus during alcohol-withdrawal kindling. Alcohol-withdrawal kindling was performed by subjecting male Wistar rats to seven weekly episodes consisting of 2 days of severe alcohol intoxication and 5 days of alcohol withdrawal. Then the kindled animals (multiple withdrawal group) and a single withdrawal group, which was fed isocalorically with the kindled animals during episodes 1-7, were exposed to 4 days of severe alcohol intoxication (episode 8). During the following withdrawal, the seizure activity was observed 9-15 h after last alcohol dose, in order to subdivide the animals from these two groups into groups with and without seizures. Subsequently, SS-IR neurons were visualized immunocytochemically and counted in the hilus of the dentate gyrus (hippocampus). The number of SS-IR neurons per unit area of the hilus was neither affected by a single nor by multiple episodes of alcohol withdrawal. We therefore concluded that a loss of these neurons is not involved in the development of alcohol-withdrawal-kindled seizures.

Alcohol Withdrawal Delirium↗
PubMed1993

The effects of alcohol abuse on readmission for trauma.

OBJECTIVE: To determine the effect of admission for trauma with concurrent acute alcohol intoxication or chronic alcohol abuse on the risk of subsequent recurrence of trauma. DESIGN: Prospective cohort study. SETTING: Level I regional trauma center. PATIENTS: A total of 2578 patients 18 years or older admitted with blunt or penetrating trauma within 24 hours of injury and surviving to discharge. All patients had a blood alcohol concentration (BAC) test, a gamma-glutamyltransferase (GGT) test, and the short Michigan Alcohol Screening Test (SMAST) performed on admission. MAIN OUTCOME MEASUREMENT: Readmission to the trauma center for new trauma. Average follow-up was 28 months (range, 16 to 40 months). RESULTS: The overall rate of readmission for new injuries was 1.3 per 1000 patient-months of follow-up. Patients who were intoxicated on the initial admission (BAC > 22 mmol/L [100 mg/dL]) were 2.5-fold as likely to be readmitted than those not intoxicated (95% confidence limits, 1.6, 3.9). The relative risks for patients with positive SMAST scores and abnormal GGT values were 2.2 (95% confidence limits, 1.4, 3.5) and 3.5 (95% confidence limits, 2.2, 5.5), respectively. The increased risks remained significant for intoxication and abnormal GGT values after adjustment for gender, race, Medicaid status, and mechanism of injury. CONCLUSION: Alcohol abuse is associated with an increased risk of readmission for new trauma. Trauma patients should be screened for alcohol problems; referral of problem drinkers for appropriate care may decrease their risk of admission for subsequent trauma.

Adult↗
PubMed1987

[Importance of alcoholism markers in the diagnosis of alcoholic heart lesions].

A study was made of opportunities for the use of some signs of alcoholic intoxication in the verification of alcoholic etiology of heart lesion. Clinical signs like hyperemia of the face with telangiectasia, venous plethora of the eyeballs, tremor of the lips, tongue, limbs, Dupuytren's contracture, enlarged liver size combined with a positive macrocytosis test and, to a lesser degree, with a higher activity of gamma-glutamyl transpeptidase, and the detection of fatty hepatosis in liver puncture biopsy were shown to suggest alcoholic intoxication, and excluding other cases of heart lesion they can be of great help in the verification of diagnosis of alcoholic heart lesion.

Adult↗
PubMed2006

Psychostimulant users are sensitive to the stimulant properties of alcohol as indexed by alcohol-induced cardiac reactivity.

One indicator of increased sensitivity to alcohol-induced reward is a heightened heart rate (HR) increase following alcohol intoxication, a characteristic associated with increased alcohol-induced dopamine (DA) release. The goal of this study was to determine whether users of drugs known to induce DA release have higher HR increases after alcohol intoxication than never users have. Sixty-four men with known drug-use histories participated in an alcohol challenge in which HR was measured. Stimulant users had significantly higher ethanol-induced HR increases than never users had, although use of marijuana or hallucinogens was not associated with this marker. Stimulant users obtained superior Sensitivity to Reward scores (R. Torrubia, C. Avila, J. Moltó, & X. Caseras, 2001) compared with never users. Stimulant drug users may be more sensitive to the stimulating properties of alcohol, and this appears to be mediated by superior activity in the Behavioral Approach System (J. A. Gray, 1991).

Adolescent↗
PubMedDate not supplied

[Significance of changes in the myocardium for the forensic-medical diagnosis of death as a result of alcoholic cardiomyopathy].

Significance, of the weight and dimensions of heart as well as of fat dystrophy of cardiomyocytes and of the related detection methods is demonstrated for the diagnosis of alcoholic cardiomyopathy (ACMP). When such patients die in a state of alcoholic intoxication, the diagnosis should be death of acute alcoholic intoxication. Lethality of ACMP can be diagnosed only in those who die in the sober condition or with an insignificant level of alcohol.

Adult↗
PubMedDate not supplied

[The effect of intravenous laser irradiation of the blood on the brain bioelectrical activity in patients in the postcomatose period].

The article presents clinical data on therapeutic effects of intravenous laser blood irradiation (BI) in severe alcohol intoxication complicated by alcohol coma. BI effectiveness was assessed by EEG changes within 3 postcomatose days. Changes in brain biopotentials in various postcomatose periods were unidirectional. Positive results were achieved after low-intensity laser radiation.

Adolescent↗