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PubMed1996

Report of the first workshop on the genetic map of bovine chromosome 23.

A report of the first workshop on the genetic map of bovine chromosome 23 (BTA23) is given. Five laboratories contributed data from 29 loci, including a total 11586 informative genotypes. The combined pedigrees represented 1930 potentially informative meioses. Eighteen of the 29 loci were common to two or more data sets and were used to construct a framework linkage map of BTA23. Twelve of the 18 could be ordered on the linkage map with a likelihood ratio of greater than 1000:1. Thus, a low resolution consensus map was constructed with a high level of support for order. The sex-averaged, female and male maps span 54.5, 52.7 and 55.8 cM, respectively. Sex-specific differences in recombination frequency were identified for eight pairs of framework loci. Average genetic distance between framework loci on the sex-averaged map is 5.0 cM.

Animals↗
PubMed1998

Report of the first workshop on the genetic map of bovine chromosome 1.

A report of the first workshop on the genetic map of bovine chromosome 1 (BTA1) is presented. Five laboratories contributed 31,962 informative meioses from 70 loci. Thirty-two loci which had been typed by at least two laboratories were used to construct a framework genetic map with a likelihood ratio support of at least 1000:1 for locus order. The resulting sex-averaged framework map contained 26 loci and spanned 163.6 CM. The lengths of the female and male maps were 159.5 CM and 165.3 CM, respectively, and there was evidence for an expansion in the telomeric one-third of the male map. Of the four cases where order for closely linked loci differed among the maps produced for each of the contributing laboratories, a consensus order was obtained for three in the framework map. The average genetic distance between framework loci on the sex-averaged map was 6.3 CM.

Animals↗
PubMed1993

Cyclosporin A in severe, therapy-resistant atopic dermatitis: report of an international workshop, April 1993.

Data on the use of oral cyclosporin A (CyA; Sandimmun) therapy for severe adult atopic dermatitis have accumulated since 1987. Details of over 200 adult patients who have received short-term CyA were presented at an international workshop in April 1993. Eighty-six of these patients had participated in three randomized, double-blind, placebo-controlled studies in which CyA was given for 6-8 weeks. The efficacy and safety of short-term CyA treatment in atopic dermatitis is established, provided that appropriate guidelines are observed. Evidence to date suggests that atopic dermatitis patients are no more prone to toxicity than patients with psoriasis, in whom more detailed and longer-term data are available. Early data also suggest that long-term CyA may be effective in atopic dermatitis, but there is concern regarding long-term safety, as experience is still limited. Careful monitoring of all CyA-treated patients is therefore mandatory. CyA should only be used under the direct and regular supervision of a hospital-based dermatologist who is knowledgeable in the use of cyclosporin A, and experienced in the management of severe skin disease and in the use of potentially toxic drugs.

Adult↗
PubMed1999

Home phototherapy: report on a workshop of the British Photodermatology Group, December 1996.

Phototherapy is a popular and effective treatment for many patients with skin diseases. However, repeated journeys to hospital for phototherapy can be inconvenient and expensive. If it were available, many patients might prefer home-based phototherapy as long as it was safe and effective. Indeed, many psoriasis patients already self-treat with ultraviolet A sunbeds at home. This report represents a consensus view from a British Photodermatology Group workshop held in December 1996, the purpose of which was to examine the potential role of home-based phototherapy in dermatological practice. We conclude that home-based therapy represents a suboptimal treatment with greater attendant risks than phototherapy in a hospital environment. The level of medical supervision of the home treatment is crucial to its safety and effectiveness. Until further studies are forthcoming, home phototherapy should be largely restricted to those with overwhelming difficulties in attending hospital.

Home Care Services↗
PubMed2006

Evidence-based practice of photopheresis 1987-2001: a report of a workshop of the British Photodermatology Group and the U.K. Skin Lymphoma Group.

Photopheresis or extracorporeal photochemotherapy (ECP) is a novel immunomodulatory therapy which involves separation of the patient's leucocyte-rich plasma, followed by ex vivo administration of a photosensitizer and ultraviolet A radiation, before reinfusion. ECP has been used successfully for the treatment of cutaneous T-cell lymphoma (CTCL: Sézary syndrome), graft-versus-host disease (GVHD) and cardiac transplant rejection. ECP has a dose-sparing effect on concurrent immunosuppressive therapy. The procedure induces apoptosis of the irradiated lymphocytes, but the exact mechanism by which ECP exerts its therapeutic effect in these different conditions is uncertain. The treatment has very few adverse effects and in particular is not associated with an increased incidence of opportunistic infections. The evidence for the efficacy of ECP has been appraised by a combined British Photodermatology Group and U.K. Skin Lymphoma Group workshop on the basis of evidence published up to the end of 2001 and on the consensus of best practice. There is fair evidence for the use of ECP in erythrodermic CTCL and steroid-refractory GVHD, but randomized controlled studies are needed. There is good evidence supporting the use of ECP in preventing cardiac rejection following transplantation. Randomized controlled trials have also shown a therapeutic benefit in type 1 diabetes mellitus, but the inconvenience associated with the procedure outweighed the clinical benefit. There is fair evidence not to use ECP for the treatment of systemic sclerosis and multiple sclerosis, and good evidence not to use ECP for other forms of CTCL.

Combined Modality Therapy↗
PubMedDate not supplied

Resolving behaviour problems in preschool children: evaluation of a workshop for health visitors.

Workshops on helping parents resolve behaviour problems in their preschool child were provided for all health visitors from one health district in Bristol, UK. An emphasis was placed upon engaging the parents as behaviour change agents, whilst providing a constructional approach to the treatment of this type of problem. The course was evaluated 3 months later. Results are discussed in terms of usefulness of course content as perceived by the health visitors, reported alterations to their health visiting practice and implications for future liaison between clinical psychologists and health visitors.

Behavior Therapy↗
PubMedDate not supplied

What do health visitors gain from behavioural workshops?

Health visitors' ratings of their role, competence, methods and effectiveness in resolving each of seven common types of preschool behaviour problem were obtained both prior to attending a behavioural training workshop and about 9 months later. At follow-up a structured interview examined their current practice in relation to preschool behaviour problems. Results suggest that these experienced health visitors perceived themselves as reasonably self-sufficient in dealing with these problems prior to training. Training had a significant but consolidating effect on these views. Possible mismatches between the health visitor's view of herself as a behaviour change agent and her training experiences in behavioural methods are examined and some suggestions are made regarding future liaison between health visitors and clinical child psychologists.

Behavior Therapy↗
PubMed2006

Workshop cluster 1+ gammadelta T-cell receptor T cells from calves express high levels of interferon-gamma in response to stimulation with interleukin-12 and -18.

Gammadelta T-cell receptor(+) T lymphocytes are an important element of the innate immune system. Early production of interferon (IFN)-gamma by gammadelta T cells may have a role in linking innate and adaptive immune responses and contribute to T helper-1 bias. We investigated the role of cytokines in the activation and induction of IFN-gamma secretion by bovine workshop cluster 1(+) (WC1(+)) gammadelta T cells. The effects of culture with interleukin (IL)-12, IL-18, IL-15 and IL-2 were investigated; these cytokines are known to influence murine and human gammadelta T cells. We report that bovine WC1(+)gammadelta T cells are synergistically stimulated by IL-12 and IL-18 to secrete large quantities of IFN-gamma. Neonatal calves were shown to have significantly higher numbers of circulating WC1(+)gammadelta T cells than adult animals. In addition, the response of peripheral blood WC1(+)gammadelta T cells was significantly higher in neonatal calves compared with adult animals. However, in adult animals the response of lymph node WC1(+)gammadelta T cells to IL-12/IL-18 was more pronounced than that of peripheral blood WC1(+)gammadelta T cells. We hypothesize that the induction of IFN-gamma secretion from WC1(+)gammadelta T cells by IL-12 and IL-18 is likely to be an important element of the innate response to pathogens such as Mycobacterium bovis. The high numbers of WC1(+)gammadelta T cells in neonatal calves, and their inherent ability to respond to inflammatory cytokines, could be a key factor in the enhanced responses seen in calves to BCG vaccination.

Aging↗
PubMed1996

Group processes in a case discussion workshop for community psychiatric nurses.

This paper describes a case discussion workshop with a team of hospital-based community psychiatric nurses (CPNs). After describing the growth of the CPN movement in Britain and the conflicting ideas surrounding the professional role of CPNs, some of the group processes within a particular group of CPNs will be illustrated. Particular attention is paid to the way in which reading material distributed to the group may reflect group processes, and the way in which institutional factors impinge on case discussions. The case for various forms of psychodynamic input into community psychiatric teams is also made.

Community Health Nursing↗
PubMed1980

The long term effectiveness of workshops in curriulum planning and design for teaching staff in Indonesian medical schools.

A programme of basic curriculum change was concurrently introduced into ten Indonesian faculties of medicine which constitute an established system of medical schools with 260 separate academic departments. The programme was based on a 2-week workshop in curriculum planning and a series of follow-up activities. Within a 3-year period almost three quarters of the academic departments involved have defined a more selective curriculum based on sets of instructional (i.e. behavioural) objectives, and are involved in its implementation. This paper describes the methods used to bring about these developments and the attempts which were made to develop a structure within each medical school which would localize and ensure continuity of the changes set in motion. Because of the context from which conclusions have been drawn they have direct significance for large scale educational change in systems of medical schools in developing countries. The conclusions are however also applicable to changes in medical education in developed countries.

Curriculum↗
PubMed1981

Research methods workshop for health professionals in Sierra Leone: an international collaborative project.

In 1979 a research methods seminar for health professionals in Sierra Leone was conducted as part of an international medical education collaborative project between Sierra Leone, Canada, the United Kingdom and the European Economic Community. The aim of the seminar was to promote research and inquiry into national health problems. Planning and administration was conducted by Sierra Leone with Canada providing teaching materials and four tutors. Twenty-seven participants attended the seminar. Participants prepared research protocols prior to the seminar which they developed and refined during the 7 days of the workshop. Using a problem-based method Sierra Leonean health problems were used as the focus to teach epidemiological and biostatistical methods. The seminar was evaluated on the basis of a number of parameters. There was 89% attendance at the nineteen sessions. Twenty-one of the twenty-seven participants presented protocols at the final evaluation session. Self-evaluation of protocols showed improvement in most aspects but particularly in research design, methods of data gathering, analysis and ethical aspects. An opinion survey of participants showed the seminar to be viewed positively. Twelve months later six participants had submitted their protocols for funding of whom four were successful. A further seminar has been conducted in which Sierra Leoneans participated as co-tutors. This seminar format has been presented as an effective means of providing professional assistance from one country to another.

Canada↗
PubMed1986

A cadaver workshop to teach medical procedures.

A seminar and workshop were conducted to train students in the indications, techniques and hazards of common diagnostic and therapeutic procedures in general medicine. Cadavers were utilized to teach the techniques of thoracentesis, pleural biopsy, chest-tube insertion, bone marrow biopsy and aspiration, paracentesis, percutaneous liver biopsy and arthrocentesis. The use of cadavers was realistic and provided standardized instruction to each student. The method gave students an opportunity to become familiar with equipment, techniques, indications and hazards of each procedure prior to actual performance. It is readily adapted to a wide variety of additional procedures.

Cadaver↗
PubMed2006

Workshop recommendations for the preconception cohort of the National Children's Study.

This paper summarises discussions on incorporating preconception recruitment in the National Children's Study (NCS); these were part of the workshop on Expanding Methodologies for Capturing Day-Specific Probabilities of Conception. Four key issues were discussed in relation to the NCS: (1) differences between pregnancy 'planners' and 'non-planners'; (2) a tiered approach to preconception data collection; (3) data gaps in preconception studies; and (4) assessment of early pregnancy in subsequent pregnancies for women with a child already in the study. Practical recommendations were developed for each theme, which have relevance for other prospective studies of conception, pregnancy and human development.

Child↗
PubMed1992

Self help for platelet serologists: the Australian Platelet Antibody Workshops.

The first three Australian Platelet Antibody Workshops (APAW) were held under the auspices of the Australasian Society of Blood Transfusion (ASBT) in 1989, 1990 and 1991. Participants submitted serum samples to the convenor who coded and distributed samples to laboratories routinely performing platelet serology. Results were summarized and discussed at the annual ASBT meetings. This report documents the evolution of platelet antibody tests in Australia and demonstrates the marked improvements in the participants' ability to differentiate platelet-specific antibodies from HLA antibodies and to identify the alloantigenic specificity of platelet antibodies. Five reference laboratories in Australia now hold panels typed for at least three platelet alloantigens.

Antigens, Human Platelet↗
PubMed1975

Progress in rhesus histocompatibility typing resulting from the Second International Nonhuman Primate Histocompatibility Workshop (1973).

The Second International Nonhuman Primate Histocompatibility Workshop permitted comparison of rhesus monkey alloantisera developed in various laboratories on a single common panel of related and unrelated monkeys. Analysis of the data permits the conclusion that at least nine specificities are recognized by more than one laboratory, including six at the first locus and three at the second locus.

Animals↗
PubMed1978

Studies on the specificity of CML. Report from a CML-workshop.

In a collaboratory study involving eight different laboratories 30 human, mixed lymphocyte culture educated cytotoxic lymphocytes (CTLs) were identified yielding reproducible cytolysis on allogenic lymphocyte target cells without detectable HLA-A, B (and C) antigenic sharing between stimulator and target cells. These CTLs were collected in one laboratory (Aarhus) and tested in parallel against a population sample of 100 unrelated, healthy Danes. The testing was only performed once and 11 CTLs did not discriminate in the population, probably due to transportation damage. On the basis of pairwise comparisons between 19 CTLs, three tentative CML-defined specificities could be recognized. These three groups may have defined monospecific traits of allelic genetic origin as judged by a mutually negative, albeit not significant, correlation and a fit to Hardy-Weinberg equilibrium. The concept of determinants other than the serologically defined HLA antigens recognized by some CTLs can thus still be maintained as can the approach to CML typing tested in this workshop.

Computers↗
PubMed1989

HLA typing with monoclonal antibodies: evaluation of 356 HLA monoclonal antibodies including 181 studied during the 10th International Histocompatibility Workshop.

During the 10th International Histocompatibility Workshop (10th WS), 181 HLA MoAbs were studied using lymphocytotoxicity micro-technique (LCT) and/or enzyme immuno-assay (EIA), and their capacity to serve as typing reagents was evaluated. 129 MoAbs were tested by both techniques. Results obtained with 92 class I and 86 class II polymorphic MoAbs (10th WS) were compared to published data concerning 180 class I and 176 class II polymorphic MoAbs, listed in an HLA-MoAbs Register maintained in our laboratory. The following conclusions can be proposed: 1/HLA-A, B typing by LCT with MoAbs is possible for about 14 specificities. Some specificities are clearly recognized (HLA-A3, B8, B13, Bw4, Bw6), others are recognized as cross-reacting groups (B7+27+w22+40), others are not currently recognized by any MoAb with restricted specificity (B5, B15). Several MoAbs confirmed the existence of shared epitopes between products from a single locus (A2-A28, A25-A32), or from A and B loci (A2-B17, Bw4-A9-A32). A single HLA-Cw MoAb has been described. 2/HLA class II typing by LCT with MoAbs is more difficult than class I typing. DR2, DR3, DR4, DR5 and DR7 as well as DRw52 and DRw53 are well defined; other DR specificities are poorly or not at all defined. Particular associations (DR1+DR4, DR3+DRw6, all DR except DR7) are recognized by several MoAbs. All DQw specificities are well recognized, including new specificities defined only by MoAbs: WA (DQw4), TA10 (DQw7), 2B3 (DQw6+w8+w9). Only two HLA-DP MoAbs have been described. 3/Satisfactory results, similar to those of LCT, were obtained with EIA using lymphoid cell lines as targets. 4/Human MoAbs (12 in the Register) are satisfactory typing reagents. They could represent in the future a significant contribution to HLA typing with MoAbs.

Antibodies, Monoclonal↗
PubMed1990

A preliminary analysis of the 11th International Histocompatibility Workshop monoclonal antibodies.

In the 11th International Histocompatibility Workshop prescreening study, HLA Class I and Class II monoclonal antibodies (mAb) were tested on panels of peripheral T and B cells and homozygous typing cell (HTC) lymphoblastoid lines. The 102 Class I mAb, of which 64 were new, were screened on 63 HTC lines and 20 peripheral T cells. The 144 Class II mAb were tested on 63 HTC lines, 20 peripheral B and 10 peripheral T cells. For Class I, 45 of the 102 mAbs tested proved to have clear and identifiable reaction patterns on both PBL and HTC lines and included several interesting new HLA-A and -C locus antibodies. Of the 144 Class II mAb, of which 99 were new, 18 DR, 22 DQ and 7 DP antibodies were judged excellent. The DR antibodies included some which were antigen-specific but the majority were complex antibodies, while the DQ antibodies, as previously, identified the majority of DQ antigens both singly and in combinations. The encouraging number of DP antibodies was interesting in the limited range of sites they appear to detect.

Antibodies, Monoclonal↗