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PubMed2006

[Preoperative fasting times: patients' perspective].

BACKGROUND: In order to improve perioperative subjective quality of care it seems desirable to shorten preoperative fasting times as much as possible within acceptable safety limits. These efforts should result in a measurable reduction of preoperative thirst and hunger as well as in improvements of patient well-being. It is unknown to what extent preoperative patient comfort is limited by thirst and hunger from a patient point of view. The purpose of this study was to determine the impact of a traditional fasting regimen on preoperative patient discomfort. PATIENTS AND METHODS: We conducted a survey on preoperative thirst and hunger in 412 adult American Society of Anesthesiologists ASA I and II patients scheduled for minor elective surgery. RESULTS: Of the patients 33% complained of moderate to strong thirst, whereas 19% had moderate to strong hunger, 47% of the participants would have liked to have been able to drink and 72% would have appreciated a light breakfast before surgery. Mean preoperative fasting times were 12.8+/-3.4 h for fluids and 15.5+/-4.4 h for solids. "Thirst" was named by 3.3% and "hunger" by 0.8% of patients as the most important factor for preoperative discomfort but "long wait" (8.5%), "tenseness" (6.5%) and "anxiety" (4.8%) were the most frequently named factors. Answers were independent of the duration of preoperative fasting. CONCLUSION: Patient comfort is compromised by traditional fasting rules and liberalization of these policies is desired by patients. However, efforts to reduce preoperative anxiety and tenseness might have an additional, important potential to improve perioperative quality of care from a patient's perspective.

Adolescent↗
PubMed1984

Effects of systemic or intracerebroventricular naloxone injection on basal and 2-deoxy-D-glucose-induced ingestive behavior.

In order to examine the role and site of action of opiates on both hunger and thirst and food and water intake in rats after short term (3 hr.) food deprivation alone or in combination with 2DG-induced glucoprivic stress, naloxone was given to rats in either the jugular vein or the lateral ventricle. Both basal and 2DG-induced food and water intake were reduced by naloxone injected either peripherally or centrally. Latencies to eat and drink were used as measures of hunger and thirst respectively. Only central injection of naloxone significantly reduced 2DG-induced but not basal hunger. These results suggest a central site of action of naloxone on both food and water intake even if some peripheral effects cannot be totally ruled out. Our findings indicate central nervous system opiate receptor involvement in the hunger response to 2DG-induced glucoprivation. In all other treatment conditions, decreases in food intake cannot be related to reduction of hunger but may be due to potentiation of satiation during opiate receptor blockade.

Animals↗
PubMed1988

Physiological, environmental, and subjective determinants of food intake in humans: a meal pattern analysis.

The spontaneous food intake of 31 adult humans was investigated with diary self-reports of ingestive behaviors and subjective hunger over 7 consecutive days. Meals were identified, using five different definitions, and their composition of total calories, carbohydrate, fat, and protein was estimated from a computer file of the nutritive value of foods. These data were analyzed by intercorrelating meal sizes with intermeal intervals, estimated stomach contents and self-reported hunger with univariate and multiple correlation techniques. Human feeding was found to be regulated on the basis of preprandial factors; the premeal interval, estimated premeal stomach content, and self-reported hunger significantly correlating with the meal size. These correlations were significant regardless of whether the meal was evaluated as spontaneous or constrained by external factors, but were stronger when the meals occurred without other people being present. The postprandial relationship between the meal size and the duration of the postmeal interval, which is present in nonhuman species, was only present in humans when meals that were eaten alone were considered separately. This suggests that the species differences may be due to the social context of observation. The intake of carbohydrate, fat, and protein was found to have a suppressive effect on subsequent intake and subjective hunger through their contributions to total food energy ingested. Protein, however, was found to suppress subsequent intake and subjective hunger independent of its contribution to total calories, suggesting that the macronutrients have differing satiating properties.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed2006

The effect of a medium-term activity- and diet-induced energy deficit on subjective appetite sensations in obese children.

OBJECTIVE: To assess the subjective appetite responses to an imposed activity- and diet-induced energy deficit during a residential intervention programme for obese children. DESIGN: A 6-week intervention of fixed, reduced dietary intake and 6 h/day of skill-based physical activity while resident in a weight loss camp. SUBJECTS: Thirty-eight obese (mean body mass index (BMI)=34.9 kg m(-2)) boys and girls (mean age 13.9+/-1.57). MEASUREMENTS: An electronic appetite rating system (EARS) was used to periodically measure subjective appetite sensations at the start (WK1) and at the end (WK6) of the camp. Subjective ratings of hunger and fullness were compared at the start and end of 6 weeks of an activity- and diet-induced-based weight loss intervention. RESULTS: At the end of the 6 weeks, the children had lost 8.4 kg in body mass. The diurnal profiles of subjective appetite sensations demonstrated clear oscillations in hunger and fullness. There was a significant increase in hunger (P<0.0001) and decrease in fullness (P<0.005) at the end (WK6) of the medium-term energy deficit. In WK6, morning ratings of hunger were higher than in WK1 (P<0.005) and the fixed energy evening meal induced a lower suppression of hunger (P<0.02). CONCLUSION: A programme of fixed, reduced-dietary intake combined with an activity and behavioural programme was successful at inducing a significant reduction in body mass in obese children. Subjective sensations of appetite were sensitive to a medium-term negative energy balance and weight loss. These data are essential as we continue to evolve methods of treatment for overweight and obese children.

Adolescent↗
PubMed2003

Eating behaviour, and preprandial and postprandial correlations in male broiler and layer chickens.

1. It has been suggested that broiler chickens have a disturbed satiety and hunger mechanism. The satiety mechanism for eating can be expressed as the positive correlation between meal length and the length of the preceding (preprandial) interval; the hunger mechanism for eating as the positive correlation between meal length and the length of the succeeding (postprandial) interval. An experiment was conducted to investigate eating behaviour of male broiler and layer chickens by measuring meal and interval lengths. 2. Eight male broilers and 8 male layer chickens were housed individually and visually isolated in floor pens (1 m2/pen) on wood shavings. From 4 to 7 weeks of age, eating behaviour of each bird was recorded for 3 h in two conditions each week. In the first condition, the birds were not deprived from feed. In the second condition, they were 24-h food deprived and feed was provided just before the observation started. Preprandial and postprandial correlations were calculated based on data of the non-deprived condition. Before and after each observation bird and feeder were weighed to measure weight gain and feed consumption during observation. 3. Under the non-deprived condition, the broilers spent initially more, but at a later age less time on eating. The broilers had fewer meals per hour, consumed more feed per hour, and had longer meal and interval lengths than the layer chickens. After 24-h feed deprivation, the broilers had a longer first meal, consumed more feed per hour and spent more time on eating than the layer chickens. Significant preprandial correlations but no postprandial correlations were found in the broilers. In the layer chickens, both significant preprandial and postprandial correlations were found. This indicates that for regulating eating behaviour, the satiety mechanism dominates the hunger mechanism in broilers, and satiety and hunger mechanisms are equally involved in layer chickens. 4. The typical eating behaviour of broilers and the calculated preprandial and postprandial correlations have given new indications that hunger and satiety mechanisms in broilers have changed compared with layer chickens. In broilers, there is no lower set point, but only an upper set point for controlling eating behaviour, which suggests that broilers eat to their maximal physical capacity.

Animals↗
PubMed1997

Relation between postprandial satiation and antral area in normal subjects.

The factors influencing appetite in humans are poorly understood. There is a weak relation between appetite and gastric emptying in normal subjects. Recent studies have shown that fasting and postprandial antral areas increase in patients with functional dyspepsia compared with normal subjects. We evaluated the hypothesis that antral area, and hence antral distention, is a significant determinant of postprandial fullness. Fourteen normal subjects had simultaneous measurements of gastric emptying by scintigraphy and antral area by ultrasound after ingestion of 350 mL 20% glucose. Fullness and hunger were assessed by visual analog scales. Measurements of the gastric-emptying half time (t1/2) by scintigraphy and ultrasound were not significantly different (129.6 +/- 11.8 min compared with 115.6 +/- 11.4 min). Fullness increased (P < 0.001) and hunger decreased (P < 0.001) after the drink. Both fullness and the magnitude of the increase in fullness after the drink were related to antral area (r > 0.56, P < 0.05), the increase in antral area (r > 0.59, P < 0.05), and the scintigraphic content of the distal stomach (r > 0.57, P < 0.05), but not to the ultrasound or scintigraphic t1/2 values. In contrast, hunger and the magnitude of the decrease in hunger after the drink were not related to either antral area, the increase in antral area, or the rate of gastric emptying. We conclude that postprandial fullness, but not hunger, was closely related to antral distention in normal subjects.

Adult↗
PubMedDate not supplied

Factors influencing food intake in patients with heart failure: a comparison with healthy elders.

BACKGROUND AND RESEARCH OBJECTIVE: Promoting adequate nutritional intake of patients with heart failure (HF) is an essential component of comprehensive management. This goal can be hampered by decreased appetite, as well as psychological, social, and HF-related factors that can affect food intake. Factors related to aging may also affect food intake in older patients. The purpose of this study was to compare patients with HF to healthy elders regarding the extent to which they perceived how appetite and hunger, emotional and social, and illness factors affected the amount of food they ate in the previous week. SUBJECTS AND METHODS: Sixty-seven patients with HF were recruited from 3 Midwestern HF clinics. As part of a larger study examining nutrition in HF, patients filled out the Food Eating Experiences and Diet (FEED) questionnaire, an instrument designed to assess factors affecting appetite and hunger. Patients were asked to rate their hunger and appetite on a visual analog scale. On Likert-type scales, they rated the extent to which appetite/hunger, emotional/social, and illness factors affected the amount of food intake. Sixty-eight healthy elders were recruited from 2 Midwestern senior citizen centers. As part of a study collecting a large data set for comparison with HF patients, healthy elders provided demographic and health information and filled out the FEED questionnaire. RESULTS AND CONCLUSIONS: Factors rated as affecting food intake most often by patients with HF were decreased hunger sensations, diet restrictions, fatigue, shortness of breath, nausea, anxiety, and sadness. Factors rated most often by healthy elders as affecting food intake were diminished hunger sensations, early satiety, eating alone, and decreased senses of taste and smell. Among patients with HF, many factors unique from those present due to age were reported to affect food intake.

Aged↗
PubMed1991

Effect of a soup preload on reduction of food intake by cholecystokinin in humans.

Cholecystokinin octapeptide (CCK-8) or saline was intravenously infused for 5 min before and 5 min during a meal of macaroni and beef, served 20 min after a preload of either 100 or 500 g of soup to 12 nonobese men. Intake of the test meal was significantly lower when CCK-8 was given, following the larger preload, than after any of the other treatments. There were no significant differences among the other three treatment conditions. These results are consistent with the hypothesis that gastric, but not merely pregastric, stimulation interacts with CCK-8 to reduce food intake in humans. Although gastric filling seems to be the most likely stimulus for the interactive effect with CCK-8, other factors such as activation of nutrient-sensitive sites cannot be eliminated. In addition, hunger ratings were significantly lower immediately after the larger soup preloads than after the smaller. Hunger ratings after the soup also correlated better with test-meal intake after the large soup preloads with and without CCK-8 than after the smaller preloads. Hunger did not correlate significantly with test meal intake after the small soup preload with CCK-8. These results suggest that hunger ratings are more sensitive predictors of intake when the stomach is relatively full (i.e., after a large preload) than when it is relatively empty (i.e., after a small preload) at the time the hunger rating is taken.

Adult↗
PubMed1997

Effects of small intestinal nutrient infusion on appetite and pyloric motility are modified by age.

The mechanisms responsible for the reduction in appetite and slowing of gastric emptying in older persons are unknown. The aims of this study were to evaluate the effects of aging on small intestinal regulation of appetite and pyloric motility. Eight healthy older (age 65-75 yr) and seven healthy young (age 20-34 yr) male subjects received isocaloric (2.9 kcal/min) intraduodenal infusions of lipid and glucose for 120 min, each on separate days. During the intraduodenal infusions, perceptions of hunger, desire to eat, and fullness were assessed by visual analog scales. Pyloric motility (isolated pyloric pressure waves and tonic pyloric pressure) was measured by manometry during the intraduodenal lipid infusion. On each day, after completion of the intraduodenal nutrient infusion the subject was offered a buffet meal and food intake was quantified. Before intraduodenal nutrient infusions, sensations of hunger (P < 0.01) and desire to eat (P < 0.05) were less in the older compared with the young subjects. In the young, intraduodenal lipid suppressed hunger to a greater extent than intraduodenal glucose (P < 0.05). In older persons, neither intraduodenal nutrient infusion suppressed hunger. Intraduodenal lipid and glucose increased fullness in both age groups (P < 0.05 for both), with no significant difference between the two nutrients. There was no significant difference in food intake from the buffet meal between the elderly and young subjects. Intraduodenal lipid infusion stimulated phasic pyloric pressure waves in both age groups (P < 0.01 for both), and this response was greater (P < 0.05) in older persons. There was an increase (P < 0.01) in tonic pyloric pressure during intraduodenal lipid infusion that was not significantly different between the two age groups. We conclude that the effect of small intestinal lipid infusion on hunger is attenuated, and the stimulation of phasic pyloric pressure waves increased in healthy older persons compared with healthy young males. Increased feedback from small intestinal nutrients does not appear to be responsible for the physiological anorexia of aging.

Adult↗
PubMed1988

[Physiology of food intake and regulation of body weight].

Feeding is often influenced by competitive needs or by environmental factors. Nevertheless, in physiological conditions hunger is elicited by depletion of macronutrients. The first question is what specific signals cause food intake? Recent data suggest that the signal comes not from exclusive depletion of carbohydrates or of anyone type of the major macronutrients but from overall decreased cellular power production (hypoischymetric signal). Locomotion free metabolic rate has been shown to decrease preceding hunger and to increase in order to determine satiety. Satiation, which occurs largely before ingested nutrients can cross the intestinal barrier and replete the inner milieu, obeys a specific mechanism. Following the stimulation by ingestion of the oro-gastro-intestinal receptors metabolic hormones such as glucagon and insulin are released and enhance metabolism of endogenous reserves. The so-induced endogenous "meal" brings about an anticipatory hypermetabolism which inhibits further ingestion. Post-absorptive satiety subsequently will replace the pre-absorptive state of satiation. The long term regulation of body weight is more subtle. When the actual body weight exceeds its defended value, responsiveness towards signals of hunger diminishes. This hyporesponsiveness seems to be a consequent of an enlargement of the microscopic fat depot at the level of hypothalamic receptive structures which parallels the peripheral increase of the macroscopic fat depot. Thus, hunger promoting signals become less effective and feeding decreases. A symmetrical process takes place in case of body weight loss which results in central hyperresponsiveness to hunger related stimuli and thus facilitates feeding and body weight recovery.

Body Weight↗
PubMed2006

Filling yet fattening: stereotypical beliefs about the weight gain potential and satiation of foods.

To what extent are stereotypes concerning the weight-gain potential and perceived hunger satisfaction of food names not congruent with views of the nutrient profiles of those same foods? Respondents rated the same 22 food names and descriptions in terms of weight-gain potential and hunger satisfaction. Half of the 22 snacks included foods from the lower two tiers of the USDA Food Guide Pyramid (fruits, vegetables, and grains: FV&G) and the other half from the upper two tiers (meats, dairy, fats, and sweets: MDF&S). FV&G and MDF&S snack names and descriptions were paired for data analyses based on energy content. Name and description ratings for weight-gain potential were not correlated, while these ratings for hunger satisfaction were strongly correlated. For weight-gain potential, fat and fiber content predicted snack-name ratings, while energy and sugar content predicted description ratings. For perceived hunger satisfaction, protein content predicted snack name ratings while energy and fat content predicted description ratings. The MDF&S snack named in each pair was always considered a greater weight gain promoter compared to its corresponding FV&G snack named. However, the description of the FV&G snack in each pair was often judged to promote greater weight-gain than the description of its corresponding MDF&S snack. Also, MDF&S names were generally judged as more filling than FV&G foods named with similar calorie content; however, a trend in the opposite direction was evident when rating the nutrient descriptions of these same foods. Apparently, food names have acquired reputation for promoting obesity and (to a lesser extent) hunger satisfaction that are not based on their nutrient profiles.

Adult↗
PubMed2006

Neural ensemble coding of satiety states.

The motivation to start or terminate a meal involves the continual updating of information on current body status by central gustatory and reward systems. Previous electrophysiological and neuroimaging investigations revealed region-specific decreases in activity as the subject's state transitions from hunger to satiety. By implanting bundles of microelectrodes in the lateral hypothalamus, orbitofrontal cortex, insular cortex, and amygdala of hungry rats that voluntarily eat to satiety, we have measured the behavior of neuronal populations through the different phases of a complete feeding cycle (hunger-satiety-hunger). Our data show that while most satiety-sensitive units preferentially responded to a unique hunger phase within a cycle, neuronal populations integrated single-unit information in order to reflect the animal's motivational state across the entire cycle, with higher activity levels during the hunger phases. This distributed population code might constitute a neural mechanism underlying meal initiation under different metabolic states.

Action Potentials↗
PubMed2006

A comparison of effects of fish and beef protein on satiety in normal weight men.

BACKGROUND: Previous studies have indicated that fish protein may have a greater effect on satiety compared to other protein sources of animal origin. OBJECTIVE: To compare the effects of fish protein and beef protein meals on hunger and satiety. DESIGN: Twenty-three normal non-smoking, healthy males aged 20-32 years, body mass index 22.5+/-1.8 (s.d.) kg/m(2) participated in a study, with within-subjects design and 1 week between test days. In the morning of the test days, subjects received a standardized breakfast. Four hours after breakfast, subjects were served an iso-energetic protein-rich (40 energy % protein) lunch meal, consisting of either a fish protein dish or a beef protein dish. Four hours after the start of the lunch meals, an ad libitum standardized evening meal was served and the intake of food was measured. Appetite was rated by visual analogue scales (VAS) immediately before and after the meals, as well as every hour between the meals. After the evening meal until bedtime, subjects were asked to record in detail foods and drinks consumed. RESULTS: The repeated VAS-ratings of hunger, satiety and prospective consumption were modelled in a random effects model, taking pre-lunch VAS-ratings into account. After the fish meal, the point estimates were lower for hunger (-2+/-4.8), higher for satiety (8.7+/-6.0) and lower for prospective consumption (-4.9+/-4.7), but they did not reach statistical significance (P satiety=0.88; P hunger=0.15; P prospective=0.30). However, the energy intake at the evening meal displayed significant differences with subjects eating less after the fish protein lunch (2765 vs 3080 KJ, P<0.01) without feeling less satiated. No later energy compensation after the evening meal was found on the test day. CONCLUSION: Although no significant differences in VAS-ratings of satiety or hunger were detected, subjects displayed an 11% reduction in energy intake at the subsequent evening meal.

Adult↗
PubMed1998

Relation between circulating leptin concentrations and appetite during a prolonged, moderate energy deficit in women.

BACKGROUND: On the basis of observations in rodents, leptin is thought to play a key role in the regulation of energy expenditure and food intake, but less is known of its influence on ingestive behavior and energy balance in humans. OBJECTIVE: We examined the effect in women of a chronic energy deficit on plasma leptin concentrations and self-reported appetite and explored possible relations between leptin and appetite sensations. DESIGN: Twelve healthy women (body mass index, in kg/m2: 23-37) participated in a metabolic ward study in which 3 wk of neutral energy balance was followed by 12 wk of energy deficit (energy intake reduced by 2 MJ/d and energy expenditure increased by 0.8 MJ/d). Body weight and composition were monitored, fasting leptin concentrations were measured 4 times, and feelings of hunger, fullness, desire to eat, and prospective consumption were monitored hourly throughout the day on 7 selected days. RESULTS: Adiposity-adjusted leptin decreased by 54% after 1 wk of a moderate energy deficit and remained low after 6 and 12 wk. Leptin was associated with self-reported hunger, desire to eat, and prospective consumption (range of r: -0.6 to -0.7, P < 0.01). The greatest hunger increase coincided with the largest percentage drop in circulating leptin and the lowest final leptin concentration. The relation between leptin and hunger was not influenced by amount of weight or body fat loss. CONCLUSIONS: These findings support the idea that leptin is a physiologic regulator of hunger during energy deficits in humans; the role of leptin in the long-term regulation of food intake warrants further study.

Adipose Tissue↗
PubMed1996

Ventilatory relief of the sensation of the urge to breathe in humans: are pulmonary receptors important?

1. The sensation of an urge to breathe (air hunger) associated with a fixed level of hypercapnia is reduced when ventilation increases. The aim of the present study was to investigate whether pulmonary receptors are important in this mechanism. 2. Five heart-lung transplant (HLT) subjects and five control subjects were studied during periods of mechanical and spontaneous ventilation. End-tidal Pco2 (PET,CO2) was increased by altering the level of inspired CO2. Throughout, subjects rated sensations of air hunger. Air hunger was also monitored during and immediately following maximal periods of breath-holding. 3. When the level of mechanical ventilation was fixed, both groups experienced a high degree of air hunger when PET,CO2 was increased by about 10 mmHg. At similar levels of hypercapnia, both groups derived relief from approximately twofold increases in tidal volume, although relief was slightly less effective in HLT subjects. This was reversible, with decreases in the level of mechanical ventilation rapidly giving rise to increased ratings of air hunger. 4. With breath-holding, all subjects obtained some respiratory relief within 2 s of the break point; there was no significant difference between the groups. 5. The results suggest that sensations of an urge to breathe induced by hypercapnia can be modulated by changes in tidal volume in the presumed absence of afferent information from the lung.

Adult↗
PubMed1996

Improved eating behavior in eating-disordered inpatients after treatment: documentation in a naturalistic setting.

OBJECTIVE: Abnormalities of eating behavior are definitional components of eating disorders (ED), but are seldom observed directly. This study assessed abnormalities of eating behavior in ED patients before treatment and documented changes after multidisciplinary treatment. METHOD: Thirty-three ED patients (13 ANR, 10 ANB, 10 BN) and 10 controls selected a lunch meal in a cafeteria before and after treatment with energy intake (kilocalories) and macronutrients covertly observed. Visual analog scales (VAS) measured hunger and satiety. RESULTS: Before treatment, all ED patient groups experienced low hunger and high fullness, compared to controls. After treatment, hunger increased and satiety decreased. ANR patients, after treatment, increased energy intake from 366 to 916.5 kcal (p < .001), while BN patients increased from 409.9 to 663 kcal (p = .03). ANB nonsignificantly increased. ANR chose significantly more fats (22.7% to 36.2%, p = .05). DISCUSSION: Treatment partially normalizes pre-meal hunger and satiety in ED patients and significantly improves eating behavior (total energy intake and fat content) in ANR and BN patients. Reasons for nonsignificant changes in ANB are not obvious. We recommend documentation of eating behavior by simple, inexpensive, observational methods in a naturalistic setting before and after treatment of ED patients.

Adolescent↗
PubMed1987

Receptor blocking drugs and amphetamine anorexia in human subjects.

The interaction between the receptor antagonist thymoxamine (THYM), propranolol (PPL) and metergoline (MTG) with dexamphetamine (d-Amp)-induced anorexia was examined in a series of studies in normal female volunteers. Visual analogue scale (VAS) ratings of hunger were made and food intake was measured using an automated solid food dispenser (AFD). d-Amp (10 mg) significantly depressed hunger ratings compared to placebo in two of the three studies and its effect was countered by the addition of MTG (4 mg). d-Amp significantly reduced food intake compared to placebo in two studies. In all trials the reduction in food intake following d-Amp was significantly greater than would have been predicted from its effect on hunger. THYM (160 mg) and PPL (40 mg) were associated with no changes in food intake when given alone or with d-Amp, MTG increased food intake (but not significantly) and the combined effects of MTG and d-Amp was the algebraic sum of the effect of each; but there appeared to be no true pharmacological interaction between blocker and anorectic. The results indicated that there may be some dissociation between the effect of d-Amp on hunger and food intake but have failed to produce evidence that noradrenergic pathways are involved. The results are consistent with the theories that d-Amp anorexia does not involve the release of 5-hydroxytryptamine (5-HT) but that 5-HT pathways are involved in the feeding process.

Adult↗
PubMed2006

Spike activity of neurons in the amygdala and hypothalamus in bilateral leads in food motivation.

Measurements of mean spike frequencies and plotting of autocorrelation histograms were performed to study the nature of the spike activity of individual neurons in the lateral hypothalamus and central nucleus of the amygdala from bilateral leads in rabbits in calm waking, after 24-h food deprivation, and after satiation. The nature of neuron spike activity changed in different ways in the hypothalamus and amygdala on transfer from hunger to satiation: 1) the mean spike frequency changed in more hypothalamic (85%) than amygdalar (56%) cells; 2) as compared with calm waking and satiation, hunger was associated with a decrease in the number of neurons with periodic discharges in the delta frequency range in the hypothalamus, while the amygdala showed an increase in periodic discharges in the beta-2 frequency range; 3) in hunger, the hypothalamus showed a decrease in the number of neurons with burst and periodic discharges, while the amygdala showed increases in the number with equiprobabilistic discharge activity. Assessed in terms of autocorrelation histogram shape, greater changes in the nature of neuron spike activity associated with changes in state occurred on the left side than on the right in both the hypothalamus and amygdala. The maximal differences in neuron spike activity on the right and left sides in the hypothalamus were seen in hunger; the greatest differences in the amygdala were seen in satiation.

Action Potentials↗