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Long-term treatment with carbamazepine affects CSF somatostatin immunoreactivity in epileptic patients.

A number of pharmacological evidence supports the view that somatostatin (SS) may be importantly involved in the seizure susceptibility both in humans and in laboratory animals. In a previous report the Authors have provided the finding that a short-term carbamazepine (CBZ) administration is able to reduce SS-CSF-IR in epileptic patients. The present study has been carried out to investigate whether a long-term treatment with CBZ affects in a similar way SS-IR content in CSF from temporal lobe epileptics (CPS). The results confirm and expand previous evidence suggesting that CBZ lowering effect on CSF-SS-IR may be relevant to its anticonvulsivant action.

Carbamazepine↗
PubMed1992

The natural history of drug resistant epilepsy: epidemiologic considerations.

Approximately 160,000 United States residents will be evaluated for newly identified unproved seizures in 1990. While the majority will have a favorable prognosis and more than 50% will ultimately be able to discontinue medication, about 10,000 will fall into the category 'intractable'. There are well established predictors for seizure remission and for successful withdrawal of medications, including seizure type, etiology, age at onset, neurologic status, and family history. There are few studies which have evaluated predictors for poor outcome, in part because of difficulties with definition. Predictors of poor outcome are not necessarily the converse of predictors of good outcome. Identification of such factors is important to allow earlier referral of patients destined to meet criteria for intractable to allow alternative therapies to be instituted.

Anticonvulsants↗