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HIV/AIDS and Native Americans: the health departments' response.

For some time, state health department HIV/AIDS programs have worked with communities of color to address their unmet needs. Because of the need for a holistic approach to the multiple issues impacting these communities, efforts to address HIV/AIDS in Native American communities are often integrated into programs addressing related issues, such as substance abuse, mental health and other STDs. Building upon a recent report from the National Alliance of State and Territorial AIDS Directors (NASTAD), this article will review the numerous challenges state and local health departments face in supporting HIV/AIDS-focused health and human services in Native American communities and how some health departments have worked with Native American communities to respond to these challenges. A series of recommendations and next steps for health departments seeking to improve services in Native American communities will be offered.

Acquired Immunodeficiency Syndrome↗

NAViFluX: a visualization‑centric platform for interactive analysis, refinement and design of genome‑scale metabolic networks.

MOTIVATION: Genome-scale metabolic network (GSMN) models enable flux-based metabolite fate discovery, metabolic engineering, drug target identification, and multi-omics integration. However, programming requirements, architectural complexity, and limited visualization support impede its adoption by the broader scientific community. Existing tools exclusively specialize in GSMN analyses or visualization while lacking important features such as pathway-specific views, database-integrated refinement, and comprehensive enrichment and perturbation analyses. RESULTS: Here, we present NAViFluX (metabolic Network Analysis and Visualization of Flux), a visualization-centric, web browser-based tool that unifies native pathway/subsystem map generation, interactive model refinement via KEGG/BiGG, pathway merging and modules for flux computations, topology, and functional enrichment all within network views. Using three independent case studies on Escherichia coli, the utility of NAViFluX for characterization of nutrient-specific metabolic adaptations, enhancing gene essentiality predictions and interpretability, and rational design of an optimized carbon-fixing metabolic state is demonstrated. AVAILABILITY AND IMPLEMENTATION: All source code and supplementary files associated with the case studies are publicly available via Zenodo at https://zenodo.org/records/19107831. NAViFluX can be easily installed as a standalone software through https://github.com/bnsb-lab-iith/NAViFluX.

Metabolic Networks and Pathways↗

Sensory integration in the rehabilitation of blind adults.

Learning difficulties displayed by the blind adult prompted an investigation of a link with sensory integrative dysfunction. A review of the literature provided evidence that tactile and vestibular deficiencies were prevalent within this population. Through observational assessment, sensory integrative dysfunction was identified in a number of clients and individual sensory integrative treatment programs were initiated. In the three case studies presented, improvements were noted in mobility, activities of daily living, handwriting, and behaviour after six months of treatment. A discussion is provided on those deficit areas responding to sensory integrative treatment.

Activities of Daily Living↗

Teaching introductory engineering: a problem based learning experience.

A freshman introductory engineering course is being taught on an experimental basis to approximately 40 cadets per semester at the United States Air Force Academy. The purpose of the course is to better address seven educational outcomes desired in Academy graduates. Problem Based Learning is used to present engineering as a problem solving process that involves a variety of interdisciplinary issues. The setting is an Air Force System Program Office responsible for planning a manned mission to Mars. Students are guided by a mentor to identify the relevant engineering requirements. Traditional instruction is used only to present skills and tools that enhance students' learning. An integrated assessment program is being used to evaluate this instructional approach and how well the educational outcomes are being met. The quantitative assessment findings are inconclusive and indicate further work is needed to develop reliable assessment instruments. Qualitative findings, however, show that the students learned important engineering fundamentals, liked the course, and enjoyed the Mars scenario. They also developed an appreciation for the interdisciplinary nature of engineering, developed confidence in their ability to make decisions for problem-solving, and they acquired self esteem not usually obtained from traditional engineering courses. This paper presents highlights from the three years this course has been offered.

Engineering↗

Ensuring quality.

The quality of the procedures associated with breast and cervical cancer screening has been demonstrated to be highly associated with mortality. Accordingly, public policy in cancer control is increasingly making the quality of a service or a program an integral requirement for funding or reimbursement. This article summarizes existing legislation related to cytology, mammography, and breast and cervical cancer screening, presents key elements of the quality assurance requirements of the federally funded Breast and Cervical Cancer Control Program (BCCCP), and presents preliminary data to demonstrate evaluation of the quality assurance markers of the Michigan BCCCP.

Breast Neoplasms↗

The effectiveness of health promotion education programs for community elderly.

The purpose of this study was to examine the effectiveness of health promotion education programs for a group of elderly residents in a community. A one group pre- and post-test design was used in this study. Nurses, dietitians, and physical education teachers worked collaboratively to provide a series of comprehensive, integrated education programs. Course content included healthy life style and health promotion, disease prevention, nutrition, exercise, and medication education. A total of 140 elderly participated in this study. Ninety- seven subjects attended all of the education programs. A structured questionnaire was used for data collection. Information about demographics, health status, health promotion knowledge and behaviors was included. The health promotion behavior data were collected twice. The initial data set was collected prior to the first course and the second after the fifth course. Health promotion knowledge was assessed pre- and post-test in the second, third, and fourth courses. The research findings revealed that the education programs were effective in improving elderly health promotion knowledge and behaviors. The scores for health promotion knowledge and positive health behaviors were high among subjects who were aged 65-69 years, were married, lived with family members and had higher education levels. The results could be used as a reference in future health promotion education in the community.

Aged↗

[Decentralization of the tuberculosis campaign and its follow-up in the Dosso Department (Niger)].

The national program for tuberculosis control has been decentralized in the dispensaries of Dosso Department since 1985. The physician appointed as departmental coordinator at the Departmental Center for Tuberculosis has organized training and ensured a close follow-up of the activities through supervision and valuation. In spite of an important decentralization and an increase of the sputum examinations, the case detection has not been improved (mean detection rate equals to 0.28/1000. In opposite, the cure rate has been increased appreciably (from 24% to 52%) and the noncompliers rate has decreased (from 42% to 19%). The follow-up of the program has got important side benefits on the other activities. The efficiency of the decentralization and of the follow-up is discussed, the costs of the start and use have been estimated. It has been recommended to integrate the program to the other health activities and to delegate the follow-up to the physicians in change in the Medical Center.

Antitubercular Agents↗

Using human rights in maternal mortality programs: from analysis to strategy.

This article describes an approach to maternal mortality reduction that uses human rights not simply to denounce the injustice of death in pregnancy and childbirth, but also to guide the design and implementation of maternal mortality policies and programs. As a first principle, programs and policies need to prioritize measures that promote universal access to high quality emergency obstetric care services, which we know from health research are essential to saving women's lives. With that priority, human rights principles can be integrated into programs at the clinical, facility management, and national policy levels. For example, a human rights 'audit' can help identify ways to encourage respectful, non-discriminatory treatment of patients, providers and staff in the clinical setting. Human rights principles of entitlement and accountability can inform mechanisms of community participation designed to improve responsiveness and functioning of health facilities. Human rights principles can inform analysis of health sector reform and its impact on access to emergency obstetric care. Whether applied to the intricacies of human relationships within a facility or to the impact of international financial institutions on health systems, the ultimate role of human rights is to identify the workings of power that keep unacceptable levels of maternal morality as they are and to use the human rights vision of dignity and social justice to work for the re-arrangements of power necessary for change.

Emergency Medical Services↗

Planning emergency medical services for children in Bolivia: part 1-the use of rapid assessment procedures.

OBJECTIVES: To describe an expedited process for collecting social and cultural data before program planning to develop emergency medical services for children in La Paz, Bolivia. The overall goal was to understand the relevant issues from the point of view of those most affected. METHODS: An interdisciplinary collaborative research team used several qualitative data collection tools in gathering and interpreting data. RESULTS: Information was collected from a wide variety of stakeholders that will allow for planning of programs that are Bolivian-driven, culturally appropriate, and socially feasible. CONCLUSIONS: By adhering to a systematic process of team building and data gathering from a variety of sources using a mix of methods, culturally appropriate information can be integrated into program planning.

Adult↗

Homelessness and mental illness in a professional- and peer-led cocaine treatment clinic.

The combined problems of substance abuse, mental illness, and homelessness among the urban poor represent a major public health issue. The study evaluated 340 patients attending a cocaine day treatment program that integrates peer leadership and professional supervision. Thirty-six percent of the sample had a major mental illness, and 39 percent were homeless. Sixty-nine percent achieved an acceptable final urine toxicology status, and the median number of program visits was 46. Homelessness, a longer history of cocaine use, and a diagnosis of schizophrenia were associated with positive treatment outcomes. The results support the feasibility of a cocaine abuse treatment model combining professional and peer leadership.

Adult↗

[Description of the development of a new model of primary care in the community of Valencia].

OBJECTIVE: The aim of this study was to determine to what extent the new model of primary care (NMPC) had been introduced and developed in the Community of Valencia by means of an assessment of the structure, procedures and results attained by the primary care teams (PCT). DESIGN: An observation study of a crossover type. SETTING: Primary health care. PATIENTS AND OTHER PARTICIPANTS: 70 health centres in the Valencia Community were studied. The criteria for inclusion in the study were that the centre should have been open for at least two years on March 1st 1991 and/or had the accreditation (or had requested it) to teach family and community medicine. MEASUREMENTS AND MAIN RESULTS: 51 indicators were applied. These evaluated the seven fundamental attributes which make up the theoretical model: accessibility, integrated care, programmed performance, ongoing care, team work, community involvement and research and teaching. Of these seven primary care attributes, the highest valued were geographical accessibility and ongoing care; and those which needed to be strengthened, non-geographical accessibility and integrated care. CONCLUSIONS: The analysis of the results obtained makes us reflect on the model of primary care which can be developed in our environment, with peoples' real needs and the resources available being borne in mind.

Cross-Over Studies↗

Aspects of IAIMS implementation that require further research.

The Integrated Advanced Information Management System (IAIMS) program promotes an integrated approach to information management within a medical center. Since the IAIMS program was conceived, many of the initial IAIMS technologic needs have been quite widely achieved or are planned for implementation in many medical centers. At the same time, the IAIMS frontier is being steadily pushed to new issues that need to be addressed to achieve the full power of the IAIMS vision. The paper discusses 1) levels of integration where IAIMS has been successfully pursued to date and 2) challenging areas in which research is required to approach the full potential of the IAIMS in the future.

Integrated Advanced Information Management Systems↗

Australian Aboriginal health and health-care.

The health status of Australia's Aborigines is far inferior to that of non-Aboriginal Australians. The factors underlying this low standard of health are complex, but relate to the gross social inequality experienced by Aborigines, even today. The social inequality, characterised by extreme socioeconomic deprivation and relative powerlessness, is the end result of the European occupation of Australia, which caused Aboriginal depopulation and dispossession. Since the early 1970s a number of special programs have attempted to overcome the health inequalities of Aborigines, but have really met with only limited success. This limited success is explicable in terms of the gross social inequalities experienced by Aborigines. Alleviation of Aboriginal ill-health requiries integrated comprehensive programs, with continued support, at least in the medium term, of special Aboriginal health programs.

Adolescent↗

Air medical transport systems as a health-care integrator. Association of Air Medical Services.

Air medical transport services are an essential, cost-effective component of health-care delivery in the United States. Air medical transport services provide rapid access to high-quality, sophisticated medical technologies over large geographic areas. They reduce the cost of duplicating resources by obviating the need to provide similar levels of access and service at multiple locals in the region. The sophistication and quality of care maintained during transport provides a level of services not available with traditional ground transport services, particularly in rural areas. Air medical transport services also facilitate linkages between primary, secondary and tertiary-care facilities, allowing integration of programs and services to create regionalized systems of healthcare. While numerous strategies are necessary to reduce health-care costs in the United States without reducing quality and access, air medical transport systems are uniquely positioned to support the efficient integration of regional healthcare services, while maintaining the highest standards of care for patients.

Air Ambulances↗

Transposable elements as the key to a 21st century view of evolution.

Cells are capable of sophisticated information processing. Cellular signal transduction networks serve to compute data from multiple inputs and make decisions about cellular behavior. Genomes are organized like integrated computer programs as systems of routines and subroutines, not as a collection of independent genetic 'units'. DNA sequences which do not code for protein structure determine the system architecture of the genome. Repetitive DNA elements serve as tags to mark and integrate different protein coding sequences into coordinately functioning groups, to build up systems for genome replication and distribution to daughter cells, and to organize chromatin. Genomes can be reorganized through the action of cellular systems for cutting, splicing and rearranging DNA molecules. Natural genetic engineering systems (including transposable elements) are capable of acting genome-wide and not just one site at a time. Transposable elements are subject to regulation by cellular signal transduction/computing networks. This regulation acts on both the timing and extent of DNA rearrangements and (in a few documented cases so far) on the location of changes in the genomes. By connecting transcriptional regulatory circuits to the action of natural genetic engineering systems, there is a plausible molecular basis for coordinated changes in the genome subject to biologically meaningful feedback.

DNA Transposable Elements↗