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PubMedDate not supplied

One-sided high-frequency oscillatory ventilation in the management of an acquired neonatal lobar emphysema: a case report and review.

We describe a premature infant (gestational age 28 weeks and birth weight 1280 g) with a left-sided acquired lobar emphysema (ALPE). Left lateral decubitus positioning, right-sided conventional ventilation (CV), tracheal high-frequency oscillatory ventilation (HFOV), and dexamethasone administration were subsequently used in the treatment without success. The emphysema was resolved and the patient was extubated after selective intubation and HFOV of the right unaffected lung. We also review the reported cases of ALPE in neonates that were treated by one-sided high-frequency ventilation (HFV).

High-Frequency Ventilation↗
PubMed2006

Risk factors and clinical outcomes of pulmonary interstitial emphysema in extremely low birth weight infants.

OBJECTIVE: We studied the ante- and postnatal risk factors and clinical outcomes associated with pulmonary interstitial emphysema (PIE) in extremely low birth weight infants (ELBW, <1000 g at birth) in the present era of tocolytics, antenatal steroid and postnatal surfactant administration. STUDY DESIGN: This was a retrospective case-controlled study of all ELBW admitted consecutively during a designated study-period in a level III nursery. Data were analyzed by performing univariate and multivariate analysis as applicable. RESULTS: Infants with PIE had lower 1 and 5 min Apgar scores (P=0.04 and 0.003 respectively), increased surfactant utilization (P=0.004), higher maximum inspired oxygen concentration (P=0.04) and mean airway pressure administration (P=0.02) during the first week of life, and increased neonatal mortality (P=0.01). They received higher antenatal doses of magnesium sulfate (MgSO(4)) (P=0.02). 56% of infants with PIE were exposed to more than 10 g of MgSO(4) (Mg10), compared to 15% in non-PIE group (P=0.01). The multivariate logistic regression analysis including significant co-variates revealed an independent association between Mg10 and PIE (P=0.01, Odds ratio 19.8, 95% CI 1.5-263). CONCLUSION: Pulmonary interstitial emphysema is associated with increased mortality in ELBW infants. Mg10 is an independent risk factor for PIE in this population.

Apgar Score↗
PubMed1991

Extent of pulmonary emphysema in man and its relation to the loss of elastic recoil.

1. We assessed lung density, determined by computerized tomography, as a measure of emphysema and related this to lung function and measurement of the elastic recoil of the lung in normal subjects and patients with chronic obstructive lung disease. 2. We found a significant correlation between measurements of elastic recoil pressure at 90% of total lung capacity and both the forced expiratory volume in 1 s (r = 0.80, P less than 0.001) and the transfer factor for carbon monoxide (r = 0.70, P less than 0.001). Measurements of elastic recoil of the lung also correlated with lung density as measured by computerized tomography scanning (P less than 0.001). 3. Multiple regression analysis demonstrated a correlation between the density of the lowest fifth percentile of the computerized tomography lung-density histogram, and both the natural logarithm of the shape parameter of the pressure-volume curve (P less than 0.01), and the transfer factor for carbon monoxide (P less than 0.01). However, the mean computerized tomography lung density correlated, in addition, with the elastic recoil pressure of the lungs at 90% of total lung capacity (P less than 0.001). 4. Since the elastic recoil pressure correlates with computerized tomography lung density, and hence with emphysema, and since elastic recoil pressure also correlates with the forced expiratory volume in 1 s, these results suggest that loss of elastic recoil is one determinant of airflow limitation in patients with chronic obstructive lung disease.

Adult↗
PubMed1999

Congenital lobar emphysema: antenatal diagnosis and follow up.

The case of an echogenic mass in the right lung that apparently resolved spontaneously prior to delivery is reported here. Postnatal investigations revealed congenital lobar emphysema. To the knowledge of the authors, this is the first reported case of spontaneous, apparently complete resolution of an echogenic lung mass on antenatal ultrasound due to lobar emphysema. The routine use of ultrasound to screen for foetal anomalies has led to the discovery of a number of incidental findings, such as an echogenic foetal lung mass, that pose a challenge to diagnosis and management. The importance of appropriate counselling and postnatal follow-up are highlighted.

Adult↗
PubMed2001

Transient exit block of a DDD pacemaker with unipolar leads in subcutaneous emphysema following pneumothorax.

This case report describes a transient pacemaker exit block due to subcutaneous emphysema following pneumothorax. Pneumothorax after pacemaker implantation is rare, but development of subcutaneous emphysema under such circumstances is even more uncommon. Exit block develops only with the use of unipolar leads; with implantation of bipolar leads, this complication cannot occur.

Aged↗
PubMed2001

Congenital lobar emphysema--the disappearing chest mass: antenatal ultrasound appearance.

Prenatal diagnosis of congenital lobar emphysema is rarely reported in the literature. This case presents a fetus with an echogenic lung diagnosed at 18 weeks' gestation, that resolved completely during the pregnancy. This case is unique in that sonographic increased echogenicity was first noted at 18 weeks' gestation and had disappeared by 29 weeks' gestation. The diagnosis was made in the postnatal period as a result of follow up of the prenatal findings. This case reinforces the importance of continuing postnatal investigations of prenatal sonographic abnormalities even when they appear to have disappeared. A discussion of the causes of congenital lobar emphysema is presented.

Adult↗
PubMed2002

Differential lung ventilation after single-lung transplantation for emphysema.

OBJECTIVE: To review outcome and cardiovascular and respiratory function after initiation of differential lung ventilation for acute severe native lung hyperinflation in patients who have had a single-lung transplant for end-stage emphysema. DESIGN: Retrospective review. SETTING: Cardiothoracic tertiary referral center. PARTICIPANTS: Thirteen patients who had differential lung ventilation for acute severe native lung hyperinflation, of a total of 132 patients who had a single-lung transplant for end-stage emphysema between 1988 and the end of 2000. INTERVENTIONS: None. measurements and main results: Thirteen patients had differential lung ventilation for acute severe native lung hyperinflation; 7 survived to 1 year after transplant. There was a highly significant (p = 0.0006) improvement in mean PaO(2) from 8.23 (95% confidence interval [CI], 6.15 to 10.3) to 16.6 (95% CI, 12.84 to 20.45) 1 hour after start of differential lung ventilation. The average ratio of estimated dynamic compliance in the native lung compared with the transplanted (donor) lung was 2.69 (95% CI, 1.75 to 3.62). CONCLUSION: In addition to previous case reports, this series shows that differential lung ventilation is an appropriate treatment for acute severe native lung hyperinflation. A difference in estimated effective dynamic compliance of > or = 2.69 between native and transplanted lung may require differential lung ventilation.

Adult↗
PubMed2002

Orbital emphysema during air travel: a case report.

Orbital emphysema is a well-recognized complication of fractures involving the orbit. Commonly, this follows nose blowing and occurs in the subcutaneous tissues. A case of emphysema within the orbital cavity caused by the pressure changes during air travel is presented. The clinical picture was similar to that seen in retrobulbar haemorrhage and required early surgical intervention. Circumstances where patients at risk may be exposed to abnormal atmospheric pressures are highlighted and the management of the condition is discussed.

Adult↗
PubMed1977

[Bronchospirometric results after single lung homotransplantation in dogs with experimentally induced pulmonary emphysema (author's transl)].

Pulmonary emphysema was induced in 8 bastard dogs by intratracheal instillation of Papain. Development of emphysema was documented by pulmonary function tests. The emphysematous animals underwent single lung homotransplantation. Postoperative bronchospirometric measurements revealed that up to the 6th week after transplantation there is no evidence of serious ventilation perfusion inbalance.

Airway Resistance↗
PubMed1975

[Lobar emphysema: differential diagnosis and treatment (author's transl)].

Lobar emphysema with acute severe respiratory distress is predominately seen in early infancy while the few cases after one year of age usually show signs of recurrent respiratory infection. Several conditions causing increased transparency on one side of the chest x-ray must be be differentiated. In case of emergency the simple chest x-ray must be sufficient for diagnosis. In this situation even the performance of a diagnostic thoracotomy can become necessary. The removal of the affected lobe is the treatment of choice. 6 cases of lobar emphysema are reported.

Age Factors↗
PubMed2002

Study on the usefulness of seratrodast in the treatment of chronic pulmonary emphysema.

It has been reported that the biosynthesis of thromboxane A2 (TXA2) is enhanced in platelets in the presence of chronic obstructive pulmonary disease (COPD), and 11-dehydro-TXB2, a urinary metabolite of thromboxane, also increases in blood. In the present study, seratrodast (CAS 112665-43-7, Bronica), a TXA2 receptor antagonist, was administered to 14 patients with chronic pulmonary emphysema in the stable phase for 8 weeks. Respiratory distress was evaluated in the attending physicians' judgments using the Hugh-Jones (H-J) classification, and also by the patients themselves using the Borg scale. Respiratory function tests, including forced vital capacity (FVC), percent of one second forced expiratory volume (FEV1.0%), arterial blood gases during respiration of room air, and peak expiratory flows (PEF) (morning and evening), and measurement of plasma 11-denhydro-TXB2 and TXB2 levels were performed before and 8 weeks after the start of administration, as well as at the time of the start of administration. The results revealed significant improvement of respiratory distress, evaluated on both the H-J classification and the Borg scale, at week 8. Although no significant changes were observed in plasma TXB2 levels, the plasma 11-dehydro-TXB2 level significantly decreased at week 8. Among the respiratory function parameters examined, only FVC was significantly improved. These results indicated that seratrodast is useful for the improvement of respiratory distress in patients with chronic pulmonary emphysema in the stable phase.

Aged↗
PubMed1999

[Reflections on the new occupational disease No. 4111: without reasonable doubt Mr. X. in his 70th year suffers from chronic obstructive bronchitis and Mr. Y. from pulmonary emphysema].

Without reasonable doubt Mr. X. suffers from a chronic obstructive bronchitis and Mr. Y. from pulmonary emphysema. With relation to the new occupational disease no. 4111 the safe diagnosis of chronic obstructive bronchitis and of pulmonary emphysema is very difficult. The various aspects are described here.

Aged↗
PubMed2001

[Orbito-palpebral emphysema due to ethmoidal fracture].

BACKGROUND: Orbito-palpebral emphysema is a frequent pathological entity due to head injury. We report on a patient and correlate the clinical view and computer tomography findings. CASE REPORT: A 17-year-old male was referred to our hospital after a blunt trauma to his head. Visual acuity was 1,0. Diplopia, restricted motility and exophthalmus about 4 mm were found. CONCLUSION: If swelling of the lid is found orbito-palpebral emphysema should be thought of to initiate appropriate therapy to avoid possible severe complications, for example, occlusion of the retinal central artery.

Adolescent↗
PubMed2002

[Severe mediastinal emphysema after temporal gunshot with a gas revolver].

Injuries after a close contact gunshot with clear or tear gas cartridges can lead to severe and life threatening complications. The high pressure of the gas may damage soft tissue, bones and organs. This mechanism is able to cause mediastinal emphysema, rupture of upper and lower pharyngeal, esophageal and tracheal structures far away from the initial trauma with diagnostic findings which are may be difficult to interpret. This case report presents a mediastinal emphysema in a 17 year old man following a temporal shot with a gas revolver. The diagnostics, focussed on CT and X-ray imaging, and the therapeutic concept of such cases will be discussed.

Adolescent↗
PubMed2004

[Congenital lobar emphysema - a radiological diagnosis at first glance?].

Congenital lobar emphysema (CLE) is a malformation of the lung of unknown etiology. The characteristic overdistension of the affected lobe leads to compression and displacement of adjacent normal lung tissue and mediastinum. In the majority of cases, symptoms appear during the neonatal period or in early childhood. Clinically, children present with signs of respiratory distress, frequently occurring with a superimposed lower respiratory tract infection that aggravates air trapping and renders the patient symptomatic. Rarely, CLE is diagnosed in adult patients who did not experience any symptoms during childhood. Knowledge of the disease is of importance because in the majority of cases a plain chest radiograph together with clinical signs is sufficient to diagnose the disease correctly. The article draws attention to this condition by presenting two children and one adult with congenital lobar emphysema. Possible clinical symptoms and diagnostic strategies are reviewed.

Adult↗
PubMed2005

A very unusual presentation of Niemann-Pick disease type B in an infant: similar findings to congenital lobar emphysema.

The main features of Niemann-Pick disease type B (NPD-B) are enlargement of the liver and spleen, and mild pulmonary involvement. Recurrent respiratory tract infection and progressive decline in pulmonary function are major contributors to morbidity and mortality in this patient group. Massive pulmonary involvement in early life is extremely rare. The most common finding on chest X-rays of NPD-B patients is reticular or nodular infiltration of the lungs. This article describes a very rare presentation of NPD-B in an infant who had suffered recurrent respiratory tract infections. Massive emphysema and marked infiltrative parenchymal changes (infiltration of the parenchyma) were initially attributed to congenital lobar emphysema and its compressive effects. However, NPD was suspected when a lung biopsy showed foamy cells and sea-blue histiocytes were detected in a bone marrow biopsy. The definitive diagnosis was established with an enzyme study for sphingomyelinase.

Diagnosis, Differential↗
PubMed2005

[One-sided acquired pulmonary lobar emphysema -- successful treatment with selective intubation and one-sided high-frequency ventilation].

Mechanical ventilation of preterm and newborn infants is associated with the risk of inducing a pulmonary baro- or volutrauma which may lead to one-sided acquired pulmonary lobar emphysema (APLE). We report a case of a preterm infant with severe APLE compromising hemodynamics due to mediastinal-shift, which was successfully treated with selective one-sided intubation and high-frequency ventilation. We assume that a brief malposition of the endotracheal tube initiated the emphysema of the left pulmonary lobe. We deduce recommendations for avoiding APLE from literature and our experience.

Barotrauma↗
PubMed1985

Surgical improvement of patients with pulmonary insufficiency due to localized bullous emphysema or giant cysts.

Patients with continuous expansion of either giant lung cysts or areas of localized bullous emphysema will eventually deteriorate into a state of extreme respiratory distress due to compression of the remaining healthy pulmonary tissue. Thirty-one patients with these 2 types of lung disease having very poor respiratory function underwent surgery for the release of compromised healthy lung by resection of the expanding processes. A rational investigation program including respiratory tests, ventilation and perfusion scintigraphy and pulmonary angiography was gradually developed and analyzed. Surgical mortality was 12.9% in unilateral operations, probably somewhat higher in later contralateral interventions. The operative risk was higher in the emphysema group than in the group with giant lung cysts. Follow-up has demonstrated encouraging results in both groups concerning increased pulmonary function as well as improved working capacity.

Adult↗