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At least 1,405 records · Page 78Linked to original sources
PubMed1984

Biological behavior of tumors and associated retroviremia in cats inoculated with Snyder-Theilen fibrosarcoma virus and the phenomenon of tumor recurrence after primary regression.

The fate of tumors and associated retroviremia was studied in 111 cats infected with the Snyder-Theilen strain of feline sarcoma virus (FeSV). Tumors appeared at the site of inoculation within 7 to 10 days. A retroviremia, due mainly to the associated feline leukemia virus helper virus (FeLV-helper), developed at the same time as tumors. Of the cats, 44 developed progressively growing tumors and therefore had to be killed, and 67 developed tumors that regressed. There was a strong correlation between the persistence of the accompanying retroviremia and the growth of the tumors. The 44 cats with progressively growing fibrosarcomas remained retroviremic until death. Conversely, 53 of the 67 cats with solitary, regressing tumors were only transiently retroviremic. Tumor regression in these cats paralleled the disappearance of retrovirus from the blood. The fate of tumors and retroviremia was not always the same, however. Twelve cats remained persistently retroviremic after all signs of gross tumors disappeared. Two other kittens became nonviremic within 20 days after inoculation, yet tumors continued to grow and even metastasize for another 3 to 5 weeks before regressing. Fibrosarcomas recurred 3 weeks to 8 months later in 8 of 12 persistently retroviremic cats with regressed tumors. Although the blood and bone marrow from these cats contained predominantly FeLV-helper, tumor cells yielded both FeSV and FeLV-helper. Of 53 animals, 3 developed recurrent fibrosarcomas 5 weeks to 8 months after all signs of tumors and retroviremia had disappeared. Cells cultured from these tumors appeared initially like normal fibroblasts and were virus nonproducers. After one to three passages in culture, however, cells became malignantly transformed and replicated both FeSV and FeLV-helper. Cultures of the bone marrow from these and other nonviremic cats with regressed tumors yielded only FeLV-helper.

Animals↗
PubMed1992

Immunological changes in cats with concurrent Toxoplasma gondii and feline immunodeficiency virus infections.

To examine the immunological changes in cats concurrently infected with feline immunodeficiency virus (FIV) and Toxoplasma gondii, kittens (four per group) were inoculated with FIV, T. gondii, both agents, or no pathogens. Blood mononuclear cells and plasma were collected weekly for lymphocyte assays and serology. At week 14, spleen and lymph node cells were used for lymphocyte assays; brains and mesenteric lymph nodes were used for isolation of T. gondii. More T. gondii organisms were present in tissues of the dually infected cats than in tissues of cats with toxoplasmosis alone. Two dually infected cats and one cat infected with T. gondii developed chorioretinitis. Spleen, lymph node, and blood mononuclear cells from dually infected cats had the greatest reduction in mitogenic responses. By week 3, cats infected with FIV underwent a decrease in the number of CD4 cells that was not changed by concurrent T. gondii infection; the number of CD8 cells increased only in cats infected with T. gondii alone. For cats infected with T. gondii, the responses of lymphocytes to T. gondii antigen were not affected by FIV infection; the responses to FIV antigen were negligible in all groups. Overall, this study indicates that FIV infection favors T. gondii proliferation. Also, the establishment of toxoplasmosis may enhance FIV-induced immunodeficiency and is likely to cause a more rapid disease progression than that from infection with FIV alone.

Animals↗
PubMed1996

Roles of the auxiliary genes and AP-1 binding site in the long terminal repeat of feline immunodeficiency virus in the early stage of infection in cats.

To examine the roles of auxiliary genes and the AP-1 binding site in the long terminal repeat of feline immunodeficiency virus (FIV) in vivo, three mutant viruses, which are defective in the vif gene ([delta]vif), ORF-A gene (deltaORF-A), and AP-1 binding site (deltaAP-1), and wild-type virus as a positive control were separately inoculated into three specific-pathogen-free cats. These cats were assessed by measuring the number of proviral DNA copies in peripheral blood mononuclear cells (PBMCs), the CD4/CD8 ratio and antibody responses to FIV for 16 weeks and then examining histological changes at necropsy. Although viral DNAs were detected in PBMCs from all 12 cats to various degrees until 16 weeks postinoculation, no virus was recovered from PBMCs of cats infected with (delta)vif virus during the observation period. However, a very weak antibody response was induced in one cat infected with the (delta)vif virus. In contrast, despite the successful recovery of virus from both groups of cats infected with deltaORF-A and deltaAP-1 virus, antibody responses and decrease in the CD4/CD8 ratio in the groups were milder than those in cats infected with wild-type virus. Furthermore, the numbers of proviral DNA copies in PBMCs from the two groups were not able to reach the level in cats infected with wild-type virus during the observation period. From these results, we conclude that these mutant viruses are still infectious for cats but failed in efficient viral replication and suggest that these auxiliary genes and enhancer element are important or essential to full viral replication kinetics and presumably to full pathogenicity during the early stage of infection in vivo.

Animals↗
PubMed1999

Kinetics of replication of a partially attenuated virus and of the challenge virus during a three-year intersubtype feline immunodeficiency virus superinfection experiment in cats.

The effects of preinfecting cats with a partially attenuated feline immunodeficiency virus (FIV) on subsequent infection with a fully virulent FIV belonging to a different subtype were investigated. Eight specific-pathogen-free cats were preinfected with graded doses of a long-term in vitro-cultured cell-free preparation of FIV Petaluma (FIV-P, subtype A). FIV-P established a low-grade or a silent infection in the inoculated animals. Seven months later, the eight preinfected cats and two uninfected cats were challenged with in vivo-grown FIV-M2 (subtype B) and periodically monitored for immunological and virological status. FIV-P-preinfected cats were not protected from acute infection by FIV-M2, and the sustained replication of this virus was accompanied by a reduction of FIV-P viral loads in the peripheral blood mononuclear cells and plasma. However, from 2 years postchallenge (p.c.) until 3 years p.c., when the experiment was terminated, preinfected cats exhibited reduced total viral burdens, and some also exhibited a diminished decline of circulating CD4(+) T lymphocytes relative to control cats infected with FIV-M2 alone. Interestingly, most of the virus detected in challenged cats at late times p.c. was of FIV-P origin, indicating that the preinfecting, attenuated virus had become largely predominant. By the end of follow-up, two challenged cats had no FIV-M2 detectable in the tissues examined. The possible mechanisms underlying the interplay between the two viral populations are discussed.

Animals↗
PubMed1996

Surgical treatment of intrahepatic portosystemic shunts in six cats.

The surgical treatment of intrahepatic portosystemic shunts in six cats is described. The preoperative diagnoses were based on the results of abdominal ultrasonography, and mesenteric portography was used during surgery to confirm the diagnosis and establish the morphology of the shunting vessel. In four of the cats the shunt vessel passed through the left division of the liver, compatible with a patent ductus venosus (PDV), in one cat the shunt passed through the central hepatic division and in the other cat it passed through the right hepatic division. During surgery the shunt vessel was manipulated directly either intrahepatically, or post hepatically in the four cats with PDV. In five cats the shunt vessel was partially ligated, and in the other the vessel was completely ligated. The attenuation procedure produced a mean increase in mesenteric venous pressure of 17 cm H2O, with a range from 14 to 20 cm. All the cats recovered from the surgical procedure, but one developed neurological signs shortly after the operation and died from respiratory failure. Four of the cats were clinically normal and required no medication by one month after the operation. One cat required long-term medication to control its continued clinical signs.

Animals↗
PubMed2000

Long-term impact on a closed household of pet cats of natural infection with feline coronavirus, feline leukaemia virus and feline immunodeficiency virus.

A closed household of 26 cats in which feline coronavirus (FCoV), feline leukaemia virus (FeLV) and feline immunodeficiency virus (FIV) were endemic was observed for 10 years. Each cat was seropositive for FCoV on at least one occasion and the infection was maintained by reinfection. After 10 years, three of six surviving cats were still seropositive. Only one cat, which was also infected with FIV, developed feline infectious peritonitis (FIP). Rising anti-FCoV antibody titres did not indicate that the cat would develop FIP. The FeLV infection was self-limiting because all seven of the initially viraemic cats died within five years and the remainder were immune. However, FeLV had the greatest impact on mortality. Nine cats were initially FIV-positive and six more cats became infected during the course of the study, without evidence of having been bitten. The FIV infection did not adversely affect the cats' life expectancy.

Animals↗
PubMed2003

Systemic uptake of buprenorphine by cats after oral mucosal administration.

The plasma concentration of buprenorphine was measured by radioimmunoassay in six female cats after the administration of 0.01 mg/kg (0.033 ml/kg) buprenorphine hydrochloride solution into the side of the cat's mouth. Blood samples were taken through a preplaced jugular catheter before and one, two, four, six, 10, 15, 30, 45 and 60 minutes, and two, four, six, 12 and 24 hours after the dose was administered. The buprenorphine was accepted well by all the cats and did not cause salivation or vomiting. Its median peak plasma concentration was 7.5 ng/ml and was reached after 15 minutes. The pharmacokinetic data were similar to the pharmacokinetic data obtained after the intramuscular and intravenous administration of buprenorphine to cats from the same colony, suggesting that the mucosal route of administration should be as effective as intravenous and intramuscular injections. In addition, the pH of the oral cavity of 26 cats was measured with pH paper, and 100 cat owners were asked their preferred method of administering drugs to cats. The pH of the cats' mouths was between 8 and 9, and the technique preferred by the cat owners was the use of drops placed in the mouth.

Administration, Buccal↗
PubMed2003

Study of factors that may predispose domestic cats to road traffic accidents: part 1.

Between March 2000 and February 2001, six veterinary practices in Cambridgeshire collected data on 117 owned cats which they had examined after a road accident. For one week every month during the same year, the practices distributed questionnaires to the owners of cats which had been examined for reasons other than a road accident, and the data from these cats were checked to ensure that they were representative of the practice records, which were compared with a survey of the owned cat population for age and sex. From this population, the cats that were allowed outdoors and had never been in a road accident were chosen as controls, and compared with the cats that had been in a road accident for age, sex, pedigree status and coat colour. The cats that had been in a road accident differed from the control population with respect to age, sex and pedigree status; for every one-year increase in age, the odds of a road accident decreased by 16 per cent; the odds for males (entire and neutered) being in a road accident were 1.9 times the odds for females (entire and neutered), and the odds for pedigree cats were 0.29 those for non-pedigree cats.

Accidents, Traffic↗
PubMed1995

Binocular interactions and visual acuity loss in esotropic cats.

Visual acuity was measured behaviorally in various groups of cats by using a two-choice discrimination procedure. Cats in group 1 were rendered strabismic soon after birth by sectioning the tendon of the lateral rectus muscle (unilateral esotropia); at adulthood, their visual acuity (VA) was evaluated, after which the optic chiasm was sectioned and VA reassessed. Cats in group 2 were not only tenotomized but also chiasmatomized neonatally, while cats in group 3 underwent a neonatal section of the optic chiasm only. VA was measured at adulthood in the two latter groups. Group 4 consisted of adult cats whose VA was evaluated before and after an optic chiasm section. Stimuli consisted of square-wave gratings of various spatial frequencies. Results showed that in normal cats, the average threshold values under monocular viewing were identical for each eye (4.76 cycles/degree); however, following optic chiasm section, monocular VA was reduced to 1.23 cycles/degree. VA in early optic chiasm section cats was lower than that of the normal cats but higher than that of late-lesioned animals (2.33 cycles/degree). In strabismic cats, mean VA was 1.25 cycles/degree for the deviated eye and 2.8 cycles/degree for the normal eye. Following the optic chiasm section at adulthood, VA was lower not only for the deviated eye (< 0.17 cycles/degree) but also for the normal eye (1.14 cycles/degree). Similar results were found when both the deviation and chiasmatomy were performed neonatally. The elimination of interocular interactions through chiasm transection failed to improve VA in the strabismic eye.

Animals↗
PubMed1991

Systolic and diastolic dysfunction of the left ventricle induced by dietary taurine deficiency in cats.

Isovolumic left ventricular (LV) preparations were used to assess myocardial failure associated with dietary taurine deficiency in cats. Adult female cats (n = 12) were fed a purified diet devoid of taurine for 6-8 mo. Six of the cats received 1,000 mg of crystalline taurine orally once daily. The remaining six cats were not provided taurine replacement. Compared with control preparations, hearts isolated from taurine-deficient cats generated significantly lower values for developed LV systolic pressure (107 +/- 6 vs. 66 +/- 15 mmHg; P less than 0.05), maximal rate of LV pressure rise (+dP/dtmax; 1,103 +/- 38 vs. 718 +/- 172 mmHg/s; P less than 0.05), and fall (-dP/dtmax; 930 +/- 46 vs. 587 +/- 129 mmHg/s; P less than 0.05). LV function curves generated by hearts from taurine-deficient cats were shifted downward and to the right of control curves, demonstrating inotropic depression. In addition, end-diastolic pressure-volume (compliance) relationships in hearts from taurine-deficient cats were shifted downward and to the right of controls in the direction of increased chamber compliance or distensibility. Ten millimolar taurine significantly improved inotropic indexes only in hearts from taurine-deficient cats but failed to affect diastolic compliance. Myocardial contractile dysfunction and LV chamber dilatation in hearts from taurine-deficient cats verify a causal association between dietary deficiency of this amino acid and dilated cardiomyopathy in this species.

Animals↗
PubMed1993

Ventilatory response to moderate hypoxia in awake chemodenervated cats.

In humans and cats the ventilatory response to 30 min of moderate hypoxia (arterial PO2 40-55 Torr) is biphasic: ventilation increases sharply for the first 5 min and then declines. In humans there is evidence that the decline is dependent on the initial increase. We therefore examined ventilatory responses to moderate isocapnic hypoxia in awake cats with and without carotid body denervation. Cats underwent denervation or a sham operation. Then they were studied in a Drorbaugh-Fenn plethysmograph while ventilation, arterial PO2, and end-tidal PO2 and PCO2 were measured. Three sham-operated and four denervated cats were studied with room air as the control. Sham animals demonstrated a biphasic response: ventilation rose to 211% of control at 5 min and fell to 114% of control at 25 min. Denervated animals showed neither the initial increase nor the subsequent decrease in ventilation. Three sham-operated and three denervated cats were studied with 2% CO2 added to the inspirate. Results were similar: intact cats showed a biphasic response to hypoxia, whereas denervated cats showed neither an increase nor a decrease in ventilation. Preliminary experiments showed that hypoxia was not associated with changes in CO2 output or systemic blood pressure in either denervated or intact animals. We conclude that depression of ventilation does not occur in awake denervated cats in response to moderate hypoxia and that the decline in ventilation that occurs in intact cats is in some way dependent on peripheral chemoreceptor output.

Animals↗
PubMed1975

Effects of early binocular deprivation on visual input to cat superior colliculus.

1. Recent work has demonstrated at least three distinct inputs to the superior colliculus in normal cats: a) the W-direct retinotectal pathway; b) the Y-direct retinotectal pathway; and c) the Y-indirect pathway which involves Y-cells in retina and lateral geniculate nucleus plus complex cells in cortex, the last being the corticotectal cells. 2. We investigated these inputs in five cats raised with binocular eyelid closure by studying the electrophysiological properties of 164 collicular neurons. After such binocular deprivation, the Y-indirect pathway was missing and the Y-direct pathway appeared reduced, although the W-direct input seemed unaffected. 3. Despite the loss of the Y-indirect input, collicular activation to electrical stimulation of cortex seemed normal in these cats. This suggested that the Y-indirect loop was affected between the optic tract and cortex, and this, in turn, correlated to the previously described reduction in recordable Y-cells from the lateral geniculate nucleus of binocularly deprived cats. 4. We found receptive-field correlates to this loss of Y-direct and Y-indirect input in the binocularly deprived cats. Compared to collicular neurons in normal cats, those in deprived cats exhibited abnormally strong dominance by the contralateral eye, loss of directional selectivity, and loss of responsiveness to fast visual stimuli. 5. These and other data lead to the suggestion that in normal and monocularly deprived cats, the corticotectal input dominates collicular receptive-field properties, whereas in binocularly deprived cats, the remaining retinotectal input dominates these properties.

Animals↗
PubMed1987

Basic electrophysiological properties of spinal cord motoneurons during old age in the cat.

1. The electrophysiological properties of alpha-motoneurons in old cats (14-15 yr) were compared with those of adult cats (1-3 yr). These properties were measured utilizing intracellular recording and stimulating techniques. 2. Unaltered in the old cat motoneurons were the membrane potential, action potential amplitude, and slopes of the initial segment (IS) and soma dendritic (SD) spikes, as well as the duration and amplitude of the action potential's afterhyperpolarization. 3. In contrast, the following changes in the electrophysiological properties of lumbar motoneurons were found in the old cats: a decrease in axonal conduction velocity, a shortening of the IS-SD delay, an increase in input resistance, and a decrease in rheobase. 4. In spite of these considerable changes in motoneuron properties in the old cat, normal correlations between different electrophysiological properties were maintained. The following key relationships, among others, were the same in adult and old cat motoneurons: membrane potential polarization versus action potential amplitude, duration of the afterhyperpolarization versus motor axon conduction velocity, and rheobase versus input conductance. 5. A review of the existing literature reveals that neither chronic spinal cord section nor deafferentation (13, 21) in adult animals produce the changes observed in old cats. Thus we consider it unlikely that a loss of synaptic contacts was responsible for the modifications in electrophysiological properties observed in old cat motoneurons. 6. We conclude that during old age there are significant changes in the soma-dendritic portion of cat motoneurons, as indicated by the modifications found in input resistance, rheobase, and IS-SD delay, as well as significant changes in their axons, as indicated by a decrease in conduction velocity.

Action Potentials↗
PubMed1989

Cable properties of spinal cord motoneurons in adult and aged cats.

1. The electrophysiological properties of spinal cord alpha-motoneurons were investigated in adult cats (1-3 yr old) and old cats (14-15 yr old) using intracellular recording techniques. Voltage transients following depolarizing pulses of current were analyzed according to the procedure described by Ito and Oshima (15). The input resistance of each cell, together with the passive electrical time constants, were used to estimate the electrotonic length and total cell capacitance of each motoneuron. 2. Adult and old motoneurons both exhibited an undershoot of the membrane potential following the cessation of a subthreshold depolarizing current pulse (15). The average time constant for the decay of this undershoot in membrane potential was statistically indistinguishable in motoneurons of adult and aged animals. 3. The average membrane time constant of motoneurons in aged cats was 19% longer than that of motoneurons in adult cats. 4. The average total cell capacitance of motoneurons in aged cats was 16% smaller than that of motoneurons in adult cats. 5. The average electrotonic length of old motoneurons was statistically indistinguishable from that of motoneurons in adult cats. 6. From these results, we conclude that there is an age-dependent increase in the membrane resistance and an age-dependent decrease in cell surface area of alpha-motoneurons of the lumbar spinal cord in aged cats. Both of these phenomena are believed to contribute to the age-dependent increase in input resistance that has been previously reported to occur in motoneurons in aged cats (18).

Aging↗
PubMed1998

Recovery of locomotion after ventral and ventrolateral spinal lesions in the cat. I. Deficits and adaptive mechanisms.

The recovery of treadmill locomotion of eight adult cats, subjected to chronic ventral and ventrolateral spinal lesions at low thoracic levels (T11 or T13), preserving at least one dorsolateral funiculus and the dorsal columns, was documented daily using electromyographic (EMG) and kinematic methods. The data show that all cats eventually recovered quadrupedal voluntary locomotion despite extensive damage to important pathways (such as the reticulospinal and the vestibulospinal) as verified by injection of wheat germ agglutinin-horseradish peroxidase (WGA-HRP) caudal to the site of lesion. Initially (in the early period after the spinal lesion), all the cats suffered from pronounced locomotor and postural deficits, and they could not support their hindquarters or walk with their hindlimbs. Gradually, during the recovery period, they regained quadrupedal walking, although their locomotion was wobbly and inconsistent, and they suffered from poor lateral stability. EMG and kinematic data analyses showed a tendency for an increase in the variability of the step cycle duration but no major changes in the step cycle structure or in the intralimb coupling of the joints. However, the homolateral fore- and hindlimb coupling was highly perturbed in cats with the largest lesions. Although the general alternating pattern of extensor and flexors was maintained, there were various changes in the duration and amplitude of the EMG bursts as well as a lack of amplitude modulation during walking uphill or downhill on the treadmill. In cats with larger lesions, the forelimbs also seem to take a greater propulsive role than usual as revealed by a consistent increase of the activity of the triceps. In cats with smaller lesions, these deficits were transient, but, for the most extensively lesioned cats, they were pronounced and lasted long term postlesion even after reaching a more or less stable locomotor behavior (plateau period). It is concluded that recovery of quadrupedal locomotion is possible even after a massive lesion to ventral and ventrolateral quadrants, severing the vestibulospinal pathway and causing severe, although incomplete, damage to the reticulospinal tract. The quick recovery in the less lesioned cats can be attributed to remaining pathways normally implicated in locomotor function. However, in the most extensively lesioned cats, the long period of recovery and the pronounced deficits during the plateau period may indicate that the compensation, attributed to remaining reticulospinal pathways, is not sufficient and that other pathways in the dorsolateral funiculi, such as the corticospinal, can sustain and adapt, up to a certain extent, the voluntary quadrupedal walking.

Animals↗
PubMed2003

Effect of altered thyroid state on the in situ mechanical properties of adult cat soleus.

To determine the responsiveness of cat hindlimb muscles to thyroid manipulation, adult female cats were made hypothyroid (thyroidectomy plus tapazole treatment), hyperthyroid (synthroid pellets), or maintained euthyroid. After 4 months, the hypothyroid soleus had slower time-to-peak (TPT, 80%) and half-relaxation (HRT) times, whereas the hyperthyroid soleus had faster TPT (20%) and HRT than euthyroid cats. The tension at low stimulation frequencies (5-15 Hz) was higher in hypothyroid and lower in hyperthyroid cats compared to euthyroid cats. Muscle weight, maximum twitch and tetanic (Po) tensions, and maximum rates of shortening (Vmax) were similar across groups. The soleus of hypothyroid cats was more fatigable than normal. The myosin heavy chain (MHC) composition, based on gel electrophoresis, was unaffected by thyroid hormone manipulation. Based on the reaction of monoclonal antibodies for specific MHCs, some fast fibers in the hypothyroid cats coexpressed developmental MHC. These data indicate that 4 months of an altered thyroid state result in changes in the isometric twitch speed properties of the cat soleus, but not the tension-related or isotonic properties. Further, a chronic decrease in thyroid hormone had a greater impact than a chronic increase in thyroid hormone on the mechanical properties of the adult cat soleus.

Animals↗
PubMed2003

Focus on cat allergen (Fel d 1): immunological and aerodynamic characteristics, modality of airway sensitization and avoidance strategies.

The increasing frequency of pet ownership (especially cats) in many industrialized countries has raised the level of exposure to the allergens produced by these animals. Moreover, it is likely that modern energy-saving systems and the wide use of upholstered furniture has resulted in closer contact between cats (and their allergens) and humans. Many different methods have been developed to quantify the main cat allergen (Fel d 1) in settled dust and in ambient air. The threshold levels of cat allergen inducing sensitization or triggering respiratory symptoms in sensitized patients have been calculated in settled dust, but airborne amounts of Fel d 1 probably represent a more reliable index of allergen exposure. Noticeably, the amount of Fel d 1 may be relatively high also in confined environments where cats have never been kept. It has been demonstrated that clothes of cat owners are the main source for dispersal of allergens in cat-free environments. This fact may be of relevance, because recent studies have shown that allergic sensitization to cats is more likely to develop in children exposed to moderate levels of this allergen than in children exposed to high amounts of Fel d 1. The ubiquity of cat allergen may justify the common observation that allergen avoidance is often insufficient to reduce the risk of developing allergic sensitization and/or symptom exacerbation in highly susceptible patients. Further efforts are needed to improve the efficacy of Fel d 1 avoidance strategies to try to reduce the risk of allergic sensitization to this allergen.

Air Pollution, Indoor↗
PubMed1981

Correlation of local blood flow, glucose consumption and probability of necrosis following a middle cerebral artery occlusion in the cat.

At defined coronal sections, the surface area of infarcted tissue was measured 4 days after the occlusion of the middle artery in 11 cats. In groups of cats treated with ifenprodil (5.6 and 16.7 microgram/kg . min over 3 h. 5 min after the occlusion), the infarcted surface was significantly decreased. The topographic localization of the infarction was studied in control and treated cats. This established necrosis was correlated with measures of focal cerebral blood flow and glucose consumption 3.5 h after the middle cerebral artery occlusion. Grey matter blood flow was universally low in untreated cats, but in cats treated with ifenprodil (5.6 microgram/kg . min) cortical and caudate nucleus blood flow was 2-3 times greater, even in those regions that were later infarcted in the treated cats. Glucose consumption was similarly reduced in untreated cats but there was little difference between the control and drug-treated cats except in some areas where drug treatment appeared to further reduce the values for focal glucose consumption. These regions correlated with those in which infarction was later found in the cats treated with ifenprodil. It is hoped that such correlations between pathology. flow and metabolism could help the search for effective pharmacotherapy of cerebrovascular disease.

Animals↗