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Depression, service utilization, and treatment costs among Medicare elderly: gender differences.

OBJECTIVE: To compare gender differences in mood disorders, service utilization, and health care costs among a random sample of Medicare elderly beneficiaries of Tennessee. DATA SOURCES: Medicare expenditure data from a 5% random sample of Tennessee Medicare beneficiaries (n = 35,673) were examined for 1991-1993. The physician reimbursement files provided data relative to ICD-9 diagnostic codes, physician visits, and the cost of physician services provided. Other service utilization and cost data were obtained for the sample from the outpatient, home health, skilled nursing, hospice and inpatient files. STUDY DESIGN: The dependent variables were: (i) patients with ICD-9 diagnosis for a mood disorder (major depression and other depression), (ii) service utilization (number of outpatient visits, skilled nursing visits, home health visits, physician visits, emergency visits, and inpatient days), and (iii) health care costs (dollar amount of physician cost, outpatient cost, inpatient cost, total mental health cost, total health cost, and other cost). The independent variable was gender. PRINCIPLE FINDINGS: Chi-square tests showed that among the patients with a mood disorder, females had a significantly higher incidence than males of major depression (1.3% vs. .4%, respectively, p < .001) and other depression (1.6% vs. .6%, respectively, p < .001). Further, t-test results indicated that females diagnosed with major depression utilized significantly more outpatient services than males (3.2 vs. 2.6, respectively, p < .04). Total health care costs for those with other depression were significantly higher for males than females ($15,060 vs. $10,240, respectively, p < .002). CONCLUSIONS: The results indicate that mood disorders, outpatient services, and total mental health costs are higher for females than males; however, total health care costs are higher for males than females.

Aged↗

Reliability of the recording of hysterectomy in the Saskatchewan health care system.

OBJECTIVE: To determine the validity of data pertaining to hysterectomy in the Saskatchewan health care utilisation datafiles. DESIGN: Retrospective analysis of routinely collected data covering hospital discharge records and practitioner claims for reimbursement of services, together with a review of clinical charts. SETTING: Province of Saskatchewan, Canada. SAMPLE: All 1905 cases of hysterectomy in one calendar year for analysis of datafiles and a random sample of 227 clinical charts for review. METHOD: Information in the hospitalisation datafile was validated through an external comparison with data extracted from a review of clinical charts, as well as an internal comparison with independent data from the practitioner claims file. Corresponding context data on drug use and performance of related procedures were also analysed. RESULTS: Concordance between hospital data and clinical charts was greater than 95% for those items of an administrative nature as well as type of hysterectomy and was around 85% for the diagnoses. When hospitalisation and practitioner claims data were compared, the concordance was 98% for type of hysterectomy but only 56% for diagnoses. CONCLUSIONS: The agreement between hospital data and clinical charts was excellent. The concordance between hospitalisation and practitioner claims data was almost exact for type of hysterectomy, while discrepancies in diagnoses between these files were mostly explainable on the basis of accepted clinical practice. Saskatchewan health care utilisation datafiles provide a source of valid data for research and evaluation studies.

Adolescent↗

How well can the chest radiograph diagnose left ventricular dysfunction?

OBJECTIVES: To review the diagnostic utility of the chest radiograph for left ventricular dysfunction. DATA SOURCES: Structured MEDLINE searches, citation reviews of relevant primary research, review articles, and textbooks, personal files, and data from experts. STUDY SELECTION: Studies of patients without valvular disease that allowed calculation of the sensitivity and specificity of selected radiographic signs compared with a criterion standard of increased left ventricular preload or reduced ejection fraction. DATA EXTRACTION: Two independent readers reviewed 29 studies. Studies were pooled after stratification by radiographic finding, criterion standard, and clinical setting. MAIN RESULTS: Redistribution best diagnosed increased preload with a sensitivity of 65% (95% confidence interval [CI] 55%, 75%) and specificity 67% (95% CI 53%, 79%). Cardiomegaly best diagnosed decreased ejection fraction with a sensitivity of of 51% (95% CI 43%, 60%) and specificity of 79% (95% CI 71%, 85%). Interrater reliability was fair to moderate for redistribution and moderate for cardiomegaly. The clinical setting affected results by decreasing the specificity of cardiomegaly to 8% in detecting increased preload in patients with severe systolic dysfunction. The absence of redistribution could only exclude increased preload in situations in which the suspicion (pretest probability) of disease was less than 9%, whereas redistribution could confirm increased preload when the pretest probability was greater than 91%. The absence of cardiomegaly could only exclude a reduced ejection fraction if the pretest probability was less than 8%, whereas cardiomegaly could confirm a reduced ejection fraction if the pretest probability was greater than 87%. CONCLUSIONS: Redistribution and cardiomegaly are the best chest radiographic findings for diagnosing increased preload and reduced ejection fraction, respectively. Unfortunately, neither finding alone can adequately exclude or confirm left ventricular dysfunction in usual clinical settings. Redistribution is not always reliably interpreted.

Confidence Intervals↗

qValue--a program to calculate comparative measures of genomic reorganisation from cytogenetic and/or linkage information.

A program qValue, which calculates a measure of the genomic reorganisation that has occurred between pairs of species since their divergence from a common ancestor, is described. The program takes a tab-delimited text file containing data describing the location of various genetic loci in multiple species and generates an output text file, also in tab-delimited format, that lists various parameters of genomic reorganisation between all possible pairs of species considered. This provides a useful tool for the developing field of comparative genome mapping, particularly in the study of the evolution of the vertebrate genome.

Animals↗

Physician behavioral response to a Medicare price reduction.

OBJECTIVE: To investigate at the individual practice level physician behavioral responses to the Medicare fee reductions mandated in the Omnibus Budget Reconciliation Act of 1989. Symmetric and nonsymmetric behavioral responses are modeled and investigated. DATA SOURCES: Volume index calculated from data in the Part B Medicare Annual Data (BMAD) Provider Files for 1989 and 1990. The pricing data are from the Procedure Files. STUDY DESIGN: A fixed-effects model in carrier and in specialty is employed. DATA COLLECTION: No direct data collection is required as BMAD files are used in the study. Price and volume variables are expressed as Fisher indexes of change. PRINCIPAL FINDINGS: The results show nonsymmetrical behavioral response because practices that did not face significant fee reductions do not exhibit behavioral change. By contrast, losers partially compensate for the fee reductions. For every dollar cut in their fees, physicians recoup approximately 40 cents by increasing volume. Loser behavioral responses vary by specialty. CONCLUSIONS: The presence of a volume response suggests that price control alone is not sufficient to cap rising healthcare costs. This indicates that additional or other tools must be considered if cost containment is to be attained.

Cost Control↗

[Microarray data analysis].

Microarrays might be used for future diagnostic and prognostic purposes. High-density oligonucleotide arrays are promising in this respect. The microarray data consist of intensity files, which are transformed into expression matrices by the application of several mathematical modifications. However, pitfalls regarding data analysis seem to be a critical factor for the impact of this new technology. This article focuses on the data analysis, from raw data file to marker gene lists used to retrieve knowledge about underlying biological processes.

Gene Expression Profiling↗

Automated acquisition and analysis of animal behavior data utilizing an Apple IIe.

A method is described for interfacing an Apple IIe computer to common programming modules which will allow the collection and organization of digitized data into files compatible with readily available statistical packages. The system will thus eliminate the need for manual entry of data for statistical analysis. The required hardware and software developed is discussed in sufficient detail to allow assembly and use by individuals with minimal computer expertise.

Animals↗

Parallel line bioassay in practice. Practical aspects of design, analysis, and regulatory requirements from the technician's point of view.

Bioassay technicians sometimes have limited statistical training and require more help when preparing bioassay data for filing with regulatory agencies. Three things should be considered when approaching problems in statistics: (i) Assess the situation: data should be checked for accuracy and bias; (ii) Is the situation resolving on its own? Are the skills in place to answer this question? (iii) If no to 2, find expert help. Some sources of variability in bioassays are listed. Some sources of expert help are listed. An example is given of how a statistics problem was solved by a technician unfamiliar with statistics. Some practical tips for design, analysis and regulatory issues are presented.

Biological Assay↗

Heritability and repeatability for milk production traits of Japanese Holsteins from an animal model.

Records of the first three lactations of cows were obtained from the file of the Dairy Herd Testing Association in Hokkaido. The data were divided into 10 files containing approximately 24,000 cows each. The derivative-free REML method was used to estimate variances with a repeatability model. The model contained herd-year, calving month, and the linear and quadratic effects of age at calving as fixed effects; additive genetic, permanent environmental, and temporary environmental effects were the random effects. Estimates from the 10 data files wer pooled into a simple arithmetic mean. Empirical standard errors were calculated from the samples. Average estimates of heritability were the same for milk and fat yields (h2 = .30). Heritabilities for protein (h2 = .26) and SNF yields (h2 = .27) are slightly lower than those for milk and fat yields. Estimates of repeatabilities, .52 to .54, are considerably different from those now used for genetic evaluations in Japan.

Algorithms↗

[Anesthesia equipment: fresh gas delivery systems. I. Mecanical systems with rotameters and calibrated vaporizers].

OBJECTIVES: To analyse the design, performance, failures, the checking before use of mechanical fresh gas delivery units (FGDUs) equipped with bobbin or ball-flowmeters delivering a continuous gas flow and calibrated vaporizers, marketed in France in 1999. DATA SOURCES: Articles were obtained from a Medline review (1960-1999; search terms: anaesthetic machine, flowmeter, vaporizer), textbooks and personal files; specific data were provided by manufacturers. STUDY SELECTION AND DATA EXTRACTION: The articles were considered for performance data, benefits and drawbacks, and characteristics, as well as the risks carried by mechanical FGDUs. DATA SYNTHESIS: Seven anaesthetic machines out of 11 are equipped with mechanical FGDUs, including rotameters delivering a gas mixture up to 30 L.min-1, calibrated vaporizers and an O2-flush valve delivering at least 500 mL O2 per second (30 L.min-1). These units allow closed circuit anaesthesia. They carry a risk for barotrauma as three out of them can deliver at the gas outlet of the FGDUs a gas mixture at a pressure reaching 3.5 bars and four others at a pressure of 150-200 mmHg. They also carry a risk for hypoxia, either from a preferential leak of oxygen at the corresponding rotameter or the O2-flush valve, or from a leak of fresh gas mixture either in a vaporizer or the selectatec manifold. The vaporizers carry a risk for vapor delivery at a concentration differing notably from the value set on the concentration dial. Therefore their accuracy must be checked periodically and the FGDUs checked for a leak after the addition to or the removal of a vaporizer from the selectatec manifold. The optimal technique for leak detection is the negative pressure test.

Anesthesia, Inhalation↗

[Anesthetic equipment: fresh gas delivery systems. II. Electronic systems].

OBJECTIVES: To analyse the design, functioning, benefits and drawbacks of electronic fresh gas delivery units (FGDUs) included in anaesthetic machines marketed in France in 1999. DATA SOURCES: Articles were obtained from a Medline review (1980-1999; search terms: anaesthetic machine, flowmeter, vaporizer), textbooks and personal files; specific data were also provided by manufacturers. STUDY SELECTION AND DATA EXTRACTION: The articles were analysed in considering the differences between mechanical and electronic FGDUs. DATA SYNTHESIS: Four anaesthetic machines out of 11 are equipped with electronic FGDUs. In comparison to mechanical units, they include the following benefits: wide range of accurate gas flow, especially in the low flow range, with analog and digital display; intermittent delivery of each gas, which is essential for automated gas delivery and quantitative anaesthesia or target controlled (FET vapor) inhalational anaesthesia; facilitated oxygen ratio control; possibility to print the gas and vapor flows on the automated anaesthetic record; interruption of gas flow when the main switch of the machine is set to off; and absence of risk for retropollution. Three FGDUs out of four are adapted for gas delivery to an accessory (ancillary) anaesthetic circuit. However, only one of them delivers a gas flow up to 30 L.min-1. The specificity of the ADU AS/3 (Datex-Ohmeda) is the bypass vaporizer included in the FGDU with an exchangeable vaporizing chamber (cassette). The specificity of the Julian (Dräger) is the delivery of fresh gas limited to the expiratory phase during mechanical ventilation. The specificity of the the FGDU from Kion (Siemens) is the possibility to act as an open circuit ventilator, similar to a Servoventilator. The specificity of the PhysioFlex is an FGDU included in the circle circuit, each gas and liquid anaesthetic being directly injected into the circuit. Data from the French medical device surveillance commission indicate that the main failures occur in the power supply device and the microprocessor.

Anesthesia, Inhalation↗

Effects of hospitals' structural clinical integration on efficiency and patient outcome.

The objective of this study was to examine the relationships among structural clinical integration, average total charge, and adverse patient outcomes. The conceptual framework of this study is based on Donabedian's triadic model for outcomes research on structure, process, and outcome. Retrospective data were obtained from multiple sources: (1) the American Hospital Association (AHA) annual survey in 1997; (2) the Area Resource File (ARF) data set in 1997; (3) the Dorenfest IHDS + database (version 2); and (4) the National Inpatient Sample (NIS) data set in 1997. A cross-sectional study design was used. Outcomes indicators were risk-adjusted with logistic regression, and the Medicare case-mix index was used for the risk-adjustment of the efficiency indicator. LISREL (LInear Structural RELationship) was used to test the hypotheses that structural clinical integration is negatively related to average total charge, and that average total charge is positively related to adverse patient outcomes. The risk-adjustment models were successful in discriminating the patients who suffered adverse events. Significant associations were found between structural clinical integration and average total charge per admission, between average total charge per admission and surgical complication, and between surgical complication and in-hospital death. However, the implementation of structural clinical integration did not show the expected reduction in total charge per admission. This study confirms Donabedian's model for outcomes research. However, the study found that hospitals with highly integrated structures showed no immediate financial benefit. Structural clinical integration has only an indirect effect on patient care outcomes.

Cross-Sectional Studies↗

Ximelagatran: an oral direct thrombin inhibitor.

OBJECTIVE: To present the chemistry, pharmacology, and pharmacokinetics of ximelagatran, an oral direct thrombin inhibitor (DTI), and to review available comparative clinical trial data evaluating its efficacy and safety relative to other antithrombotic agents in the prevention and treatment of thromboembolism. DATA SOURCES: A search of the PubMed and Cochrane databases (1995-August 2004), supplemented by a manual search of article bibliographies, conference abstracts, and data on file from the manufacturer, was conducted. Key search terms were ximelagatran, melagatran, H376/95, and direct thrombin inhibitors. STUDY SELECTION AND DATA EXTRACTION: Pertinent information from available clinical trials, including study design, patient demographics, dosing regimens, anticoagulant comparators, methods for evaluating effectiveness, treatment outcomes, adverse events, and pharmacokinetic and pharmacodynamic evaluations, was extracted. DATA SYNTHESIS: Ximelagatran is an orally administered DTI under development for use in the treatment of venous thromboembolism (VTE), long-term prevention of a second VTE event, stroke secondary to atrial fibrillation, prevention of VTE after orthopedic procedures, and recurrent ischemic events after acute myocardial infarction. CONCLUSIONS: Ximelagatran, in twice-daily doses of 24 or 36 mg, is an alternative to low-molecular-weight heparins or warfarin in thromboprophylaxis following orthopedic knee replacement, atrial fibrillation, or initial treatment of VTE. Improved outcomes versus placebo were seen in the long-term prevention of VTE in patients who completed an initial 6 months of treatment. Liver-related effects need further clarification.

Adult↗

A processing system for elaboration of data obtained by the oxygraph.

A Data Processing System is presented to resolve some problems usually present in the oxygraph research. The possibility to obtain a file of data in which each experiment is arranged as completely as possible in the description of experimental conditions and the corresponding data permits the execution of some operations such as calculations, statistical elaborations, kinetic studies, research and comparation of experiments and plotting. This system may result very helpful in the programmation of the experiments and in the elaboration of the data obtained by the oxygraph technique.

Computers↗

Design and development of an interactive medical teleconsultation system over the World Wide Web.

The objective of the medical teleconsultation system presented in this paper is to demonstrate the use of the World Wide Web (WWW) for telemedicine and interactive medical information exchange. The system, which is developed based on Java, could provide several basic Java tools to fulfill the requirements of medical applications, including a file manager, data tool, bulletin board, and digital audio tool. The digital audio tool uses point-to-point structure to enable two physicians to communicate directly through voice. The others use multipoint structure. The file manager manages the medical images stored in the WWW information server, which come from a hospital database. The data tool supports cooperative operations on the medical data between the participating physicians. The bulletin board enables the users to discuss special cases by writing text on the board, send their personal or group diagnostic reports on the cases, and reorganize the reports and store them in its report file for later use. The system provides a hardware-independent platform for physicians to interact with one another as well as to access medical information over the WWW.

Internet↗

ViewPoint and ViewDist: utilities for rapid graphing of linkage distributions and identification of outliers.

ViewPoint and ViewDist are stand alone Java utilities designed to provide an interactive visual representation of data from files which may be created by the user or produced directly from analyses packages such as Mx. ViewPoint is designed for representation of linkage results and can be used for summarizing multiple univariate linkage results or providing detailed comparison of univariate and multivariate results, with optional dynamic sub-plots designed to display the QTL path coefficients at each marker. ViewDist is an easy to use distribution plotter designed for use with raw data or case-wise likelihood statistics. The utility can produce Q-Q plots (assuming either normal or chi(2)-distributions) and by allowing data to be read simultaneously from two files readily produces difference plots allowing comparison of the case-wise likelihood under two competing models.

Chromosome Mapping↗

Best clinical practice with ziprasidone: update after one year of experience.

This article presents clinical recommendations for using ziprasidone based on information from a year of post-marketing experience. The recommendations are based on the clinical literature, the package insert, presentations at recent meetings, data on file with the manufacturer, and the consensus of a panel of expert psychiatrists. The article provides updates on efficacy and safety data and gives recommendations for dosing and switching strategies. With regard to the QTc issue, there has not been any case of torsades de pointes reported in the more than 150,000 patients who have received ziprasidone since its approval. Ziprasidone is weight neutral and does not appear to cause increases in glucose or lipid levels or in insulin resistance. The panel generally recommends beginning with an initial dose of 80 mg/day (40 mg b.i.d.) rather than the 40 mg/day dose recommended in the package insert. The ability to begin with a therapeutic dose and to titrate up rapidly is an advantage of ziprasidone, especially in treatment settings where admission time is short. In making an elective switch to ziprasidone, the panel recommends a variety of different switching strategies but stresses the importance of trying to maintain a therapeutic dose of one antipsychotic at all times.

Journal Article↗

The influence of year-end bonuses on colorectal cancer screening.

OBJECTIVE: To estimate the effect of physician bonus eligibility on colorectal cancer (CRC) screening, controlling for patient and primary care physician characteristics. STUDY DESIGN: Retrospective study using managed care plan claims data from 2000 and 2001. METHODS: Data on 50-year-old commercially insured patients in a managed care health plan were linked to enrollment and provider files. The data included information on 6749 patients (3058 in 2000 and 3691 in 2001). Multivariate logistic regression models were used to assess the association between CRC screening receipt and physician bonus eligibility. RESULTS: From 2000 to 2001, CRC screening use increased from 23.4% to 26.4% (P < .01). Results from the multivariate logistic regression analysis revealed that the probability that a patient received a CRC screening was approximately 3 percentage points higher in the bonus year, 2001 (P < .01). CONCLUSIONS: Bonuses targeted at individual physicians were associated with increased use of CRC screening tests. However, more research is needed to examine the effect of performance-based incentives on resource use and the quality of medical care. Specifically, there is a need to determine whether explicit financial incentives are effective in reducing racial disparities in the quality of patient care. This has particular relevance for CRC screening given that black patients are less likely to be screened, they have higher CRC incidence and mortality rates compared with other racial groups, and screening has been shown to be more cost effective in this population.

Colorectal Neoplasms↗