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Results for “LEVULINIC ACID”

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At least 1,369 records · Page 76Linked to original sources
PubMed1975

Incorporation of ALA-14C in circulating bilirubin and hemoglobin heme of hepatectomized dogs.

After intravenous injection of delta amino-levulinic acid-14C (ALA-14C) (50 muCi) in hepatectomized dogs, bilirubin-14C reaches a peak after 3-6 hours and then slowly falls. During this time radioactivity of hemoglobin heme is much lower and rises sluggishly. Bilirubin specific activity is several hundred times that of hemoglobin heme. Incorporation of isotope is also much greater for bilirubin. This difference between bilirubin-14C and hemoglobin heme-14C provides evidence that bilirubin is produced outside the liver by a mechanism other than breakdown of hemoglobin. In intact dogs with cannulated common duct, intravenous injection of ALA-14C produces similar results but the rise of bilirubin-14C produced in 9 hours in the hepatectomized dogs is about 12% of the total blood bilirubin-14C of non hepatectomized animals with cannulated common duct. If we include bile bilirubin-14C produced in the same time by intact animals with cannulated common duct, nonhemoglobin bile production is only 4.2% of the total.

Aminolevulinic Acid↗
PubMed1999

[Blockade of opioid tolerance and dependence by NMDA receptor antagonist].

The present review summarizes the effects of drugs that block N-methyl D-aspartate receptor complex (NMDA-RC) on the development of opiate tolerance and abstinence. Using behavioral pharmacological approaches, pre-clinical studies demonstrate that noncompetitive and competitive NMDA receptor antagonists and glycine binding site antagonists can inhibit opioid tolerance and some symptoms of opioid withdrawal. The biochemical mechanisms underlying the inhibition of NMDA receptor antagonists on opioid tolerance and dependence are discussed. There is some extent of neurotoxicity associated with the therapeutic use of NMDA receptor antagonists.

Animals↗
PubMed1990

[High-dosage oral magnesium therapy in arrhythmias. Results of an observational study in 1.160 patients with arrhythmia].

In the treatment of cardiac arrhythmias of varying genesis, an "observational study" in 1,160 patients showed that a high-dose oral magnesium preparation (Magnesium-Diasporal N 300 Granulat) was effective. In 82% of the patients observed, a dose of at least 300 mg magnesium/day produced good to very good results. Adverse effects of the drug were observed in only 1.6% of the patients. For all groups, the "success parameters" improved significantly. High-rate arrhythmias showed a better response to magnesium treatment than did low-rate arrhythmias, with a close correlation being found with the heart rate at the start of treatment. High-dose oral magnesium had a positive effect on concomitant hypertension. At a dosage of 300 mg treatment should be continued for at least 6 weeks.

Adult↗
PubMed1972

Lead and zinc poisoning and the interaction between Pb and Zn poisoning in the foal.

Groups of young growing horses were fed toxic amounts of lead only, zinc only and the same amounts of lead and zinc together. Those fed Pb only developed pharyngeal and laryngeal paralysis ("roaring") whereas those fed Zn only and Pb and Zn together developed the same clinical syndrome which included swelling at the epiphyseal region of the long bones, stiffness and lameness. Anemia and decreased weight gains were most pronounced in animals fed Zn for the longest periods. Animals fed Pb only did not become anemic and weight loss did not occur until after there was an interference in swallowing. The clinical signs and tissue Pb values from animals fed toxic amounts of both Pb and Zn continuously, differed markedly from those present in animals fed comparable amounts of Pb only. Th clinical signs were similar to those caused by Zn poisoning. The hepatic and renal tissue Pb values were approximately twice as high and the epiphyseal and cancellous bone sample results were one half as high as the comparable Pb values from animals fed toxic amounts of Pb only. It appeared that toxic amounts of Zn prevented the development of clinical signs of Pb poisoning in the young growing horse.

Animal Feed↗