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PubMed2003

[Glycaemic index].

Glycaemic index is a measure of blood glucose increase two hours after intake of food containing 50 g of carbohydrate. The reference is measurements after intake of 50 g glucose or white bread containing 50 g carbohydrate, which is set to the value of 100. The glycaemic index was developed to help persons with diabetes improve their blood glucose control in order to avoid long-term complications. Apple can have an index of approximately 40, while a baguette has 95 and pumpernickel bread 41. Some observational studies suggest that a carbohydrate diet with low glycaemic index may reduce the risk of overweight, diabetes type 2 and colon cancer. There are at present few published controlled clinical trials supporting this conclusion. The food industry and some people working with weight reduction have shown interest in using the glycaemic index. The system may easily cause confusion and leave the impression that important and nutritious carbohydrate-containing foods should be avoided. The glycaemic index could be a tool for dieticians and physicians counselling persons with metabolic syndrome, overweight, diabetes type 1 or 2.

Diabetes Mellitus↗
PubMed2003

Automated indexing of the Hazardous Substances Data Bank (HSDB).

The Hazardous Substances Data Bank (HSDB), produced and maintained by the National Library of Medicine (NLM), contains over 4600 records on potentially hazardous chemicals. To enhance information retrieval from HSDB, NLM has undertaken the development of an automated HSDB indexing protocol as part of its Indexing Initiative. The NLM Indexing Initiative investigates methods whereby automated indexing may partially or completely substitute for human indexing. The poster's purpose is to describe the HSDB Automated Indexing Project.

Abstracting and Indexing↗
PubMed2004

Postmenopausal endometrial cancer screening: is there a correlation between transvaginal sonographic measurement of endometrial thickness and body mass index?

OBJECTIVE: The aim of this study was to correlate the body mass index with transvaginal sonographic measurement of endometrial thickness in a cohort of postmenopausal women who were admitted for endometrial cancer surveillance. MATERIAL AND METHODS: Transvaginal sonographic measurement of endometrial thickness was performed in 97 postmenopausal women who attended the gynecology clinic for endometrial cancer screening with no history of hormone replacement therapy and correlated with body mass index. Baseline characteristics including age, years since menopause and body mass index were recorded for each subject. The relationship between transvaginal sonographic endometrial thickness and baseline characteristics was assessed in each. RESULTS: Body mass index was significantly correlated with years since menopause (r = 0.292, p = 0.004) and age (r = 0.243, p = 0.01) but not with endometrial thickness (r = -0.07, p = 0.454). Endometrial thickness versus time since menopause correlation was found to be significant (r = 0.274, p = 0.03) in patients with a body mass index lower than 30. CONCLUSION: The present findings indicate that endometrial thickness does not differ with body mass index in the screening of postmenopausal women for endometrial cancer.

Body Mass Index↗
PubMed2002

Automatic conceptual indexing of French pharmaceutical theses.

French pharmaceutical theses are rarely quoted. If the main obstacles originate from language or access barriers, proper indexation could also be blamed. Manually extracted key-words don't necessary come from a structured thesaurus. In the following work, this manual indexing method is compared to an automated one, "Nomindex", based on UMLS. The automated method is improved by the addition of a relevance scoring system. The first indexing step consists of downloading, adapting and indexing theses in electronic format. Results will then be analyzed and sorted by relevance, through the comparison of classic statistical indices (noise, silence and relevance). It was assumed that the manually obtained key-words were always relevant. The silence of manual indexing is nevertheless high: seven new key-words are proposed by Nomindex, which results are mixed (10% of silence, but 50% of noise). These results are promising on the first experiment on pharmaceutical document without lexicon improvement. The indexing, if it is currently insufficient for a real life use, could easily be improved by specific updates of the lexicon.

Abstracting and Indexing↗
PubMed2006

Body mass index and risk of diabetes mellitus in the Asia-Pacific region.

Few prospective data from the Asia Pacific region are available relating body mass index to the risk of diabetes. Our objective was to provide reliable age, sex and region specific estimates of the associations between body mass index and diabetes. Twenty-seven cohort studies from Asia, New Zealand and Australia, including 154,989 participants, contributed 1,244,793 person-years of follow-up. Outcome data included a combination of incidence of diabetes (based on blood glucose measurements) and fatal diabetes events. Hazard ratios were calculated from Cox models, stratified by sex and cohort, and adjusted for age at risk and smoking. During follow-up (mean = 8 years), 75 fatal diabetes events and 242 new cases of diabetes were documented. There were continuous positive associations between baseline body mass index and risk of diabetes with each 2 kg/m2 lower body mass index associated with a 27% (23-30%) lower risk of diabetes. The associations were stronger in younger age groups, and regional comparisons demonstrated slightly stronger associations in Asian than in Australasian cohorts (P = 0.04). This overview provides evidence of a strong continuous association between body mass index and diabetes in the Asia Pacific region. The results indicate considerable potential for reduction in incidence of diabetes with population-wide lowering of body mass index in this region.

Adult↗
PubMed2005

Semi-automatic indexing of full text biomedical articles.

The main application of U.S. National Library of Medicine's Medical Text Indexer (MTI) is to provide indexing recommendations to the Library's indexing staff. The current input to MTI consists of the titles and abstracts of articles to be indexed. This study reports on an extension of MTI to the full text of articles appearing in online medical journals that are indexed for Medline. Using a collection of 17 journal issues containing 500 articles, we report on the effectiveness of the contribution of terms by the whole article and also by each section. We obtain the best results using a model consisting of the sections Results, Results and Discussion, and Conclusions together with the article's title and abstract, the captions of tables and figures, and sections that have no titles. The resulting model provides indexing significantly better (7.4%) than what is currently achieved using only titles and abstracts.

Abstracting and Indexing↗
PubMed1991

A hospital capital price index.

This paper describes the development of a price index for hospital equipment. Based on 10 years of hospital capital acquisition data from a large teaching hospital, equipment acquisitions were categorized and weights derived for each category. Using national producer price indexes for each of these categories, a national hospital equipment index was derived for 1981 to 1991. Forecasts for 1991 and 1992 were then made. The resulting index indicated that price movements of our hospital capital equipment index were very similar to the Implicit Gross Domestic Product Deflator, an index that measures price changes for the nation's Gross Domestic Product. However, because of the relative importance of several categories of equipment (scientific instruments, computers), more widespread data on hospital equipment expenditure patterns would be desirable in order to validate these results.

Abstracting and Indexing↗
PubMedDate not supplied

Classic prognostic factors, flow cytometric data, nuclear morphometric variables and mitotic indexes as predictors in transitional cell bladder cancer.

One hundred and eighty-seven patients with a transitional cell bladder cancer were followed by retrospectively for a mean of 9.5 years. Clinical stage (p less than 0.0001), histological grade (p less than 0.0001), papillary (p less than 0.0001), SPF (p less than 0.0001), M/V index (p less than 0.0001), MAI (p less than 0.0001), DNA index (p = 0.0001) SDNA (p = 0.0004), NA10 (p = 0.0023), NA (p = 0.0044) and G2% (p = 0.0158) were significantly correlated with survival in univariate analysis. In Cox's analysis T-category, papillarity and MAI had independent prognostic value and in combination they predicted bladder cancer-related survival significantly (X2 = 117.5, p less than 0.0001). When histological parameters only were analysed, WHO grade, SPF and papillarity were independent predictors and their combined prognostic significance was high (X2 = 76.6, p less than 0.0001). In papillary tumours SPF (p v 0.0005), MAI (p = 0.0009), DNA index (p = 0.0010) and M/V index (p = 0.0021) predicted survival significantly in addition to stage (P less than 0.0001) and grade (p = 0.0003) in univariate analysis. In Cox's analysis T-category, MAI and M/V index were independent predictors and their combined prognostic value was high (X2 = 54.1, p less than 0.0001). In Ta-T1 and in T2-T3 tumours, WHO grade, papillarity, SPF, mitotic indexes and DI were significant predictors in univariate analysis. In Cox's analysis of Ta-T1 tumours papillarity had independent prognostic value, whereas in papillary Ta-T1 tumours mitotic activity included all prognostic information. In T2-T3 tumours WHO grade and SPF were independent predictors. In conclusion, in papillary bladder tumours T-category is the most important predictor of survival followed by parameters reflecting proliferative activity of cancer cells.

Aged↗
PubMedDate not supplied

Comparing treatment options for occlusal surfaces utilizing an invasive index.

The purpose of this project was to develop an invasive index to: 1) compare the treatments recommended by dentists for the occlusal surfaces of molars; 2) compare the invasive index score of each tooth with the extent of the carious lesion as determined by electrical resistance and histological examination; and 3) compare the relative extent of the total crown destruction resulting from the carious lesion and the cavity preparation. Twenty dentists examined 19 extracted permanent molar teeth using a #23 explorer and selected the most appropriate treatment from the following options: no treatment (score 0), occlusal sealant (score 1), preventive resin (score 2), occlusal amalgam (score 3). The invasive index scores determined for each dentist and each tooth were compared using an analysis of variance. The electrical conductivity of each tooth was measured with an electronic caries detector (Vanguard). Electrical resistance scores were compared to the invasive index scores and to a histological examination. The results demonstrate that the invasive index is a useful means to compare treatments recommended by different dentists. The invasive index suggests there is considerable variation among dentists in the treatment they recommend for occlusal surfaces. Electrical resistance testing did not provide helpful information for treatment planning of questionably carious occlusal surfaces.

Adolescent↗
PubMedDate not supplied

[Simplified gingival index for ages 4 to 6 and 7 to 10. (Deciduous and mixed dentition)].

The main purpose of this research is to obtain an simplified gingival index. Four hundred and twenty children, both sexes 4 to 10 years of age were selected. They are divided in two groups: 4-6 years and 7-10 years. For gingival index, the criteria based on SCHOUR & MASSLER, 1947, were used. To obtain the total data of the studied conditions, a simplification of the total index was performed. For the ages 4 to 6 years, we selected labial surfaces of the 54, 61, 75, 82. For the ages 7 to 10 years, we added the labial surfaces of 26 and 46. The means for the total and simplified index were obtained for each age group sex. The data were analysed by Pearson's correlation coefficient and linear regression. In both dentitions, the simplified index showed significant correlation with the total index.

Child↗
PubMed1989

The INTERSALT study: relations of body mass index to blood pressure. INTERSALT Co-operative Research Group.

In INTERSALT, the relationship between body mass index (kg/m2) and blood pressure was studied in 10,079 men and women aged 20-59, sampled from 52 centres around the world, based on a standardised protocol with central training of observers, a central laboratory and extensive quality control. Body mass index-blood pressure relationships were first studied in men and women within each centre, and results of these regression analyses were then pooled for all 52 centres. With adjustment for age, alcohol intake, smoking, and sodium and potassium excretion, body mass index was positively associated with systolic blood pressure among men in 51 of 52 centres and among women in 47, significantly so in 24 and 27, respectively. Body mass index was positively associated with diastolic blood pressure in 51 and 49 centres in men and women, respectively, significantly so in 33 and 31. When the within centre regression coefficients were pooled, the pooled coefficients were highly significant in all analyses (P less than 0.001), and were similar for those aged 20-39 and 40-59. Overall, a 10 kg difference in body weight was associated on average with a 3.0 mmHg difference in systolic and a 2.2 mmHg difference in diastolic pressure. In further analyses across centres, median body mass index was related significantly to median systolic blood pressure, median diastolic pressure and the prevalence of hypertension in both men and women. Body mass index was related to the slopes of systolic and diastolic blood pressure with age in women, but not in men. These INTERSALT findings confirm the importance of the association between body weight and blood pressure. Differences of 2-3 mmHg in systolic blood pressure on a population basis have been shown to be associated with differences in stroke mortality rates of 6-9 per cent and in coronary death rates of 4-6 per cent.

Adult↗
PubMed1986

A comparison of journal coverage in Psychological Abstracts and the primary health sciences indexes: implications for cooperative serials acquisition and retention.

An overlap study was performed to identify important psychology journals that are also of interest to biomedical scientists and health care practitioners. The journal lists of Index Medicus, Hospital Literature Index, Cumulative Index to Nursing and Allied Health Literature, and International Nursing Index were compared with the journal list of Psychological Abstracts. A total of 357 Psychological Abstracts titles were also in one or more of the health sciences indexes. A core list of forty-five titles covered by all of the indexes is presented in the Appendix. Results of the study are discussed vis-à-vis cooperative serials acquisition and retention efforts.

Abstracting and Indexing↗
PubMed1971

Fifty years of the Index to Dental Literature: a critical appraisal.

The year 1971 marks the fiftieth anniversary of the Index to Dental Literature. The Index had a slow and stormy birth, with twenty-three years of hard work put in until the first volume was issued. The first Index is described and the changes in its contents and format are traced through the years until its production in 1965 by the National Library of Medicine. The current Index is analyzed with attention paid to nomenclature, classification scheme, quality of the index entries and cross references. The results of a survey of regular users of the Index are interpreted, and suggestions gleaned for the improvement of this most useful tool in dental research.

Abstracting and Indexing↗
PubMed1995

Validation of an algofunctional index for osteoarthritis of the hand.

Although hand osteoarthritis is common, it has been the focus of few therapeutic trials. In addition to the problems raised by clinical trials in osteoarthritis in general and to the difficulties due to the unforeseeable course of osteoarthritis of the trapezometacarpal and finger joints, the lack of a clinical tool for assessing pain and function over time is an additional obstacle. We propose an algofunctional index designed for evaluation and symptomatic follow-up of patients with digital osteoarthritis. The index is based on a physician-administered questionnaire on 10 daily activities involving the hands. The patient is asked to answer each item using a 4-point verbal scale, from "possible without difficulty" (0) to "impossible" (3 points); thus, total scores range from 0 to 30. This index has been used in a few clinical placebo-controlled trials and was found sensitive to change. The aim of this study was to assess the metrological qualities of this index, including consistency (internal and external), sensitivity and specificity (by scoring the index in different groups of subjects), intra-observer reproducibility, and ease of use. Three hundred patients were recruited by 25 rheumatologists: 100 had a painful attack of digital and/or trapezometacarpal osteoarthritis (mean age: 64.9 years) with a score of more than 40 mm on a visual analog scale for overall pain severity (mean: 57.3 +/- 14 mm), 100 had "inactive" hand osteoarthritis (mean age 67.0 years), and 100 had no diseases of the upper limbs. Specificity/sensitivity: the mean index score was 12.41 +/- 5.41 in patients with painful OA, 4.28 +/- 3.87 in "inactive" cases, and 0.59 +/- 1.23 in controls. External consistency: the overall mean score was well correlated with pain severity: r = 0.49 (p < 0.001). Internal consistency: principal component analysis identified a primary axis responsible for 44.2% of the variance and two secondary axes each responsible for slightly more than 9% of the variance. None of the questions seemed redundant. Intra-observer reproducibility: two evaluations done one hour apart in symptomatic patients yielded the following scores: 12.32 +/- 5.41 and 12.5 +/- 5.51 (correlation: 0.95; mean difference: 0.17 +/- 1.64; coefficient of variation: 9.32%). Kappa values for both measurements of each item ranged from 0.68 to 0.87. Ease of use: mean time needed to determine the score 2.5 +/- 2 min. The scoring process was considered simple by 100% of investigators and easy/very easy by 98% of patients.(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗
PubMed1994

A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index.

OBJECTIVE: Disease status, in terms of disease activity, disease progression and prognosis is difficult to define in ankylosing spondylitis (AS). No gold standard exists. Therefore, the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), a self-administered instrument, has been developed as a new approach to defining disease activity in patients with AS. METHODS: The index, designed by a multidisciplinary team with input from patients, consists of six 10 cm horizontal visual analog scales to measure severity of fatigue, spinal and peripheral joint pain, localized tenderness and morning stiffness (both qualitative and quantitative). The final BASDAI score has a range of 0 to 10. The index was distributed to a cross section of patients, including inpatients receiving 3 weeks of intensive physiotherapy treatment and hospital outpatients. BASDAI was completed by a total of 154 patients. Validation of the new instrument was achieved through analysis of user friendliness, reliability (consistency), score distribution and sensitivity to change. Comparisons were made with a previous Bath disease activity index (DAI) and the Newcastle Enthesis Index. RESULTS: The BASDAI was found by patients to be quick and simple to complete (mean: 67 s). Test-retest reliability was good (r = 0.93; p < 0.001), as was the distribution of scores across the scale (score range: 0.5-10; mean: 4.31). BASDAI was sensitive to change, reflecting a 16% (mean) improvement in inpatient scores after 3 weeks of treatment. It is superior to the DAI in terms of construct and content validity and to the Enthesis Index in all aspects. CONCLUSION: In summary, BASDAI is user friendly, reliability, sensitive to change and reflects the entire spectrum of disease. It is a comprehensive self-administered instrument for assessing disease activity in AS.

Data Interpretation, Statistical↗
PubMed1994

[Validation of the reproducibility of the DMF Index used in bucco-dental epidemiology and evaluation of its 2 clinical forms].

The DMF index is the one most commonly used in oral epidemiology to quantify the extent of caries. It represents the total of untreated decayed, missing and filled teeth in a person's mouth. A review of the literature shows that while this index is internationally recognized by the scientific community and people engaged in clinical dental practice, information demonstrating its reproducibility is scanty. The initiation and promotion of studies on the validity of the DMF index depend on first evaluating its reproducibility. This evaluation is based on an analysis of the rate of concordance between the results observed when a sample of subjects is examined twice, either by the same examiner or by two examiners at different times. Three types of comparison were carried out as part of this presentation: comparisons of results by one examiner, between two examiners, and between the two clinical forms of the DMF index according to whether it is calculated by tooth (DMFT) or tooth surface (DMFS). Each of the comparisons covered a group of 50 or so adult subjects selected solely for having an adequate number of teeth presenting different conditions. In all 215 persons were examined twice, making up a total of over 21,000 characters recorded. The state of each of the 32 permanent teeth, or of their 148 surfaces for the DMFS index, was codified using a digit selected from the seven possibilities corresponding to the letters D, M, F, and S (tooth that has not developed, untreated decayed, extracted, filled, healthy, replaced by a fixed or removable prosthesis). The statistical analysis covered 5 variables: the number of decayed, missing, filled and healthy teeth and the DMF index, for the whole mouth and tooth by tooth. The main finding emerging from this study is that for each comparison the rates of concordance are very high, higher for the one-examiner comparisons (> 64%) than for the two-examiner comparisons (> 45%). Comparison between the two types of data-gathering shows rates of over 72% for all the variables. The correlation coefficients between the scores attributed in two successive examinations are all over 0.9, with very small variation intervals even when the rates of concordance are lower. In fact, the differences between the results are generally of the order of +/- 1 tooth. Except in two cases, the Student test (t test) is not significant, which indicates that the means of each of the 5 variables did not differ statistically from one observation to another.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗
PubMed1994

Growth patterns in the National Library of Medicine's serials collection and in Index Medicus journals, 1966-1985.

Data from the National Library of Medicine (NLM) automated Master Serials System and its MEDLINE database were used to chart the growth of NLM's serials collection and of the journals indexed in Index Medicus from 1966 to 1985. The number of live serial titles in the subset of NLM's collection examined increased 30% in the twenty years. The average number of articles per Index Medicus journal increased 56%. The average number of articles in U.S. Index Medicus journals grew more rapidly than the average number in journals published elsewhere. The NLM data provide clear evidence that the years from 1966 to 1985 saw a substantial increase in the percentage of the biomedical serial literature published in English. The period from 1966 to 1985 saw substantial but uneven growth in the number of serial titles in the NLM collection and in the average number of articles in Index Medicus journals. Although data on the number of articles published in Index Medicus journals is unlikely to reflect the number of articles in other journals, the pattern of growth in the number of serials held by NLM probably reflects trends in the universe of all biomedical serials.

Abstracting and Indexing↗
PubMed1993

[Early detection of obesity in male adults using a combination of body index and bioelectrical impedance method].

Obesity is an excess of body fat frequently resulting in a significant impairment of health. Body index derived from body weight and height is widely available in Japan. However, body index cannot express the fat deposition in the body. Screening for early obesity was studied using a combination of body index and bioelectrical impedance for detecting fat deposition. Three hundred twenty-nine male subjects with normal body index participated in this study. Blood pressure, uric acid, total cholesterol, high density lipoprotein cholesterol, triglyceride, GOT, GPT, gamma-GTP, choline esterase and glucose tolerance after a 75-gram glucose load were measured. The following results were obtained. 1. Among 321 subjects with normal body index, 95 subjects had body fat exceeding 23% as measured by bioelectrical impedance. 2. By matched-pair comparison in the subjects whose body mass indices were within +/- 10% fasting plasma glucose, triglyceride, GOT, GPT, gamma-GTP and choline esterase were significantly higher and high density lipoprotein cholesterol was significantly lower in subjects with fat deposition over 23% than in the 92 matched controls with body fat less than 23%. In conclusion, bioelectrical impedance appears to be useful for detecting early stages of obesity in subjects with normal body index.

Adult↗