Deficits in consummatory responses to regulatory challenges following basal ganglialesions in rats.
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To appreciate the contribution of oral and post-absorptive factors in the control of schedule-induced polydipsia (SIP), body fluid balance was determined at various times into the 4 hr session. Although dehydrated at the start of the session, rats quickly returned to normal balance which was maintained, despite excessive intake, by a brisk water diuresis. Plasma, as measured via the T-1824 technique, was also normal. Gastric infusion of water following each pellet delivery failed to eliminate the polydipsia despite marked hemodilution, whereas, oral infusion of equivalent amounts of water completely abolished the phenomenon. Taken together, these results suggest that SIP is mediated by oropharyngeal rather than hydration controls.
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Two experiments are reported in which rats were run in the straight alley with partial (PR) or continuous (CR) food reinforcement during acquisition and then extinguished. Hormone treatment (with estradiol benzoate, EB, or testosterone propionate, TP) was given during acquisition on both CR and PR schedules, but not during extinction. The results showed no effect of EB on the partial reinforcement extinction effect (PREE) in female rats. In males TP was found to reduce the PREE by differentially reducing resistance to extinction in the PR condition. Thus TP but not EB attenuates the behavioural effects of nonreward.
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