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PubMedDate not supplied

[Pathogenic role of anaerobic bacteria in postoperative patients with digestive system surgery].

The cases of patients with anaerobic organisms were collected for a period of one year from the results of bacteriological examinations sent to the Bacteriology Laboratory and from the file of operation reports of all the gastrointestinal surgery performed at the University Surgical Clinic of Amiens. The authors wanted to determine whether the anaerobic bacteria were really responsible for the infections observed, whether they acted alone or in association, what antibiotics should be used specifically against them, and what was the incidence of the initial infection in the discovery of the anaerobic organisms. It was found that the rate of infectious complications was higher in men than in pre-menopausal women and higher in emergency operations than in routine scheduled operations. Overall, it seems that the anaerobic bacteria, considered individually, do not have an important pathogenic action. They are widespread saprophytes which are present before the post-operative immune depression. It is their extraordinary development under certain local conditions and their association with other organisms which explain their pathological emergencies.

Adult↗
PubMedDate not supplied

[Comparative studies on thiamine, pantothenic acid and nicotinic acid metabolism in the digestive system of rats].

Thiamine is metabolized in the alimentary system to form phosphoric ethers, thiamine disulfide, thiochrome, and other unidentified products. The contents of the small intestine shows the same metabolites, among which thiamine sulfate in detectable in a greater amount. Labeled pantothenate administered parenterally is progressively metabolized largely to 4-phosphopantothenate, CoA and an unidentified metabolite which are detectable in the liver, in the mucous membrane and contents of the small intestine. Labeled nicotinate is metabolized to nicotinamide within the first 15 to 30 min of research, being metabolized to a less measure to the nucleotide forms of metabolites. The contents of the small intestine manifests the same metabolites, among which nicotinamide is predominant. It has been demonstrated that the basis of the retention of vitamins in the body is formed by their transport-metabolic transformations associated with metabolite reception in the biomembranes of the alimentary tract during recycling of different duration.

Animals↗
PubMed1983

[Incidence of intramural digestive system hematoma in anticoagulation. Epidemiologic study and clinical aspects of 59 cases observed in Switzerland (1970-1975)].

Intramural hematoma of the small intestine is a relatively rare but serious complication of oral anticoagulant therapy. On the basis of a retrospective epidemiological survey the authors estimate its incidence at 1 case per 20 000 admissions to medical and surgical services or 1 case per 2500 anticoagulated patients per year. The classical trial of clinical symptoms comprises abdominal pain, small bowel obstruction and multiple hemorrhagic symptoms (hematuria, hematomas, ecchymoses, hematemesis and melaena). The most important etiologic factors appear to be overanticoagulation with vitamin K antagonists (the thromboplastin time is prolonged in over 70% of cases) or correct oral anticoagulation associated with additional impairment of hemostasis due to the administration of drugs inhibiting platelet function. Radiologic examination of the gastrointestinal tract reveals that the jejunum and the ileum are sites of predilection for intramural intestinal hematoma. The treatment of choice is conservative; surgery should be reserved for cases in which the diagnosis is doubtful and for patients who exhibit signs of bowel necrosis or peritonitis.

Adult↗