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PubMed2000

Temperature and photoperiod interact to affect reproduction and GnRH synthesis in male prairie voles.

Prairie voles (Microtus ochrogaster), like most rodent species, exhibit a phenotypic polymorphism in reproductive response to winter conditions or to short day lengths in the laboratory. Laboratory studies on seasonally breeding species have traditionally focused on the role of photoperiod in modulating reproduction and other seasonal adaptions. However, because animals use proximate environmental factors in addition to photoperiod to phase seasonal adaptions with the appropriate time of year, the present study investigated the interaction of photoperiod and temperature on reproductive function and the gonadotropin-releasing hormone (GnRH) neuronal system. Male prairie voles were housed in either long (LD 16:8) or short (LD 8:16) photoperiods. Voles in each photoperiodic condition were also exposed to either mild (20 degrees C) or low (8 degrees C) temperatures. After 10 weeks, voles were killed and their brains were processed using in situ hybridization for mRNA for proGnRH. The results suggest that GnRH synthesis is not affected by exposure to a single inhibitory proximate factor (i.e. short days or low temperatures alone), even when reproduction is inhibited, whereas a combination of inhibitory proximate factors leads to a decrease in GnRH synthesis (i.e. fewer neurones staining for mRNA for proGnRH). These data suggest that the neuroendocrine mechanisms regulating seasonal alterations in reproductive function are likely to differ between harsh and mild winters.

Animals↗
PubMed2003

Reproduction and resistance to stress: when and how.

Environmental and social stresses have deleterious effects on reproductive function in vertebrates. Global climate change, human disturbance and endocrine disruption from pollutants are increasingly likely to pose additional stresses that could have a major impact on human society. Nonetheless, some populations of vertebrates (from fish to mammals) are able to temporarily resist environmental and social stresses, and breed successfully. A classical trade-off of reproductive success for potential survival is involved. We define five examples. (i) Aged individuals with minimal future reproductive success that should attempt to breed despite potential acute stressors. (ii) Seasonal breeders when time for actual breeding is so short that acute stress should be resisted in favour of reproductive success. (iii) If both members of a breeding pair provide parental care, then loss of a mate should be compensated for by the remaining individual. (iv) Semelparous species in which there is only one breeding period followed by programmed death. (v) Species where, because of the transience of dominance status in a social group, individuals may only have a short window of opportunity for mating. We suggest four mechanisms underlying resistance of the gonadal axis to stress. (i) Blockade at the central nervous system level, i.e. an individual no longer perceives the perturbation as stressful. (ii) Blockade at the level of the hypothalamic-pituitary-adrenal axis (i.e. failure to increase secretion of glucocorticosteroids). (iii) Blockade at the level of the hypothalamic-pituitary-gonad axis (i.e. resistance of the reproductive system to the actions of glucocorticosteroids). (iv) Compensatory stimulation of the gonadal axis to counteract inhibitory glucocorticosteroid actions. Although these mechanisms are likely genetically determined, their expression may depend upon a complex interaction with environmental factors. Future research will provide valuable information on the biology of stress and how organisms cope. Such mechanisms would be particularly insightful as the spectre of global change continues to unfold.

Animals↗
PubMed1999

Reproductive mode and population genetic structure of the cereal aphid Sitobion avenae studied using phenotypic and microsatellite markers.

As French populations of the aphid Sitobion avenae exhibit a range of reproductive modes, this species provides a good opportunity for studying the evolution of breeding system variation. The present analysis combined ecological and genetic investigations into the spatial distribution of variation in reproductive mode. Reproductive mode was characterized in 277 lineages of S. avenae from France, and these aphids were scored for five microsatellite loci. The analyses revealed strong geographical partitioning of breeding systems, with obligate asexuals mostly restricted to the south of France, while lineages producing sexual forms were more common in the north. Contrary to what might be anticipated for organisms with frequent parthenogenesis, there was substantial genic and genotypic diversity, even in the obligately asexual lineages. More than 120 different genotypes were detected among the 277 aphid lineages, with an average of 5.9 alleles per locus (range four to 16) and heterozygosity of 56.7%. As with previous studies of allozyme variation in aphids, most loci showed heterozygote deficits, and disequilibrium was common among allelic variants at different loci, even after removal of replicate copies of genotypes that might have been derived through clonal reproduction. Our results suggest that selection is important in structuring reproductive systems and genetic variation in French S. avenae. Canonical correspondence analysis was employed to examine the associations between genotypic and phenotypic variables, enabling the identification of alleles correlated with life-history traits.

Animals↗
PubMed2000

Men's sexual health matters: promoting reproductive health in an international context.

Recent concern regarding the control of sexually transmitted infections (STIs) has resulted in an increased interest in the sexual health of men. This interest has primarily focused on strategies to 'encourage and enable men to take responsibility for their sexual and reproductive behaviour and their social and family roles' (United Nations 1994). Whilst men are deemed to have 'responsibilities', women are said to have 'rights' with regard to making choices about reproductive health and accessing appropriate and effective services. Here it is argued that, whilst provision of services and interventions against STIs in men should never be at the expense of those for women, it is often clinically easier and more effective to diagnose and treat men with STIs compared to women in resource-poor settings. Indeed, this may prove to be an effective strategy in controlling the spread of STIs, and hence reducing the disproportionate burden of their complications suffered by women. The paper reviews key issues in relation to improved service delivery for sexual and reproductive health in men, notably: the heterogeneity of male populations; current knowledge regarding men's sexual behaviour; the role of sexuality; methods of studying sexual behaviour in resource poor countries; men's own concerns in relation to sexual and reproductive health; and where and how they access treatment. It is argued that the time has now come to determine and address men's sexual health needs if we are to expect them to participate fully as responsible partners in improving and protecting their own and others' sexual and reproductive health.

Delivery of Health Care↗
PubMed2003

Reproductive performance of rats supplemented with L-carnitine.

It has been shown previously that supplementation of sows with l-carnitine increases their reproduction performance. The current study was carried out to investigate if feeding of l-carnitine also affects the reproduction performance of rats. Thirty female rats at 4 weeks of age were divided into two groups. The rats were fed diets with or without l-carnitine (1 g/kg diet) over a period of 34 weeks. After 8 weeks of feeding, the female rats were mated the first time. Two more reproductive cycles followed, with 3-week intervals in between. Body weight development of the females was similar in both groups during the whole experimental period. Number of pregnancies and number of total rat pups, pups born alive and stillborn pups were not influenced by l-carnitine. There was also no influence of dietary l-carnitine on the body weight of individual pups and the litter weights at birth. Weight development of litters differed between both groups on several days, but no uniform effect of l-carnitine was observed. Body weight development of weaned rats fed a commercial diet was different between both groups, but only in one reproduction cycle. In conclusion, this study shows that l-carnitine supplementation does not improve the reproductive performance of rats.

Animals↗
PubMedDate not supplied

Developmental constraints on the mode of reproduction in the facultatively parthenogenetic cockroach Nauphoeta cinerea.

Considerable work in evolutionary biology has focused on the question of why sex persists. Both advantages to sex and constraints limiting a return to asexual reproduction are hypothesized to maintain sex once it evolves. Developmental constraints would limit asexual reproduction from a sexual species if it were difficult for females to switch from making eggs that do not develop without fertilization to making zygotes that are capable of developing in the absence of fertilization. Nauphoeta cinerea is an ovoviviparous cockroach in which some females are capable of switching from a sexual mode of reproduction to an asexual mode when isolated from males. Yet, while facultative parthenogenesis can occur in individuals, few females make the switch. Thus, this cockroach provides an ideal system for examining the potential role of developmental constraints in maintaining sex. Here we compare the cytogenetics and embryonic development of sexual and parthenogenetic offspring in N. cinerea. We find that deviations from normal ploidy levels are associated with abnormal development. All viable N. cinerea embryos exhibit typically hemimetabolous insect embryogenesis. Although there is no variation among embryos in development within a sexually produced clutch, we see extreme variation in asexually derived clutches. These results suggest that developmental constraints limit the success of asexual reproduction in this facultatively parthenogenetic cockroach. Our data further suggest that the specific constraint occurs in the switch from a meiotic mode of reproduction requiring fertilization to diploid zygotes that develop in the absence of fertilization.

Animals↗
PubMed2001

Assessing fertility in women of advanced reproductive age.

Reproductive capacity in women declines dramatically beyond the fourth decade of life. Oocyte quality seems to be the primary determinant of reproductive potential, although age-related uterine changes may also contribute. Underlying reasons for reproductive decline in women remain unclear, and both ovarian and neuroendocrine mechanisms have been proposed.A number of age-related endocrinologic changes precede menopause and predict diminished reproductive capacity. Thus, "ovarian reserve" screening may identify patients in whom attempts at conventional assisted reproduction is warranted before proceeding with ovum donation. Techniques to preserve the maternal genetic contribution to offspring (in lieu of egg donation), including germinal vesicle transfer and donor ooplasm, are under investigation.

Adult↗
PubMed2002

Providing research and research training infrastructures for clinical research in the reproductive sciences.

The Reproductive Sciences Branch of the National Institutes of Child Health and Human Development has created pioneering new research and research training programs that address the impending shortage of physician-scientists in obstetrics, gynecology, and women's health and the need to bolster translational and clinical research. This article provides a brief overview of the Specialized Cooperative Centers Program in Reproduction Research, the National Cooperative Program for Infertility Research, the Reproductive Medicine Network, the Reproductive Scientist Development Program, the Women's Reproductive Health Research Career Development Program, and the Contraception and Infertility Research Loan Repayment Program and describes how these programs collectively create an infrastructure to promote the next generation of physician-scientists and to provide an information exchange between basic and clinical investigators. A key component in increasing the number of clinical investigators is the Contraception and Infertility Research Loan Repayment Program. This program has enabled clinicians to be involved in research without having to be concerned about educational loan debt. Other component programs provide basic/translational, clinical hypothesis-oriented research and clinical trials research infrastructure. The programs created are individually strong and collectively poised to support translational and clinical research efforts and to build a well-trained cadre of physician-scientists. The collective use of these types of programs is proposed as a model for the National Institutes of Health.

Contraception↗
PubMed2006

Preachers, policies and power: the reproductive health of adolescent Aboriginal and Torres Strait Islander peoples in Australia.

The sexual abuses of Indigenous peoples are not a new phenomenon. Many historical documents attest to the active ruination of the sexual and reproductive health of Indigenous peoples in Australia; however, reproductive health is rarely considered to be an appropriate strategy through which Aboriginal and Torres Strait Islander people's lives can be improved. Reproductive health is essential for the replication and evolution of societies and therefore warrants close attention, especially as contemporary policy frameworks place Aboriginal and Torres Strait Islander women approximately 50 years behind non-Indigenous women in our capacities to practice individual autonomy in reproductive decision making, including the positive resolution of pregnancies and ensuring the health, dignity, security and autonomy of victims of gender-based violence. This paper is an examination of contemporary reproductive health issues for adolescents in Aboriginal and Torres Strait Islander communities and a call to action to assist young men and young women in particular to value and have every capacity to control their fertility.

Abortion, Legal↗
PubMed2004

Reproductive performance in female Clock Delta19 mutant mice.

The relationship between circadian rhythmicity and rodent reproductive cyclicity is well established, but the impact of disrupted clock gene function on reproduction has not been well established. The present study evaluated the reproductive performance of mice carrying the Clock(Delta19) mutation that were either melatonin deficient (Clock(Delta19/Delta19)) or had the capacity to synthesise melatonin reinstated (Clock(Delta19/Delta19)+MEL). The Clock(Delta19/Delta19) mice took 2-3 days longer to mate, and to subsequently deliver pups, than their control line. The melatonin-competent mutants had a smaller, but still significant (P < 0.05), delay. The Clock(Delta19) mutation resulted in smaller median litter sizes compared with control lines (seven v. eight pups; P < 0.05), whereas melatonin proficiency reversed this difference. Survival to weaning was 84% and 80% for the Clock(Delta19/Delta19) and Clock(Delta19/Delta19)+MEL lines, respectively, compared with 94-96% for the two control lines. The Clock(Delta19/Delta19) mutants became behaviourally arrhythmic in constant darkness but, despite this, seven of seven became pregnant when paired with males after at least 14 days of constant darkness (five of seven within 4 days of pairing). In the Clock(Delta19/Delta19)+MEL mice, seven of 15 became arrhythmic in constant darkness but still became pregnant. The seven mice that free ran for at least 14 days in constant darkness with a period of 27.1 h also became pregnant. The present study has demonstrated that the Clock(Delta19) mutation has significant, but subtle, effects on reproductive performance. The reintroduction of melatonin competency and/or other genes as a result of crosses with CBA mice reduced the impact of the mutation further. It would appear that redundancy in genes in the circadian system allows the reproductive cyclicity to persist in mice, albeit at a suboptimal level.

Animals↗
PubMed2006

Society for Reproductive Biology Founders' Lecture 2006 - life in the pouch: womb with a view.

Marsupials give birth to an undeveloped altricial young after a relatively short gestation period, but have a long and sophisticated lactation with the young usually developing in a pouch. Their viviparous mode of reproduction trades placentation for lactation, exchanging the umbilical cord for the teat. The special adaptations that marsupials have developed provide us with unique insights into the evolution of all mammalian reproduction. Marsupials hold many mammalian reproductive 'records', for example they have the shortest known gestation but the longest embryonic diapause, the smallest neonate but the longest sperm. They have contributed to our knowledge of many mammalian reproductive events including embryonic diapause and development, birth behaviour, sex determination, sexual differentiation, lactation and seasonal breeding. Because marsupials have been genetically isolated from eutherian mammals for over 125 million years, sequencing of the genome of two marsupial species has made comparative genomic biology an exciting and important new area of investigation. This review will show how the study of marsupials has widened our understanding of mammalian reproduction and development, highlighting some mechanisms that are so fundamental that they are shared by all today's marsupial and eutherian mammals.

Animals↗
PubMed2004

Reproductive ground plan may mediate colony-level selection effects on individual foraging behavior in honey bees.

The colony-level phenotype of an insect society emerges from interactions between large numbers of individuals that may differ considerably in their morphology, physiology, and behavior. The proximate and ultimate mechanisms that allow this complex integrated system to form are not fully known, and understanding the evolution of social life strategies is a major topic in systems biology. In solitary insects, behavior, sensory tuning, and reproductive physiology are linked. These associations are controlled in part by pleiotropic networks that organize the sequential expression of phases in the reproductive cycle. Here we explore whether similar associations give rise to different behavioral phenotypes in a eusocial worker caste. We document that the pleiotropic genetic network that controls foraging behavior in functionally sterile honey bee workers (Apis mellifera) has a reproductive component. Associations between behavior, physiology, and sensory tuning in workers with different foraging strategies indicate that the underlying genetic architectures were designed to control a reproductive cycle. Genetic circuits that make up the regulatory "ground plan" of a reproductive strategy may provide powerful building blocks for social life. We suggest that exploitation of this ground plan plays a fundamental role in the evolution of social insect societies.

Animals↗
PubMed2005

Mountain gorilla tug-of-war: silverbacks have limited control over reproduction in multimale groups.

To determine who fathers the offspring in wild mountain gorilla groups containing more than one adult male silverback, we genotyped nearly one-fourth (n = 92) of the mountain gorillas (Gorilla beringei beringei) living in the Virunga Volcanoes region of Africa. Paternity analysis of 48 offspring born into four groups between 1985 and 1999 revealed that, although all infants were sired by within-group males, the socially dominant silverback did not always monopolize reproduction within his group. Instead, the second-ranking male sired an average of 15% of group offspring. This result, in combination with previous findings that second-ranking males fare best by not leaving the group but by staying and waiting to assume dominance even if no reproduction is possible while waiting, is not consistent with expectations from a reproductive skew model in which the silverback concedes controllable reproduction to the second-ranking male. Instead, the data suggest a "tug-of-war" scenario in which neither the dominant nor the second-ranking male has full control over his relative reproductive share. The two top-ranked males were typically unrelated and this, in combination with the mixed paternity of group offspring, means that multimale gorilla groups do not approximate family groups. Instead, as long-term assemblages of related and unrelated individuals, gorilla groups are similar to chimpanzee groups and so offer interesting possibilities for kin-biased interactions among individuals.

Animals↗
PubMed1996

Oxytocin is required for nursing but is not essential for parturition or reproductive behavior.

Oxytocin, a neurohypophyseal hormone, has been traditionally considered essential for mammalian reproduction. In addition to uterine contractions during labor and milk ejection during nursing, oxytocin has been implicated in anterior pituitary function, paracrine effects in the testis and ovary and the neural control of maternal and sexual behaviors. To determine the essential role(s) of oxytocin in mammalian reproductive function, mice deficient in oxytocin have been generated using embryonic stem cell technology. A deletion of exon 1 encoding the oxytocin peptide was generated in embryonic stem cells at a high frequency and was successfully transmitted in the germ line. Southern blot analysis of genomic DNA from homozygote offspring and in situ hybridization with an exonic probe 3' of the deletion failed to detect any oxytocin or neurophysin sequences, respectively, confirming that the mutation was a null mutation. Mice lacking oxytocin are both viable and fertile. Males do not have any reproductive behavioral or functional defects in the absence of oxytocin. Similarly, females lacking oxytocin have no obvious deficits in fertility or reproduction, including gestation and parturition. However, although oxytocin-deficient females demonstrate normal maternal behavior, all offspring die shortly after birth because of the dam's inability to nurse. Postpartum injections of oxytocin to the oxytocin deficient mothers restore milk ejection and rescue the offspring. Thus, despite the multiple reproductive activities that have been attributed to oxytocin, oxytocin plays an essential role only in milk ejection in the mouse.

Animals↗
PubMed2005

Effects of artificial supplemental light on the reproductive season of geese kept in open houses.

1. New lighting programmes were designed to change the pattern of goose reproduction, based on the response of predictable avian photoperiodic stimulation. The objective of this study was to evaluate the efficiency of a long photoperiod of 20L on shifting goose reproduction to the non-breeding season in an open housing system. 2. Eighty mature White Roman geese were randomly allocated into 4 groups (male:female = 1:4). The supplemental lighting programmes with a daily photoperiod of 20 h were initiated on 22 November and withdrawn when 90% of geese were moulting in the treatment groups. Artificial light intensities of 220, 120 and 20 lux were provided to experimental groups A, B and C, respectively. In contrast, the geese in control group D were kept under natural lighting conditions throughout this study. 3. The annual reproductive curves of all the experimental groups consisted of two separate laying periods. The first period was induced by the supplemental lighting programme while the second was induced by the naturally increasing photoperiod in this subtropical region. The first laying period of the experimental groups occurred in the breeding season, and the second was relocated to the non-breeding season. 4. The supplemental lighting could shift the laying periods of geese to the non-breeding season and had no significant effect on annual reproductive performance. The supplemental light programmes described here were able to manipulate the reproductive season of geese reared in open houses, which would be of practical value.

Animal Husbandry↗
PubMed1991

Influence of thyroidectomy on reproductive responses of male domestic turkeys (Meleagris gallopavo).

1. The influence of age at thyroidectomy on reproductive activity of male turkeys was investigated. 2. Thyroidectomy of 53-week-old male domestic turkeys that had been reproductively active for 25 weeks resulted in undetectable plasma thyroxine concentrations, termination of semen production and testicular regression. Daily light-dark treatment was 14L:10D before and after thyroidectomy. 3. Thyroidectomy of 28-week-old, reproductively inactive, males maintained on a daily light-dark cycle of 8L:16D resulted in increased semen volumes following photostimulation with 14L:10D at 32 weeks of age. Semen quality was not affected, while plasma thyroid hormone concentrations were undetectable. The moult and termination of semen production that occurred in response to changing the daily light-dark cycle from 14L:10D to 8L:16D near the end of the study were inhibited by thyroidectomy. 4. The requirement for the thyroid glands in the reproductive processes of male turkeys changes either with age or after an extended period of reproductive activity.

Animals↗
PubMed1996

Repeatability and phenotypic correlations for body weight and reproduction in commercial ostrich breeding pairs.

1. Reproduction is an important aspect of ostrich farming, where income is mainly derived from hides and meat. No estimates of repeatability or phenotypic correlations for reproduction and body weight are currently available for commercial ostriches. 2. Means, standard deviations, repeatability coefficients and phenotypic correlations for and among reproductive traits and body weight were computed for the average yearly production of 42 to 67 mixed age ostrich breeding pairs maintained on the Klein Karoo Agricultural Development Centre from 1990 to 1994. The among-breeding-pair variance component was used in the repeatability estimations, as the pairing off of the same male:female combinations repeatedly resulted in the confounding of these effects. 3. Phenotypic correlations of male body weight with egg production performance (-0.20) and female body weight with hatchability percentage (-0.16) were negative. Correlations of egg production performance with infertility (-0.20) and hatchability (0.23) percentages were favourable. 4. The repeatability of annual adult body weight was 0.68 +/- 0.05 in male ostriches and 0.61 +/- 0.05 in females. 5. Ostrich reproduction traits were extremely variable. An appreciable portion of this variation could be attributed to the repeatable nature of breeding pair performance from year to year. All the reproduction traits analysed were moderately repeatable, ranging from 0.38 +/- 0.07 (hatchability percentage) to 0.51 +/- 0.06 (percentage of embryonic deaths). Egg production performance during the first breeding season of 17 breeding pairs for which data were available predicted subsequent performance satisfactorily, suggesting that selection decisions can be made at quite an early age.

Animals↗
PubMed1998

Effects on pubertal growth and reproduction in rats exposed to lead perinatally or continuously throughout development.

The reproductive, endocrine, and growth effects of developmental lead exposure were assessed using a rat model in which 0.6% lead acetate (w/v) was administered in the drinking water ad libitum during different developmental periods to determine if lead actions were a result of direct effects of continuous exposure to the metal ion or secondary to disrupted neonatal "endocrine imprinting." Sprague Dawley rats were exposed to lead: (1) from gestational d 5 through birth; (2) during pregnancy and lactation; (3) during lactation only; (4) from birth through adulthood; or (5) from gestational d 5 through adulthood. Lead effects were measured on the development of aspects of the reproductive system, adult sex steroid levels, and growth rates in both male and female animals. The relative weights of male secondary sex organs in adult offspring were not significantly affected in any of the lead-treated groups. In contrast, female pups exposed to lead from birth through adulthood or from gestational day 5 through adulthood were observed to have significantly delayed vaginal opening and disrupted estrus cycling. These effects on female reproductive physiology were not observed in animals where lead exposure was confined only to pregnancy or lactation. Significant suppression of adult mean serum testosterone levels was only observed in male pups exposed to lead continuously from gestational age 5 d throughout life. Lead decreased birth weight in all animals exposed in utero and mean body weights were significantly decreased in all lead-treated groups up to weaning. Analysis of growth curves revealed that all lead-treated groups had significantly reduced growth rates during lactation. However, in addition, in male pups exposed to lead during pregnancy and lactation, from birth or from gestational age 5 d, growth rates were also significantly reduced during puberty. Postpubertal growth rates were unaffected in any lead-treated group. Thus, delayed female reproductive development and suppression of adult male serum testosterone concentration required continuous exposure to the heavy metal. Little evidence was observed for an alteration of "endocrine imprinting" by lead on either reproductive or growth parameters. Exposure during early development (pregnancy and lactation) resulted in no permanent effects in this model other than small (10%) decreases in the body weight of pups postpuberty.

Administration, Oral↗