Transient cardiac apical ballooning syndrome: prevalence and clinical implications of right ventricular involvement.
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BACKGROUND: The role of the right atrium in adaptation to the hemodynamic changes produced by extension of myocardial infarction (MI) of the left ventricular inferior wall to the right ventricle is fundamental. HYPOTHESIS: The aim of this study was analyze a group of patients with MI with extension of right chambers, and particularly right atrial alterations, by transesophageal echocardiography and to correlate it with clinical and angiographic variables. METHODS: Thirty patients with right ventricular (RV) MI involving obstruction of the right coronary artery without stenosis of the left coronary artery were included; 18 underwent early reperfusion. Transesophageal echocardiography was performed on all within 5 days of coronary angiography. Follow-up was continued from hospitalization to the present. RESULTS: When patients with right atrial ischemia were compared with those with normal right atrium, the RV wall movement score was significantly greater in the group with right atrial ischemia, severe RV dilatation was more frequent, and association with proximal occlusion of the artery responsible for the MI, as well as absence of right atrial branches and poor collateral circulation, were significant. Hospitalization was more prolonged in this group, and there was a higher incidence of arrhythmias, complete atrioventricular block, and mortality. CONCLUSIONS: Right atrial ischemia associated with RV infarction leads to a higher incidence of complications and higher mortality. Transesophageal echocardiography is a safe, reproducible technique that provides detailed anatomic information about right chambers and aids in the determination of prognosis and therapeutic decisions.
Diffuse systemic-pulmonary anastomoses and chronic hypoxemia may result in increase in ventricular work in bronchiectasis. We aimed to assess right ventricular (RV) and left ventricular (LV) functions in patients with bronchiectasis by using tissue Doppler-derived myocardial performance index (MPI), which is a novel and more sensitive parameter than conventional ventricular function parameters. To assess the possibility of RV and LV dysfunctions occurring in bronchiectasis, we studied 25 patients with bronchiectasis, and compared them with 22 age- and gender-matched control subjects. MPI, which is a combined index of both systolic and diastolic ventricular function, was calculated for both ventricles. RV and LV MPIs were also significantly different in patients and the controls. RV MPI was associated with the number of involved lobe, arterial blood oxygen pressure, and acceleration time/ejection time of pulmonary flow. LV MPI was not related to any clinical parameter, but it was correlated only with RV MPI. Ventricular functions are impaired in bronchiectasis. The impairment of RV function is related to involved lung lobe number, arterial oxygen pressure, and acceleration time/ejection time of pulmonary flow. LV dysfunction was correlated only with RV function.
We present the case of a 79-year-old man suffering from chronic atrial fibrillation, severe left ventricular dysfunction, massive right atrial thrombosis, and pulmonary hypertension. Complete coronary sinus thrombosis was found incidentally during preoperative screening. Successful coronary sinus, right atrial, and pulmonary operative embolectomy was followed soon after by a dramatic improvement of cardiac performance; the patient's left ventricular function recovery, in particular, suggests that cardiac venous system played an important role in the genesis of myocardial impairment.
A 64 year old man presented with a traumatic ventricular septal defect following blunt chest trauma 40 years before. Echocardiography and left ventriculography were helpful in locating the unusual septal defect, which was subpulmonary. The shunt was small, but the anomalous chronic overload led to right ventricular failure. The surgical correction was thus too late to improve right ventricular function.
Right ventricular arrhythmias predominantly occur in young patients with rare cardiac diseases. Underlying cardiac conditions include idiopathic right ventricular outflow-tract tachycardia (RVOT-VT), arrhythmogenic right ventricular cardiomyopathy (ARVC), Brugada syndrome, and postoperative congenital heart disease (i.e. tetralogy of Fallot). According to the underlying cardiac disease, there are significant differences in the diagnostic and therapeutic management and prognosis which is mainly determined by life-threatening ventricular arrhythmia recurrences and sudden cardiac death. To provide optimal treatment for affected patients, a detailed diagnostic evaluation and risk stratification is mandatory. Tailored treatment strategies aim at the suppression or effective termination of recurrent ventricular tachyarrhythmias and prevention of sudden death by antiarrhythmic drug therapy, catheter ablation, and the implantation of cardioverter-defibrillators. This review summarizes the current knowledge on pathogenesis, diagnosis, treatment and prognosis of those conditions that are associated with arrhythmias originating from the right ventricle.
A variety of tachycardias originate from the right ventricle or use right ventricular structures as part of their circuit. They are characterized by a left bundle branch block pattern. Many of these tachycardias are relatively easy targets for radiofrequency catheter ablation. Ventricular tachycardia (VT) is the most common manifestation of arrhythmogenic right ventricular dysplasia, an often familial disease that can cause sudden death. Catheter ablation, antiarrhythmic drugs, or an implantable cardioverter-defibrillator may be used as therapy. Idiopathic right ventricular tachycardia has a benign course. It most often arises from the septal region of the right ventricular outflow tract. It commonly presents as nonsustained, repetitive monomorphic VT. The success rate of catheter ablation is greater than 90%. Bundle branch reentry occurs in patients with cardiomyopathy and His-Purkinje disease. It uses the right bundle branch anterogradely and the left bundle branch retrogradely. The QRS is very similar during VT and sinus rhythm. It can be cured by catheter ablation of the right bundle branch. VT seldom originates from the right ventricle in patients with coronary artery disease, idiopathic cardiomyopathy, or myocarditis. Atriofascicular (so-called Mahaim) fibers can sustain antidromic AV reentrant tachycardia. They represent an accessory AV node and His-Purkinje-like conduction system with atrial insertion in the right free wall near the tricuspid annulus and distal insertion directly into the right bundle branch. The accessory connection is ablated at the level of the tricuspid ring.
Right ventricular (RV) dysfunction is a cause of exercise intolerance, hypotension, syncope, and heart failure in dogs with cardiac and respiratory disorders. The study objective was to determine Doppler-derived reference values that reflect global RV function in healthy dogs. We measured systolic time intervals and an RV index of myocardial performance (IMP) in 45 healthy dogs between 8 months and 8 years of age. Pulsed-wave Doppler recordings of mitral, tricuspid, aortic, and pulmonic were acquired. Pre-ejection period (PEP), ejection time (ET), PEP/ET, and IMP were determined for both ventricles by separate cardiac cycles. Compared to the mean left ventricular (LV) IMP (0.410; 95% confidence intervals [CI] 0.378-0.442), mean RV IMP (0.250; 95% CI 0.222-0.278) was significantly smaller, and mean ET for the RV (187 millisecond [ms]; 95% CI 182-192) was significantly longer than the LV (173 ms; 95% CI 168-179). A clinically relevant correlation was not found among RV IMP and body weight, heart rate, RV ET, RV PEP, or RV PEP/ET. Calculation of LV IMP with 2 separate sample volumes yielded smaller values than from a single sample volume, with a difference in means of 0.040. We conclude that the RV IMP is relatively independent of body weight and heart rate within the ranges studied and is consistently lower than values derived from the LV in healthy dogs. This study provides additional reference values for RV function in dogs and may be useful for identification of RV dysfunction in dogs.
The T-wave of the electrocardiogram (ECG) is generated both from the left and the right ventricles of the heart. Each ventricle may produce a normal, an "ischemic", or a "secondary" T-wave, depending on segmental perfusion, intraventricular pressure, or QRS complex duration. The direction of the T-wave is determined by the particular inward rectifier potassium channels recruited by various layers and segments in the two ventricles. The observed T-wave in the clinical ECG is the summation of the left and right ventricular T waves, and is thus biventricular. Clinical observations in right bundle branch block (RBBB) and in right ventricular hypertensive states such as pulmonary embolism suggest that many ECG's interpreted as inferior or anterior left ventricular ischemia are in fact examples of abnormal potassium channel recruitment in the right ventricle. Consideration of the right ventricular component of the T-wave in every electrocardiographic interpretation improves diagnostic understanding and accuracy, as the possible right ventricular origin of observed anterior or superior T waves will not be overlooked.
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A 15-year-old boy with severe pulmonary stenosis associated with severe right and left ventricular systolic dysfunction is reported. After successful percutaneous pulmonary valvuloplasty, there was an initial and early improvement in right ventricular (RV) function, followed by a delayed and more gradual improvement in left ventricular (LV) function. At long-term follow up, both RV and LV systolic functions were nearly normalized. Several mechanisms may be implicated, including ventricular interdependence, geometric factors, altered compliance and intrinsic alteration in the LV muscle. A delayed, but sustained, improvement in LV systolic function following relief of RV pressure overload suggests that the latter mechanism must have played an important role in the genesis of the LV dysfunction. Pulmonary stenosis associated with severe biventricular dysfunction may be treated primarily by percutaneous pulmonary balloon valvuloplasty with near-total recovery of the ventricular function.
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Surface electrocardiograph of twelve cases of isolated left ventricular inferior infarction and 24 cases of biventricular inferior infarction confirmed by two-dimensional echocardiography were analysed. ST segment elevation in lead III more than in lead II and ST segment depression in leads I and aVL were highly sensitive in diagnosing right ventricular involvement. ST segment depression in lead V3 equal to or greater than ST segment elevation in lead III was highly specific but had low sensitivity. These findings can be helpful in cases where right sided chest leads have not been recorded or are inconclusive.
The thin-walled right ventricle compensates poorly for any increase in afterload, and its output abruptly decreases with small elevations in pulmonary vascular resistance. In patients who have acute right ventricular (RV) dysfunction following bypass, it is, therefore, important to maintain pulmonary vascular resistance at normal or reduced levels. The location and movement of the RV septum may have a dramatic impact on RV contraction, and abnormalities of left ventricular function all affect RV function. Inadequate intraoperative protection has also been implicated in impaired RV function, and there is some evidence that caution is required during removal of air from the left side of the heart and resumption of ventilation. Volume expansion, pharmacological intervention, and mechanical devices have all been used successfully in patients with RV failure. Volume loading is the basis of treatment when the pulmonary vascular resistance is normal. When this alone is insufficient, or when pulmonary vascular resistance is elevated, inotropic agents may be useful. Clinical reports have demonstrated that amrinone, a member of the new class of inotropic fraction-III phosphodiesterase inhibitors, is an effective agent for the management of RV dysfunction following bypass. Correction of septal wall dislocation may be achieved with intraaortic balloon pumps.
In a series of articles authors discuss the literature data concerning epidemiology of pulmonary hypertension, its modern classification, peculiarities of pathogenesis and treatment in various diseases. In first communication they examine questions of terminology and classification of pulmonary hypertension and also discuss peculiarities of anatomy, physiology and pathophysiology of pulmonary circulation and right ventricle of the heart.