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Results for “Pyoderma Gangrenosum”

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PubMed2001

Thalidomide and its dermatologic uses.

This article reviews how the drug thalidomide can be used for various dermatologic disorders. Also included is a short discussion of the chemistry and physiologic mechanisms of thalidomide. Thalidomide, now available again in the United States, is another drug that can be considered by dermatologists for some severe, unusual disorders.

Acquired Immunodeficiency Syndrome↗
PubMed1996

Immune-related systemic manifestations of inflammatory bowel disease. A prospective study of 792 patients.

The prevalence of immune-related systemic manifestations associated with inflammatory bowel disease varies widely in different studies. This prospective hospital study examines the prevalence and clinical aspects of these manifestations. A total of 792 patients, 449 with Crohn's disease and 343 with ulcerative colitis, were followed up from diagnosis to 20 years. Data related to systemic manifestations and to the extent and severity of intestinal lesions were obtained at diagnosis and during follow-up. Extraintestinal manifestations related to the activity of intestinal inflammation appeared at least once in 25.8% of the patients. The cumulative probability of extraintestinal manifestations increased from 12%-30% during the 20-year follow-up; it was significantly higher in patients with Crohn's disease (p < 0.01). Arthritis (p < 0.001) and erythema nodosum (p < 0.01) were more frequent in Crohn's disease. A significant positive association of arthritis with skin, eye, and mouth complications was observed (p < 0.001). Bowel-related systemic manifestations appeared frequently together in the same patient (p < 0.001). Patients with any of these manifestations ran a higher risk of developing another one. Autoimmune manifestations were associated with both Crohn's disease and ulcerative colitis.

Adult↗
PubMed1997

Treatment of extraintestinal complications of ulcerative colitis.

Extraintestinal complications affect 25-30% of patients with ulcerative colitis. These extraintestinal disorders significantly contribute to morbidity and mortality of ulcerative colitis patients. While some disorders parallel the activity of the colitis, other abnormalities run a clinical course independent of the bowel disease. The pathogenesis of these disorders is unknown, but the variable relationships to the severity of colitis and the variable responses to a proctocolectomy suggest considerable heterogeneity. The present therapy for the various manifestations is reviewed in depth. In this respect it is important to note that colectomy should never be mandated by the extraintestinal complications of ulcerative colitis.

Arthritis↗
PubMedDate not supplied

Pyoderma gangraenosum caused by Rhizopus arrhizus.

A rare case of pyoderma gangraenosum caused by Rhizopus arrhizus is reported. The patient, a 50-year-old male farmer, was admitted to hospital complaining of gangrening and festering of the right upper arm with severe pain for nearly 2 months. A lesion was found on the inside of right upper arm. The central skin part of the lesion became black dry gangrenous, the periphery was deeply ulcerated with yellow-green pus. The necrotic crust, biceps, triceps and vessels inherited a histopathologically proven fungal infection. The fungus isolated was identified as Rhizopus arrhizus. The infection was successfully treated with itraconazole.

Humans↗