Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Permits”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,387 records · Page 77Linked to original sources
PubMed1986

Modification of a hand splint to permit playing of the guitar.

Modification of a hand splint for a musician who had suffered an incomplete disruption of the left ring finger extensor tendon is described. This modification enabled the patient to receive the benefit of conservative treatment of this disruption while continuing his employment. The modification can be performed easily with the standard stack splint; the success of this method is described.

Adult↗
PubMed1986

Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products.

Twelve monoclonal antibodies (HC-MoAb) were prepared against a mixture of denatured HLA-B7 and -B40 heavy chains and were characterized by biochemical methods. The patterns of reactivity of 11 out of 12 of these MoAb were very similar and showed marked preference for the HLA-B locus heavy chains. A single antibody, HC-3, reacted with a subset of the HLA class I heavy chains recognized by the other HC-MoAb, which react with all HLA-B locus heavy chains tested. In pulse-chase experiments, only biosynthetic intermediates consisting of free class I heavy chains were precipitated by the HC MoAb. In addition to free HLA-B and minor quantities of some HLA-A heavy chains, additional class I polypeptides were recognized by the HC-MoAb. A number of these additional class I polypeptides showed a striking correlation with HLA-C as determined serologically. None of these polypeptides could be clearly identified in immunoprecipitations prepared from continuously labeled cells with the MoAb W6/32, previously thought to recognize all HLA-A, B, and C specificities. These findings suggest that in human cells, HLA-C locus products may be associated only weakly with B2m, explaining some of the difficulties encountered in biochemical studies of HLA-C antigens.

Antibodies, Monoclonal↗
PubMed1979

A fluorescent derivative of ribosomal protein S18 which permits direct observation of messenger RNA binding.

70 S Escherichia coli ribosomes were reacted with the fluorescent dye N-(iodoacetylaminoethyl)-5-naphthylamine-1-sulfonic acid for 10 min under mild conditions. The resulting ribosomes were fully active. 30 S subunits isolated from these particles were also fully active. They contain approximately 0.7 eq of fluorescent dye. Nearly all of it is attached to protein S18. Competitive reaction with N-ethylmaleimide implies that the fluorescent dye is located at cysteine 10 of the protein. The labeled 30 S particles will recombine with 50 S subunits to form stable 70 S particles. Thus the procedures we have developed allow the large scale preparation of an active fluorescent conjugate of the 70 S ribosome. The fluorescence of the 70 S particles is sensitive to the binding of mRNA, showing both quenching and a shift in emission spectra. Thus it affords a simple way to quantitate mRNA binding directly. In pilot studies without tRNA, the binding constant of the initiation triplet codon adenylyl-(3' leads to 5')-uridylyl-(3' leads to 5')-guanosine to 70 S ribosome was found to be an order of magnitude larger than that of polyuridylic acid.

Escherichia coli↗
PubMedDate not supplied

[Does nocturnal monitoring of gastric pH permit the prediction of therapeutic response in severe duodenal ulcer treated with ranitidine?].

The present work was conducted in patients with severe cimetidine-resistant duodenal ulcer, in order to correlate the response (i. e. healing or no healing of the ulcer) to ranitidine therapy and the results of 24 h gastric pH monitoring performed under therapeutic conditions. Twenty patients who fulfilled the criteria of cimetidine resistance (i. e. with an ulcer not healed after a treatment with cimetidine given at a dose of at least 1 g/d for at least 6 weeks) received 150 mg ranitidine twice daily for 6 weeks and were then controlled endoscopically; ulcer was healed in 8 cases, not healed in 12 cases. Nocturnal gastric acid inhibition was significantly greater in patients who responded to ranitidine than in those whose ulcer did not heal. During daytime the gastric pH profiles were not different between these two groups. Nocturnal pH score was also calculated in each patient by reference to the mean inhibitory effect observed in 8 normal subjects in whom gastric pH was monitored in the same therapeutic conditions. In 7 patients the nocturnal pH score was greater than 10; none of these patients was healed after 6 weeks ranitidine treatment. Among the 13 patients with a pH score lower than 10, 8 had an ulcer healed at the end of the ranitidine course. In 5 cases gastric pH monitoring was repeated after continuation of the ranitidine treatment; healing of ulcer was observed in 4 cases, always associated with a nocturnal pH score lower than 10 (in 2 cases after increasing the dosage of ranitidine).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1978

Cervical esophagostomy to permit extraoral feeding of the horse.

An indwelling stomach tube was placed through a cervical esophagostomy in 5 clinically normal horses and in 3 horses requiring artificial alimentation. In all but one case, surgery was performed on conscious horses following tranquilization and infiltration of the surgical sites with a local anesthetic. Six horses were fed liquid rations through the indwelling tubes, which were left in place from 3 to 26 days. After the tubes were removed, the stomas healed rapidly and with minimal complications. Cervical esophagostomy proved to be a safe, easy, and effective method for the provision of extraoral feeding of the horse.

Animals↗