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Topographic analysis of epidural pure-tone-evoked potentials in gerbil auditory cortex.

This study investigated the tonotopic organization of pure-tone-evoked middle latency auditory evoked potentials (MAEPs) recorded at the auditory cortical surface in unanesthetized gerbils. Multielectrode array recording and multiple linear regression analysis of the MAEP demonstrated different degrees of tonotopic organization of early and late MAEP components. The early MAEP components P1 and N1 showed focal topography and clear dependence in location and size of cortical area covered on pure-tone frequency. The later components P2 and N2 showed a widespread topography which was largely unaffected in location and size of cortical area covered by pure-tone frequency. These results allow delimitation of the neural generators of the early and late MAEP components in terms of the spectral properties of functionally defined neural populations.

Acoustic Stimulation↗

[Receptive fields of neurons of primary auditory cortex neurons in the cat].

Receptive fields of primary auditory cortical neurons were investigated by direct stimulation of nerve fibers in different parts of the cochlea in cats anesthetized with nembutal. The size of the excitatory receptive field depends on the location of te neuron in the cortical auditory area. The more caudal is the position of the neuron in the primary auditory cortical projection of the cochlea, the more extended its receptive field is. The most narrow and symmetrical receptive fields were found in the basal coil of the cochlea. A suggestion is made that the region of finest discrimination of acoustic signals is located in the basal coil of the cochlea which has the largest representation in the primary cortex.

Animals↗

Neurophysiological evidence for context-dependent encoding of sensory input in human auditory cortex.

Attention biases the way in which sound information is stored in auditory memory. Little is known, however, about the contribution of stimulus-driven processes in forming and storing coherent sound events. An electrophysiological index of cortical auditory change detection (mismatch negativity [MMN]) was used to assess whether sensory memory representations could be biased toward one organization over another (one or two auditory streams) without attentional control. Results revealed that sound representations held in sensory memory biased the organization of subsequent auditory input. The results demonstrate that context-dependent sound representations modulate stimulus-dependent neural encoding at early stages of auditory cortical processing.

Acoustic Stimulation↗