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At least 1,387 records · Page 77Linked to original sources
PubMed1993

Pattern recognition in DNA sequences and its application to consensus foot-printing.

We consider the problem of comparing several nucleic acid sequences to identify words occurring imperfectly (patterns with no gap) with unusual frequency. Methods for computing, representing, and inspecting interactively the structure of such repeating motifs in nucleic acids and more generally any text are described. Multiple sequences are treated as one large concatenate. In a preprocessing step, a lexical index is created to provide rapid string matching for the enumeration of the words matching a pattern. For given word features (word length, minimal frequency), a sequence profile is displayed. The profile can be inspected interactively with on-line algorithms. Applications to the identification of regulatory elements in DNA regions involved in the control of gene expression are presented. Our program ('DNA-Lexemics') runs on the Macintosh.

Algorithms↗
PubMed2002

Communication mode and the processing of printed words: evidence from readers with prelingually acquired deafness.

The aim of this study was to elucidate how the primary communication background of prelingual deafened readers affects the way they mediate the recognition of written words. A computer-controlled research paradigm (a semantic decision task) asking for the categorization of familiar Hebrew nouns was used to investigate the participants' sensibility to phonological and orthographic manipulations in the target stimuli. Two groups of readers with hearing impairments and a hearing control group participated in the study. Twenty-seven of the participants with deafness (mean grade 6.9) were raised by hearing parents advocating a strict oral approach at home and at school. For an additional 22 students who were deaf (mean grade 6.9), the majority of them children of deaf parents, Israeli Sign Language was the preferred means of communication. The mean grade of the 39 participants in the hearing control group was 6.5. Findings indicate that both the hearing participants and the participants with prelingual deafness who were trained to communicate orally recoded visually presented target words phonologically. No such evidence was found for participants with deafness who were native signers. Although participants from signing backgrounds seemed to generate nonphonological representations of written words, there was no evidence that for them, the absence of recoding to phonology detrimentally affected on their ability to process such representations flexibly. In all, findings suggest a causal link between an individual's processing strategy for some written words and the modal nature of his or her primary language.

Journal Article↗
PubMed2005

Detection and normalization of biases present in spotted cDNA microarray data: a composite method addressing dye, intensity-dependent, spatially-dependent, and print-order biases.

Microarrays are often used to identify target genes that trigger specific diseases, to elucidate the mechanisms of drug effects, and to check SNPs. However, data from microarray experiments are well known to contain biases resulting from the experimental protocols. Therefore, in order to elucidate biological knowledge from the data, systematic biases arising from their protocols must be removed prior to any data analysis. To remove these biases, many normalization methods are used by researchers. However, not all biases are eliminated from the microarray data because not all types of errors from experimental protocols are known. In this paper, we report an effective way of removing various types of biases by treating each microarray dataset independently to detect biases present in the dataset. After the biases contained in each dataset were identified, a combination of normalization methods specifically made for each dataset was applied to remove biases one at a time.

Algorithms↗
PubMed2000

ICPC-2-E: the electronic version of ICPC-2. Differences from the printed version and the consequences.

BACKGROUND: In 1998, ICPC-2 was published as a book. In the process of translating the book, and preparing an electronic version of chapter 10 (the actual classification), ICPC-2 proved to contain many errors and inconsistencies. Particularly, major problems were identified in the conversion between ICPC-2 and ICD-10, which could lead to major errors when used in electronic patient records. OBJECTIVES: We prepared an electronic version of chapter 10 of ICPC-2, ICPC-2-E, with all necessary corrections, to be published on the Oxford University Press web site as a part of this article. METHODS: Errors and inconsistencies were redressed, including particularly those in the con-version structure with all consequences on the level of inclusion and exclusion criteria, through a process of careful checking. RESULTS AND CONCLUSION: ICPC-2-E, the electronic version of chapter 10 of ICPC-2, is specifically to be used in an electronic patient record and for research purposes. It is to be used together with the first nine chapters of ICPC-2, since the book is indispensable to make a correct use of ICPC.

Bias↗
PubMed2003

Providing information on metered dose inhaler technique: is multimedia as effective as print?

BACKGROUND: Metered dose inhalers (MDIs) are not easy to use well. Every MDI user receives a manufacturer's patient information leaflet (PIL). However, not everyone is able or willing to read written information. Multimedia offers an alternative method for teaching or reinforcing correct inhaler technique. OBJECTIVE: The aim of this study was to compare the effects of brief exposure to the same key information, given by PIL and multimedia touchscreen computer (MTS). METHODS: A single-blind randomized trial was conducted in 105 fluent English speakers (53% female; 93% White) aged 12-87 years in London general practices. All patients had had at least one repeat prescription for a bronchodilator MDI in the last 6 months. Inhaler technique was videotaped before and after viewing information from a PIL (n = 48) or MTS (n = 57). Key steps were rated blind using a checklist and videotape timings. The main outcome measures were a change in (i) global technique; (ii) co-ordination of inspiration and inhaler actuation; (iii) breathing-in time; and (iv) information acceptability. RESULTS: Initially, over a third of both groups had poor technique. After information, 44% (MTS) and 19% (PIL) were rated as improved. Co-ordination improved significantly after viewing information via MTS, but not after PIL. Breathing-in time increased significantly in both groups. Half the subjects said they had learned 'something new'. The MTS group were more likely to mention co-ordination and breathing. CONCLUSIONS: Short-term, multimedia is as least as effective as a good leaflet, and may have advantages for steps involving movement. MTS was acceptable to all age groups. The method could be used more widely in primary care.

Adolescent↗
PubMed2000

The three faces of Occupational Medicine: printed paper, problems in practice, and professional purpose.

The 50-year run of the journal Occupational Medicine and its forbears demonstrates the ways in which UK occupational medical practice has developed and changed since 1950. This has been in response to changes in society, technology and medicine. The journal has played an important part in education and professional development. It has also been the voice for the aspirations and concerns of its readers. Two aspects stand out: the development of occupational medicine as a specialty, and the way in which a medical model for occupational health service provision has been championed. A distinguished line of journal editors has been central to the crystallization of ideas within occupational medicine and their editorials map out professional successes and challenges over the years.

Chronology as Topic↗