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PubMed1997

Management of infections due to resistant enterococci: a review of therapeutic options.

The incidence of nosocomial enterococcal infection has increased steadily over the past two decades. The treatment of patients with enterococcal infection has been complicated by the emergence of strains possessing high level resistance to aminoglycosides, penicillins and, most recently, glycopeptides. Several recent studies have evaluated alternative antimicrobial agents for use against strains resistant to some or all standard agents. In this report, we review the therapeutic options for the management of antibiotic-resistant enterococcal infection.

Aminoglycosides↗
PubMed1998

Pharmacodynamic properties of HMR 3647, a novel ketolide, on respiratory pathogens, enterococci and Bacteroides fragilis demonstrated by studies of time-kill kinetics and postantibiotic effect.

The pharmacodynamic properties of a novel ketolide (a new class of macrolide), HMR 3647, were investigated by studying time-kill kinetics and postantibiotic effect (PAE). The time-kill kinetics were studied at two inocula against three strains each of Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecalis, Enterococcus faecium and Bacteroides fragilis. The PAEs of HMR 3647 were also investigated on these organisms at concentrations equivalent to 1, 4 and 10 x MIC. The time-kill kinetic data demonstrated that HMR 3647 is predominantly bacteriostatic and only slowly bactericidal at higher concentrations. HMR 3647 exhibited a significant PAE with all strains studied, ranging from 1.2 h to 8.2 h at 10 x MIC. The bacteriostatic activity and significant PAE demonstrated by HMR 3647 are similar to those previously obtained with other macrolides.

Anti-Bacterial Agents↗