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PubMed1994

Changes in craniofacial development induced by growth hormone therapy in children treated with bone marrow transplantation.

The effect of growth hormone (GH) treatment on craniofacial development was studied in nine children exhibiting low growth velocity after bone marrow transplantation (BMT). Comparisons were made with seven BMT children who had not received GH. Two groups of age- and sex-matched healthy children served as controls for the respective patient groups. After an average observation period of 3.5 years, the BMT children not treated with GH exhibited significantly reduced mandibular length and alveolar height (p < 0.01). The increase in mandibular length was only 30% of that found in healthy controls. Maxillary growth was less affected by BMT treatment. In the GH treated group, no significant differences were found in craniofacial growth increments compared with controls. Although exogenous GH therapy in this group of children did not induce a catch-up growth, it appears to have prevented further loss in growth potential.

Adolescent↗
PubMed1991

Effect of timing of palatal repair on the transverse development of maxillary alveolar arch in complete-cleft cases.

Forty cleft cases in the age range of 5-12 years where the palatal repair had been performed at 16-24 months (17 cases), 24-36 months (15 cases) and 36-72 months (8 cases) were assessed retrospectively, for the status of maxillary arch and were segregated as acceptable and unacceptable. Plaster casts were prepared from alginate impressions and their graphical reproduction using Huddart's technique, were used to measure the alveolar arch. Anterior palatal measurement (C-C') and posterior palatal measurement (P-P') of the cleft subjects were compared with that in the non-cleft matched controls. The 16-24 month group showed 41.2% acceptable and 58.8% unacceptable arch cases. The 24-36 month group showed that 73.4% had acceptable arches and 26.6% had unacceptable arches. In the 36-72 months group the arch was acceptable in 62.5% cases and unacceptable in 37.5% cases. It was concluded that palatal repair performed before 24 months of age adversely affected the maxillary growth, whereas most favourable growth of maxillary arch occurred when the repair was done between 24-36 months.

Age Factors↗
PubMed2005

Identification of novel CBP interacting proteins in embryonic orofacial tissue.

cAMP response element-binding protein (CREB)-binding protein (CBP) plays an important role as a general co-integrator of multiple signaling pathways and interacts with a large number of transcription factors and co-factors, through its numerous protein-binding domains. To identify nuclear factors associated with CBP in developing orofacial tissue, a yeast two-hybrid screen of a cDNA library derived from orofacial tissue from gestational day 11 to 13 mouse embryos was conducted. Using the carboxy terminus (amino acid residues 1676-2441) of CBP as bait, several novel proteins that bind CBP were identified, including an Msx-interacting-zinc finger protein, CDC42 interaction protein 4/thyroid hormone receptor interactor 10, SH3-domain GRB2-like 1, CCR4-NOT transcription complex subunit 3, adaptor protein complex AP-1 beta1 subunit, eukaryotic translation initiation factor 2B subunit 1 (alpha), and cyclin G-associated kinase. Results of the yeast two-hybrid screen were confirmed by glutathione S-transferase pull-down assays. The identification of these proteins as novel CBP-binding partners allows exploration of new mechanisms by which CBP regulates and integrates diverse cell signaling pathways.

Animals↗
PubMed1998

Mandibular changes in persons with untreated and treated Class II division 1 malocclusion.

The growth potential of individuals with Class II malocclusions is of interest to the practicing orthodontist because such malocclusions constitute a significant percentage of cases. The purpose of this study was to evaluate on cross-sectional and longitudinal bases the changes in mandibular length and relationship and maxillary-mandibular relationships in untreated Class II subjects from deciduous to permanent dentition and also to evaluate the effects of orthodontic treatment, with and without the extraction of first premolars, on these relationships. Class II samples were compared with matched normal, untreated individuals. The Class II division 1 (Class II/1) untreated sample comprised 30 subjects, 15 males and 15 females. Each subject had a complete set of data at three stages of dental development-namely, Stage I, after the completion of eruption of the deciduous dentition; Stage II, at the time when the permanent first molars and most of the incisors have erupted (i.e., in mixed dentition); and Stage III, at the completion of eruption of the permanent dentition, excluding third molars. The Class II treated sample comprised 44 subjects (21 males, 23 females) treated with four first-premolar extractions and 47 subjects (20 males, 27 females) treated without extraction. Treatment was accomplished with the use of an edgewise appliance, appropriate extraoral traction, and Class II elastics. The extraction decision was based mainly on the presence of crowding and profile consideration. Records on 35 normal subjects (20 males, 15 females) were available from the Iowa Longitudinal Facial Growth Study. Cephalograms for the normal individuals were matched to the corresponding ages of the Class II cases. With regard to these findings, few consistent differences were noted between the untreated Class II/1 and normal subjects on cross-sectional comparisons. The differences in mandibular length and position were more evident in the early stages of development than at later stages. Longitudinal comparisons of growth profiles indicated that the growth trends were essentially similar between the untreated Class II/1 and normal subjects in the various parameters compared. The comparisons of growth magnitude indicated the presence of greater skeletal facial convexity in the untreated Class II/1 subjects, accompanied by a tendency for a more retruded mandible. Initial comparisons between the Class II/1 treated groups and normal subjects indicated that the Class II/1 malocclusions were associated with a larger overjet, deeper overbite, and greater ANB angle. After a 5-year treatment and observation period, an overall "normalization" in the mandibular and maxillary-mandibular skeletal relationships was noted in the treated Class II/1 subjects in both the extraction and the nonextraction groups compared with normal subjects. The changes were more pronounced in the extraction group.

Adolescent↗
PubMed1990

Growth patterns in subjects with long and short faces.

The purpose of this study was to assess skeletal factors associated with the development of vertical facial disproportions. Angular measurements based on longitudinal lateral cephalometric radiographs of 16 male and 16 female subjects, from the ages of 4 through 18 years, were used. Subjects were selected on the basis of lower face height (ANS-Me) as a percentage of morphologic face height (N-Me). A single x-ray photograph at age 15 for the boys and 13.5 for the girls was used to classify each subject's occlusion as either open-bite or deep-bite. Sella-nasion/palatal plane, sella-nasion/mandibular plane, sella-nasion/anatomic occlusal plane, palatal plane/mandibular plane, and cranial base angle were analyzed statistically and graphically. It was found that (1) with the exception of sella-nasion/palatal plane and cranial base angles, all angular measurements demonstrated a progressive reduction throughout development in both open bites and deep bites; (2) the palatomandibular angle discriminated between open bites and deep bites throughout the developmental phase; (3) within each sex, typologic differences were evident in all angular measurements, with the exception of cranial base and occlusal plane; and (4) the cranial base angle demonstrated clear sexual dimorphism, and its magnitude was not associated with vertical dysplasia. The progressive reduction of angles in skeletal open bite reduced or maintained the magnitude of the imbalances, while the reduction of angles accentuated the skeletal deep bite with age. The inclination of the palatal plane and its constancy suggested that downward and backward rotation of the mandible in open bite subjects is precommitted in response to dentoalveolar compensatory changes with the center of rotation at the molars. The magnitude of the mandibular plane angle is not adequate for assessment of diagnostic or prognostic predictive value in determining the pattern of growth.

Adolescent↗
PubMed2003

Longitudinal observation of basic mandibular movements: report of a case.

Sound development of mandibular function during childhood is indispensable to establishing healthy function in adults. To examine this developmental process, longitudinal recordings of basic mandibular movements were done using an optoelectronic analysis. Mandibular movements were recorded on five separate occasions in one boy, from an age of six years and five months to 14 years and five months. The incisor pathways during protrusion and lateral excursion were initially shallow, with more anterior than inferior movement, but as he grew the amount of inferior movement and the amount of rotation both increased. Similarly, at his first recording there was very little hinge-like rotation during mouth closing, but rotation increased markedly after eruption of his permanent second molars. These findings suggest that mandibular movements change from being relatively simple with more translation in younger children to more complex movements with more rotation once the permanent dentition is established.

Adolescent↗
PubMed1993

Effect on the dentofacial complex of Macaca irus of functional tongue forces imparted on a palatal bar.

I determined the effect tongue forces imparted on a palatal bar has on the growth and development of the dentofacial complex of the Macaca irus. Ten female Macaca irus monkeys with mixed dentition were used in this experiment. The animals were divided into four groups, two animals were treated for 30 days, two for 90 days, and four for 180 days, with the remaining two animals serving as controls. The following results were obtained. 1. There was disocclusion on the maxillary and mandibular first molars. 2. Elongation of the mandibular first molars resulted from intrusion of the maxillary first molars. 3. The maxillary complex displayed a positional change with slight clockwise rotation. 4. Growth of the frontozygomatic site in the anteroinferior direction was inhibited. 5. There was no anterosuperior mandibular growth. 6. Changes in the maxillary suture and positioning of the teeth were mainly due to the effects of the tongue function imparted on the palatal bar. With enough control of the vertical growth of the maxilla can be validated. This is one of many methods of treating Class II malocclusion.

Animals↗
PubMed1997

Changes of craniofacial growth and development in males with complete unilateral cleft lip and palate between the age of 5 to 20 years.

The study is based on an anthropometric assessment of X-ray films obtained in two series of males with complete unilateral cleft lip and palate. The first series was examined at the age of 5, 10 and 15 years, the second series at 15 and 20 years. The films were assessed with Jarabak's analysis. The aim of our study was to compare the amount of growth and character of developmental changes in the prepubertal, pubertal and postpubertal period of life. The highest growth rate of skeletal structures was present in the prepubertal period, it was somewhat slighter in the pubertal period and it still continued in the postpubertal period. The high growth rate in the prepubertal period was probably related to the eruption of permanent teeth. In spite of a marked deterioration of sagittal jaw relations during the prepubertal period an improvement of an overjet was attained. However during the puberty and the postpubertal period a further improvement was not recorded. The results are in agreement with facial type of growth characterized by a slight pubertal spurt.

Adolescent↗
PubMed1998

Oxidative capacity of rat masseter muscle after implantation of thyrotropin-releasing hormone microspheres in proximity to trigeminal motoneurones.

Earlier work has shown that two important consequences of implanting thyrotropin-releasing hormone (TRH) microspheres near motoneurones within the trigeminal motor nucleus of actively growing rats are increased muscle mass and a darkening of the implant-side masticatory muscles. These phenomena have been associated with altered neuromuscular activity patterns and biomechanical forces that directly influence craniofacial growth and development. Now, whether the implantation of TRH microspheres in proximity to trigeminal motoneurones would affect the oxidative capacity of the implant-side masseter muscles was investigated. Cytochrome C oxidase (COX) assays were carried out for both implant- and non-implant-side masseters of TRH (n = 5) and blank microsphere (n = 6) Sprague-Dawley rats after stereotactic surgery at 35 days of age. Analyses of both groups at 14 days post-implantation revealed that the COX activity levels of implant-side masseters in TRH-implanted rats was significantly (P< or =0.05) greater than that of non-implant-side masseters; rats implanted with blank microsphere exhibited no significant difference between implant- and non-implant-side masseter COX activity levels. The stated null hypothesis was therefore rejected. These data suggest that TRH implants in proximity to trigeminal motoneurones effect increased oxidative capacity of the masseter muscle as measured by COX activity.

Animals↗
PubMed1997

Isolated maxillary bending in CL/FR strain mice: observation of craniofacial deformity and inheritance pattern.

OBJECTIVE: The CL/Fr mouse, known as a strain with spontaneous cleft lip and/or palate (CL/P), has been used as an animal model to investigate etiology in CL/P. METHOD: We examined a facial asymmetry mutant discovered in a CL/Fr mouse colony that was not associated with CL/P and was shown to be inheritable in subsequent generations. Facial asymmetry became apparent with postnatal growth, whereas it was not detectable at birth, and was termed "maxillary bending" (MB) based on the characteristic bending of the maxilla. RESULTS: As a result of selective breeding, an 'MB line', In which MB was observed in 21.68% (67/309) in addition to CL/P in 17.80% (55/309) of the offspring, was developed in the CL/Fr colony. In mating experiments between the MB line and C57BL/6J, all F1 progeny showed the normal phenotype. MB was observed in 0.72% (1/139) of the F2 generation, and the backcross generation showed segregation of MB in 6.25% (22/352) and CL/P in 1.42% (5/352). These instances suggested the occurrence of an additional mutation in the CL/Fr mouse genome controlled by an autosomal recessive gene with low penetrance. However, since the CL/Fr mouse primarily has a developmental deficiency in the maxilla, the possibility that CL/P and MB share common etiologic factors cannot be completely ruled out. CONCLUSION: The maxillary bending retains significance, as this mutant can serve as an animal model of abnormal facial growth. Elucidation of the etiologic relationship between MB and CL/P may provide clues to clarifying the deficiency in first branchial arch in the mouse.

Animals↗
PubMed2005

Craniofacial development in children with unilateral cleft lip and palate.

Unilateral cleft lip and palate is the most common cleft in humans. We investigated the craniofacial morphology of Turkish children with unilateral complete cleft lip and palate who had operations to close the cleft lip when they were 3 months old and to close the palate at 12 months. They were not given orthopaedic or orthodontic treatment. We compared 42 patients with unilateral complete cleft lip and palate (UCCLP) with 45 control children without UCCLP at mean ages of 13 and 15 years. The children with UCCLP had considerable morphological deviations compared with the matched children without clefts. They had significantly shorter and more posteriorly positioned maxillas (p<0.01). There was also an increase in cranial base angle (p<0.05), mandibular plane and gonial angle (p<0.01). There was a reduction in the posterior facial height (p<0.05) and an increase in the anterior facial height (p<0.01). The profile of the soft tissue was more convex (p<0.001) and the upper lip was thinner than in the children in the control group (p<0.01), and their noses were relatively further backwards and downwards (p<0.01).

Adolescent↗
PubMed2004

Association between vertical development of the cervical spine and the face in subjects with varying vertical facial patterns.

The upper cervical spine and face were compared longitudinally from 6 to 15 years of age in 2 groups of children with low (n = 16) and high (n = 14) MP-SN angles. The purpose of the study was to assess morphological and incremental associations between the vertical development of the cervical spine and the face in subjects with varying vertical facial patterns. Morphological associations were not detected during the observation period. Long faces were found on children with short necks, and short, square faces on those with long necks. Vertical growth of the upper cervical spine and face were weakly correlated in the 6-to-12-year period but strongly correlated later during puberty. The vertical distance between gonion and the body of the second cervical vertebra was remarkable for its constancy during childhood and puberty, indicating that gonion and the second cervical vertebra body were anatomically interrelated. This anatomical relationship strongly suggests that a mutual relationship also exists between vertical growth of the upper cervical spine and the face, especially the lower face. In addition, the lower face had the ability for independent vertical growth that was not coordinated with vertical cervical growth. This was the case in the 6-to-12-year period, but not later.

Adolescent↗
PubMed2002

Tgf-beta1, Tgf-beta2, Tgf-beta3 and Msx2 expression is elevated during frontonasal suture morphogenesis and during active postnatal facial growth.

OBJECTIVES: It is hypothesized that regulation of facial suture morphogenesis is similar to that of cranial sutures, with expression of similar regulatory molecules, governing suture formation and patency. The present study was designed to characterize the morphology of the frontonasal (FN) suture of the rat at different developmental stages and to investigate the presence and temporal-spatial expression of transforming growth factor-beta 1 (Tgf-beta1), Tgf-beta2, Tgf-beta3 and Msx2 mRNA within these structures. SETTING AND SAMPLE POPULATION: The Department of Biomedical Sciences at Texas A&M University System Health Science Center, Baylor College of Dentistry, Dallas, TX USA. Histological sections and RNA isolated from FN suture tissues of Sprague-Dawley rats, aged embryonic day 16 through postnatal day 20. METHOD: Sections were examined after immunohistochemical staining. Gene expression was determined by densitometric analysis of RT-PCR products run on agarose gels. RESULTS: FN sutures develop slightly later than cranial sutures and show increased complexity over time when compared to cranial sutures. FN sutures were closely associated with the nasal capsular cartilage, with intervening layers of perichondrium and periosteum. The pattern of expression of Tgf-betas within the FN suture tissues was similar to that seen in the cranial sutures. However, mRNA and protein of the Tgf-betas were differentially expressed over time compared to cranial sutures. In FN sutures, Tgf-beta mRNA levels were elevated both during the period of suture morphogenesis and during active bone growth from the suture in the early postnatal period. Msx2 mRNA expression was elevated in both the prenatal and postnatal periods, similar to Tgf-beta mRNA expression. CONCLUSION: Tgf-beta and Msx2 are present in facial sutures similar to cranial sutures, but are differentially expressed over time, perhaps reflecting different bone growth rates from these sutures.

Animals↗
PubMed2006

[Interception in the primary dentition: mastication and neuro-occlusal rehabilitation].

After evoking the characteristics of masticatory movements, their control and their adaptability, a review of the literature illustrates how the masticatory work and its variations can influence the dentoalveolar, as well as the maxillary growth, by adapting the morphological structures to the functional context. The conceptions of Planas, and especially his "neuro-occlusal rehabilitation", are widely explained: unilateral alternate mastication, "Planas' Functional Masticatory Angles (PFMA) and the vertical dimension, the "atrophies" of maxillary development resulting from reduced mastication, the "dominant unilateral mastication syndrome" and, of course, all the original treatments introduced by Planas. These specific orthodontic treatments can be applied as interceptive procedure as early as during the deciduous dentition. The selective occlusal grinding, implemented to reduce and balance the "PFMA", and the expansion devices using "running track plates" are described in concepts and clinical uses. Planas' Class II treatments of Class II, also using "direct occlusal bonded tracks" and several mandibular propulsion auxiliaries are explained as well as the early treatments of lateral cross-bite and the use of the "Equiplan". Mastication, the first of the functions assigned and carried out by the masticatory apparatus, is a genuine "functional matrix" able to stimulate the growth of the dental arches and of the maxillaries. When perfectly understood and applied, the "neuro-occlusal rehabilitation" according to Planas allows to restore a functional balance for the masticatory apparatus from an early age, and subsequently, reorientates growth to a morphological normalization.

Child, Preschool↗
PubMed1993

Orthopedic protraction of the upper jaw in cleft lip and palate patients during the deciduous and mixed dentition periods in comparison with normal growth and development.

Cleft lip and palate (CLP) patients often develop maxillary retrusion after cleft repair. Since 1977, a group of 98 cases with negative overjet (anterior crossbite) during the period of deciduous dentition has been treated by the Bergen CLP team. The purpose of treatment has been to achieve favorable occlusion with positive overjet and overbite by means of anterior orthopedic traction (protraction). The average age at start of treatment was 6 years 11 months, and mean treatment duration was 13 months. The protraction force was 700 g. The serial lateral cephalograms of the treated CLP group were compared with those of a noncleft group with normal growth. Normalization of the sagittal maxillomandibular relationship (ANB angle) was achieved. Significant changes were a more anterior position of the upper jaw, and a more posterior position of the lower jaw, due to mandibular clockwise rotation. The variation was considerable. This paper reports the overall changes in the whole CLP group (ALL-C group).

Cephalometry↗
PubMed2002

TMJ fractures in children: importance of functional activation of muscles in preventing mandibular asymmetries and facial maldevelopment.

Normal development of the mandible as well as some portions of the upper jaw and face are related to good function of the masticatory apparatus: the integrity and interaction of bony and soft-tissue structures may be highly disturbed by injury of the TM joints and result in facial and occlusal disharmonies. When the neuromuscular system is in harmony, the mandibular muscles collectively exert their effect on both position and movement of the jaw and the loading of forces on the TM joints is optimal and balanced. Unfortunately, TMJ fractures may alter completely this balance with loss of the support to the mandible against the temporal component and loss of the functional effect of the lateral pterygoid muscle on the mandible. Disturbances in the harmonious interplay of the masticatory muscles may result in facial alteration and asymmetries. If not treated, the dysplastic patterns of growth continues and worsens during the years.

Cephalometry↗
PubMed1993

Fetal cleft lip repair in rabbits: long-term clinical and cephalometric results.

We have developed a model for fetal cleft lip (CL) repair in rabbits. To date, the in utero CL procedure has been performed on 174 fetuses in 98 pregnant does. Details of the model, wound healing characteristics, and early growth results have been published previously. In this study, we report long-term clinical and cephalometric findings in 23 fetuses who underwent the fetal CL procedure, were born alive, and survived until completion of growth. The surgically created and repaired CL in fetal rabbits described here resulted in healing without scar formation. The deformity varies from an incomplete to a severe complete cleft, resembling the clinical spectrum of spontaneous clefts in humans. Cephalometric studies indicate that there were no statistically significant differences in premaxillary width, anterior maxillary length, or anterior and posterior maxillary width among control, unrepaired, and repaired animals. Documentation of this phenomenon in higher animals is necessary before the technique can be applied to humans with cleft lip.

Animals↗
PubMed1995

Endocrine regulation of craniofacial growth.

This paper presents an updated review of the role of endocrine factors in craniofacial and dental development. Some unpublished results of the author's own studies are presented. Longitudinal growth studies have shown the similarity of facial and somatic growth rates, whereas dental development has been found to be independent. The increased therapeutic use of the growth hormone (GH) has focused attention on the dental and craniofacial effects of GH. Whereas delayed and advanced cranial base and facial growth is obvious in conditions with either lack or excess of GH, the effect of GH on the dentition is less clear. Thyroid hormones seem to be necessary for the eruptive movement of teeth. Sex steroids clearly have an effect on facial and cranial base growth and are also odontogenic, but the effects have not been much studied. The growth-inhibiting effect of corticosteroids is explained partly by the reduced response of cartilage cells to insulin-like growth factor-1. Experimentally, the effect is also seen in the condylar cartilage, but clinical studies have not been published. In tooth eruption an accelerating effect has been noted in experimental animals. The role of androgenic hormones in mandibular growth stimulation is discussed.

Adrenal Cortex Hormones↗