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Split-rib graft for reconstruction of the mandible.

Defects in the mandible after tumor surgery were reconstructed with split-rib grafts in 23 patients. Twenty of the patients were preoperatively irradiated with fractioned radiotherapy, ranging from 40 to 85 gray. Partial sequestration appeared in five patients. The ingrowth of the transplant was examined with technetium scintigraphy. Satisfactory cosmetic and functional results were achieved in the great majority of the patients. Split-rib grafting is recommended for reconstruction of the mandible as a safe procedure with little increased operation time and morbidity for the patient and good functional and cosmetic results.

Aged↗

Metastatic renal cell carcinoma to the mandible: report of case.

A rare instance of a primary clear cell renal carcinoma metastasizing to the left mandible has been presented. Metastatic tumors to the jaws are relatively uncommon and involve the mandible more frequently than the maxilla. When they occur, the primary tumor is most likely to be an adenocarcinoma from the breast, lung, or kidney. A pulsatile mandibular lesion, found not to be an arteriovenous fistula, suggests a metastatic renal carcinoma until it is disproved.

Adenocarcinoma↗

[Mucoepidermoid tumor of the mandible (author's transl)].

The diagnosis of a mucoepidermoid tumor of the mandible has been made by pathological examination. This asymptomatic tumor was discovered on a routine radiographic film. Our 44 years old male patient was treated by surgical means. We have found 62 cases in the literature; intra-osseous cases of mucoepidermoid tumor seem to be rather scarce. Let us recall the presence of salivary glands in the mandible, a possible explanation of the occurrence of intra-osseous glandular tumor.

Adult↗

[Cryptogenetic osteolysis of the mandible (author's transl)].

A case of "cryptogenetic osteolysis of the mandible" is reported. This is a rare affection as only 13 cases of "phantom mandible" are known, but other sites exist (91 cases of phantom bone are known). The diagnosis is suspected after radiography, and confirmed by anatomopathological examination. No treatment for this affection has been described.

Adult↗

The subperiosteal implant as a viable long-term treatment modality in the severely atrophied mandible: a patient's 40-year case history.

Subperiosteal implants have been a treatment modality for atrophied edentulous mandibles for almost 50 years. A case is presented tracing a patient's 40-year history with treatment of his severely atrophied fully edentulous mandible with a subperiosteal implant and removable implant-borne prosthesis. The subperiosteal implant should be considered as a long-term treatment option in those patients who are unable to wear a lower full denture due to resorption of the ridge and osseous defects that provide inadequate bone for placement of endosseous blade- or root-form implants. This case demonstrates the long-term viability of the subperiosteal implant.

Adult↗

[Tumors of the mandible. Justification of a second reconstruction after recurrence on the first revascularized bone graft].

The use of free vascularized bone grafts for mandibular reconstruction has led to a consideration of the new entity of recurrent tumour on bone grafts. Exeresis of the mandible was performed in 4 patients with bone tumours: osteosarcoma 1, osteochondroma 1, carcinoma 1 and ameloblastoma 1. A free vascularized bone graft was used for the reconstruction. Tumours recurred with a delay of 10 to 18 months after the initial reconstruction. The frequency of tumoural recurrence can be measured in our series of 46 patients (24 with fibular grafts, 15 with scapular grafts, 4 with radius grafts and 3 with iliac bone grafts). Recurrence rate at our institution was 4.3%. The 2 other cases involved patients from other institutions. The main factor involved in tumoural recurrence is the aggressive nature of the primary tumours, even after extensive initial resection as performed in our patients. Free bone grafts were invaded as were neighbouring tissues. Secondary reconstruction of the mandible was performed in 3 cases with a fibula graft. In the fourth patient, no operation was possible due to the diffuse nature of the invasion and the poor status of the patient's vessels and general health. Local extension, and not the tumour histology, is the main factor in deciding upon reoperation. The explosive nature of recurrences is linked more to the aggressive character of the tumour than to the status of the revascularized free bone graft. Secondary reconstruction is justified after recurrence on bone grafts depending on the complexity of the major resection involving extensive tissue exeresis.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

[Pulmonary tuberculosis complicated with tuberculosis of oral mucosa, mandible and cervical lymph nodes].

A case of pulmonary tuberculosis complicated with tuberculous of oral mucosa, mandible and cervical lymph nodes in 53-year-old man is reported. He was firstly treated for right side dental caries. He also received routinely an empiric antibiotic therapy, but discharge of pus continued. Then, pain of oral cavities spread to the right shoulder. The diagnosis of oral mucosa, osteomyelitis of mandible and lymph node tuberculosis was made by the histological examination of biopsy specimens and positive smear test for M. tuberculosis in granulation. The chest X-ray film showed multiple nodular shadows in bilateral lungs. The combination of INH, RFP and SM was applied initially and then SM was replaced by CS due to its side effect. Negative smear test for M. tuberculosis of oral mucosa was achieved five months after the initiation of treatment.

Humans↗

An immunocytochemical study of bone morphogenetic protein in experimental fracture healing of the rabbit mandible.

A monoclonal antibody raised against bone morphogenetic protein (BMP-McAb) has been used to demonstrate the presence of bone morphogenetic protein (BMP) in experimental fracture healing. Rabbit mandibles were fractured using standardized methods and left to heal for 3, 7, 14, 21 and 24 d, respectively. The avidin-biotin complex (ABC) method demonstrated an accumulation of positively stained primitive mesenchymal cells at the fracture site in the hematoma stage of bone repair. These cells appeared to undergo differentiation into positively-stained chondroblasts and osteoblasts during the phase of callus formation. Undifferentiated mesenchymal cells showed a high positive reactivity in the early post-fracture stages but a much lower reactivity during the remodelling phase. The results of our study suggest that bone inductive processes are accompanied by the presence of BMP in osteoprogenitor cells during fracture healing of the mandible and that BMP may play a significant role in osteogenesis during bone healing.

Animals↗

Solitary lag screw fixation in the treatment of angle fractures in the mandible: state of the art.

The angle of the mandible forms an area of weakness and is a common site at which fractures occur. This review presents the current state of lag screw fixation of mandibular angle fractures. Treatment philosophies are discussed and the special advantages of this method are mentioned. Despite the positive results of treating angle fractures in the mandible with the solitary lag screw fixation technique, the limitations and complications are clearly pointed out in this article.

Bone Screws↗

Dento-skeletal components of class II malocclusions for children with normal and retruded mandibles.

A random sample of 150 British school children aged 9 to 12 years was selected. Lateral skull radiographs were taken and traced. None of the subjects had any orthodontic treatment before. Out of the sample of 150 children, 41 children (18 boys and 23 girls) were selected on the basis of ANB angle > or = 4.5 degrees, as having class II skeletal relationship. Average age of the children was 10 years, 16 angular and 8 linear, skeletal and dental parameters were used. The 41 class II skeletal sample was divided according to the value of SNB angle into subjects with normal anteroposterior positioned mandibles (SNB > or = 76 degrees--19 children) and retruded mandibles (SNB < or = 75.5 degrees--22 children). Descriptive statistics for the skeletal class II sample was done, which confirmed earlier studies. In addition, descriptive statistic was done for each SNB group in order to characterize them. Student t test was done to identify significant differences between both groups of skeletal class II. The results revealed significant difference for SNA (P < 0.001); SN-Pog (P < 0.001); NS Gn (P < 0.001); SN-MP (P 0.001); ANS-PNS-Go-Me (P, 0.01); SN-occl (P < 0.001); 1-MP (P < 0.01); N-Me (P < 0.001); N-ANS (P < 0.05).

Cephalometry↗

[Significance of vascularization of jejunal transplants in secondary reconstruction of the mandible].

There is a difference in the vascular architecture of myocutaneous flaps and jejunal free flaps both available to replace resected mucosal tissue of the oral cavity after surgical treatment of oral cancer. The question in whether the mobilization of jejunal free flaps is possible without respect to the anastomized vessels in particular in secondary reconstruction procedures to achieve a bony continuity of the mandible. From 1985-1992 22 patients were operated on using microsurgically anastomized jejunal free flaps. In 7 cases a secondary mandibular reconstruction by means of microsurgically anastomized iliac crest grafts was performed. In respect of our results we recommend in cases of secondary mandibular reconstruction with mobilisation of the jejunal flap. 1. preoperative digital subtraction angiography, 2. temporary clamp of anastomized vessels with observation of the perfusion of the jejunal flap, 3. intraoperative doppler-sonography. These techniques allow a save evaluation of the vessels of the donor site prior to microvascular anastomoses for secondary bony reconstruction of the mandible.

Anastomosis, Surgical↗

[Osseous desmoid fibroma of the mandible. An unusual case in a 15-month-old infant].

The authors present a rare case, unique in the literature, of an osseous desmoid fibroma in which the histological diagnosis was made at the age of fifteen months. The signs were of a slight swelling with complete trismus of the mandible. After excision of the tumour, with a resultant defect in the superior ramus of the mandible, the trismus disappeared spontaneously after two weeks.

Diagnosis, Differential↗

Condyle transplantation in free flap mandible reconstruction.

Fourteen patients requiring hemimandible resection were reconstructed with bone free flaps onto which the resected condyle was mounted as a nonvascularized graft. Postoperative mandible function, facial aesthetics, and patient symptoms were reviewed. The follow-up period ranged from 13 to 56 months (average 30.4 months). Interincisal opening ranged from 25 to 52 mm (average 37.10 mm). Opening ability inversely correlated with a need for intraoral soft tissue replacement and with the administration of postoperative radiation therapy. Eight patients were available for late study of the transplanted condyle with lateral tomograms and computed tomographic scans. Condyle volume diminished considerably in some, but this did not correlate with a decrease in function. Dual joint function and preoperative occlusion were maintained long term with this technique. Aesthetic results were enhanced by the contribution of the transplanted condyle to improved accuracy of free flap bone graft fabrication and insetting. There were neither postoperative morbidity nor abnormal symptoms due to the use of the condyle as a nonvascularized graft. This study demonstrates the effectiveness and safety of condyle transplantation in free flap mandible reconstruction.

Adolescent↗

Mandible reconstruction with metallic endoprosthesis following Commando's operation for advanced head and neck cancer. Personal experience.

Invasion of the mandible is found in 22% to 29% of advanced (Stage III-IV) head and neck cancers; only an aggressive surgical technique, such as Commando's operation with subsequent reconstruction of tissue defects, can give a chance of cure to these patients. The reconstruction is feasible both by means of microsurgical free-tissue transfers or with alloplastic materials and myocutaneous flaps. Between 1982 and 1991, 34 patients in Stage III (n = 6; 17.7%) and IV (n = 28; 82.3%) head and neck cancers underwent Commando's operation with different types of reconstruction in 30 patients: pectoralis myocutaneous flap (n = 9), osteo-myocutaneous flap with the underlying segment of the fifth rib (n = 2), myocutaneous flap plus prosthesis (n = 17), or prosthesis alone (n = 2). Two different prostheses were implanted: the linear A-O mandibular reconstruction plate (n = 13), and the Dumbach titanium cage (n = 6). In the group of patients in which the linear A-O mandibular reconstruction plate was used there were four cases of prosthesis dislodgement and major exposure and one case of prosthesis breakage while in patients who were given the Dumbach titanium cage there were four cases of major exposure. Prosthesis removal was required in five and two patients with linear A-O and Dumbach titanium cage prosthesis, respectively. Median survival was 14 months with 28% five-year survival. In our experience, metallic prostheses with a shape and arrangement that allow a distribution of traction forces on a wider surface, with screws drilled in nonaligned points of the mandible, seem to be more reliable as they reduce the risk of dislodgement and breakage.

Bone Plates↗

[Surgical results of osteosynthesis in fracture of the mandible].

In the study the results of osteosynthesis in fracture of the mandible with miniplates and osteosuture. The 80 patients in two groups with 40 subjects in each were suffering from fracture of the mandible. In 25 of them the miniplate osteosynthesis was performed. The healing of wound, functional evaluation and the state of postoperative scar were described. Complication in both examined groups were similar. No difference was noticed in size and picture of scars after miniplate osteosynthesis and osteosuture. In 62.5% of miniplate osteosynthesis the intraoral way was used to diminish the postoperative scar. The good results of this method indicate an usefulness in clinical practice.

Adult↗

Chronic diffuse sclerosing osteomyelitis of the mandible or mandibular location of S.A.P.H.O. syndrome.

The chronic diffuse sclerosing osteomyelitis (CDSO) of the mandible has been described as an inflammatory disease characterized by recurrent episodes of intense pain in the mandible, often accompanied by trismus, paresthesia and progressive mandibular deformity. The etiopathogeny of this entity is not fully known. The differential diagnosis must be carried out very carefully, and the treatment results are very disappointing. Recently, evidence that suggests that CDSO may be the mandibular location of a more diffuse condition, the synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome, has been offered. We describe two clinical cases of CDSO of typical evolution which fulfill the criteria for SAPHO syndrome, offering us an occasion for a review of the current literature.

Acne Vulgaris↗

Cranial, iliac, and demineralized freeze-dried bone grafts of the mandible in dogs.

Both autogenous bone grafts and demineralized freeze-dried allogeneic bone implants were evaluated for mandibular reconstruction. Four-centimeter segmental defects of the midbody of the edentulous mandible were reconstructed in 36 dogs, with specimens recovered at 3 and 6 months and quantitatively compared for total and new bone by histomorphometric analysis. Autogenous grafts consisted of corticocancellous cranial block (CB), corticocancellous iliac block (IB), and particulate cancellous iliac marrow (PM). The allogeneic bone was demineralized and freeze-dried, and consisted of particulate cortical endochondral bone (FP), cranial cortical block (FCB), and iliac cortical block (FIB). Clinically and histomorphometrically, results appeared to indicate that (1) CB compared favorably with IB at 3 and 6 months for total bone, but IB showed a trend for more new bone formation at 6 months, a trend that may be due to the thicker cortical component of CB, which requires longer time periods to remodel than the cancellous rich IB; (2) FP failed to achieve bony union at 3 months, with inadequate rates of new bone formation; and (3) FCB and FIB compared favorably for total bone with CB and IB at 6 months, although new bone for autogenous CB and IB was 26.9% and 45.4%, while new bone for allogeneic FCB and FIB represented only 7.9% and 17.4%.

Animals↗