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PubMed1985

Antisperm antibodies in infertile and homosexual men: relationship to serologic and clinical findings.

The incidence and significance of antisperm antibodies in different groups of men were evaluated by a modified enzyme-linked immunosorbent assay. In serum, 4.0% of dermatologic patients (n = 223), 9.6% of andrologic patients (n = 178), and 28.6% of homosexual men (n = 42) were positive for IgG and/or IgM antibodies. In seminal fluids, 7.3% of the andrologic patients had IgA (and IgG) antibodies to spermatozoa. Only 1 of 29 positive men had antibodies both in serum and in seminal fluid. No correlation between antisperm antibodies and IgG/IgM concentrations was found in serum, whereas in seminal plasma men with antisperm antibodies showed higher IgG/IgA concentrations than men without (IgA, 3.2 versus 1.7 mg/dl; IgG, 9.8 versus 6.3 mg/dl). It is concluded that there is a high incidence of antisperm antibodies among homosexual men, probably because of contact of spermatozoa with the immune system by passive anal intercourse. There is little correlation between antisperm antibodies in serum and seminal plasma of infertile men because of a lack of relevant antibody transfer from the serum and the formation of local antibodies in seminal plasma. Antisperm antibodies in seminal fluid are associated with elevated local IgG and IgA concentrations.

Autoantibodies↗
PubMed1985

Decreasing incidence of gonorrhea in homosexually active men--minimal effect on risk of AIDS.

The incidence of gonorrhea in homosexually active men in Seattle-King County and in Washington State as a whole decreased by 57% from 1982 to 1984, compared with a 20% decrease among heterosexual men and women. This probably reflects behavioral changes of homosexual men in response to the epidemic of the acquired immunodeficiency syndrome (AIDS). Nevertheless, changes in sexual behavior that greatly reduce the incidence of gonorrhea do not necessarily result in a similar reduction in the risk of exposure to the virus that causes AIDS.

Acquired Immunodeficiency Syndrome↗
PubMed1977

Examining the homosexual male for sexually transmitted diseases.

Homosexual men may be deterred from seeking an examination for sexually transmitted diseases because it would require an open admission of sexual preference. For these diseases to be controlled, gay men must be motivated to be examined for sexually transmitted diseases. If a medical or health professional feels unable to respond to a gay patient's needs, he should refer the patient to someone who deals well with gay patients. Health care services must be offered in a way that minimizes the anxiety many homosexuals associate with examination and treatment for sexually transmitted diseases.

Anxiety↗
PubMed1983

Value of lymph node biopsy in unexplained lymphadenopathy in homosexual men.

The acquired immune deficiency syndrome (AIDS) manifested by severe opportunistic infections, Kaposi's sarcoma, or lymphoma often has a prodrome of lymphadenopathy accompanied by constitutional symptoms. We studied the histopathologic findings of lymph node biopsy specimens and peripheral blood immunologic parameters of 24 clinically indistinguishable homosexual men with chronic generalized lymphadenopathy. Two different morphological patterns were observed: (1) lymph nodes with follicular and paracortical hyperplasia in 21 patients who had had no clinical deterioration and (2) an atypical pattern of lymphoid proliferation in three patients who experienced rapid development of non-Hodgkin's lymphoma and/or opportunistic infections. Several immunologic laboratory results paralleled these changes. Lymph node morphological findings seem to be a useful predictor of outcome in homosexual men with generalized lymphadenopathy.

Acquired Immunodeficiency Syndrome↗
PubMed1984

[The lymphadenopathy syndrome. Immunologic studies of young homosexual men with and without lymphadenopathy].

Investigations on 147 young homosexual men living in Berlin (West) revealed lymphadenopathy in 61.2% (90 pat.). This finding was prominent in 43.4% of all cases. Evaluation of total T-, T-helper und T-suppressor lymphocytes by means of immunofluorescence with monoclonal antibodies showed an unchanged total number of T-lymphocytes; in contrast, the T-helper subpopulation was decreased and the T-suppressor subpopulation was increased in the peripheral blood, in comparison to a control group of heterosexual men. Therefore, a significantly reduced Th/Ts-ratio was supposed. These changes were more pronounced in the group with marked lymphadenopathy. Our investigations prove a high prevalence of lymphadenopathy and immune dysfunction among young homosexual men in Germany. Both are correlates of one syndrome characterized by persisting unexplained lymphadenopathy, immune dysfunction, and general clinical symptoms (including loss of weight, fever, diarrhoea, etc.). This so called lymphadenopathy syndrome (LAS) with the above mentioned clinical symptoms and reduction of the Th/Ts-ratio may represent a prodrome of AIDS. A long-term and careful follow-up of these patients is therefore necessary.

Adolescent↗
PubMed1982

Kaposi's sarcoma in young homosexual men.

An outbreak of KS has been observed in young homosexual men. These patients are different from those with classical KS for the following reasons: 1. geographic distribution (clustering in New York and California); 2. age (younger, mean--39 years); 3. higher incidence; 4. sexual preference (homosexual); 5. distribution of skin lesions (face, upper extremities, trunk); 6. lymph node involvement; 7. visceral lesions; 8. associated opportunistic infections (Pneumocystis carinii, toxoplasmosis); 9. history of sexually-transmitted diseases (hepatitis, syphilis, gonorrhea); and 10. aggressive course of the disease. Awareness of these features of the new KS will enable the practitioner to better recognize this important, emerging disease.

Adult↗
PubMed1982

[Acquired immunologic deficiency syndrome, opportunistic infections and homosexuality. Presentation of 3 cases studied in Switzerland].

Three cases of multiple opportunistic infections in previously healthy homosexual males were observed in 3 different University Hospitals in Switzerland. Two of the patients died. Infections were multiple, with P. carinii pneumonia (3 cases), chronic mucocutaneous ulcers probably due to Herpes simplex virus (2 cases), mucosal candidiasis (2 cases) and disseminated infections due to cytomegalovirus (1 case) and Mycobacterium avium (1 case). All patients had depressed cellular immunity with marked lymphopenia. These cases are similar to those recently observed in the United States, but two of the patients had never been to the USA although both had vacationed in Haïti where the syndrome has been described. These patients illustrate that this new syndrome should also be suspected outside the USA when a patient (especially a male homosexual) presents with persistent fever of unknown origin and develops opportunistic infections without obvious underlying disease.

Adult↗
PubMed1983

Virus-associated colitis in homosexual men: two case reports.

Two homosexual men with colitis are described. In each case there was evidence of viral infection of the colon. One patient developed toxic megacolon that responded to conservative therapy. The other patient had proctosigmoiditis and opportunistic infections that eventually led to his death. An intensive search for viruses should be made in all homosexual men with proctitis and/or colitis.

Adult↗
PubMed1983

Early lesions of Kaposi's sarcoma in homosexual men. An ultrastructural comparison with other vascular proliferations in skin.

An aggressive variant of Kaposi's sarcoma (KS) has appeared in young homosexual men with evidence of systemic immunosuppression. The ultrastructure in biopsy specimens from 8 KS cases in young homosexual men has been compared with that in biopsy specimens from 4 KS cases in elderly heterosexuals and with that in biopsy specimens from 23 cases of benign vascular disorders of skin. In all cases of KS the small blood vessels lacked a prominent investment of pericytes and their processes, had a fragmented and often absent basal lamina, had frequent discontinuities in the endothelial lining, and had only a few small junctional densities between endothelial cells. Some clinically aggressive cases of KS also had necrosis of individual endothelial cells and had prominent cytoplasmic processes entrapping individual collagen fibers. The benign disorders lacked these features. These differences in the structure of the small vessels may be of diagnostic value in some early cases of KS. The loss of dendritic pericytes in blood capillaries in KS might relate to the telangiectasia which is a prominent feature of the early lesions of KS.

Adult↗
PubMed1982

Acquired immunodeficiency syndrome (AIDS) in homosexual men--a new public health concern.

The acquired immunodeficiency syndrome (AIDS) is a new, serious condition of major public health concern. It is most prevalent among young homosexuals and may be present with Kaposi's sarcoma and serious opportunistic infections. Physicians dealing with male homosexuals should be aware of this diagnostic possibility in any patient with unusual skin lesions or unusual clinical findings indicating infection. AIDS may be preceded by persistent generalized lymphadenopathy which may be accompanied by fatigue, low grade fever, night sweats and weight loss. The prognosis is poor with high mortality rates and no indication of spontaneous recovery of cellular immunocompetence.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Cytologic findings in homosexual males with acquired immunodeficiency.

During a three-year period (1979 to 1982), 248 cytology specimens were obtained from 38 homosexual males who were admitted for treatment and had a variety of nonspecific symptoms, such as general malaise and weight loss. Twenty patients had Kaposi's sarcoma. Exfoliative and aspiration/brush specimens were prepared mainly from cerebrospinal fluids and tracheobronchial secretions. One hundred twenty-four specimens were of diagnostic value, exhibiting cytologic abnormalities: acute inflammation (11 specimens), marked cellular atypia (39 specimens), increased number of mature and immature lymphoreticular elements (31 specimens) and organisms such as parasites and fungi (43 specimens). Awareness of an epidemic of acquired immuno-deficiency-associated disease among male homosexuals, in conjunction with special processing and careful interpretation of cytologic specimens, contributed to the identification of organisms and the ruling out of malignancy. Despite prompt treatment, a swiftly progressive clinical course resulted in the death of 20 patients.

Acquired Immunodeficiency Syndrome↗
PubMed1983

Intestinal parasitic infections in homosexual men at a San Francisco health fair.

In a sample of homosexual men attending a San Francisco Bay Area health fair, there were strikingly higher prevalence rates of intestinal parasitic infections compared with rates in a control group of health plan members who had a routine multiphasic health examination. Physicians treating homosexual men must be aware of the likelihood of such infections, whether or not the patients are symptomatic.

Adult↗
PubMed1978

Homosexual behavior and child molestation: a review of the evidence.

Male homosexuality and child molestation tend to be associated with each other in the minds of a large percentage of the general public. Designing a research study to test this hypothesis presents a number of methodological problems which are not easily resolved. Existing studies which contain data on this general question provide no reason to believe that anything other than a random connection exists between homosexual behavior and child molestation.

Age Factors↗
PubMedDate not supplied

Vices, gods, and virtues: cosmology as a mediating factor in attitudes toward male homosexuality.

Using historical and anthropological evidence, the article examines the relationship of the polytheistic and monotheistic cosmologies and attitudes toward sexuality, in particular, male homosexuality. The polytheistic cosmology included the ideas of the continuity of creation, the generative forces of the universe as a whole, and gender blurring in the realm of the supernatural. In the monotheistic cosmology the godhead (Yahweh) is unborn and does not father any generations, the universe is desexualized, and the conception of gender is rigidified. The author concludes that polytheism created the conditions for a wide variety of sexual expression and sex-role behavior and did not preclude any particular form of sexual activity. In contradistinction, the monotheistic cosmology was highly restrictive of permissible male and female behavior and sexual expression and conduct. Consequently, polytheism was able to embrace the crossing of gender lines and homosexual relationships while monotheism was incapable of making these accommodations.

Attitude↗
PubMed1983

Kaposi's sarcoma in a young homosexual man. Association with angiofollicular lymphoid hyperplasia and a malignant lymphoproliferative disorder.

Recent reports have described an unexpected number of cases of a virulent form of a Kaposi's sarcoma (KS) as well as acquired immunodeficiency in young homosexual men. A 31-year-old man initially had a benign disorder, angiofollicular lymphoid hyperplasia. Kaposi's sarcoma then developed, and he died of a malignant lymphoproliferative disorder. We believe that this is unique among the recently described cases of KS in homosexual men because of the occurrence of this second malignancy. It may be that similar cases will be recognized in this population.

Adult↗
PubMed1984

Anxiety and the restitutional function of homosexual cruising.

Psychoanalytical exploration of latent homosexuality, of homosexual cruising and the related fantasies indicates that it is (among other things) an act of restitution, an effort to resurrect the father, to contradict the ambivalent wishes to rob and murder him, to make sure that he is alive and well and not the victim of the cruiser's competitiveness and destructiveness, to idealize him and render him into an object of love; thus to avoid anxiety and to preclude the father's wrath and retaliation. That such restitutional attempts fail and instead reflect the murderous (both the anal and the genital) intent is no surprise for the psychoanalyst who regularly witnesses contradictory aims in the manifestations of all the neuroses and psychoses including the obsessional. The observations (as well as a host of other clinical phenomena) indicate the intimate relation of anxiety to the aggressive strivings (despite the fact that anxiety instigates repression of the sexual wishes). Anxiety serves as a precipitant of repression and symptom formation while guilt, both conscious and unconscious manifestations, is a product of the oedipal sexual wishes.

Adult↗
PubMed1983

Specific translocations characterize Burkitt's-like lymphoma of homosexual men with the acquired immunodeficiency syndrome.

A Burkitt's-like B-cell lymphoma (BLL) has recently been shown to be associated with the acquired immunodeficiency syndrome (AIDS), which affects homosexual men. We report cytogenetic studies of two BLL tumors in homosexual men. Both tumors had chromosome translocations characteristic of Burkitt's lymphoma (BL), one the t(8;14) and the other the t(8;22). The pathway of lymphomagenesis in this disorder is discussed in the light of recent data on chromosome change and localization of immunoglobulin genes and oncogenes.

Acquired Immunodeficiency Syndrome↗