ADMISSIBILITY in evidence of chemical tests for intoxication.
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Alcoholic Intoxication↗
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ADMISSIBILITY in evidence of results of chemical tests for intoxication.
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Alcoholic Intoxication↗
The effects of alcohol and expectancies on risk perception and behavioral skills relevant to safer sex among heterosexual young adult women.
OBJECTIVE: This study was undertaken to test the hypotheses that acute alcohol intoxication and alcohol-rated sex expectancies are negatively related to both risk perception (a motivational factor) and ability to negotiate safer sex (a behavioral skills factor) with a partner. Motivation and behavioral skills are determinants of safer sex according to the Information-Motivation-Behavioral Skills (IMB) model. METHOD: A total of 102 heterosexual females ages 21-30 years participated in two sessions. The first session involved the administration of various measures to confirm eligibility status, and random assignment to one of three beverage conditions: "water control:" "alcohol" (0.65 g alcohol/kg body weight) or "placebo:" The second session involved administration of the beverage and then completion of a risk perception measure and an audiovisual role-play measure of behavioral skills. RESULTS: Regression analyses showed that alcohol expectancies and the perception of intoxication contributed independent variance to both risk perception and behavioral skills. Actual alcohol intoxication had little influence on these dependent variables. CONCLUSIONS: Alcohol expectancies and related factors can be related to variables that theoretically precede the occurrence of risky sex. Research is needed on the processes through which expectancies might be related to the occurrence of safer sex, as well as on person and situation variables that moderate the effects of alcohol and alcohol expectancies on safer sex.
Adult↗
[Alcohol abuse in adolescence: a growing problem].
Alcohol intoxication appears to be a growing problem among adolescents in The Netherlands. Alcohol abuse has led to more hospitalisation over the last years. In the Reinier de GraafGasthuis, in Delft, there was a marked increase in the number of adolescents hospitalised due to alcohol intoxication in 2001-2005, with 2, 3,4, 5 and 8 admissions, respectively. Most of these patients drank in a domestic setting or during a school party. Usually, they drank many kinds of alcoholic beverages at the same time. The changes in drinking habits and the increase in hospitalisation of adolescents due to alcohol intoxication are of concern. This trend obliges physicians to do more research, possibly in co-operation with local policy makers and the government.
Adolescent↗
[Interrelationship among factors associated with drinking behaviors in dental students].
We analyzed the Kurihama Alcoholism Screening Test (KAST), the Adolescent Alcohol Involvement Scale (AAIS), the Fagerstroem Tolerance Questionnaire (FTQ), the Tokyo University ALDH2-Phenotype Screening Test (TAST), results of ethanol patch tests, the presence or absence of a smoking habit, and gender by "Hayashi's quantification theory, type II" in 415 senior students (232 males and 183 females) of a dental college between 2000 and 2003, and evaluated their relationships. When drinking education is given to dental students, both the prevention of acute alcohol intoxication by chugging and the prevention of alcohol dependence in students with drinking behavior suggesting this tendency are necessary. For acute alcohol intoxication, attention can be aroused in students with positive ethanol patch tests. However, there is no definite instruction method for the prevention of alcohol dependence. Therefore, we analyzed the relationships among drinking, smoking, and constitution based on data obtained during the 4 years when the above 3 types of surveys were performed. Plotting of the results of analysis showed that the students can be classified by the ethanol patch test and TAST into those with "alcohol-sensitive" constitution and those with "alcohol-tolerant" constitution. Most problem drinkers were "alcohol-tolerant". KAST showed plotting along the constitution axis from "normal drinking group" to "problem drinking borderline group" but a change in the angle to an L shape at the transfer point from "problem drinking borderline group" to "problem drinking group", showing more serious states along the smoking axis. These results suggest that drinking behavior is first regulated by alcohol- sensitive or alcohol-tolerate constitution, and alcohol-tolerate students with a smoking habit have alcohol dependence tendency, and tend to show serious problem drinking. Improvement in the drinking habit is necessary in alcohol-tolerate students with a smoking habit so that they will not develop alcohol dependence.
Adult↗
[Effect of ethyl alcohol on oxidation-reduction processes in the myocardium].
Evidence is given of disturbances of aerobic oxidative process in the myocardial mitochondria occurring in acute and chronic alcoholic intoxication. A single introduction of alcohol in a dose of 1 and 3 g/kg to rats and dogs produces "hypoxyform" changes in the myocardium, viz. a fall of PO2, a reduced activity of most NAD-independent enzymes, activation of succinate- and lactate-dehydrogenases in a moderate dissociation of oxidative phosphorylation reactions. The damaging effect of the alcohol persists for 24 hours after its one-time introduction. Following a 2-month long alcoholic intoxication there was seen a depressed respiratory activity of the mitochondria and of the study enzymes, except for cytochrome-C-oxidase. It is assumed that the cardiotoxic effect of alcohol is due to the damage of the energy-producing system of the mitochondria.
Alcoholic Intoxication↗
Irreversibility of kindled alcohol-withdrawal behaviour in rats.
In order to investigate whether alcohol-withdrawal kindling is an irreversible process, male Wistar rats were exposed to 12 episodes, each consisting of 2 days of severe alcohol intoxication and 5 days of alcohol withdrawal. Spontaneous withdrawal seizures were found in 15% of the animals during episodes 10-12. After an alcohol-free period of 26 days, the animals were subjected to three more episodes of alcohol dependence (i.e. episodes 13-15) in which 12% of the animals developed spontaneous withdrawal seizures. Based on several statistical tests, we concluded that there was no true difference between the seizure activity in episodes 10-12 and episodes 13-15, indicating that alcohol-withdrawal kindling is a long-lasting and perhaps irreversible process. In a second experiment, an alcohol-withdrawal kindled group was first exposed to seven episodes of alcohol dependence. A diazepam group went through the same alcohol regimen, but each withdrawal reaction was blocked by diazepam treatment. Finally, a single episode group was included which was fed isocalorically with the kindled animals. After an alcohol-free period of 11 days, all three groups were subjected to 4 days of severe alcohol intoxication. During the subsequent withdrawal reaction seizures were observed in 22-26% of the animals with no significant differences across the groups. These results call for a modification of the kindling hypothesis of alcohol withdrawal and suggest that kindling-induced alterations may be overlooked if convulsive behaviour is tested during a relatively strong withdrawal reaction.
Alcohol Withdrawal Delirium↗
[Alcoholic disease].
A new concept of alcoholic disease has been developed on the basis of the study of 355 corpses of persons abusing ethanol and 335 white male rats with experimental alcoholic intoxication. A new nosological entity "alcoholic disease" (AD) is suggested instead of "chronic alcoholism". Pathogenesis of AD consists of 3 stages: I--repeated acute alcoholic intoxication, II--drunkenness, III--alcoholism and its complications. The definition of AD is given. A leading role in it belongs to the damage of the liver, heart, lungs and brain. The stage 1 involves degenerative changes in the organs, stage II--spectrum of the damage is larger but the changes are still reversible. The patients are treated in hospitals where the role of ethanol in the heart and liver damage is not taken into consideration. Stage III--irreversible changes. Hence, the diagnosis and treatment of stage II is necessary as it is curable.
Alcoholism↗
Alcohol and secobarbital effects as a function of familial alcoholism: extended intoxication and increased withdrawal effects.
Response differences following administration of alcohol between adult males with a positive (FHP) versus negative (FHN) family history of alcoholism have been demonstrated in previous research and are thought to be related to risk for developing alcoholism. If this is so, the pharmacological breadth of addiction risk conferred by a positive family alcoholism history might be studied by determining whether FHP subjects show different responses than FHN to drug classes other than alcohol. We have previously reported on the acute effects of ethanol as compared with secobarbital in FHP and FHN subjects and found that FHP subjects showed greater sensitivity across a variety of subjective measures than FHN subjects for both drug classes. The data reported here are based on an extended data collection period of 3 to 18 hr postingestion, following completion of the acute laboratory portion of the study. Specifically, in the present study, dose-effect timecourse functions for a variety of physiological (heart rate, blood pressure, and breath alcohol level), subjective (analog mood, drug effect, and withdrawal, Subjective High Assessment Scale (SHAS], and psychomotor measures (Digit Symbol Substitution Test and numeric recall) were examined in FHP and FHN college-aged males for secobarbital (0, 100, 200 mg daily) and ethanol (1 g/kg daily). FHP and FHN subjects were matched on light-to-moderate drinking patterns, anthropometric dimensions, age, years of schooling, and drug use. FHP subjects reported more extended intoxication and greater withdrawal effects following both ethanol and the high dose of secobarbital than did FHN subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
Adolescent↗
Alcohol-induced suppression of lung chemokine production and the host defense response to Streptococcus pneumoniae.
BACKGROUND: Acute alcohol intoxication impairs neutrophil migration in response to intrapulmonary infection with Streptococcus pneumoniae, the most common bacterial cause of pneumonia. Many of the same host defense functions that are impaired in the alcohol-intoxicated host are mechanistically associated with chemokines, a group of proinflammatory molecules that enhance neutrophil adhesion and direct neutrophil migration to sites of inflammation. The purpose of this study was to determine whether alcohol-induced chemokine suppression is responsible for impaired neutrophil recruitment into the lung during infection of the alcohol-intoxicated host. METHODS: S. pneumoniae was administered (107 colony-forming units) intratracheally 30 min after intraperitoneal injection of 20% alcohol (5.5 g/kg) or saline. Four hours after bacterial challenge, bronchoalveolar lavage fluid (BALF) was collected, and the ability of BALF to induce neutrophil chemotaxis and adhesion molecule expression was measured by using chemotactic and flow cytometric assays. In another experiment, intratracheal challenge was performed by using recombinant macrophage inflammatory protein-2 (MIP-2), and BALF neutrophils were measured. RESULTS: BALF MIP-2 and cytokine-induced neutrophil chemoattractant were decreased by alcohol, and BALF from alcohol-intoxicated animals had decreased chemotactic activity for neutrophils, as well as a decreased ability to up-regulate neutrophil adhesion molecule expression, compared with controls. This decreased chemotactic activity was significantly increased in the alcohol group by repletion of chemokines to control levels. Alcohol also suppressed neutrophil recruitment after intrapulmonary challenge with MIP-2, suggesting that mechanisms other than chemokine suppression contribute to the alcohol-induced effect. CONCLUSIONS: At least two mechanisms, suppressed chemokine production and impaired neutrophil adhesion molecule expression, likely work in concert in the alcohol-intoxicated host to impair neutrophil adhesion and migration into the lung during pneumococcal infection. These alterations in neutrophil function likely increase the susceptibility of alcohol-consuming hosts to pneumonia.
Animals↗
Teenage alcohol and intoxication debut: the impact of family socialization factors, living area and participation in organized sports.
The aim of the present study was to examine the age distribution of alcohol and intoxication debut and factors associated with this among a representative sample of Norwegian teenagers. A sample of 3368 teenagers aged 12-18 years was recruited from 34 Norwegian secondary schools to complete an 87-item questionnaire under examination conditions; 5.2% (168/3239) reported drinking alcohol for the first time when 10 years or younger, 25.2% (816/3239) when they were 13 years or younger and 60.1% (1948/3239) when 16 years or younger, with 39.9% having never drunk alcohol; 1.3% (44/3239) were first intoxicated by 10 years or younger, 12.8% (418/3239) when 13 years or younger and 37.5% (1649/3239) when 16 years or younger. Pupils with early alcohol or intoxication debut (<14 years) tended to come from single-parent families, from cities, experienced less family support and a more highly organized family life, reported more frequent peer and parental drinking, and did not participate in sports. They also showed a substantially elevated total yearly current alcohol consumption, compared to the group with alcohol debut at 14 years or later (8.1 and 2.5 l pure alcohol, respectively). Poor family support but high family organization, living in single-parent families and in cities, and more frequent parental and peer drinking are associated with early alcohol debut, whereas participation in organized sport activities may delay drinking and intoxication debut in teenagers. Sports organizations should be included in drinking prevention programmes.
Adolescent↗
Alcohol-related aggression in the general population.
OBJECTIVE: This study estimates the relationships between drinking in the event and drinking patterns and different levels of aggression severity. METHOD: A telephone survey of 1,001 adults (542 women) age 18 and over was conducted (response rate of 67%) using computer assisted telephone interviewing (CATI). Respondents were asked whether they had been personally involved in a serious argument, an incident involving threat, or physical aggression in the past year and whether anyone had been drinking alcohol in the most recent incident. Respondents also reported their typical alcohol consumption patterns. RESULTS: The proportion of respondents reporting involvement in serious arguments, threats or physical aggression was 19.8%, 11.8% and 12.0%, respectively. Someone in the incident had been drinking in 38.1% of serious arguments, 56.5% of threats and 67.9% of incidents of physical aggression. When gender, age, education, marital status and employment status were controlled for, high quantity drinking (as measured by the largest number of drinks consumed on one drinking occasion in the past year), overall estimated annual volume of alcohol consumed, and frequency of consuming five drinks per occasion were significantly greater for physical aggression, compared with arguments and no aggression. However, drinker status (abstainer/drinker) and frequency of drinking were not significantly associated with involvement in aggression. In a logistic regression analysis controlling for demographic variables, a composite measure of alcohol consumption was highly significant for physical aggression versus no aggression and for physical versus verbal aggression. Physical aggression was also associated with being younger, separated/ divorced and a student. CONCLUSIONS: The results suggest that alcohol intoxication, rather than mere alcohol consumption, is associated with aggression. Moreover, alcohol intoxication is more strongly associated with physical aggression than with verbal aggression.
Adolescent↗
Substance abuse, violence, and outcome after traumatic spinal cord injury.
Alcohol and drug use have been shown to contribute to the onset of traumatic spinal cord injury and to be a marker for later onset substance abuse issues. Admission toxicology (drug and alcohol) screens were collected from 87 consecutive rehabilitation medicine patients with a diagnosis of acute traumatic spinal cord injury. Forty-six patients (53%) presented with positive screens (44% alcohol only, 30% drug only, 26% both). Seventy-five percent of those with positive alcohol screens met state criteria for alcohol intoxication (blood alcohol level, > or =0.08 mg/dl). Compared with individuals with negative screens, those with positive screens were significantly (P < 0.05) younger and unmarried. Compared with nonviolence-related spinal cord injury, patients with violence-related spinal cord injury (gunshot wound and assault) were significantly (P < 0.01) more likely to have positive admission toxicology screens (76% v 41%), drug screens (62% v 14%), and intoxication screens (72% v 34%). Rehabilitation outcome comparisons between those with positive and negative screens revealed similar length of stay, admission and discharge Functional Independence Measure (FIM) scores, FIM change scores, and FIM efficiency scores. This study has important implications with regard to substance abuse issues and their impact on traumatic spinal cord injury outcome, which may assist in better targeting prevention.
Activities of Daily Living↗
Does alcohol-induced blood cell agglutination cause brain damage?
After 3 weeks of alcohol intoxication, the brains of rats were searched with light- and electron microscopy for degenerating nervous tissue and agglutination of erythrocytes in the blood vessels. There was no sign of degeneration of nerve cells or synapses in the cerebral cortex, hippocampus, cerebellum, midbrain or hindbrain. No histological sections showed blood vessels with erythrocytes inside them. It is concluded that the agglutination of red blood cells seen in the conjunctivae of intoxicated human alcoholics is not necessarily an indication that vascular congestion is also occurring in the brain of such patients, nor that this is the primary mechanism of alcohol-related brain damage.
Alcoholism↗
The use of an alcometer in clinical forensic practice.
Forensic physicians are at times required to provide a professional opinion on a person's degree of intoxication through alcohol, particularly with regard to fitness for interview by the police. Inherent to these assessments is an estimation of the blood alcohol concentration (BAC). Most forensic physicians rely on taking a history regarding recent alcohol consumption and a clinical assessment to estimate the BAC. We report a study in which the BAC of 118 detainees was estimated and compared with the BAC measured by an alcometer. Our estimations were accurate in 66% of cases. Most errors resulted from underestimating the BAC. Additionally, we attempted to determine fitness for interview using a single measurement of the BAC without a clinical assessment. 19% of those who were assessed as unfit for interview had a BAC of less than the UK legal limit for driving (currently 80 mg%) and 37% considered fit, had a BAC above that level. We conclude that the routine use of alcometers would enhance the practice of forensic medicine but could not replace its role in the assessment of levels of alcohol intoxication.
Journal Article↗
Human blood acetaldehyde levels: with improved methods, a clearer picture emerges.
New reliable methods for the determination of acetaldehyde in human blood, either from separated plasma or from acid-precipitated whole blood, demonstrate that the blood of healthy Caucasians contains at most only extremely small amounts of acetaldehyde (less than 1 microM) after moderate alcohol intoxication. On the other hand, among about 50% of the Japanese population ethanol ingestion results in elevated blood acetaldehyde levels (10-50 microM) with consequent unpleasant cardiovascular responses such as facial flushing and tachycardia, apparently because of a lack of one of the acetaldehyde-oxidizing aldehyde dehydrogenase isozymes. Elevated acetaldehyde levels may eventually occur also among intoxicated Caucasian alcoholics, primarily as a consequence of abuse-induced loss of hepatic aldehyde dehydrogenase activity, but accentuated by an accelerated ethanol oxidation rate. The elevation is probably reversible, since no acetaldehyde is seen in alcoholics after abstinence and hospital treatment. There is thus little evidence that an elevation of acetaldehyde could serve as a marker for predisposition for alcoholism.
Acetaldehyde↗
[The effect of medikhronal on the biogenic amine level in the brain structures and blood of animals with alcohol dependence].
Peculiarities of changes in the content of biogenic amines in the brain structures (hypothalamus, midbrain and new cortex) and blood of rats under alcohol intoxication and formation of alcohol dependence were investigated, and the effect of medichronal and its components on the mentioned processes was found out. It has been established that accumulation of acetaldehide plays a considerable role in the mechanism of formation of alcohol dependence. Changes in the level of ethanol (E) and AcA in blood after the arrival of exogenic E to the organism evokes phase dynamics of content of biogenic amines in the blood and brain sections. Medichronal components, binding and inactivating AcA, as well as taking the mutually supplementing effect on synthesis of biogenic amines, promote normalization of the mentioned processes and elimination of alcohol dependence.
Alcohol Deterrents↗
[The nurse's role in the identification and management of alcohol abuser in the Emergency Department].
The emergency department (ED) nurse plays a major role both in recognizing and in the management of the patients affected by alcohol related problems, such-as acute alcohol intoxication (AAI), alcohol withdrawal (AW), traumatic or spontaneous illness due to acute or chronic effects of alcohol abuse. Here are described both the clinical problems and the diagnostic instruments that nurse can use in ED to increase diagnostic sensibility. Furthermore both clinical features of AAI in relation with blood alcohol concentration (BAC), diagnostic criteria and test to evaluate AW severity are reported in this review. Even diagnostic instruments to identify alcohol abuse also in trauma are reported: the alcohol breath test, BAC and laboratory test. Even the Alcohol Use Disorders Identification Test (A.U.D.I.T.) questionnaire is reported to recognize the alcohol abuser. In conclusion acquiring a specific training, nurse can play a major role in the complex intervention net of alcoholics rehabilitation.
Accidental Falls↗