Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “phasing”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,387 records · Page 77Linked to original sources
PubMed2005

Phased array 1-to-N-way resonator with a convex mirror for phase conjugation.

Phased array 1-to-N-way resonators can be relevant in the realization of high output powers from semiconductor laser arrays and have significant advantages over Talbot resonators. However, depending on the number of array elements, the intracavity power density on the output facet can be high, resulting in catastrophic optical mirror damage. We present a variant of the original design that overcomes these power density problems while maintaining the desirable phase-locking and power-combining properties.

Journal Article↗
PubMed2007

Real-time heterodyne imaging interferometry: focal-plane amplitude and phase demodulation using a three-phase correlation image sensor.

A method of real-time heterodyne imaging interferometry using a three-phase correlation image sensor (3PCIS) is proposed. It simultaneously demodulates the amplitude and phase images of an incident interference pattern at an ordinary frame rate with good accuracy, thus overcoming the trade-off among measurement time, spatial resolution, and demodulation accuracy suffered in conventional interferometry. An experimental system is constructed with a 64x64 3PCIS camera operated at 30 frames/s and a two-frequency He-Ne laser with a beat frequency of 25 kHz. The results obtained for a scanning mirror and heated silicone oil confirm the proposed method.

Journal Article↗
PubMed2001

Improved compensation of turbulence-induced amplitude and phase distortions by means of multiple near-field phase adjustments.

An approach for compensation of turbulence-induced amplitude and phase distortions is described. Two deformable mirrors are placed optically conjugate to the collecting aperture and to a finite range from this aperture. Two control algorithms are presented. The first is a sequential generalized projection algorithm (SGPA) that is similar to the Gerchberg-Saxton phase retrieval algorithm. The second is a parallel generalized projection algorithm (PGPA) that introduces constraints that minimize the number of branch points in the control commands for the deformable mirrors. These approaches are compared with the approach of placing the second deformable mirror conjugate to the far field of the collecting aperture and using the Gerchberg-Saxton algorithm to determine the optimal mirror commands. Simulation results show that placing the second deformable mirror at a finite range can achieve near-unity Strehl ratio regardless of the strength of the scintillation induced by propagation through extended paths, while the maximum Strehl ratio of the far-field approach drops off with increasing scintillation. The feasibility of the solutions is evaluated by counting the branch points contained in the deformable mirror commands. There are large numbers of branch points contained in the control commands that are generated by the Gerchberg-Saxton SGPA-based algorithms, irrespective of where the second deformable mirror is located. However, the control commands generated by the PGPA with branch point constraints achieves excellent Strehl ratio and minimizes the number of branch points.

Journal Article↗
PubMed2002

Modulo 2pi fringe orientation angle estimation by phase unwrapping with a regularized phase tracking algorithm.

The fringe orientation angle provides useful information for many fringe-pattern-processing techniques. From a single normalized fringe pattern (background suppressed and modulation normalized), the fringe orientation angle can be obtained by computing the irradiance gradient and performing a further arctangent computation. Because of the 180 degrees ambiguity of the fringe direction, the orientation angle computed from the gradient of a single fringe pattern can be determined only modulo pi. Recently, several studies have shown that a reliable determination of the fringe orientation angle modulo 2pi is a key point for a robust demodulation of the phase from a single fringe pattern. We present an algorithm for the computation of the modulo 2pi fringe orientation angle by unwrapping the orientation angle obtained from the gradient computation with a regularized phase tracking method. Simulated as well as experimental results are presented.

Journal Article↗
PubMed2003

Diversity selection for phase-diverse phase retrieval.

Wavefront-sensing performance is assessed for focus-diverse phase retrieval as the aberration spatial frequency and the diversity defocus are varied. The analysis includes analytical predictions for optimal diversity values corresponding to the recovery of a dominant spatial-frequency component in the pupil. The calculation is shown to be consistent with the Cramér-Rao lower bound by considering a sensitivity analysis of the point-spread function to the spatial frequency being estimated. A maximum value of diversity defocus is also calculated, beyond which wavefront-sensing performance decreases as diversity defocus is increased. The results are shown to be consistent with the Talbot imaging phenomena, explaining multiple periodic regions of maximum and minimum contrast as a function of aberration spatial frequency and defocus. Wavefront-sensing performance for an iterative-transform phase-retrieval algorithm is also considered as diversity defocus and aberration spatial frequency are varied.

Journal Article↗
PubMed2005

Generation of phase singularity through diffracting a plane or Gaussian beam by a spiral phase plate.

We deduce and study an analytical expression for Fresnel diffraction of a plane wave by a spiral phase plate (SPP) that imparts an arbitrary-order phase singularity on the light field. Estimates for the optical vortex radius that depends on the singularity's integer order n (also termed topological charge, or order of the dislocation) have been derived. The near-zero vortex intensity is shown to be proportional to rho2n, where p is the radial coordinate. Also, an analytical expression for Fresnel diffraction of the Gaussian beam by a SPP with nth-order singularity is analyzed. The far-field intensity distribution is derived. The radius of maximal intensity is shown to depend on the singularity number. The behavior of the Gaussian beam intensity after a SPP with second-order singularity (n = 2) is studied in more detail. The parameters of the light beams generated numerically with the Fresnel transform and via analytical formulas are in good agreement. In addition, the light fields with first- and second-order singularities were generated by a 32-level SPP fabricated on the resist by use of the electron-beam lithography technique.

Journal Article↗
PubMed2006

Purely numerical compensation for microscope objective phase curvature in digital holographic microscopy: influence of digital phase mask position.

Introducing a microscope objective in an interferometric setup induces a phase curvature on the resulting wavefront. In digital holography, the compensation of this curvature is often done by introducing an identical curvature in the reference arm and the hologram is then processed using a plane wave in the reconstruction. This physical compensation can be avoided, and several numerical methods exist to retrieve phase contrast images in which the microscope curvature is compensated. Usually, a digital array of complex numbers is introduced in the reconstruction process to perform this curvature correction. Different corrections are discussed in terms of their influence on the reconstructed image size and location in space. The results are presented according to two different expressions of the Fresnel transform, the single Fourier transform and convolution approaches, used to propagate the reconstructed wavefront from the hologram plane to the final image plane.

Algorithms↗
PubMed2004

Performance of a phase-conjugate engine implementing a finite-bit phase correction.

The achievable Strehl ratio when a finite-bit correction to an aberrated wave front is implemented is examined. The phase-conjugate engine used to measure the aberrated wave front consists of a quadrature interferometric wave-front sensor, a liquid-crystal spatial light modulator, and computer hardware-software to calculate and apply the correction. A finite-bit approximation to the conjugate phase is calculated and applied to the spatial light modulator to remove the aberrations from the optical beam. The experimentally determined Strehl ratio of the corrected beam is compared with analytical expressions for the expected Strehl ratio and shown to be in good agreement with those predictions.

Journal Article↗
PubMed2005

Variation of the carrier-envelope phase of few-cycle laser pulses owing to the Gouy phase: a solid-state-based measurement.

The carrier-envelope phase of a laser pulse has recently become an important quantity in extreme nonlinear optics. Because of the topological Gouy phase, it changes while the pulse propagates through the focus of a lens. This variation is measured by a simple solid-state-based approach. The experimental results are analyzed by comparison with simple analytical model calculations.

Journal Article↗
PubMed2005

Phase matching, quasi-phase matching, and pulse compression in a single waveguide for enhanced high-harmonic generation.

We demonstrate, for the first time to our knowledge, that the efficient region of high-harmonic generation can be shifted from lower to higher photon energies by combining phase matching, quasi-phase matching, and pulse compression in a single gas-filled waveguide. An intrawaveguide pulse compression process that works through a combination of ionization-induced refraction and guiding shortens the laser pulse as it propagates through an Ar-filled waveguide. This leads to enhanced harmonic emission at high photon energies near 95 eV while it reduces emission at low photon energies near 45 eV. The waveguide geometry also mitigates ionization-induced refraction, allowing Ar gas with high effective nonlinear susceptibility to be used.

Journal Article↗
PubMed2006

Balanced optical-microwave phase detectors for optoelectronic phase-locked loops.

A balanced optical-microwave phase detector for the extraction of low-jitter, high-power, and drift-free microwave signals from optical pulse trains is presented. The phase detection is based on electro-optic sampling with a differentially biased Sagnac loop. Because the timing information is transferred in the optical domain, the regenerated microwave signal is robust against drifts and photodetector nonlinearities. In a first experimental implementation, 3 fs in-loop relative timing jitter (integrated from 1 Hz to 10 MHz) between a 44 MHz optical pulse train and a 10.225 GHz microwave signal is demonstrated.

Journal Article↗
PubMed1986

Comparison of a within-day solid-phase immunoradiometric assay with a solution-phase radioimmunoassay for the measurement of alpha-fetoprotein in amniotic fluid.

Using 231 amniotic fluid samples from a Regional Screening Service, the performance of a monoclonal antibody-based solid-phase immunoradiometric assay (IRMA) for alpha-fetoprotein was compared with that of a polyclonal antiserum-based solution phase radioimmunoassay (RIA). alpha-Fetoprotein values determined from these samples by the two methods were in excellent agreement (r = 0.992) and the diagnostic performance of the two assays was identical. However, the IRMA assay displayed a greater working range than the RIA, and in addition was more rapid to perform, allowing within-day turnaround of laboratory results.

Amniotic Fluid↗
PubMed2006

Solid phase peptide synthesis in water VI: evaluation of water-soluble coupling reagents for solid phase peptide synthesis in aqueous media.

Solid phase peptide synthesis requires large amounts of organic solvents, the safe disposal of which is an important environmental issue. Peptide synthesis, if performed in water and using less or nontoxic reagents, circumvents the disposal problem. Our ultimate aim is to develop an "environment-friendly" solid phase peptide synthesis (SPPS) methodology. Previously, we showed that SPPS in water is feasible. To perform SPPS in water, the coupling reagent must be water-soluble and maintain its reactivity in water. For this report, we tested the efficacy of the water-soluble coupling reagents, 2-(5-norbornene-2,3-dicarboximido)-1,1,3,3-tetramethyluronium tetrafluoroborate (TNTU) and 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM), towards SPPS in water. We successfully synthesized Leu-enkephalin amide on a solid support suspended in aqueous 50% EtOH using DMT-MM and 2-(4-sulfophenylsulfonyl)ethoxycarbonylamino acids.

Amino Acid Sequence↗
PubMed2002

Solid-phase and solution-phase parallel synthesis of tetrahydro-isoquinolines via Pictet-Spengler reaction.

An efficient parallel synthesis of 6,7-dimethoxytetrahydroisoquinolines is reported. The key reaction step is 3,4-dimethoxyphenethylimines reacting with acid chlorides to form an N-acyliminium ion intermediate, which undergoes Pictet-Spengler condensation to give the desired products in >80% yield. Both solution-phase and solid-phase synthesis of 6,7-dimethoxytetrahydroisoquinolines are described.

Chromatography, High Pressure Liquid↗
PubMed2001

Improvement of phase-contrast flow measurements: opposite directional flow-encoding technique to eliminate the influence of the Maxwell term phase errors.

A new method termed the opposite directional flow-encoding (ODFE) technique is proposed to increase the accuracy and the reproducibility of phase-contrast flow measurements by correcting the non-linear background of velocity images induced by concomitant magnetic fields (Maxwell terms). In this technique, the volume flow rate is calculated from the difference of two region of interest (ROI) values derived from two velocity images obtained by reversing the flow-encoding direction. To evaluate the technique, various phantom experiments were carried out and volume blood flow rates of internal carotid arteries (ICAs) were measured in four volunteers. The technique could measure the volume flow rates of the phantom with higher accuracy (mean absolute percentage error = 1.04%) and reproducibility (coefficient of variation = 1.18%) than conventional methods. Flow measurements with the technique was not significantly affected by ROI size variation, measuring position, and flow obliquity not exceeding 30 degrees. The volume flow rates in the ICAs of a volunteer were measured with high reproducibility (coefficient of variation = 2.89% on the right, 1.48% on the left), and the flow measurement was not significantly affected by ROI size variation. The ODFE technique can minimize the effect of the non-linear background due to Maxwell terms. The technique allows use of ROIs of approximate size including the flow signal and provides accurate and objective phase-contrast flow measurements.

Adult↗
PubMed1997

Dual-phase helical CT of the liver: value of an early-phase acquisition in the differential diagnosis of noncystic focal lesions.

OBJECTIVE: Contrast-enhanced helical CT images of the liver are usually obtained during the portal vein phase (PVP), during which the parenchyma achieves peak enhancement. The purpose of this study was to determine whether the addition of arterial-phase (AP) scans would lead to improved characterization of focal lesions. MATERIALS AND METHODS: We reviewed the CT appearance of 102 focal lesions with a proven diagnosis. In the first part of the study, we assessed whether the addition of AP scans influenced the diagnostic performance of the three observers. In the second part of the study, we analyzed the morphologic appearance revealed on CT scans of the different types of lesions in the AP and PVP. RESULTS: The addition of AP scans led to a significant increase in the number of correct diagnoses: 71 lesions (70%) were correctly diagnosed with CT scans in both the AP and the PVP, compared with 54 lesions (53%) correctly diagnosed with CT scans in the PVP alone (p < .01). The largest difference was observed in the diagnosis of focal nodular hyperplasia (FNH) and adenoma (16/24 correct diagnoses instead of 6/24) (p < .005). Conversely, AP images did not significantly contribute to the diagnosis of hemangiomas and metastases. The following morphologic features were seen much more often on AP scans than on PVP scans and had a high positive predictive value (PPV): spoke-wheel pattern (FNH; PPV, 100%), central feeding vessel (FNH; PPV, 100%), and heterogeneous appearance with hyperdense components (hepatocellular carcinoma; PPV, 75%). CONCLUSION: Our data show that the radiologists' evaluation of CT scans in both the AP and the PVP improves the differentiation of hepatocellular carcinoma and FNH from other types of hepatic neoplasms.

Adenoma, Liver Cell↗