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PubMed2004

[Phylogenetic aspects of lip function].

Lips can be considered a phylogenic summary of nasolabial and facial muscle evolution. They represent the central point of facial morphogenesis. The progressive development of oral and facial functions is an elementary human necessity for feeding, suction, oral competence, swallowing, language, and mimics. Each discontinuity causes functional and anatomic disorders. Any damage to the lips creates facial unbalance. Precise knowledge of lip function is indispensable for optimal reconstruction.

Adolescent↗
PubMed2000

[Associated anomalies in lip-maxillopalatal clefts].

BACKGROUND: Retrospective studies of cleft lip and palate patients suggest a multifactorial aetiology for this condition. Many patients exhibit multiple defects, often removed from the orofacial region. The frequency and location of such coexistent abnormalities vary between studies. PATIENTS: A retrospective case-note study of 1,737 individuals with orofacial cleft, treated between 1974 and 1998 at our centre, was undertaken to assess the frequency of associated malformations and syndromes. RESULTS: Associated malformations were found to be present in 33% of all cases investigated. In nearly one half of these individuals (48%), defects could be attributed to recognisable syndromes. Patients with isolated palatal clefts (45.6%) and those with bilateral clefts of the lip and palate (35.3%) were particularly well-represented. The following problems were observed relatively frequently: Cerebral anomalies (16%), facial anomalies (14%), heart malformations (15%), anomalies of the extremities (9%) and urogenital tract abnormalities (8%). In contrast, endocrine aberrations were identified sporadically (0.5%). A partial situs inversus was found only in one case. CONCLUSION: As clefts of the lip and palate are frequently associated with additional malformations, the importance of thorough interdisciplinary neonatal screening cannot be over emphasised.

Abnormalities, Multiple↗
PubMed1980

Movement of maxillary segments after expansion and/or secondary bone grafting in cleft lip and palate: a roentgen stereophotogrammetric study with the aid of metallic implants.

The study was undertaken to examine the effects of expansion treatment and secondary bone grafting in cleft lip and palate. Movement of the lateral maxillary segments in four patients with complete bilateral cleft lip and palate (BCLP) was complicated and asymmetric, and a greater relative widening of the dental arch was observed. The least expansion was found in the oldest patient. Bone grafting did not bring about a stable relationship between the segments. The width of the dental arch was mostly maintained despite segmental movement. In one patient with unilateral cleft of the lip and primary palate (UCL) growth in the midpalatal suture followed the pattern observed in noncleft patients but was less extensive. Accurate and comprehensive recording of the relatively small maxillary movements requires that implant stability is checked and that a reference is established outside the maxilla.

Adolescent↗
PubMed1979

Carcinoma of the lip.

(1) Carcinoma of the lip occurs predominantly in men in their seventh and eighth decades of life. (2) Epidermoid carcinoma is the most common malignant lip tumor. (3) Metastases to cervical lymph nodes are uncommon. (4) Elective neck dissection is not indicated. (5) Therapeutic radical neck dissection can benefit the patient in the presence of proved suprahyoid lymph node metastases. (6) The five year survival rate for epidermoid carcinoma of the lip is higher than the rate for epidermoid carcinoma of other sites in the oral cavity or pharynx. (7) Local recurrence does not correlate with the size of the primary tumor. (8) Initial treatment failures can frequently be salvaged surgically.

Aged↗
PubMed1984

Secretion of saliva by human lip mucous glands and parotid glands in response to gustatory stimuli and chewing.

To test the suggestion that minor salivary glands, such as the lower lip mucous glands, respond to stimulation in a similar manner to major glands such as the parotid, an appliance was constructed for each subject using an organopolysiloxane dental impression material which held a strip of filter paper against the inner aspect of the lower lip. The volume of labial secretion produced was determined by weight difference. Saliva from the right parotid duct was collected into pre-weighed tubes using a Lashley cannula. Test stimuli, applied for 4-min periods in triplicate, were ascorbic acid (0.08 and 0.16 M), sodium chloride (0.4 and 0.8 M) and the chewing of pieces of polyurethane foam and chicle. In 7 of 13 subjects, the response patterns of labial and parotid glands were qualitatively similar. With acid stimulation, the percentage increase in flow from the parotid was much greater than from labial glands. A significant difference was noted between the mean volumes of unstimulated secretion from the lip glands in a group of 8 subjects with restorations in lower anterior teeth and in 12 controls.

Ascorbic Acid↗
PubMed1975

Two sisters with unoperated bilateral cleft lip and palate, age 6 and 4 years.

Two sisters with unoperated bilateral cleft lip and palate, aged 5 years 8 months and 3 years II months, are described. The degree of premaxillary protrusion in both was similar to that in unoperated infants. On the other hand, children operated in infancy showed less midfacial protrusion than the sisters following repair of their lips at a later age suggesting that the repaired lip has a long-acting effect in restricting growth of the premaxillary-vomerine complex. Later, forwards growth of the mandible and elongation of the face also serve to minimise the convexity due to the projecting premaxilla.

Age Factors↗
PubMed1981

Lip lifting.

The changing appearance of the upper lip may be a significant component in the "ageing face" syndrome. Its typical features are described. These can be corrected by a simple "lip lift". Complications are few and the manoeuvre has proved to be an excellent adjunct in restoring a more youthful outlook. It has little effect on "purse-string" lines of the upper lip that usually require dermabrasion or a chemical peel.

Female↗
PubMed1984

Radical muscle mobilisation in the surgical repair of a unilateral cleft lip: a follow up report.

This is a follow-up report on an earlier paper (Thatte, 1981) in which the idea of radical mobilisation of the orbicularis oris muscle in the treatment of unilateral cleft lip was presented. This paper includes eight late post-operative photographs of cases with unilateral cleft lip treated by radical mobilisation of muscle and suture without any recourse to incisions in the philtral area to gain height on the non-cleft side. Legends for the post-operative photographs describe our assessment of the results. Observations made while operating on these cases are noted. A discussion is included to view the manoeuvre of mobilisation of muscle against the background of existing methods of treatment of unilateral cleft lip. A postscript is added.

Cleft Lip↗
PubMed1988

Reconstruction of the vermilion after "lip-shave".

During the year 1986, 12 "lip-shave" defects were reconstructed using orbicularis oris myomucosal flaps, in the Northern Ireland Plastic and Maxillo-Facial Service. Three of these were extended lip-shaves. The planning of a V-Y plasty for myomucusal advancement is described and some representative results are shown. We feel that the myomucosal advancement flap is a valuable technique to overcome some of the problems in reconstruction of the vermilion after lip-shave.

Adult↗
PubMed1993

The modified Z-plasty for unilateral cleft lip repair.

In 1965 Davies described a Z-plasty technique for the repair of a unilateral cleft lip. The technique has been modified so that the scars are more aesthetically placed and the orbicularis muscle correctly aligned. A prospective study was performed comparing the results of this modified Z-plasty with the rotation advancement repair. Twelve patients had a modified Z-plasty and 10 a rotation advancement repair. The modified Z-plasty compares favourably with the rotation advancement technique for the repair of a unilateral cleft lip. In particular, the incidence of asymmetry of lip height was greater in the rotation advancement group.

Child↗
PubMed1990

Cerebral rhinocele, hydrocephalus, and cleft lip and palate in infants with cardiac fibroma.

Cardiac transplantation was performed in two infants with unresectable fibromas of the myocardium. In one patient, lip surgery was also required for unilateral cleft lip and palate. At autopsy, communicating hydrocephalus of mild to moderate degree was found in both cases. In the patient with facial clefts, there was also a large, ipsilateral cyst, or rhinocele, of the olfactory lobe. This unusual lesion, which seems to represent a previously unreported malformation, was apparently formed by segmental dilatation of a persistent olfactory ventricle. Cerebral or cranial anomalies are thought to be rare in cases of cardiac fibroma; however, macrocephaly was present in five patients. Furthermore, presenting abnormalities among previously reported cases included hydrocephalus in one case, and cleft lip and palate in another. These and other findings suggest that, at least in some cases, cardiac fibroma is a manifestation of a more extensive developmental disorder.

Brain↗
PubMed1987

The prevalence of cleft lip and palate in the Japanese: their birth prevalence in 40,304 infants born during 1982.

To determine the prevalence of cleft lip and palate (CL/P) among the Japanese, 40,304 infants born between Jan. 1, 1982, and Dec. 31, 1982, were investigated. Eighty-three infants (0.206%) were found with these abnormalities in approximately 2.06/1000 live births. Among fifty-two infants in whom it was possible to classify the types of cleft, seventeen (32.7%) had cleft lip only (CL), twenty-four (46.1%) had cleft lip and palate (CLP), and eleven (21.2%) had isolated cleft palate (CP).

Cleft Lip↗
PubMed1988

Concurrent anomalies: cheilitis glandularis and double lip. Report of a case.

Double lip and cheilitis glandularis are uncommon anomalies involving the minor salivary glands of the lip. A unique case of concurrent double lip and cheilitis glandularis is presented. The development, diagnosis, and treatment of both lesions are reviewed. Their concurrent development in this patient appears to be unrelated.

Aged↗
PubMed1990

A rare variant of acinic cell carcinoma of the upper lip: a case report and review of the literature.

Acinic cell carcinomas of the lip are most uncommon. An exhaustive search of the Japanese- and English-language literature has revealed only 17 previously reported cases. One additional occurrence, a rare variant of this type of neoplasm, with mucous differentiation, that occurred in the upper lip of a 60-year-old man is described here. A brief review of the literature on this type of lip tumor is also given.

Carcinoma↗
PubMed1993

Clinical diagnosis of caliber-persistent labial artery of the lower lip.

Only 14 cases of caliber-persistent labial artery of the lower lip have been reported to date. Six of these were misdiagnosed and treated as squamous cell carcinoma, another as a mucocele. The correct diagnosis emerged only after the wedge resections were examined histopathologically. We report the first cases of caliber-persistent labial artery to be diagnosed clinically since the original description of the condition by Howell and Freeman in 1973. Our first case was a nonpulsatile hard, linear, "gooseneck lamp" submucosal nodule of the lower lip. On the basis of an initial misdiagnosis of sclerosing sialadenitis, a biopsy was attempted. Brisk pulsatile bleeding proved the lesion to be an artery, and the superficial location and large diameter of the vessel lead to the clinical diagnosis of caliber-persistent labial artery. The "gooseneck lamp" hardening is typical of Monckeberg's arteriosclerosis. The second case was a pulsatile blue linear submucosal nodule of the lower lip. The clinical diagnosis of caliber-persistent labial artery was confirmed when angiography showed the lesion to be an abnormally dilated labial artery. Both cases were successfully ligated with no complications at 16 and 10 months after surgery.

Adult↗
PubMed1989

Selective activation of 5HT1A receptors induces lower lip retraction in the rat.

The induction of lower lip retraction (LLR) by serotonergic (5HT) compounds and antagonism of LLR by compounds acting via a variety of receptor systems was investigated. LLR could be induced by subcutaneous injection of 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT), buspirone, ipsapirone or RU 24969. Inactive were the putative 5HT1B,1C agonist 1-(3'chlorophenyl)-piperazine (mCCP), the 5HT2,1C agonist (dl)-1-(2,5 dimethoxy-4-iodophenyl)-2-aminopropane (DOI), the 5HT reuptake inhibitors citalopram and paroxetine and the 5HT-releasing compounds parachloroamphetamine (PCA) and fenfluramine. 5-Methoxy-N,N-dimethyltryptamine (5-MeODMT) induced lower lip retraction after pretreatment with metergoline, cyproheptadine or ritanserin but not by itself. 8-OH-DPAT-induced LLR could be antagonised by the direct and indirect 5HT agonists mCPP, DOI, 5-MeODMT, PCA, fenfluramine and high doses of paroxetine, but not by the 5HT antagonists metergoline, methysergide, mesulergine, GR38032F, xylamidine or pirenperone. The dopamine agonists apomorphine and pergolide antagonised 8-OH-DPAT-induced LLR, whereas SKF 38393 was weakly active. No significant antagonism was found with the dopamine antagonists haloperidol and spiperone, the alpha 2 agonist clonidine and the alpha 1 antagonist prazosin and the alpha 2 antagonist idazoxan. Also inactive were the antihistaminic mepyramine, the anticholinergic atropine, the opiate antagonist naloxone and the anxiolytic chlordiazepoxide. The results suggest that, in vivo, functional interactions take place between the various 5HT receptors. The hypothesis that lower lip retraction is induced by compounds directly and selectively stimulating 5HT1A receptors is discussed.

8-Hydroxy-2-(di-n-propylamino)tetralin↗
PubMed1991

Parasympathetic innervation of cutaneous blood vessels examined by retrograde tracing in the rat lower lip.

The origin of vasoactive intestinal polypeptide (VIP)-immunoreactive and acetylcholinesterase (AChE)-positive perivascular nerve fibers in the lower lip of rats was investigated using the retrograde tracer, wheat germ agglutinin conjugated to enzymatically inactive horseradish peroxidase gold complex (WGAapoHRP-Au), in combination with immunohistochemistry and enzyme histochemistry, by comparing the cells of origin of projection to the parotid gland. After the application of the tracer to the lip, small- to medium-sized nerve cells were labelled exclusively in the ipsilateral otic ganglion. Most of them showed moderate VIP-immunoreactivity and AChE activity. In contrast, injection into the parotid gland resulted in labelling of mostly large-sized cells of the otic ganglion which showed intense VIP-immunoreactivity and AChE activity. These results confirmed that the parasympathetic innervation of the rat lip originates from the otic ganglion. It was further suggested that there are at least two subpopulations in the otic ganglion cells, different from each other in size and in VIP-immunoreactivity, which separately innervate the salivary gland and the blood vessels.

Acetylcholinesterase↗
PubMedDate not supplied

Squamous cell carcinoma of the lower lip.

PURPOSE: Most patients with squamous cell carcinoma of the lower lip present with early disease and follow a rather indolent clinical course. Determinant 5-year survival rates range from 85% to 95%. This study was undertaken in an attempt to gain insight into the cause of failure in those few patients who develop recurrent disease. PATIENTS AND METHODS: A retrospective review was completed on patients treated between 1964 and 1990. Patients were staged according to the American Joint Committee. Patients with no palpable adenopathy had either a unilateral or bilateral suprahyoid dissection performed. Patients with palpable adenopathy underwent radical neck dissection. All patients were followed for evidence of recurrent disease. RESULTS: The records of 92 patients treated surgically for squamous cell carcinoma of the lower lip were available and complete. Palpable adenopathy was present in 38 patients; however, only 8 of these patients (21%) were histologically positive. Of the 54 patients judged to be free of disease, 3 (5.5%) had histologic evidence of metastasis. Overall, the incidence of cervical metastasis was 12%. CONCLUSION: The incidence of cervical metastasis in patients with squamous cell carcinoma of the lip is low; however, these data suggest that the size of the primary tumor does not correlate closely with predicting the incidence of regional lymph node metastases.

Carcinoma, Squamous Cell↗