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PubMed1981

Electrocardiographic signs of pulmonary hypertension in children who snore.

Two children presented with sleep disturbances due to enlarged tonsils and adenoids. One child died during induction of anaesthesia, and postmortem examination showed hypertrophy of the right ventricle and atrium. As a result a prospective survey was carried out of children undergoing tonsillectomy or adenoidectomy, or both. During a nine-month period an electrocardiogram was taken in 92 children. Three electrocardiograms (3.3%) showed evidence of right heart strain. The children with abnormal electrocardiograms had symptoms of sleep disturbance with apnoea, snoring, and daytime somnolence. These symptoms and the electrocardiographic changes were reserved by adenotonsillectomy. The prevalence of pulmonary hypertension in children with enlarged tonsils and adenoids is still underestimated. When signs and symptoms of sleep disturbance, particularly snoring, are present an electrocardiogram should be obtained and a cardiologist's opinion sought before embarking on routine surgery in view of the potentially fatal consequences.

Adenoids↗
PubMed2000

Haematopoietic cancer and medical history: a multicentre case control study.

BACKGROUND: Viruses (such as Epstein-Barr virus) and pathological conditions (mainly involving immunosuppression) have been shown to increase the risk of haematolymphopoietic malignancies. Other associations (diabetes, tonsillectomy, autoimmune diseases) have been inconsistently reported. METHODS: The association between different haematolymphopoietic malignancies (lymphomas, myelomas and leukaemias) and the previous medical history has been studied in a population-based case-control investigation conducted in Italy, based on face to face interviews to 2669 cases and 1718 population controls (refusal rates 10% and 19%, respectively). Controls were a random sample of the general population. RESULTS: Previous findings were confirmed concerning the association between non-Hodgkin's lymphoma (NHL) and lupus erythematosus (odds ratio, OR=8.4; 95% CI 1. 6, 45), tuberculosis (OR=1.6; 1.05, 2.5) and hepatitis (1.8; 1.4, 2. 3). An association was found also between NHL and maternal (OR=2.8; 1.1, 6.9) or paternal tuberculosis (OR=1.7; 0.7, 3.9). Odds ratios of 4.0 (1.4, 11.8) and 4.4 (1.1, 6.6) were detected for the association between NHL and Hodgkin's disease, respectively, and previous infectious mononucleosis, but recall bias cannot be ruled out. No association was found with diabetes, tonsillectomy and adenoidectomy. An association with malaria at young age and "low grade" lymphatic malignancies is suggested. One interesting finding was the observation of four cases of poliomyelitis among NHL patients, one among Hodgkin's disease and one among myeloid leukaemia patients, compared with none among the controls (Fisher's exact test for NHL and Hodgkin's disease, p= 0.03, one tail). CONCLUSIONS: Some of these findings are confirmatory of previous evidence. Other observations, such as the putative role of the polio virus and of malaria are new. A unifying theory on the mechanisms by which previous medical history may increase the risk of haematolymphopoietic malignancies is still lacking.

Adult↗
PubMed2000

Otorhinolaryngology.

Otorhinolaryngology, a product of the early 20th century, developed from the joining together of the separate departments of otology, whose practitioners were surgeons, and laryngology which was managed by physicians who also treated diseases of the nose and chest. The 20th century opened with brave attempts to perform skilful surgery under conditions of primitive anaesthesia and no antibiotics. The stimulus of two world wars led to significant advances in technology and greater opportunities to explore new and resurrect old surgical procedures. The discovery of antibiotics saw an end to acute mastoiditis and the complications of otitis media and sinusitis, as well as a decline in the number of tonsillectomy and adenoidectomy operations. Over the last 30 years the specialty has undergone dramatic development and has taken advantage of new advances in endoscopy, microsurgery, the use of lasers, cytotoxic drugs, flap reconstruction and microchip technology. During the same period, although still calling themselves otorinolaryngologists, individual surgeons have subspecialised in otology, otoneurosurgery and skull-base surgery, head and neck surgery, phonosurgery, rhinology and facioplastic surgery, and paediatric otothinolaryngology. Each of these subspecialties has its own societies and specialist journals.

History, 20th Century↗
PubMed1994

Upper airway collapsibility in children with obstructive sleep apnea syndrome.

In adults, the critical nasal pressure (Pcrit) at which the upper airway collapses is higher in patients with the obstructive sleep apnea syndrome (OSAS) than in those with primary snoring. Pediatric OSAS differs clinically from adult OSAS. We therefore compared Pcrit between prepubertal children with OSAS and primary snoring. Pcrit was determined by correlating the maximal inspiratory airflow with the level of positive or negative nasal pressure applied via a nasal mask. As in adults, we found that the maximal inspiratory airflow varied in proportion to the upstream (nasal) rather than the downstream (esophageal) pressure changes. Pcrit was 1 +/- 3 cmH2O in OSAS compared with -20 +/- 9 cmH2O in primary snorers (P < 0.002). In three OSAS patients reevaluated after tonsillectomy and adenoidectomy, Pcrit declined to -7.2 +/- 4.0 cmH2O. We conclude that the pediatric airway behaved as predicted by the Starling resistor model and that Pcrit, a measure of airway collapsibility, correlated with the degree of upper airway obstruction and was reduced postoperatively, consistent with increased upper airway stability.

Adenoids↗
PubMed2006

Pharyngeal critical pressure in children with mild sleep-disordered breathing.

There is evidence that narrowing or collapse of the pharynx can contribute to obstructive sleep-disordered breathing (SDB) in adults and children. However, studies in children have focused on those with relatively severe SDB who generally were recruited from sleep clinics. It is unclear whether children with mild SDB who primarily have hypopneas, and not frank apnea, also have more collapsible airways. We estimated airway collapsibility in 10 control subjects (9.4 +/- 0.5 yr old; 1.9 +/- 0.2 hypopneas/h) and 7 children with mild SDB (10.6 +/- 0.5 yr old; 11.5 +/- 0.1 hypopneas/h) during stable, non-rapid eye movement sleep. None of the subjects had clinically significant enlargement of the tonsils or adenoids, nor had any undergone previous tonsillectomy or adenoidectomy. Airway collapsibility was measured by brief (2-breath duration) and sudden reductions in pharyngeal pressure by connecting the breathing mask to a negative pressure source. Negative pressure applications ranging from -1 to -20 cmH(2)O were randomly applied in each subject while respiratory airflow and mask pressure were measured. Flow-pressure curves were constructed for each subject, and the x-intercept gave the pressure at zero flow, the so-called critical pressure of the upper airway (Pcrit). Pcrit was significantly higher in children with SDB than in controls (-10.8 +/- 2.8 vs. -15.7 +/- 1.2 cmH(2)O; P < 0.05). There were no significant differences in the slopes of the pressure-flow relations or in baseline airflow resistance. These data support the concept that intrinsic pharyngeal collapsibility contributes to mild SDB in children.

Child↗
PubMed2006

[Anesthesias for the youngest and the oldest: pediatric and geriatric practice in Catalonia, Spain].

BACKGROUND AND OBJECTIVE: The objective of this arm of the ANESCAT 2003 study was to analyze the characteristics of the youngest and oldest patients receiving anesthesia in Catalonia, Spain, and the procedures for which they require it. PATIENTS AND METHOD: We analyzed data from questionnaires pertaining to pediatric (under age 14 years) and geriatric patients (older than age 65 years). RESULTS: Pediatric patients underwent 6.3% of all anesthetic procedures and patients over 65 years old accounted for 32.9% of the sample population. Two of every 3 pediatric patients were males, whereas 55% of patients over age 65 years were females. The most frequently performed interventions requiring anesthesia in patients under 14 years of age were tonsillectomy and/or adenoidectomy (19.3%), nonsurgical procedures (11.5%), circumcision (10.6%), inguinal herniorrhaphy (8.3%), and appendectomy (4.2%). The most common procedures in elderly patients were cataract extraction (31.9%), nonsurgical procedures (9.5%), inguinal herniorrhaphy (4.4%), total knee replacement (3.6%), transurethral bladder surgery (3.2%), and repair of femoral neck fractures (2.6%). Because of the high incidence of appendectomy in patients between 8 and 14 years old and of femoral neck fractures in patients over 85 years old, the rate of emergency anesthesias in patients in those age brackets was around 30%. CONCLUSIONS: Pediatric and geriatric patients and the interventions for which they are administered anesthesia have particular features. Taking them into consideration in the short term would facilitate the development of new therapeutic strategies and the introduction of changes in health care organization.

Adolescent↗
PubMed2005

Tonsillectomy using the thermal welding system.

OBJECTIVE: To evaluate and introduce a new method of tonsillectomy using the Thermal Welding System (TWS). METHOD: The TWS is a new surgical instrument which uses direct heat and pressure to seal and divide tissues. Fifty consecutive patients underwent tonsillectomy with the use of the TWS. Inclusion criteria were chronic tonsillitis, peritonsilar abscess history and obstructive sleep apnea syndrome. Patients undergoing adenoidectomy or any other procedure together with tonsillectomy and patients with bleeding disorders were excluded. Intraoperative bleeding, operative time, complication rates and return to normal diet were evaluated. RESULTS: There was no measurable bleeding during surgery in any case. No postoperative hemorrhage or other complication occurred. Mean operative time was 23 min. Mean time for return to normal diet was 8.7 days. CONCLUSIONS: The TWS was found quite effective and safe, providing sufficient hemostasis and minimal intraoperative blood loss.

Adolescent↗
PubMed1994

[Synopsis of results with 1,300 children with language developmental delay from the etiopathogenetic, audiologic and speech pathology viewpoint].

This study presents the results of 1,305 children with speech disorders. The examination included ENT inspection, audiometry, speech evaluations and if required, psychological tests. In 48% we found hearing loss, most frequently in the age-group up to 4 years. In 95% hearing loss fluctuated about 20 dB, caused by malfunction of the tube or by adenoids, not only in autumn and winter, but throughout the year. In this case, the total hearing input of these children is reduced. In only 5% we found cochlear hearing loss. In hearing-impaired children the speech development was significantly depressed in all dimensions in comparison with normal-hearing children. 19% of the children were generally delayed in development. Other causes of speech disorders were less important. This study demonstrates the necessity of follow-up microscopy of the tympanic membrane, audiometry and operative therapy including adenoidectomy and insertion of ventilation tubes. With this concept, only 37% of the children required speech therapy.

Child↗
PubMed1981

Tympanometry in three-year-old children. The 3-year follow-up of a cohort study.

All 3-year-old children in a region were screened by tympanometry in January 1976 (503 children), and the 6-year-olds of the same region had tympanometric and tone audiometric screening in January 1979 (498 children), 70% being included both times. Significant improvement in middle ear status had occurred from the age of 3-6 years, but otherwise there was surprisingly little difference between the two age levels, e.g., about one-third of the tympanograms were abnormal in both age groups. Ears having a middle ear pressure of 0 to -99mm H2O at 3 years showed significantly better impedance audiology at 6 years, but as regards hearing loss they proved to be like cases who had previously had more or less negative pressure in the middle ear. Out of the flat tympanograms at 3 years a quarter were still flat at 6 years, and every sixth child did not pass tone audiometric screening. The subgroups boys/girls, nursery school/homecare children, urban/rural children that had exhibited differences in middle ear function at 3 years showed identical results at 6 years. A favourable effect of systematic tracing and active treatment of middle ear pathology from the age of 3 years could not be found at tone audiometry and impedance testing at 6 years. This must, inter alia, shake faith in adenoidectomy as a therapeutic or preventive procedure in dealing with middle ear pathology.

Acoustic Impedance Tests↗
PubMed1994

Internal carotid artery redundancy is significantly associated with dissection.

BACKGROUND AND PURPOSE: Redundant internal carotid arteries have been considered a risk factor in tonsillectomy, adenoidectomy, and surgical treatment of peritonsillar abscess and also a potentially treatable cause of stroke. However, an association between internal carotid artery redundancy and spontaneous dissection has not yet been clearly demonstrated. METHODS: We reviewed, for spontaneous carotid artery dissection, records of all patients admitted to our institution during the period from 1986 through 1992 with the diagnosis of stroke or transient ischemic attack. We also reviewed 108 percutaneous cerebral arteriograms performed between September 1992 and December 1992 for presence of carotid artery redundancies. RESULTS: Thirteen patients exhibited spontaneous dissection. Of these, 8 of 13 (62%) patients and 13 of 20 (65%) internal carotid arteries, viewed to the siphon, had significant redundancies, kinks, coils, or loops. Of 108 consecutive arteriograms of patients without dissection, in which 187 internal carotid arteries were viewed to the siphon, there were 20 (19%) patients and 22 (12%) of 187 vessels with significant redundancy. Five patients in the dissection group and 2 in the nondissection group had bilateral internal carotid artery redundancy (P = .0019 and P = .0001, respectively). CONCLUSIONS: We found a significant correlation between internal carotid artery redundancy and dissection, particularly if redundancy is present bilaterally.

Adult↗
PubMed2000

Mastoiditis and acute otitis media in children with cochlear implants: recommendations for medical management.

Acute otitis media (OM) or mastoiditis is a very dangerous condition for the ear after cochlear implantation. However, acute OM is very common in childhood and can occasionally occur in an implanted ear. Most cases of acute OM can be successfully treated with intravenous high-dosage antibiotics. In cases of mastoiditis and clinical signs of mastoid abscess, retroauricular drainage is necessary to prevent infection of the implant bed. In a series of 366 children given implants (1 to 14 years), acute OM occurred in 5.6% during a follow-up period of 1 to 8 years. Seven ears had to be opened by means of myringotomy. Five ears were opened by retroauricular incision with mastoid revision on the implanted side. Adenoidectomy and use of ventilation tubes before cochlear implantation, as well as careful subtotal mastoidectomy during the implantation, can reduce the incidence of acute OM in children after implantation. Early and subsequent treatment with operative mastoid drainage can prevent implant loss and should be performed at the implantation center.

Acute Disease↗
PubMed2001

Retropharyngeal autologous fat transplantation for congenital short palate: a nasometric assessment of functional results.

Seventeen patients (4 to 24 years old; mean, 9.7 years) with mild velopharyngeal insufficiency were treated in our department during the period 1996 to 1999 with augmentation of the posterior pharyngeal wall with autologous fat. The main disorder was a congenital short palate without a cleft, in most cases revealed by adenoidectomy. Four patients had previously undergone pharyngoplasty, and 1 had already been injected in the posterior pharyngeal wall with Teflon paste. All patients had been exhaustively treated with speech therapy, and the result remained unsatisfactory. The functional outcome of the surgical procedure was quantified by acoustic nasometry. The decrease of the nasalance percentage for a standardized spoken passage was significant 1 to 3 months after the fat transplantation, and there was a slight tendency to further reduction of nasality at the late follow-up visit, more than 6 months (average, 9.4 months) after the intervention. The mean value of the nasalance score for the "normal passage" (running speech) then reached the limit of normal values. A long-term follow-up (average, 24.3 months) by telephone questionnaire confirmed the persistence of the beneficial results. Autologous fat seems an excellent alternative for Teflon in this indication. Acoustic nasometry allows a precise quantitative assessment of functional velopharyngeal surgery.

Adipose Tissue↗
PubMed2002

Interference of nontypeable Haemophilus influenzae and Moraxella catarrhalis by Streptococcus oralis in adenoid organ culture: a possible strategy for the treatment of the otitis-prone child.

The role of viridans group streptococci (Streptococcus oralis) in the prevention of colonization with nontypeable Haemophilus influenzae and Moraxella catarrhalis was investigated in an adenoid organ culture system. The adenoids from 100 patients who were undergoing adenoidectomy for either hypertrophy or recurrent otitis media were used. Streptococcus oralis Parker uniformly inhibited colonization with nontypeable H. influenzae or M. catarrhalis over a 24-hour period of incubation in adenoid organ culture. Streptococcus oralis Booth, a noninhibitory strain, did not significantly reduce colonization with nontypeable H. influenzae and M. catarrhalis. The results indicate that some strains of S. oralis may inhibit colonization with potential pathogens in the nasopharynx. It is therefore possible that colonization with inhibitory strains of viridans streptococci may be used in the nasopharynx as a relatively safe and inexpensive approach to prevention of recurrent otitis media in some children.

Adenoids↗
PubMed2004

Effect of antimicrobial therapy with amoxicillin and cefprozil on bacterial interference and beta-lactamase production in the adenoids.

To compare the effects on the bacterial flora of the adenoids of antimicrobial therapy with amoxicillin or cefprozil, we enrolled in a prospective randomized study 60 children scheduled for elective adenoidectomy because of recurrent otitis media. They were randomized before surgery into 3 groups of 20 patients each: a no-therapy group, and groups with 10 days of either amoxicillin or cefprozil therapy. Core adenoid materials were quantitatively cultured for aerobic and facultative bacteria. The in vitro ability of alpha-hemolytic streptococci (AHS) to inhibit the growth of non-type B Haemophilus influenzae and Streptococcus pneumoniae was determined. The number of organisms in adenoids obtained from patients treated with either antibiotic was reduced as compared to that in adenoids from controls. However, in patients treated with amoxicillin, a significant decline in the number of AHS, and an increase (in Staphylococcus aureus) or no change in the number of other beta-lactamase-producing bacteria (BLPB) was noted. In contrast, in those treated with cefprozil, no change was noted in the frequency of recovery of AHS, and the number of BLPB decreased. Interfering AHS were more often recovered in patients treated with cefprozil. We conclude that the adenoids contain more interfering AHS after therapy with a second-generation oral cephalosporin (cefprozil) than after amoxicillin therapy. This study suggests a potential beneficial effect of using an antimicrobial that selectively spares interfering AHS while inhibiting BLPB.

Adenoids↗
PubMedDate not supplied

Pediatrician's view of middle ear effusions: more questions than answers.

Although middle ear effusion is the most common of the chronic conditions encountered in pediatric practice, it frequently goes unrecognized, and relatively little is known about its epidemiology or its natural history. More importantly, the impact of middle ear effusion on the overall well-being of infants and children, and on their cognitive and language development, remains essentially unexplored. In part because of these gaps in our knowledge, and also because prospective, controlled treatment trials have not been reported, uncertainty and controversy exist concerning: 1) the necessity, in many instances, of treating middle ear effusion; 2) the choice of various treatment methods; and 3) the timing of those treatments that are undertaken. Finally, the widespread use of adenoidectomy to prevent middle ear inflammation is seriously lacking in supporting evidence. A few reported studies bear on some of these questions, but both their scope and the information they provide are limited. In order to resolve important prognostic and treatment issues concerning middle ear effusion during infancy and childhood, carefully designed epidemiologic and clinical studies of types not hitherto reported are urgently needed.

Child↗
PubMedDate not supplied

Papillary hypertrophy of the palatine tonsils.

Papillary hypertrophy of the tonsils is one of the rare abnormalities of the palatine tonsils. Since the first reports of papillary hypertrophy of the tonsils by Ogino and Matsui, only 30 cases of this disease have been reported in Japan. The etiology of papillary hypertrophy remains a myster. A 5-year-old female visited our clinic with a complaint of obstructive feeling in the throat. Papillary surface of the palatine tonils were noticed. Tonsillectomy and adenoidectomy were performed under general anesthesia on October 25, 1977. the histopathological examination of the tonsils revealed the lymphoid hyperplasia with poor subepithelial connective tissues. Only slight chronic inflammation was present. This papillary hypertrophy of the tonsils was found in 13 members (6 male, 7 female) of her family pedigree. Genetical analysis of the pedigree showed this disease is transmitted by an autosomal dominant gene.

Adolescent↗
PubMedDate not supplied

Acoustic reflex as a predictor of middle ear effusion.

The comparative efficacy of tympanometry and the acoustic reflex (threshold and supraliminal amplitude) in predicting the presence of fluid in the middle ear was studied just before myringotomy in 50 children (99 ears) prior to adenoidectomy. Impedance audiometry was carried out under a general anesthetic (ketamine and nitrous oxide) in 60%, and without anesthesia in 40% of the cases. The comparative efficacy of this test was assessed using objective criteria which were independent of the cut-off point between normal and abnormal groups. The prediction efficacy of acoustic reflex threshold and amplitude (Youden's index = 0.58) was superior to that of tympanometry peak amplitude and pressure (Youden's indexes = 0.29 and 0.36). The efficacy of the gradient was 0.41. Modifications due to anesthesia were not statistically significant for the whole group, but temporary abolition of the acoustic reflex at the start of anesthesia is probably related to the high percentage of false positives noted when the acoustic reflex is used alone in patients given a general anesthetic.

Acoustic Impedance Tests↗
PubMedDate not supplied

Serous otitis media and type 1 tympanoplasties in children. A retrospective study.

The prevalence of serous otitis media has caused a philosophical difference as to when a tympanoplasty should be performed in children. This retrospective study of 74 children (aged 3-17) who underwent 80 operations was undertaken to investigate this problem. The overall success rate for type 1 tympanoplasty was 66%. Age was not a reliable factor in predicting successful results. A history of recurrent serous otitis media was not an important indicator. Adenoidectomy did not influence the surgical outcome. The status of the nonoperated ear was probably a significant factor. Type 1 tympanoplasty has a reasonably good chance of success in children regardless of age and/or previous middle ear ventilation problems. However, a good clinical test of eustachian tube function is still needed to improve further the predictability of timpanoplasty in children.

Adolescent↗