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[Metastatic and paraneoplastic lesions of the optic nerve].

We review the involvement of the optic nerve in distinct neoplastic disorders and differentiate the metastases from the paraneoplastic disorders. We also review and discuss the role of malignant lymphoreticular disorders, solid tumors and meningeal carcinomatosis in relation to the changes in the optic nerve caused by these conditions.

Carcinoma↗
PubMed2001

The orthopaedic presentation of acute leukaemia in childhood.

In children, acute leukaemia can mimic several orthopaedic pathologies and this variable presentation creates difficulties in achieving the correct diagnosis. Four consecutive cases are reported, all of which initially presented via the orthopaedic department, representing 17% of all new cases of leukaemia presenting to our hospital. This series is presented to highlight the need to place acute leukaemia on the list of differential diagnoses of acute joint pathology in children: the associated literature is reviewed.

Adolescent↗
PubMed1999

[Study on the expression of interleukin-8 and its receptors in acute leukemia].

OBJECTIVE: To evaluate the expression of interleukin 8 (IL-8) and its A, B type receptors (IL-8RA, IL-8RB) in acute leukemia (AL). METHODS: Plasma IL-8 concentrations in peripheral blood and IL-8R expressions on bone marrow mononuclear cell (MNC) membrane of 77 newly diagnosed AL patients were assayed by ELISA and FACS, respectively. IL-8 concentration in cerebral spinal fluid (CSF) of 15 AL patients in complete remission (CR) were kinetically measured. RESULTS: Plasma IL-8 levels in newly diagnosed AL patients were increased. IL-8 levels were higher in AML than in ALL, in AML-M4, M5 were higher than in AML-M1-M3, and in B-ALL were higher than in T-ALL, respectively (P < 0.05). In ALL, CR rate in patients with IL-8 > 100 ng/L was lower than in those with IL-8 < or = 100 ng/L (P < 0.05). 36.36% of the patients were MNC IL-8R positive. Peripheral blood WBC and blasts amounts in IL-8R(+) group were significantly higher than IL-8R (-) group (P < 0.05). CSF IL-8 levels in CR patients were not different from newly diagnosed patients (P > 0.05) and were increased while central nervous system leukemia (CNSL) developed. CONCLUSION: Detection of IL-8 and IL-8R might help to identify AL types and predict prognosis and the development of CNSL.

Adolescent↗
PubMed2001

Adult T-cell leukemia showing different immunophenotypes in invaded organs.

We report here a case of adult T-cell leukemia (ATL) who presented acute renal failure and skin eruption. Renal and skin biopsies showed diffuse invasion of ATL cells. Furthermore, the surface phenotype of tumor cells taken from the bone marrow (BM) or peripheral blood (PB)(CD4-CD8-) differed from that of cells taken from the kidney or skin (CD4+CD8-). These findings suggested that CD4-CD8-ATL cells in the BM and PB had differentiated to CD4+CD8- cells in the kidney and skin.

Acute Kidney Injury↗
PubMed2001

Uveitis in a child: masquerade syndrome revisit.

We present a case of relapsing acute lymphoblastic leukemia (ALL) in the anterior chamber, uveitis masquerade syndrome, which was confirmed by anterior chamber paracentesis and aqueous fluid cytology. Three months previously, the patient developed anterior uveitis without hematologic relapse. The uveitis responded well to topical steroid. After anterior chamber paracentesis, bone marrow relapse was detected. High doses of chemotherapy were prescribed. Ocular radiation was planned but the patient developed septicemia and expired. In our opinion, paracentesis should be performed without delay when uveitis develops in ALL, regardless of systemic relapse. Ocular manifestation may be the only sign of leukemic relapse or may present several months prior to systemic relapse.

Administration, Topical↗
PubMed2002

Aleukemic monocytic leukemia cutis.

Aleukemic leukemia cutis is a rare condition in which leukemic cells invade the skin before they appear in peripheral blood or bone marrow specimens. The condition frequently is misdiagnosed as atypical lymphoma. Generally, the diagnosis is made retrospectively, after the leukemic cells appear in peripheral blood or bone marrow samples. Immunohistochemical studies are the primary methods for diagnosis. Prognosis is usually poor. We describe the case of a 75-year-old woman with acute aleukemic monocytic leukemia cutis who developed systemic disease 1 1/2 years after skin involvement.

Aged↗