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At least 1,405 records · Page 78Linked to original sources
PubMed2003

Cytoskeletons in prokaryotes.

Not only eukaryotes, but also prokaryotes possess a cytoskeleton. Tubulin-related bacterial protein FtsZ, and actin-related bacterial proteins MreB/Mbl have recently been described as constituents of bacterial cytoskeletons. Genes coding for MreB/Mbl could only be found in elongated bacteria, not in coccoid forms. It was speculated that constituents of today's eukaryotic cytoskeleton (tubulin, actin) may have evolved from prokaryotic precursor proteins closely related to today's bacterial proteins FtsZ and MreB/Mbl. Prior to the description of proteins MreB/Mbl, evidence had been obtained for the existence of a shape-preserving cytoskeleton ubiquitously present in all bacteria. In the meantime, structural studies allow to speculate on a possible role of bacterial elongation factor Tu (EF-Tu) as a structural element in such a "cytoskeletal web". EF-Tu was long known to form fibrillar structures in vitro; now experimental data accumulate, pointing towards formation of intracellular protofilaments containing EF-Tu, and networks thereof as well. In addition, results of these structural studies suggest a so far unknown mode of complex formation of EF-Tu with active ribosomes: ribosomes/polysomes were seen to be attached to intracellular protofilaments. Implications for the understanding of EF-Tu-ribosome interaction, and a role of such a kind of putative protofilaments as a general site of attachment for cellular functional macromolecules are discussed. The notion is discussed that an EF-Tu-containing cytoskeletal web might have been the "primary" or "basic" kind of prokaryotic cytoskeleton, already in existence prior to the "invention" of precursors of today's MreB.

Bacterial Proteins↗
PubMed1997

Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification.

Mice carrying transgenic rearranged V region genes in their IgH and Igkappa loci to encode an autoreactive specificity direct the emerging autoreactive progenitors into a pre-B cell compartment, in which their receptors are edited by secondary Vkappa-Jkappa rearrangements and RS recombination. Editing is an efficient process, because the mutant mice generate normal numbers of B cells. In a similar nonautoreactive transgenic strain, neither a pre-B cell compartment nor receptor editing was seen. Thus, the pre-B cell compartment may have evolved to edit the receptors of autoreactive cells and later been generally exploited for efficient antibody diversification through the invention of the pre-B cell receptor, mimicking an autoreactive antibody to direct the bulk of the progenitors into that compartment.

Animals↗
PubMed2003

The effect of two nursing interventions on the postoperative outcomes of gynecologic laparoscopic patients.

Anecdotal reports support research findings in documenting the high incidence of negative postoperative outcomes after gynecologic (GYN) laparoscopic surgery. Three outcome measures, postoperative pain, postoperative nausea and vomiting (PONV), and length of stay, have received considerable attention. Two nursing interventions frequently suggested for their positive effects are guided imagery and music therapy. An experimental pilot study was conducted to determine the effects of these nursing inventions on postoperative pain, PONV, and length of stay for GYN laparoscopic patients (n = 84). During the perioperative period, patients were randomly assigned to one of 3 interventions: guided imagery audiotapes (GI), music audiotapes (MU), or standard care (C), and outcome measures were evaluated. Results indicated that patients in both the guided imagery and music groups had significantly less pain on PACU discharge to home than the patients in the control group. These findings suggest that both guided imagery and music are effective strategies in improving pain, a difference that becomes apparent when the patient is ready to be discharged. It is possible that these interventions act as distractions in reducing the report of negative postoperative outcomes.

Adult↗
PubMed2002

1999 ICP Distinguished Scientist Award. The history of positron emission tomography.

The history of Positron Emission Tomography (PET) is rich in technological achievements and advancements. The advancements that have benchmarked PET progress are the result of key components that include human intellect and passion for PET technology, relentless persuasion of key political forces to eliminate the barriers precluding PET usage, tireless efforts to raise awareness about PET and a crucial network of support throughout the PET community. This article sets forth a timeline of significant events that have contributed to the development of PET as it is known today. It introduces the earliest physicist and physician, for instance, who were responsible for the first medical applications for positron emitting radioisotopes using a simple brain probe that utilized coincidence to localize brain tumors. Additionally, it identifies landmark technological achievements that have helped pave the way to modern PET. This study includes historical accounts surrounding the use of the first human PET tomograph, discovery of the Bismuth Germanate (BGO) scintillator, development of the Fluorodeoxyglucose (FDG) PET method, the design of the first PET medical cyclotron with automated chemistry and operated by a PC and a technologist, Food and Drug Administration's approval of FDG, HCFA reimbursement, and the capacity of Lutetium Oxyorthosilicate (LSO) to produce a revolutionary advance in PET scanners. The main thrust of this article is to recognize via a timeline of PET accomplishments the noteworthy work of scientists, physicians and others who have been key players in various aspects of the continuous activity to move PET technology forward from invention to research, and to become a major clinical imaging modality.

Journal Article↗
PubMed2005

Is non-insulin dependent glucose uptake a therapeutic alternative? Part 2: Do such mechanisms fulfil the required combination of power and tolerability?

The worldwide burden of diabetes, the unavoidable worsening which is observed in long-term clinical trials despite treatment and the close link between glycaemia and microangiopathy appeal for much stronger treatment strategies. This, in turn, either requires polypharmacy (with new risks) or new, more powerful drugs to be invented. The first part of this review dealt with a thorough analysis of pros and cons for some selected pathways which could potentially increase glucose uptake without necessitating insulin. The choice of such targets for developing completely new drugs, however, requires a favourable background from existing tentatives with either drugs or cell biology approaches. Moreover, because vascular complications are what must ultimately be avoided when treating diabetic patients, we must be sure that increasing glucose uptake in a fashion which is no more controlled by normal physiology is compatible with the physiology of vascular cells (long-term tolerance). The aspect of drug side-effects must therefore be considered systematically. For reasons which are individually developed, it appears that each of the potential pathways analyzed either lacks sufficient power and/or is likely to induce side effects which are not acceptable for long-term application. The fact that GLUT-1 transporters are ubiquitously distributed even extends this cardinal question to the general principle of increasing glucose uptake. In conclusion a precise evaluation suggests that, although non-insulin dependent glucose uptake represents (3/4) of whole body glucose transport, it is difficult to consider such mechanisms able to generate a new treatment fulfilling the unavoidable request of combined efficacy and tolerability.

Blood Glucose↗
PubMed2001

Effective decision-making: progressing compounds through clinical development.

In today's drug-development environment, companies are under increasing pressure to improve efficiency and maintain returns on investment. Tomorrow's environment is likely to be harsher still, and companies that survive and prosper will be those that are already responding by re-inventing their structures and culture to meet the challenges that lie ahead. In this review, we explore some of the strategies and issues that are central to this process, with particular reference to decision-making in drug development.

Journal Article↗
PubMed1998

Non-invasive Tearscope Plus routine for contact lens fitting.

The Keeler Tearscope Plus was invented by the author as a multi-use instrument for the non-invasive examination of the tear film, its appearance, volume, stability and, its effect on the ocular and contact lens surface. Its use is maximised by following a step-by-step approach described which is based on simple clinical principles of tear film stability.

Journal Article↗
PubMed2002

The origin of DNA genomes and DNA replication proteins.

In recent years, it has became clear that most proteins involved in cellular DNA precursor synthesis or DNA replication have been 'invented' more than once, indicating that the transition from RNA to DNA genomes was more complex than previously thought. Several authors have suggested that DNA viruses, which often encode their own version of these proteins, played an important role in this process. The nature of the genome of the last universal cellular ancestor (LUCA) -- that is, RNA or DNA, prokaryotic-like or eukaryotic-like -- remains in dispute. A hyperthermophilic LUCA would have suggested a circular, double-stranded DNA genome; however, recent data favor a mesophilic or moderately thermophilic LUCA.

Biological Evolution↗
PubMed2002

Health care and ICT, partnership is a must.

This article comments on the article 'Health Care in the Information Society; A Prognosis for the Year 2013' by Reinhold Haux et al. It is emphasised that besides the driving forces as identified in that article, the changes in the composition of the population will lead to a structural shortage of health professionals. So, despite the willingness of both individual patients and the society as a whole to pay more for health care no significant change will occur in the percentage of the gross domestic product spent on health care. By consequence we can not meet the challenges health care is facing by 'more of the same'. New forms of health care delivery have to be invented and implemented that lead to higher efficiency. The question is discussed whether health care is lagging behind other sectors of society in the application of ICT, the answer to that question is negative. It is explained why the percentage of the budget spent on ICT is no valuable yardstick. Comments are made to the quantitative expectations of Haux et al. Finally it is recommended that IMIA takes the initiative to organise in co-operation with international associations of health professionals a multidisciplinary working conference on the future role of ICT in health care.

Budgets↗
PubMed2003

Open Source software in medical informatics--why, how and what.

'Open Source' is a 20-40 year old approach to licensing and distributing software that has recently burst into public view. Against conventional wisdom this approach has been wildly successful in the general software market--probably because the openness lets programmers the world over obtain, critique, use, and build upon the source code without licensing fees. Linux, a UNIX-like operating system, is the best known success. But computer scientists at the University of California, Berkeley began the tradition of software sharing in the mid 1970s with BSD UNIX and distributed the major internet network protocols as source code without a fee. Medical informatics has its own history of Open Source distribution: Massachusetts General's COSTAR and the Veterans Administration's VISTA software have been distributed as source code at no cost for decades. Bioinformatics, our sister field, has embraced the Open Source movement and developed rich libraries of open-source software. Open Source has now gained a tiny foothold in health care (OSCAR GEHR, OpenEMed). Medical informatics researchers and funding agencies should support and nurture this movement. In a world where open-source modules were integrated into operational health care systems, informatics researchers would have real world niches into which they could engraft and test their software inventions. This could produce a burst of innovation that would help solve the many problems of the health care system. We at the Regenstrief Institute are doing our part by moving all of our development to the open-source model.

Database Management Systems↗
PubMed1998

Security in perspective; luxury or must?

In this paper, security in health information systems is put into perspective. The further penetration of information technology into health care is discussed and it is concluded that information systems have already become a vital component, not only for the logistics of the health care institution but also for the rendering of care and cure. Health care depends heavily on adequate data, so availability and integrity are equally important. In view of the sensitive nature of many patient data, the importance of confidentiality was recognised long before computers were invented. For widespread use of IT in health care it is of vital importance that computers can be trusted in respect of confidentiality. This paper emphasises the need to pay attention to security and suggests a responsible approach with implementation of both technical and organisational measures.

Computer Security↗
PubMed1995

The politics of patent legislation in biotechnology: an international review.

The realization of the economic value of the genetic resources has prompted an international debate about property rights to genetic resources. The international debate pertaining to patenting of genetic material is the main theme of this chapter. As a backdrop for the international debate, the chapter starts out with a summary of the main events and arguments in the expanding scope of patent legislation in biotechnological inventions. Summing up, the new biotechnologies represent a tool which meets the legal requirements for patenting biological material. From the industry's point of view, biotechnology also necessitates patenting. On the negative side, defending a patent is often a long and costly business, and the trend is that patenting will mainly benefit the bigger and stronger companies and thus weaken public control over the rapid developments in biotechnology. A central argument in the chapter is that without sophisticated biotechnological tools, trained scientists, and adequate infrastructure, patenting is, as yet, hardly a viable solution for the majority of developing countries. Gene-rich developing countries fear that developments in patent legislation will pave the way for increased Northern control over Third World natural resources. The International Convention on Biological Diversity goes some way in making amends to this situation, but the gene-poor, least developed countries may still have reason to fear that they will lose access to breeding material. In a long-term perspective, the implications may be detrimental for resource conservation in developing countries. In conclusion, the patent question seems to remain unresolved and may still be one of the most likely stumbling blocks for future ratifications and implementation of the Biodiversity Convention.

Animals↗
PubMed2006

Vitrification of mouse pronuclear oocytes with no direct liquid nitrogen contact.

The ability to routinely cryopreserve human oocytes and embryos represents a significant advancement in the field of assisted reproductive technology. Although the method of slow freezing is commonly employed, research on the alternative technique of vitrification is promising. Vitrification involves incubation of the cell in a cryoprotectant rich solution, which permits a glass-like state to occur almost instantaneously in liquid nitrogen. A number of different techniques have been invented for holding oocytes and embryos in the cryoprotectant solution during rapid vitrification and subsequent storage. Most of these involve direct contact with liquid nitrogen. Recently, concerns have been raised regarding the sterility of such a method and the potential of viral contamination from the liquid nitrogen. The present study shows that the previously reported Cryoloop method can be used to vitrify and store embryos without direct liquid nitrogen contact (during vitrification and storage). When such vitrified embryos are warmed, they are capable of subsequent development comparable with non-vitrified embryos.

Analysis of Variance↗
PubMed2002

Changing perspectives of apheresis in India in the twentieth century.

Globally, the last century (20th) has seen many changes in terms of amazing advancements and applications of modern science, medicine, biotechnology and computers. One of the dramatic outcomes of such great inventions and discoveries was that the medical profession got the wonderful tool of immunomodulation and haemapheresis which has changed the outlook of the entire spectrum of immune complex disorders both in terms of the great success in treatment and the rehabilitation from so-called incurable diseases. Additionally this has resulted in a better quality of life and lower morbidity and mortality. Organ transplants have become a reality and immunomodulation plays a pivotal role in their success. India also has tasted this sweet recipe of modern medicine and has imbibed it in its medical culture. India is not only famous for the Taj Mahal and Hawa Mahal (Agra and Jaipur) but also for its brain (of brain drain/otherwise) and betz cells which have brought glories and laurels in the field of medicine, mathematics, engineering, literature, physics and computers, etc. to the native countries and India equally. Apheresis has now invaded the Indian scenario also and there is a growing interest, demand and application for it in the clinical field. But, being a unique country, the problems encountered are also unique. This paper deals with an overview of the changing perspectives of apheresis in India in the 20th century.

Blood Component Removal↗
PubMed2003

Learning to leverage existing information systems: Part 2. Case studies.

BACKGROUND: The ability to use available administrative and clinical information to produce performance reports is a key element of quality improvement. Six health care systems were identified that have done a particularly effective or innovative job of creating and implementing performance measurement tools and systems by using data available in existing clinical and administrative information systems: Dean Health System (Madison, WI), Sharp HealthCare (San Diego), Henry Ford Health System (Detroit), Scripps Health (San Diego), Legacy Health System (Portland, OR), and Lovelace Health System (Albuquerque). SUMMARY THOUGHTS: Interest in comparative performance information for health care organizations remains strong. The perfect measure set has not yet been invented. Every measure has one or more flaws, as do the data systems available to support them. Managers may take comfort, however, in the knowledge that performance measures need not be perfect to be useful. Measures tend to improve when people use the data to inform decisions that matter. Even the most accurate data, though, are not useful if there is either too much or too little "organizational distance" between the unit of analysis for the data and the unit of control for making change. Some systems have adopted a layered approach to performance measurement, in which measures are aggregated for reporting and use at the level of major operating units or divisions and then disaggregated for reporting and use at smaller levels and eventually to the level of individual clinicians.

California↗
PubMed1976

Twin resemblances in creativity and in esthetic and emotional expression.

Three sources of observation relevant to the measurement of individual differences in emotional and esthetic expressiveness were employed to study their heritability by application to a sample of some 60 pairs of young adult like-sexed twins, approximately evenly divided between male and female and MZ and DZ pairs. The sources of observation were objective test performances, trait ascription using a standard list of adjectives, and videotaped enactments of mood and esthetic performances. Perceptual and esthetic abilities do appear to have substantial heritability, although esthetic preferences do not. Heritability is also indicated for such adjectives as artistic, inventive, original, and independent. Ratings of the videotape performances yielded somewhat ambiguous results, due to the presence of a marked halo effect; the most likely interpretation congruent with earlier results is that greater MZ twin resemblances in social extroversion generated greater resemblances in the videotape situation on such other trait-rating variables as creativity, naturalness, and dominance.

Adolescent↗
PubMed2002

Huxley and scientific agnosticism: the strange history of a failed rhetorical strategy.

Huxley's invention of the term 'agnostic' in 1869 is often seen as a brilliant rhetorical strategy. Portrayed as an effective weapon in Huxley's public debates with defenders of the Anglican establishment, the creation of scientific agnosticism has been interpreted as a turning point in the relationship between science and religion. In this paper I will challenge this interpretation of the rise of scientific agnosticism. Huxley was reluctant to identify himself unambiguously as an agnostic in public until 1883 and his restricted use of agnostic concepts during the 1870s and 1880s was compromised when other unbelievers, with different agendas, sought to capitalize on the polemical advantages of referring to themselves as agnostics. As a result, he was not always associated with agnosticism in the public mind and his original conception of it was modified by others to the point where he felt compelled to intervene in 1889 to set the record straight. But Huxley could not control the public meaning of 'agnosticism' and its value to him as a rhetorical strategy was severely limited.

Biological Evolution↗
PubMed2005

Core groups and the transmission of HIV: learning from male sex workers.

A growing and substantial body of research suggests that female sex workers play a disproportionately large role in the transmission of HIV in many parts of the world, and they are often referred to as core groups by epidemiologists, mathematical modellers, clinicians and policymakers. Male sex workers, by contrast, have received little attention and it is not known whether it is helpful to conceptualize them as a core group. This paper draws upon ethnographic research documenting social and sexual networks in London and looks at the position of five male sex workers within a network comprising 193 men and seven women (as well as 1378 anonymous sexual contacts and 780 commercial contacts). In so doing, it suggests that there is no evidence to show that male sex workers are more or less likely to acquire or transmit HIV in the course of commercial sex compared with other types of sexual relationships. In addition, men engaging in non-commercial sex all reported having unprotected sex in a variety of contexts and relationships and there is no evidence to suggest that men who are not sex workers play less of a role in the transmission of HIV. In short, these data suggest that it would be inappropriate to conceptualize male sex workers as a core group. This is not to suggest that public policy should continue to overlook male sex workers. New and inventive approaches are required to reach out to a vulnerable but diverse group of men, selling sex for a variety of reasons; even if these men are no more vulnerable to acquiring and/or transmitting HIV than other men and women that form part of their network.

Adult↗