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Caliciviruses infecting monkeys and possibly man.

Caliciviruses have, for the 1st time, been shown experimentally to infect a primate. Twenty-four hours after being inoculated with San Miguel sea lion virus (SMSV), an African green monkey developed a febrile response and vesicular lesions at injection sites. Virus was recovered from lesion material 96 hours later and from the stool at 48 hours. Possible human infection with SMSV was indicated by serologic evidence. Three persons working with 4 distinct serotypes of SMSV developed neutralizing antibody titers to 2 SMSV types. The positive serum-neutralization test results were confirmed, using immunoelectron microscopy to demonstrate complexes of viruses and antibodies.

Animals↗

[Comparative morphologic features of the retinas of insectivores and primates].

By means of scanning electron microscopy and by neurohistological methods with subsequent quantitative treatment of the data, it is demonstrated that the retina of the hedgehog differs from that of the green monkey. In the former, the density of photoreceptors convergence is higher, that corresponds to the night mode of life of the hedgehog Monotony in the cells of all the layers, lack of photoreceptor differentiation according to the form of their external segments corresponds to general low level in the organization of the hedgehog nervous system. The retina of the hedgehog possessing the above mentioned structural peculiarities can be considered as a model reflecting the organization in the peripheral portion of the optic analyzer of the original forms in Mammalia placentalia.

Animals↗

[Pathogenic properties of the LEIV23 Astrakhan strain of Batai virus for primates].

Pathogenic properties of Batai virus, LEIV23 Astrakhañ strain, isolated from Aedes vexans mosquitoes in Astrakhañ region were studied comparatively. The degree of susceptibility to the virus of green monkeys and rodents (white mice, Syrian hamsters), and the pattern of lesions produced by the virus in organs of these animals were established. The virus was shown to have a comparatively wide host range affecting phylogenetically far distant animals. Monkeys were found to have virus-carrier state for 50 days (the observation period). The virus is pantropic. Apparently mammals may be virus hosts in nature, but human infection cannot be ruled out. This requires further study in an epidemiological experiment.

Aedes↗

Hepatitis A and B: serologic survey of human and nonhuman primate sera.

Sera of humans and seven species of nonhuman primates were tested by radioimmunoassay and enzyme immunoassay for the presence of hepatitis A antibody, hepatitis B surface antigen and antibody to hepatitis B surface antigen. The outcome of testing a total of 276 serum or plasma specimens was as follows: with the exception of squirrel monkeys (0%) and cotton-top marmosets (0%), a considerable percentage of all other species tested had detectable antibodies to hepatitis A virus: humans 45.9%, chimpanzees 36.6%, baboons 38.2%, vervets 57.9%, cebus monkeys 40.0% and common marmosets 50.0%. Only one human and two chimpanzees were carriers of hepatitis B surface antigen. Antibodies to hepatitis B surface antigen were detected in human (11.3%), chimpanzees (29.9%), baboons (36.2%) and squirrel monkeys (5%). Chimpanzees showed an increasing prevalence of antibodies to hepatitis A virus and hepatitis B surface antigen with age.

Animals↗

[Spontaneous contamination of primary green monkey kidney cell cultures by foamy virus].

Examinations of 1653 batches of green monkey kidney cell cultures revealed contamination with foamy virus (FV) in 243 (16%) batches. From some of these cultures 65 strains of virus belonging to two serotypes were isolated. Tests on sera from 1122 monkeys revealed antibody to FV in 985 (87.8%) animals. No correlation between the presence of antibody in the serum and virus recovery from monkey kidney cell cultures was observed, however. This might be due either to the lack of the virus in the kidneys or to the failure in its isolation from primary cultures. Passages of cell cultures were shown to facilitate additional recovery of FV. These experimental results may be used for screening and selection of FV-free cultures and for control purposes in the course of vaccine manufacture.

Animals↗