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Left ventricular mass, geometry and filling in elite female and male endurance athletes.

We compared echocardiographic findings in female (n=30) and male (n=30) endurance athletes to age-matched female (n=15) and male (n=15) sedentary controls. The differences between athletes and controls were similar in both sexes; only left ventricular (LV) mass and septum thickness differed slightly more in men than in women (67% vs 55%, P=0.004, and 36% vs 30%, P=0.03, respectively). LV wall thicknesses were in the normal range in all women, while four (13%) male athletes exceeded 13 mm. In conclusion, the effects of endurance training on echocardiographic findings appear to be quite similar in women and men. However, in female athletes with an abnormally thick left ventricular wall a thorough cardiac evaluation is indicated. This contrasts with male athletes, in whom LV wall thicknesses of over 13 mm are a not uncommon finding.

Adult↗

Substance use by college students: the role of intrinsic versus extrinsic motivation for athletic involvement.

Certain types of athletic involvement may confer risk for substance use by college students. This study investigated whether motivational factors play a role in the relationship between athletic involvement and substance use. Intercollegiate athletes (n=98) and exercisers (n=120) were surveyed about substance use and motivation for athletic involvement. Athletes and exercisers who were extrinsically motivated had significantly higher rates of alcohol use than their intrinsically motivated counterparts. Results suggest that college students who are extrinsically motivated for involvement in physical activity/athletics--particularly those involved in team sports--may be in need of targeted prevention efforts.

Adolescent↗

Relationships between body weight change and cardiovascular disease risk factors in male former athletes.

OBJECTIVE: To evaluate the cardiovascular disease risk factor profile in former athletes according to their weight-change patterns during the postcompetitive period. DESIGN: Cohort study with a retrospective assessment of baseline weight of male former top-level athletes. SUBJECTS: One-hundred and fifty top-level athletes aged 35-60 y were divided into four groups according to the weight-change patterns during the postcompetitive period (weight loss, constant weight, weight gain over 3.0 kg and weight gain over 10.0 kg). MEASUREMENTS: Anthropometric measurements (height, weight, BMI, percentage fat, skinfolds, waist-to-hip-ratio (WHR), resting systolic and diastolic blood pressure (SBP, DBP), serum lipids and lipoproteins (CHOL, HDL-C, LDL-C, TG), and physical working capacity. A questionnaire was drawn up to evaluate current and previous physical activity, lifestyle indices and to record weight at the age of 20 (according to sports diaries). RESULTS: Weight gain over 10.0 kg in former athletes was closely associated with higher body mass index, percentage body fat, skinfold thickness, WHR, SBP, DBP, LDL-C and TG values, as well as lower HDL-C, HDL-C/CHOL ratio and physical working capacity values. After adjustment for confounders, the weight gainers over 10.0 kg revealed a higher risk of hypertension (OR 6.65; 95% CI 2.99-11.65), abdominal fat distribution pattern (OR 10.51; 95% CI 6.11-16.24), elevated LDL-C (OR 1.88; 95% CI 1.15-3.06) and hypertriglyceridemia (OR 3.52; 95% CI 1.12-8.56) compared with those whose weight was constant. Weight loss and weight gain less than 10.0 kg were significantly related to increased risk for abdominal fat distribution pattern. CONCLUSION: The results of the present study showed that weight gain during the postcompetitive period was associated with a higher prevalence of cardiovascular disease risk factors in male former athletes.

Adult↗

Weight cycling of athletes and subsequent weight gain in middleage.

OBJECTIVE: To study the effects of repeated cycles of weight loss and regain as young adults on long-term weight development. DESIGN: A follow-up study with questionnaires in 1985, 1995 and 2001. SETTING: Finland. SUBJECTS: A national cohort of 1838 male elite athletes who had represented Finland in major international sport competitions in 1920-1965, including 370 men engaged in sports in which weight-related performance classes are associated with weight cycling (boxers, weight lifters and wrestlers; further called as weight cyclers), and 834 matched control men with no athletic background. OUTCOME MEASURE: Weight change since the age of 20 years, body mass index (BMI) and prevalence of obesity and overweight. RESULTS: The weight cyclers gained 5.2 BMI units from age 20 years to their maximum mean weight, which was at age 58.7 years. Corresponding figures for the controls were 4.2 BMI units at 58.5 years and for other athletes 3.3 BMI units at age 62.5 years. The proportion of obese (BMI> or =30 kg/m(2)) subjects was greatest among the weight cyclers both in 1985 and 1995. In 2001, the weight cyclers were more often obese than other athletes, but did not differ from the controls. The odds ratio for the weight cyclers to be obese compared to other athletes in 1985 was 3.18 (95% confidence intervals 2.09-4.83), and compared to the controls 2.0 (1.35-2.96). The enhanced weight gain of the weight cyclers was not accounted for by present health habits (smoking, alcohol use, use of high-fat milk or physical activity) or weight at age 20 years. CONCLUSIONS: Repeated cycles of weight loss and regain appear to enhance subsequent weight gain and may predispose to obesity. Chronic dieting with weight cycling may be harmful for permanent weight control.

Adult↗

Left ventricular long-axis diastolic function is augmented in the hearts of endurance-trained compared with strength-trained athletes.

In order to determine left ventricular global and regional myocardial functional reserve in endurance-trained and strength-trained athletes, and to identify predictors of exercise capacity, we studied 18 endurance-trained and 11 strength-trained athletes with left ventricular hypertrophy (172+/-27 and 188+/-39 g/m(2) respectively), and compared them with 14 sedentary controls. Global systolic (ejection fraction) and diastolic (transmitral flow) function, and regional longitudinal and transverse myocardial velocities [tissue Doppler echocardiography (TDE)], were measured at rest and immediately after exercise. In endurance-trained compared with strength-trained athletes, resting heart rate was lower (59+/-11 and 76+/-9 beats/min respectively; P<0.001), and the increase at peak exercise was greater (+211% and +139% respectively; P<0.001). In addition, exercise duration, workload, maximal oxygen consumption and global systolic functional reserve (but not peak ejection fraction) were higher in the endurance-trained athletes, and resting global diastolic function (E/A ratio 1.62+/-0.40 compared with 1.18+/-0.23; P<0.01) (where E-wave is peak velocity of early-diastolic mitral inflow and A-wave is peak velocity of mitral inflow during atrial contraction) and long-axis diastolic velocities (E(TDE)/A(TDE) ratio 2.2+/-1.2 compared with 1.1+/-0.3; P<0.01) (where E(TDE) and A(TDE) represent peak early- and late-diastolic myocardial or tissue velocity respectively) were augmented. Systolic velocities were similar. Exercise capacity was best predicted from end-diastolic diameter index and E/A ratio at rest, and end-diastolic volume index and diastolic longitudinal velocity during exercise (r=0.74, n=43, P<0.001). In conclusion, endurance-trained athletes had higher left ventricular long-axis diastolic velocities, augmented global early diastolic filling, and greater chronotropic and global systolic functional reserve. Maximal oxygen consumption was determined by diastolic loading and early relaxation rather than by systolic function, suggesting that dynamic exercise training improves cardiac performance by an effect on diastolic filling.

Adult↗

Endurance training, overtraining and baroreflex sensitivity in female athletes.

We examined heavy training-induced changes in baroreflex sensitivity, plasma volume and resting heart rate and blood pressure variability in female endurance athletes. Nine athletes (experimental training group, ETG) increased intense training (70-90% VO2max) volume by 130% and low-intensity training (< 70% Vo2max) volume by 100% during 6-9 weeks, whereas the corresponding increases in six control athletes (CG) were 5% and 10% respectively. Maximal oxygen uptake (VO2max) in the ETG and CG did not change, but in five ETG athletes VO2max decreased from 53.0 +/- 2.2 (mean +/- SEM) (CI 46.8-59.2) ml kg-1 min-1 to 50.2 +/- 2.3 (43.8-56.6) ml kg-1 min-1 (P < 0.01), indicating overtraining. Baroreflex sensitivity (BRS) measured using the phenylephrine technique and blood pressure variability (BPV) did not change, but the low-frequency power of the R-R interval variability increased in the ETG (P < 0.05). The relative change in plasma volume was 7% in the ETG and 3% in the CG. The changes in BRS did not correlate with the changes in plasma volume, heart rate variability and BPV. We conclude that heavy endurance training and overtraining did not change baroreflex sensitivity or BPV but significantly increased the low-frequency power of the R-R interval variability during supine rest in female athletes as a marker of increased cardiac sympathetic modulation.

Adult↗

Prevalence of obesity in International Special Olympic athletes as determined by body mass index.

The heights and weights of 1,749 Special Olympics athlete volunteers participating in the Special Olympics Games in 1999 and 2001 were measured, and body mass index (BMI) was computed. Results indicated that athletes from the United States (US) under 18 years of age had a significantly (P<.001) higher prevalence of being overweight or at risk of being overweight compared with athletes from other countries. Similarly, adult athletes from the United States were at least 3.1 times more likely to be overweight or obese compared with their non-US counterparts. The risk of obesity in US Special Olympic athletes parallels the prevalence of obesity in the general US population. There is a clear need for further research, surveillance, and treatment of the risky health behaviors that contribute to the development of obesity in this group.

Adolescent↗

The influence of athletic status and gender on experimental pain responses.

To examine the role of athletic status and gender on experimental pain responses, 24 athletes (12 male, 12 female) and 24 nonathletes (12 male, 12 female) participated in 3 experimental pain tasks. After a series of psychologic inventories and demographic questionnaires, pressure pain thresholds (4 sites: pectoralis, trapezius, biceps, quadriceps), ischemic pain threshold and tolerance (lower arm), and cold pressor pain threshold and tolerance (lower arm) were assessed. No significant overall effects of athletic status or gender were identified for measures of pressure pain threshold. No group differences emerged for ischemic pain threshold. Athletes demonstrated significantly higher tolerance for ischemic pain, and cold pressor pain threshold and tolerance were higher among athletes than nonathletes. Overall analyses indicated higher pain thresholds and tolerance for cold pain among men than among women. A final interview found that many participants who approached the upper limits of these pain tasks reported using a competitive coping strategy.

Journal Article↗

Mucosal immunity and respiratory illness in elite athletes.

This review focuses on studies of immunity in elite athletes and specifically addresses the role of mucosal immunity in respiratory illness and associations with the intensity, volume and duration of exercise. Investigations of mucosal immunity have mostly studied the response of salivary immunoglobulins to exercise, although nasopharyngeal secretions and breast milk have also been examined. Habitual exercise at an intense level can cause suppression of mucosal immune parameters. Salivary IgA and IgM concentrations decline immediately after a bout of intense exercise and usually recover within 24 h. Training at an intense level can result in a chronic suppression of mucosal immunoglobulin levels over many years, and in some endurance sports a decline over a training season has been observed. The degree of suppression is associated with the intensity of the exercise and the duration or volume of the training. Low levels of salivary IgM and IgA, particularly the IgA1 subclass, are associated with an increased risk of respiratory illness. Monitoring mucosal immune parameters during critical training periods and establishing personal profiles for individual athletes may provide an assessment of the risk status of an athlete for URTI and allow effective management by the athlete and coach. Despite suppression of mucosal immune parameters, elite athletes are capable of normal responses to novel oral vaccinations, indicating that mucosal immune mechanisms are intact. The mechanisms underlying the mucosal immune suppression are unknown but most likely reflect alterations in T-lymphocyte cytokine control mechanisms.

Exercise↗

Training strategies to maintain immunocompetence in athletes.

Clinical experience and empirical evidence have led to the modeling of exercise and training as a form of stress on the immune system. Coaches, athletes, and medical personnel are seeking guidelines on ways to reduce the risk of illness that compromises training or competitive performance. The immune system is influenced by a wide range of physical, environmental, psychological, and behavioural factors which, combined with clinical assessment, collectively form the basis of the following intervention strategies: 1) training: careful management of training volume and intensity, variety to overcome training monotony and strain, a periodised approach to increasing loads, and provision of adequate rest and recovery periods; 2) environmental: limiting initial exposure when training or competing in adverse environmental conditions (heat, humidity, altitude, air pollution) and acclimatising where appropriate; 3) psychological: teaching athletes self-management and coping skills and monitoring of athletes' responses to the psychological and psychosocial stresses of high-level training and competition; 4) behavioural: adopting a well-balanced diet with adequate intake of macro- and micro-nutrients, limiting transmission of contagious illnesses by reducing exposure to common infections, airborne pathogens, and physical contact with infected individuals; and 5) clinical considerations: medical screening, pathology testing, immunization and prophylaxis, and routine management of illness-prone athletes. Future experimental studies are required to develop and enhance the effectiveness of these strategies in reducing illness in athletes.

Australia↗

Exercise immunology: future directions for research related to athletes, nutrition, and the elderly.

This article examines three questions related to exercise immunology: 1) Can exercise attenuate changes in the immune system related to aging? The few research papers available suggest that the answer may be "yes", but exercise training may have to be long-term and of sufficient volume to induce changes in body weight and fitness before any change in immunity can be expected in old age. 2) Is the athlete an immunocompromised host? For most athletes, probably not, although the answer may be 'yes' during certain periods when the athlete exceeds normal training limits or competes in endurance events. Most studies have reported that the immune systems of athletes and nonathletes in the resting state are more similar than disparate with the exception of natural killer cell activity which tends to be elevated in athletes. Infection risk may be more related to the acute changes in immunity that occur following heavy exercise, but this hypothesis has not been sufficiently studied. 3) Are nutrition supplements effective countermeasures to exercise-induced inflammation and immunosuppression? Except for carbohydrate, the answer at this time for all other nutrients studied is 'no'. While data from the vitamin and mineral studies have been negative, and those involving glutamine conflicting, several investigations indicate that carbohydrate compared to placebo ingestion is associated with attenuated hormonal and immune responses.

Aged↗

Comparison of anti-leukemic immunity against U937 cells in endurance athletes versus sedentary controls.

To examine whether endurance athletes have higher anti-leukemic immunity than sedentary controls or not, we isolated peripheral blood mononuclear cells (MNC) from cyclists and sedentary controls to prepare conditioned media (CM) with various doses of phytohemagglutinin (PHA). The proliferation-inhibiting and differentiation-inducing activities of these PHA-MNC-CM on human leukemic U937 cells were investigated. Our results show that the growth inhibition activity of cyclists' PHA-MNC-CM were higher than that of controls. The dosage of PHA used to prepare MNC-CM to achieve about 90% growth inhibition was 5 microg/ml in the control group and was 2 microg/ml in the athletes group. The differentiation-inducing effects were evaluated by morphological scoring, superoxide production, and monocyte-associated antigen expression (CD14 and CD68). These three parameters all demonstrated the differentiation-inducing effect of MNC-CM increased with increasing dose of PHA. These effects were significantly greater in the athletic when compared to the sedentary control group at all doses of PHA. The levels of TNF-alpha and IFN-gamma PHA-MNC-CM increased in a PHA dose-dependent manner and were much higher in the athletic group when compared to the controls. We conclude that the capacity of endurance athletes to activate anti-leukemic immunity is significantly higher than that of sedentary controls.

Adult↗

Physiological cyclic variation of the myocardial integrated backscatter signal in athlete's heart.

BACKGROUND: Left ventricular hypertrophy which realizes in athlete's heart could create some problems of acoustic reflection related to the increase of myocytic and not-myocytic elements of the heart. The aim of the present study was to analyze the ultrasonic backscatter myocardial indexes both as peak end-diastolic signal intensity and as its cardiac-cyclic variation in athlete's heart, compared to healthy sedentary controls. METHODS: Two groups of ten subjects each, all males of mean age (31.6+/-3.5), and of comparable weight and height were analyzed: group (A) comprised ten cyclists of good professional level and group (C) included ten healthy subjects acting as controls. A 2D-color Doppler echocardiography with a digital echograph Agilent Technologies (AT) Sonos 5500 was carried out on all subjects in the study for the conventional analysis of the left ventricular mass and function. The ultrasonic myocardial integrated backscatter signal (IBS) was analyzed with an "Acoustic Densitometry" module implemented on an AT echograph. The signal was also sampled with a R.O.I. placed at interventricular septum and at posterior left ventricular wall level. The systo-diastolic variation of the backscatter was also considered as Cyclic Variation Index (CVIibs). RESULTS: The left ventricular mass was significantly higher in athletes in comparison with controls (LVMbs: A: 154.5+/-18.7; C: 101.4+/-12.4; p<0.001). The end diastolic IBS signal did not show significant statistical differences between the two groups. The CVIibs both at septum (A: 30.5+/-5.3; C: 27.2+/-7.3; p<0.002) and posterior wall level (A: 43.7+/-9.1; C: 40.7+/-9.1; p<0.001) though was comparable in both groups. CONCLUSION: The conclusions reached in the present study confirmed the physiology of the left ventricular hypertrophy of the athlete's heart evaluated with an ultrasonic integrated backscatter tissue characterization, in particular through the cyclic variation of integrated backscatter myocardial signal. This finding is probably the expression of a preserved intramural myocardial function in the athlete's heart despite the increase of left ventricular mass induced by physical training.

Adult↗

Hematologic and biochemical profile of juvenile and adult athletes of both sexes: implications for clinical evaluation.

The aim of the present study was to compare the values of seventeen hematologic and biochemical parameters between juvenile and adult athletes and non-athletes of both sexes. 579 athletes and 241 non-athletes participated in the study. We measured packed-cell volume, hemoglobin, red blood cell count, white blood cell count, platelet count, iron, glucose, urea, triacylglycerols, total cholesterol, high-density lipoprotein cholesterol, total/high-density lipoprotein cholesterol ratio, calcium, magnesium, creatine kinase, as well as alanine and aspartate aminotransferases. We found significant differences according to age, sex, and physical activity in the majority of the parameters. The effect size of physical activity on most parameters was small (< 0.5); however, that on packed-cell volume, glucose, urea, calcium, magnesium, and creatine kinase was moderate to high (0.5 to 0.8). It is remarkable that three of the highest effect sizes of physical activity appeared on parameters thought to be under tight homeostatic control (i. e., glucose, calcium, and magnesium). We conclude that physical training influences most of the biochemical parameters routinely measured in athletes, although, in some cases, its effect appears to be of limited biological importance. Therefore, clinical assessment on the basis of blood tests has to take into account not only the age and sex, but also the training status of individuals.

Adaptation, Physiological↗

Inhaled salbutamol and endurance cycling performance in non-asthmatic athletes.

Beta(2)-adrenergic agonists are important therapeutic agents for the prevention and treatment of (exercise-induced) asthma in athletes, but may have ergogenic effects. In this study we investigated whether inhalation of a supra-therapeutic dose of 800 microg salbutamol before exercise affects endurance performance during a cycling trial in non-asthmatic athletes. In a double-blind, randomized cross-over study, 16 athletes performed two trials, where they had to perform a certain amount of work as fast as possible on a cycle ergometer, 30 minutes after inhalation of 800 micro g salbutamol or placebo. Peak expiratory flow (PEF), forced vital capacity (FVC), and forced expiratory volume in 1 second (FEV(1)) were measured before and after exercise and blood samples were obtained before and during exercise. Cycling performance time was 4010.2 +/- 327.7 s after placebo inhalation and 3927.6 +/- 231.3 s after inhalation salbutamol (p < 0.05). Although salbutamol inhalation increased plasma free fatty acids, glycerol and lactate concentrations and decreased plasma potassium concentrations at rest, no differences between placebo and salbutamol in these variables were found during exercise. PEF and FEV(1) were increased after salbutamol inhalation at rest compared with placebo, but the difference between placebo and salbutamol after exercise was no longer significant. Inhalation of a supratherapeutic dose of 800 micro g salbutamol improved endurance cycling performance by 1.9 +/- 1.8 % in non-asthmatic athletes, which indicates that this route of administration does not exclude the possibility of an ergogenic effect of beta(2)-adrenergic agents in athletes. The increase in performance was not explained by changes in plasma concentrations of free fatty acids, glycerol, lactate, and potassium during exercise or by changes in ventilatory parameters at rest and after exercise. Therefore, the mechanism of the increase in performance remains to be determined.

Administration, Inhalation↗

A three-week traditional altitude training increases hemoglobin mass and red cell volume in elite biathlon athletes.

It is well known that altitude training stimulates erythropoiesis, but only few data are available concerning the direct altitude effect on red blood cell volume (RCV) in world class endurance athletes during exposure to continued hypoxia. The purpose of this study was to evaluate the impact of three weeks of traditional altitude training at 2050 m on total hemoglobin mass (tHb), RCV and erythropoietic activity in highly-trained endurance athletes. Total hemoglobin mass, RCV, plasma volume (PV), and blood volume (BV) from 6 males and 4 females, all members of a world class biathlon team, were determined on days 1 and 20 during their stay at altitude as well as 16 days after returning to sea-level conditions (800 m, only males) by using the CO-rebreathing method. In males tHb (14.0 +/- 0.2 to 15.3 +/- 1.0 g/kg, p < 0.05) and RCV (38.9 +/- 1.5 to 43.5 +/- 3.9 ml/kg, p < 0.05) increased at altitude and returned to near sea-level values 16 days after descent. Similarly in females, tHb (13.0 +/- 1.0 to 14.2 +/- 1.3 g/kg, p < 0.05) and RCV (37.3 +/- 3.3 to 42.2 +/- 4.1 ml/kg, p < 0.05) increased. Compared to their sea-level values, the BV of male and female athletes showed a tendency to increase at the end of the altitude training period, whereas PV was not altered. In male athletes, plasma erythropoietin concentration increased up to day 4 at altitude (11.8 +/- 5.0 to 20.8 +/- 6.0 mU/ml, p < 0.05) and the plasma concentration of the soluble transferrin receptor was elevated by about 11 % during the second part of the altitude training period, both parameters indicating enhanced erythropoietic activity. In conclusion, we show for the first time that a three-week traditional altitude training increases erythropoietic activity even in world class endurance athletes leading to elevated tHb and RCV. Considering the relatively fast return of tHb and RCV to sea-level values after hypoxic exposure, our data suggest to precisely schedule training at altitude and competition at sea level.

Adaptation, Physiological↗

Eating problems and calorie intake levels in Swiss adolescent athletes.

The purpose of this study was to investigate the incidence of eating disorders (ED), calorie intake levels and body fat measures in Swiss female athletes. Thirty athletic and 34 non-athletic adolescent Swiss females were assessed for tendencies toward eating disorders and weight preoccupation using the Eating Disorders Inventory (EDI). Calorie intakes were calculated from 7-day intake records. Body compositions were determined using skin-fold measures. The athletes were divided into two groups: Those whose activities emphasize leanness (12 gymnasts, means age = 12.5 +/- 1.1 yrs), and those whose activities do not emphasize leanness (18 swimmers, mean age = 12.8 +/- 0.9 yrs). The non-athletic school-girls (mean age = 13.4 +/- 1.2 yrs) served as controls. ANOVA indicated that the gymnasts had lower body fat levels (p less than 0.01) and consumed fewer total calories (p less than 0.05) than swimmers or controls, but all groups consumed similar calories per kg/body weight. Chi square analysis indicated that similar numbers of swimmers (11%), gymnasts (1%) and controls (6%) were exceptionally preoccupied with weight (p greater than 0.05). However, more swimmers (38%) scored high on the body dissatisfaction subscale of the EDI than the gymnasts (1%) or control (9%) (p less than 0.01). In fact, more swimmers scored high on 3 subscales of the EDI compared to the other groups (p less than 0.05). It appears that disturbances in eating behaviors are not limited to sports that emphasize leanness.

Adolescent↗

Coactivation of the flexor muscles as a synergist with the extensors during ballistic finger extension movement in trained kendo and karate athletes.

To analyse the effects of ballistic property training on ballistic finger extension movement, surface electromyographic pattern (EMGs) of the finger extensor and flexor muscles and the acceleration signal of the middle finger were recorded in trained kendo and karate athletes, and sedentary non-athletic men. Ballistic finger extension did not show the characteristic triphasic EMG pattern reported in single joint, but a coactivation of flexor and extensor muscles. Reaction time (RT) in kendo (143 +/- 12 msec) and karate (146 +/- 11 msec) athletes were significantly shorter than that in the control (176 +/- 12 msec). The shortenings of the RT were attributed to both the shortenings of premotor time and motor time. The delay of the flexor muscles discharge after those of the extensors in kendo (0.8 +/- 7.0 msec) and karate (-0.2 +/- 5.0 msec) athletes was significantly shorter than in control (12.7 +/-5.6 msec). These results suggest that the RT is shortened through motor learning in the kendo and karate athletes who trained for momentary movements; and that the flexor muscles may play an important role as a synergist in heightening the efficiency of ballistic finger extension in coordination with the extensor muscles.

Adolescent↗