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At least 1,369 records · Page 76Linked to original sources
PubMed2004

An outbreak of ammonia poisoning from chicken tenders served in a school lunch.

Although foodborne outbreaks of illness are relatively common, they are rarely caused by chemical agents. An outbreak of gastrointestinal illness occurred among students at two schools shortly after lunch was served. A cohort study, an environmental investigation, and microbiological and toxicological laboratory testing of food samples were performed. A case was defined as a student or teacher who ate food prepared in the kitchen at school A on 25 November 2002 (and served at schools A and B) and who later developed headache or symptoms of gastrointestinal tract irritation, with onset within 180 min of eating lunch. Among 312 persons interviewed, 157 persons became ill (attack rate = 49%; attack rate 41% for school A, 11% for school B). Onset of illness occurred within 60 min for 81% of cases; 91% of students reported that their chicken tenders smelled unusual. Eating chicken tenders that smelled unusual was associated with being a case (relative risk 9.2, 95% confidence interval 1.4 to 62.6, P < 0.05). Ammonia was detected in uncooked chicken tenders at levels as high as 2,468 ppm. The chicken had been contaminated during a warehouse leak of ammonia refrigerant. This outbreak of ammonia poisoning is only the second reported in food, and the first in a solid food. Heated chicken tenders contaminated with ammonia can cause acute illness within a short period of time.

Adolescent↗
PubMed1999

[The efficacy of subterranean therapy in the salt chamber of Kinga Spa in Wieliczka for patients suffering from allergic rhinitis].

42 patients (27 women and 15 men aged 14-65 years) suffering from atopic and non atopic rhinitis were submitted for 24 days to the subterraneo-therapy in salt chambers of Kinga Spa in Wieliczka during the exacerbation of their illness. 20 patients suffered from pollen or dust mites allergy and the next 22 patients from non atopic rhinitis with recurrent nasal polyposis. In the first week and at the end of the therapy rhinoscopy, peak nasal inspiratory flow and smell were evaluated as well as daily symptoms score was noted in each treated patient. The results of performed observations indicate that unrelatively to the type of the rhinitis: 1. the nasal symptoms (running nose, sneezing, block of the nose) resolved directly during the stay of the patient in the salt chamber but the more constant effect was visible with the time of the therapy. 2. an increase in the peak nasal expiratory flow was connected with the decrease of nasal mucosal edema, 3. the smell disturbances disappeared in the patients together with the decrease of mucosal edema. The observed changes seem to be connected with the influence of the salt chambers' microclimate on the cells osmolarity disturbances in the nasal mucosa provoked by the non infectious chronic inflammation.

Adolescent↗
PubMed2000

[Bad breath--etiological, diagnostic and therapeutic problems].

Oral malodor has many etiologies and is a clinical problem for many people. This paper reviews the causes and management of oral malador. In the majority of cases the problem has been shown to originate in the oral cavity. Oral malodor, a generic descriptor term for foul smells emanating from the mouth, encompasses ozostomia, stomatodysodia, halitosis (both pathological halitosis and physiological halitosis) and fetor oris or fetor ex ore. These latter terms, in turn, denote different sources of oral malodor. All conditions that favour the retention of anaerobic, mainly gram-negative, bacteria will predispose for the development of bad breath. In addition to periodontal pockets, the most important retention site is the dorsum of the tongue with its numerous papillae. During the night and between meals the conditions are optimal for odour production. Systemic pathological states, such as diabetes mellitus, uremia and hepatic diseases, induce metabolic products that are detectable as oral smells. It is always easy to recognize halitosis, but identifying the exact cause is more complex. The clinical labelling and interpretation of different oral malodors both contribute to the diagnosis and treatment of underlying disease. Treatment is directed at the underlying cause.

Anti-Bacterial Agents↗
PubMed1998

[Olfactory event-related potentials to isoamyl acetate in congenital anosmia].

OBJECTIVE: To investigate the olfactory origin of the event-related potential (OEP) by evaluating OEP and standardized psychophysical measures in patients with congenital anosmia. METHODS: Olfactory function was evaluated by OEP and standardized psychophysical measures including smell identification test and odor detection threshold tests for 3 chemosensory stimulants: phenylethyl alcohol (PEA), isoamyl acetate (IAA), and chloracetyl phenone (CAP) in 9 subjects with isolated congenital anosmia and 9 age- and gender-matched normosmic controls. RESULTS: There was a significant difference in the smell identification test score (P < 0.001) and odor detection thresholds for PEA and IAA (P < 0.001) between the anosmic and normosmic subjects. Detection thresholds for CAP, a trigeminal stimulant, did not differ between the 2 groups. In the control subjects, OEP to IAA was characterized by 4 reproducible components (P1, N1, P2 and N2). In the subjects with congenital anosmia, no reproducible evoked potential components were identified in response to IAA. No reproducible evoked potential components were seen in response to the air control stimulus in either the anosmic or normosmic groups. CONCLUSION: These data suggest that OEP provide a specific and objective measure of olfactory function.

Adult↗
PubMed2000

Chiral recognition of sandalwood odorants.

Looking for more efficient sandalwood oil smelling compounds, new campholenic aldehyde derivatives with rigidifying cyclopropane rings were prepared. For some of them, having the lowest odor threshold ever measured for this type of odorants and a very appreciated scent, close to that of the scarce natural sandalwood oils, pure stereoisomers were obtained and their olfactory properties were evaluated. Thus acquired structure-odor relationship data, together with consolidated and completed previous knowledge on structurally different sandalwood-smelling compounds, allowed to propose new models of the sandalwood olfactophore.

Journal Article↗
PubMed2001

Patterns of non-conductive olfactory disorders in eastern Austria: a study of 120 patients from the Department of Otorhinolaryngology at the University of Vienna.

BACKGROUND: About 1% of the population suffer from disorders of the chemosensory system. In the United States at least two million people have problems related to smell and taste. The sense of smell enables the individual to determine the flavour of food and beverages and is most important as a sophisticated warning system. For the present investigation, we collected data on the age pattern and causes of olfactory disorders in eastern Austria. METHODS: 120 patients with non-conductive olfactory disorders were examined over a 9-month period starting from July 1998 at the outpatient clinic of the Ear Nose and Throat Department of the University of Vienna. Data concerning the underlying population taken from the 1998 population census in Vienna were used for comparison, in order to gain a more representative estimation of the distribution of these disorders. The diagnosis was based on thorough history taking, physical examination, CT scan, and olfactory testing for sensitivity by means of so-called "sniffin' sticks". RESULTS: The patients' ages ranged from 16 to 86 years (mean, 54.5 years; 74 females, 46 males). Those older than 50 years seem to have a higher risk of developing olfactory disorders. Only 15 of the female patients were pre-menopausal. Olfactory disorders were most frequently caused by viral infections in the upper respiratory tract (n = 51). Fifteen patients reported head trauma as a cause of olfactory loss, and 45 causes were idiopathic. Most of those in whom the olfactory disorder had been in existence for less than 3 months were anosmic (84%), very few were hyposmic (16% of a total of 19 patients). In contrast, 38% (of a total of 29 patients) in whom the disease had been in existence for 3 and 6 months were hyposmic. Parosmia was reported in 16 cases. Most parosmias appeared after viral infection (56%). Eight of the 120 patients reported dysgeusia. CONCLUSIONS: The present study is a first step towards an assessment of olfactory disorders in Austria. We found similar causes of non-conductive olfactory disorders as have been reported in the literature for other countries, namely upper respiratory infection leading to postviral olfactory disorders, and head trauma. With increasing age women seem to suffer more often from chemosensory dysfunction than men, which may be related to hormonal factors.

Adolescent↗
PubMedDate not supplied

[Toxicological and sanitary evaluation of air pollution by substances discharged during managing of urban dumping soil].

The paper presents the results of sanitary and hygienic investigations whose reason was the situation established with the removal of dumping earth in the dwelling area of Mitino Microdistrict 8 gamma. The removed dumping earth found to have formaldehyde, benzenes, acetaldehyde, phenols, aromatic hydro carbons, polyaromatic compounds was a source of bad smelling substances that had entered the ambient air. A special study of the earth showed that it might yield volatile and bad smelling compounds, such as organic sulfides, aldehydes, mercaptans, ketones, etc. Their harmful health effects (during operations and in the late period) seem to be unlikely. When such work is under way, it is necessary to inform the population about possible consequences.

Air Pollutants↗
PubMedDate not supplied

[Evaluation of a dessert in patients with deglutition changes, one more step in advanced basic feeding].

BACKGROUND: Decrease in the capacity to deglutition solids and liquids is a problem in many people, this problem decreases quality of life. The objective of our work is to evaluate the acceptance degree of a dessert (stewed fruit) (including in the normal diet of the Hospital) in a group of patients with dysphagia. METHODS: Forty seven patients were studied in Hospital Universitario del Río Hortega (Valladolid) in July of 2000. The main pathology of these patients was; (n = 12) 25.5% acute stroke, (n = 16) 34% aerodigestive tumors (Jarynx carcinoma (n = 5), cavum carcinoma (n = 9), oesophagus carcinoma (n = 2)) and 40.4% (n = 19) chronic neurologic disease (Alzheimer, vascular dementia, and parkinson). All patients took a oral triturated diet, a dessert with apple and pear (Resource fruits Instant). All patients took a portion of the dessert and after that a acceptance questionnaire was filled. RESULTS: Global acceptance of the product was 7.25 +/- 1.5, this punctuation was higher in the tumoral group 8 +/- 1.1 points, 6.86 +/- 1.4 in patients with acute stroke and 6.7 +/- 1.5 in patients with chronic neurologic disease (p < 0.05). Different organoleptic characteristics were analyzed, mean punctuation in texture was 1.79 +/- 0.6, color 2.2 +/- 0.5, smell 2.24 +/- 0.59 and taste 1.95 +/- 0.61, in a scale of 1 (very good) until 5 (very bad), a total of 57.9% patients responded very good (1) or good (2) in texture scale, 71.1% in color scale, 60.5% in smell scale and 63.2% in taste scale. CONCLUSIONS: Acceptance of this product in patients with dysphagia has been elevated, showing useful in these patients with nutrition alterations.

Aged↗
PubMed2001

Two episodes of ethylene oxide poisoning--a case report.

Ethylene oxide is used as a sterilizer, a solvent, a plasticizer and in the manufacture of special solvents, antifreeze, polyester resins and non-ionic surfactants. Its toxicity is caused by an alkylating reaction with most organic substances in the body. Four workers, without any protection, managed the leakage of ethylene oxide from the collecting tank improperly on July 29, 2000. In the same factory, the overflow of ethylene oxide in process resulted in leakage of ethylene oxide again on Aug. 7, 2000. Two workers were poisoned despite wearing full-face respirators with ethylene oxide approved canisters. In these two events, the workers all smelled an ether-like odor. Six workers experienced nausea, vomiting, chest tightness, shortness of breath, dizziness, cough and ocular irritation. One worker had transient loss of consciousness. Oxygen therapy and supportive care were used. Patients were discharged in stable condition. The permissible exposure limit of ethylene oxide in air is 1 ppm as an eight hour TWA. Above 50 ppm, the odor threshold, a positive-pressure supplied air respirator is needed to protect the worker. Full-face respirators with ethylene oxide approved canisters could not protect our cases who smelled the odor and were exposed to an unknown concentration. It is important to wear positive-pressure self-contained breathing apparatuses equipped with full facepieces to clean up the contamination area and rescue the patients.

Adult↗
PubMed1998

[Hygiene and body odors across time].

Since Ancient Times, the Middle Ages and Modern times, there have been references to hygiene and body smells as well. According to each time there is a change in hygienic criteria and methods to avoid or diminish these annoying smells. Several beliefs and also science give their explanation to the different evolutionary stages of this process.

History, Ancient↗
PubMed2001

Effects of leukotriene receptor antagonist therapy in patients with chronic rhinosinusitis in a real life rhinology clinic setting.

Although there is evidence from randomised controlled trials that leukotriene receptor antagonists are efficacious in chronic rhinosinusitis there are still little data on their use in everyday real life clinical practice. We report on a pragmatic case series of 32 patients referred from primary care with uncontrolled chronic rhinosinusitis (allergic or non-allergic) who have been treated with montelukast in our joint medical/surgical rhinology clinic. Patients' symptoms were scored according to "facial pain", "headache", "nasal blockage", "nasal discharge", "sense of smell" and "daily activity", and measurements of peak inspiratory nasal flow were made, before and after the introduction of montelukast 10 mg/day. There were significant (p < 0.05) improvements in subjective scoring for headache, nasal discharge & blockage, sense of smell and daily activity but not for facial pain, when montelukast was added along with other alterations in chronic rhinosinusitis medication (all receiving intra-nasal corticosteroids). Subgroup analysis of 10 patients, were the addition of montelukast was the only change to medical therapy, showed significant (p < 0.05) improvements in headache, nasal discharge and blockage and their daily activity. There was no significant improvements in nasal peak inspiratory flow or spirometry. In conclusion, montelukast may be a useful therapeutic option in addition to standard therapy (i.e. intra-nasal corticosteroids or anti-histamines) when treating patients with chronic rhinosinusitis in a real life clinical setting.

Acetates↗
PubMed2001

[The coriander story].

The etymology of coriander starts with the Greek koriannon, a combination of koris (a stinking bug) and annon (a fragrant anise). In Latin, it was spelled coriandrum, and by way of Old French it came into English as coriander in the 14th century. A historical account of Coriandrum sativum mainly Japan is presented. It had been known as a foodstuff in the 10th century, but it disappeared in the next century perhaps because of its disagreeable smell. It was reintroduced by the Portuguese in the 18th century as ko-en-do-ro in Japanese, from the Portuguses word coentro. The smell of the fresh leaves should be a product of a mixture of essential oils including d-linalol or coriandrol.

Coriandrum↗
PubMed2002

Stress-like responses to common procedures in rats: effect of the estrous cycle.

The objective of this study was to assess cardiovascular and behavioral responses of Sprague-Dawley female rats subjected to or witnessing common husbandry and experimental procedures at various points during the estrous cycle. Heart rate (HR) and mean arterial blood pressure (MAP) were determined using radiotelemetry for 2 h before and 3 h after: cage change, restraint and subcutaneous (s.c.) injection, restraint and tail-vein injection, witnessing decapitation of other rats, smelling urine and feces from stressed rats, and smelling dried rat blood. Home cage behaviors (sleeping, awake, moving, rearing, and grooming) were scored once each minute for 15 min before and 45 min after the incidents. Being subjected to cage change, restraint and injections, and odors significantly increased HR and MAP 60-120 beats per min and 10-20 mm Hg over baseline respectively for 45 to 90 min. Witnessing these procedures also significantly increased HR and MAP but the magnitude was reduced by 20% to 30% compared to that seen in rats subjected to the procedures. Witnessing decapitation of other rats induced cardiovascular responses which were not different from those of rats witnessing other procedures. The cardiovascular responses were not enhanced during proestrus-estrus compared to metestrus-diestrus. There were also no significant effects of the estrous cycle on home cage behavior after these procedures. We conclude that cycling female rats show stress-like effects when they are subjected to or witness common husbandry and experimental procedures, but there is little to no effect of the estrous cycle.

Animal Husbandry↗
PubMedDate not supplied

[Use of lyophilized products in texture modified diets at a hospital].

BACKGROUND: Decrease in the capacity to deglutition solids and liquids is a problem in many people, this problem decreases quality of life. The objective of our study is to compare the acceptance of texture modifies courses against conventional courses. METHODS: A total of 70 patients were studied in our Hospital. First, 35 patients received a modified texture diet with conventional products and the next 35 patients received a modified texture diet with lyophilised products. All patients responded the next questions after to take the diets; texture, taste, smell and color. RESULTS: A total of 70 patients were studied (38 males and 32 females), the mean age was 74.9 +/- 16.8 years, no differences were detected between both groups (76.6 +/- 17.1 years vs 73.7 +/- 16.67 years). Lyophilised diets had better medians than conventional diets in all parameters; taste, smell, color and texture. CONCLUSION: Acceptance of lyophilised dishes were better than conventional dishes. These products could improve nutritional state in these patients.

Aged↗
PubMed2003

[Congenital anosmia].

A 72-year-old woman with congenital familiar lack of smell is described. General ENT and otoneurological examination were normal. The ability to smell was totally absent. By MR scan normal conditions were found in the nose, paranasal sinuses, the cribriform plate in the anterior cranial fossa and in the brain especially in the olfactory bulbs. Microscopic examinations of biopsy specimens from the olfactory region showed no signs of olfactory epithelium.

Aged↗
PubMedDate not supplied

A comparison of topical Phenytoin with Silverex in the treatment of superficial dermal burn wounds.

OBJECTIVE: To compare topical diphenylhydantion (Phenytoin) with silver sulphadiazine/chlorhexidine (Silverex) in terms of rate of wound healing, analgesic and antibacterial properties in small to moderate-sized (< 30% TBSA) superficial dermal (second degree) burn wounds. DESIGN: A prospective randomized controlled study. SETTING: Surgical wards, Muhimbili National Hospital from July 2000 to February 2001. SUBJECTS: Sixty four patients with acute burns, 32 in each group. INTERVENTIONS: Study group treated by sprinkling Phenytoin powder and control group by sprinkling Silverex powder on the wounds for 14 days or until the wound epithelialised or was ready for skin grafting. The data collected included demographic characteristics of patients, aetiology of burn injury, circumstances of injury, site and extent of burns, pus discharge and smell from the wound, pain and discomfort from the wound, bacterial cultures of wound swabs, rate of reduction in wound size and outcome of treatment. RESULTS: The study enrolled 33 male and 31 female patients, 69% being children under five years of age. Hot liquids (80%) and open flames (20%) were the only causes of burns. In 97% of patients injury was due to domestic accidents. In half of the patients burns involved the trunk, and 52% of all patients had less than 15% total body surface burnt. Pus discharge was recorded in 59% of Phenytoin-treated and 75% in Silverex-treated patients while foul smell was noted in 19% and 31% of cases respectively. There were more negative bacterial wound cultures in Phenytoin-than Silverex-treated wounds on day five and day 10 of treatment, the difference being statistically significant (p < 0.01 and 0.001 respectively). There was also a statistically significant difference in wound pain in favour of Phenytoin (p < 0.01). There was no statistically significant difference in the rate of healing in the two groups. CONCLUSION: Phenytoin is a cheap and easy-to-use medicament, effective in suppressing burn wound bacteria and relieving pain thereby promoting healing, and may be advocated for the purpose in resource-scarce environments.

Administration, Topical↗
PubMed2001

A re-examination of the rate of vocational dysfunction among patients with anosmia and mild to moderate closed head injury.

This study sought to verify two earlier reports that up to 93% of patients with closed head injury (CHI) and anosmia are vocationally dysfunctional due to executive impairments associated with orbitofrontal damage. Participants were 11 men and 4 women identified from a pool of 60 potential subjects referred for evaluation of trauma-related chemosensory dysfunction at the University of Pennsylvania Smell and Taste Center from 1988 to 1994. These 15 subjects met four criteria: (i) willingness to complete a brief semi-structured interview concerning their pre- and post-CHI work history; (ii) age <60 years; (iii) evidence of mild to moderate CHI; and (iv) scores on the University of Pennsylvania Smell Identification Test indicative of anosmia or severe microsmia and non-malingering. In contrast to the earlier reports, only 7% of the subjects were vocationally dysfunctional. This study calls into question previous reports suggesting that anosmia is a reliable predictor of post-CHI vocational outcome.

Journal Article↗
PubMed2003

[Exploration of olfactory difficulties].

Sense-of-smell disorders are a frequent occurrence at ORL clinics. The clinical exploration must include a thorough and comprehensive interview to discover the etiology. The clinical examination is easily performed using cold-light endoscopes, which can reveal anatomical or mucous membrane pathologies, even in far- situated anatomical parts. The access to olfactometric examinations is limited by the small number of health centers which have the proper equipment and trained staff. Guided by the initial interview and clinical exploration, the diagnosis of smell disorder can benefit from the conclusive and factual contribution of the CAT scan and MRI.

Diagnostic Imaging↗