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At least 1,369 records · Page 76Linked to original sources
PubMed1998

NCCN Internet-based data system for the conduct of outcomes research.

The National Comprehensive Cancer Network (NCCN), an alliance of 17 of the world's leading cancer centers, is currently conducting its first shared outcomes project in breast cancer. City of Hope National Medical Center serves as the data coordinating center for the project. A database system has been designed and deployed which allows project staff located all over the United States to submit data to the central repository at City of Hope via the Internet. The database application consists of a series of webenabled front-end screens linked to a Microsoft SQL Server database. The NCCN system incorporates high levels of data security, confidentiality, and integrity via data encryption, password and ID protection, submission of anonymous data, and quality-control processing on several levels. The application also provides the flexibility of entering the data via the web-based screens, or transferring electronic files of data from existing database systems. Recently released SAS statistical software tools have been integrated into the system to allow for a seamless interface for analysis and web-enabled output of reports. The goals and strategies in designing the NCCN system are described and sample screens are shown. Our experience to date indicates that this system is highly effective in providing the ability to perform nationwide retrieval and analysis of outcomes data.

Breast Neoplasms↗
PubMedDate not supplied

A program evaluation of classroom data collection with bar codes.

A technology incorporating bar code symbols and hand-held optical scanners was evaluated for its utility for routine data collection in a special education classroom. A different bar code symbol was created for each Individualized Educational Plan objective, each type of response occurrence, and each student in the first author's classroom. These symbols were organized by activity and printed as data sheets. The teacher and paraprofessionals scanned relevant codes with scanners when the students emitted targeted behaviors. The codes, dates, and approximate times of the scans were retained in the scanner's electronic memory until they could be transferred by communication software to a computer file. The data from the computer file were organized weekly into a printed report of student performance using a program written with commercially available database software. Advantages, disadvantages, and costs of using the system are discussed.

Child↗
PubMed1984

[An electronic data processing program for respiratory function diagnosis with the KRS 4201 computer].

The computer program LSD 1 published in 1973 which was used for daily processing of lung function data in a number of hospitals is at present realized on the computer KRS 4 201. In the last years new reference values and new valuations of parameters lead to changed and more complete programs. The here presented new program is based consequently in magnetic files from data input with DEG 1 370 to output of the computed parameters. It concludes new reference values and SI-units also. With the computer KRS 4 201 parameters were corrected and computed, respectively, derivated diagnostic valuations were printed out and all data stored by magnetic files.

Acid-Base Equilibrium↗
PubMed1991

Computerised method for acquisition and display of gastrointestinal motility data.

A computerised system is developed for the acquisition and display of gastrointestinal motility data which utilises a purpose developed software program called 'PC-motil', running on an IBM compatible microcomputer. 'PC-motil' displays data during collection, writes data to disk file and compresses all data at the end of a study on to a single monitor screen for convenient overview. Any area of interest, in single or multiple channels, may be selected and expanded for detailed examination. This system is tested by the recording of gastric and jejunal motility patterns of 11 healthy volunteers in fasting and fed states. All antral and jejunal migrating motor complexes (MMCs) in fasting studies, as well as all fed motility patterns were recognisable in both 'compressed' and 'expanded' form. The reproduction of motility patterns by the computer based system was indistinguishable from that of a conventional analogue chart recorder. This computerised system provides a convenient and cost-effective means of acquisition, storage and display of motility data in digital form.

Adult↗
PubMed2006

MitoP2: the mitochondrial proteome database--now including mouse data.

The MitoP2 database (http://www.mitop.de) integrates information on mitochondrial proteins, their molecular functions and associated diseases. The central database features are manually annotated reference proteins localized or functionally associated with mitochondria supplied for yeast, human and mouse. MitoP2 enables (i) the identification of putative orthologous proteins between these species to study evolutionarily conserved functions and pathways; (ii) the integration of data from systematic genome-wide studies such as proteomics and deletion phenotype screening; (iii) the prediction of novel mitochondrial proteins using data integration and the assignment of evidence scores; and (iv) systematic searches that aim to find the genes that underlie common and rare mitochondrial diseases. The data and analysis files are referenced to data sources in PubMed and other online databases and can be easily downloaded. MitoP2 users can explore the relationship between mitochondrial dysfunctions and disease and utilize this information to conduct systems biology approaches on mitochondria.

Animals↗
PubMed2006

Development, validation, and use of English and Spanish versions of the telemedicine satisfaction and usefulness questionnaire.

OBJECTIVES: To describe the development and validation of low literacy English and Spanish versions of the 26-item Telemedicine Satisfaction and Usefulness Questionnaire (TSUQ), report telemedicine satisfaction and usefulness ratings of urban and rural participants in the Informatics for Diabetes Education and Telemedicine (IDEATel) project, and explore relationships between utilization and perceptions of satisfaction and usefulness. METHODS: Data sources included TSUQ, utilization data from IDEATel log files, and sociodemographic data from the annual IDEATel interview. Psychometric analyses were conducted to examine the reliability and validity of TSUQ. Data were analyzed using descriptive, correlational techniques. RESULTS: The principal components factor analysis extracted two factors (Video Visits, alpha=.96, and Use and Impact, alpha=.92) that explained 63.6% of the variance in TSUQ satisfaction scores. All satisfaction and usefulness items had mean scores of greater than 4 on a 5-point scale. Those from urban areas reported significantly higher ratings on both factors than rural participants as did those who did not know how to use a computer at baseline. Mean frequency of utilization of IDEATel components was highest for blood sugar testing followed by web site for reviewing results, blood pressure testing, video visits, and ADA educational Web pages. Associations between utilization and perceptions of satisfaction and usefulness varied among IDEATel components. CONCLUSION: Psychometric analyses support the construct validity and internal consistency reliability of TSUQ, which is available in both English and Spanish at a readability level of 8th grade. Both rural and urban participants reported high levels of satisfaction and found all IDEATel components useful. Further work is needed to examine the relationships between utilization and perceptions of satisfaction and usefulness and to explore the effects of location (urban versus rural) and ethnicity on satisfaction with telemedicine services.

Diabetes Mellitus↗
PubMed1998

Streptogramins and their potential role in geriatric medicine.

Despite advances in antimicrobial chemotherapy over recent decades, morbidity and mortality secondary to infection continues to rise. In addition, the incidence of infection caused by resistant organisms has also increased. Concurrently, the elderly are living longer than prior generations, often with disabling chronic diseases. The more debilitated of the geriatric population are at greater risk for infection, and more likely to acquire or develop antimicrobial resistant organisms. Gram-positive organisms are a source of resistance and commonly cause infection in older patients. Whereas resistance is a concern in all patients, in the elderly this is magnified by limitations in treatment options because of differences in pharmacokinetics and tolerance as compared with younger counterparts. Pharmacokinetic differences include changes in drug distribution and may arise as a result of diminished end organ function. Age-related decreases in renal function often impact on commonly prescribed antimicrobials. In addition, the elderly are more susceptible to drug-drug interactions because polypharmacy is common in this patient population. Streptogramins may offer a useful alternative in the treatment of infections in the elderly due to their coverage of organisms commonly causing infections in this population and because of their favourable pharmacokinetic profiles. While published experience is limited, streptogramins are not appreciably eliminated by the kidney and, therefore, they are less subject to age-related changes in renal elimination. What is required is multi-dose pharmacokinetic analysis of streptogramins in geriatric populations and subset analysis of patient use data on file. The following will provide the reader with the most recently presented data on streptogramin use and their potential. While focusing on potential use in the elderly, we have cited data and issues which we believe will be relevant in the geriatric population.

Aged↗
PubMed2002

Misoprostal use for therapeutic abortion in Siriraj Hospital: the year 2000.

OBJECTIVE: To evaluate the efficacy and the adverse effects of misoprostal usage for therapeutic abortion in Siriraj Hospital. STUDY DESIGN: Cross-sectional, descriptive study. MATERIAL AND METHOD: A consecutive series of 101 therapeutic abortions was performed in the Department of Obstetrics & Gynecology, Siriraj Hospital in the year 2000. The patients were interviewed for general information and registered, as well as in-patient data. Any adverse events were recorded and collected from the inpatient record file. All data were analyzed statistically. RESULTS: 42 therapeutic abortions were conducted in association with misoprostal usage. Misoprostal was used for cervical ripening in 8 patients with a good outcome. 31 therapeutic abortions were induced by misoprostal alone regimen. A higher success rate (74.1%) was correlated with higher gestational age. 27 out of 31 cases were second trimester abortion. The induction to abortion interval was 18.0+/-10.5 hours (range 5-48). No factor, including age, weight, total dose of misoprostal use, nulliparity and viability of the fetus, could be demonstrated to affect the misoprostal activity defined by induction to abortion interval. There was no serious adverse event, except for severe abdominal cramping (26.2%) and fever (14.3%). CONCLUSION: Misoprostal alone can be used with caution for abortion induction especially in second trimester abortion.

Abortifacient Agents, Nonsteroidal↗
PubMed1991

[EDP based medical records].

In our department we have begun to write our patients' medical history files in a computer data base. Each file is organized as a series of questions where it is possible to choose among several alternative answers instead of writing out each patient's history. We use a commercial software package modified to our specific needs. Statistical analysis of patients' files is included in the programme, to enable continuous quality control analysis of our performance.

Hospital Departments↗
PubMed1993

[Reporting and evaluation and a blood alcohol laboratory--automated by using a new databank system].

For the processing and evaluation of a large number of data obtained in the course of blood alcohol determination the use of computerized systems is essential. By applying the software Skylight a data management program was developed under Windows. After entering the case data (name of the person involved, type of offence, time of accident and of blood sampling etc.) and BAC-values the evaluation of the data is automatically performed, e.g. calculation of the mean value, BACs at the time of event (minimum and maximum value). The user is guided by screen menus, which facilitate the entry of data. Reports are created by using predesigned formats retrieved from a report file. The data base system is installed on a local network. Access is permitted by password only to guarantee optimal security of the data.

Accidents, Traffic↗
PubMed1990

A new system for follow-up patients with permanent pacemakers.

The use of a new computerized system for coordinating technical and clinical data and especially for filing the parameters found during out-patient checkups enables us to rationally carry out follow-up of approximately 900 patients with pacemakers in our electrostimulation laboratory without wasting time or data. The system is composed of a personal Olivetti M240 computer, with a 20 Bbyte and 640 Kram hard disk, an analog-digital interface and a personalized data base for coordinating and filing the parameters found. The type of pacemaker implanted (monocameral, dual chamber or rate responsive) is of no consequence to the system that is based on the acquisition of the surface electrocardiogram. A comparison of the filed data on printouts or graphs allows us to note every type of misfunction or anomaly in the stimulation system in real time.

Computer Systems↗
PubMedDate not supplied

The Automated Cognitive Test (ACT) system.

The ACT system is a key-press, menu-driven system for selecting, administering, and storing raw data from a series of specially designed psychological tasks. Associated task analysis programs process the raw data and store the resulting summary data for later statistical analysis. The system utilizes a cognitive approach to assessments of marginal toxicity by employing multiple performance parameters to specify a profile of deficits that, on the basis of a task's internal structure, can be related to functionally discrete cognitive systems. The tasks have been developed from a consideration of current cognitive theory and the areas of cognition include those of learning, memory, attention, reasoning, verbal, and spatial abilities. The ACT system is described in terms of its four major components: the cognitive tasks, the stimulus materials, the analysis methods, and the process of saving and combining summary data into files suitable for transfer to statistical analysis programs. The system thus automates the data collection to statistical analysis process.

Cognition↗
PubMed1997

[Limitations of the protein profile for diagnostic orientation in initial internal medicine consultation. Prospective study on 76 patients].

Determination of the protein profile of orientation (PPO) is now considered by some authors as a means of improving the diagnosis in internal medicine. The feasibility of systematizing this practice was investigated in 76 outpatients (79 included, three excluded secondarily) seen for pathology of undetermined diagnosis. The 79 patients (mean age: 52 years) underwent the classical biological explorations plus PPO. The physicians were divided into two groups (seniors and assistants). Two complete clinical files were established for each patient, with one difference concerning inflammatory and immunologic data: one file included the minimum number of tests considered necessary by the physician and the other the complete PPO (nine proteins). Each file (with or without PPO) was randomly distributed to one of two physicians in the same group. Each physician filled in a diagnostic evaluation sheet indicating whether there was organic pathology or not, the main diagnosis (inflammatory, neoplastic, infectious or other), the secondary diagnosis and the hypothesis of probability. The relevance of the clinical opinion was analyzed by an internal medicine specialist from outside the department with 40 years of clinical experience. The duration of symptoms before the medical visit was from 3 weeks to 5 years (mean 6 months). A diagnosis of organic pathology was reached for three out of four patients. Sixty-seven patients were seen again after a minimum of 6 months, and nine were lost to follow-up. Diagnostic efficiency was no greater for cases with PPO, which appears to be a biological examination of second intention. We suggest that the term "protein profile of orientation" be replaced by "broad protein profile."

Adult↗
PubMedDate not supplied

Rosuvastatin: a high-potency HMG-CoA reductase inhibitor.

OBJECTIVE: To summarize the relevant pharmacologic, clinical, and safety data regarding rosuvastatin (Crestor--AstraZeneca), the most recently marketed 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor approved for the treatment of dyslipidemia. DATA SOURCES: Medline search from years 1990 thru 2005 using the keywords HMG-CoA reductase inhibitor, hypercholesterolemia, lipid-lowering agents, rosuvastatin, and statins. STUDY SELECTION: Review articles, clinical trials, case reports, abstracts, and data on file from the manufacturer concerning rosuvastatin and other statins were considered for inclusion. DATA EXTRACTION: English-language studies were selected for inclusion. DATA SYNTHESIS: Multiple clinical trials have revealed that use of rosuvastatin is associated with greater reductions in low-density lipoprotein cholesterol (LDL-C) across the dose range of 5-40 mg/day than any other currently available statins. Rosuvastatin also significantly increases high-density lipoprotein cholesterol and reduces triglycerides significantly as well. In clinical trials, rosuvastatin was well tolerated, with a low incidence of adverse events and a safety profile similar to that of the other marketed statins. At present, no large-scale primary or secondary prevention clinical trials document either long-term safety of rosuvastatin or its effectiveness in preventing coronary events. CONCLUSION: Compared with other statins, rosuvastatin offers the greatest lipid-lowering efficacy at the lowest dose in treating patients with dyslipidemia and with a similar safety profile over the short-term. Rosuvastatin may allow more patients to achieve their LDL-C goals than any other statin and at a lower dose than other agents.

Cholesterol, LDL↗
PubMed2003

Olmesartan medoxomil: the seventh angiotensin receptor antagonist.

OBJECTIVE: To review the pharmacology, pharmacokinetics, efficacy, and adverse effects of olmesartan medoxomil, an angiotensin II receptor antagonist for the treatment of hypertension. DATA SOURCES: Information was obtained from MEDLINE searches (1996-April 2002) of English-language medical literature. Search terms included CS-866, olmesartan, olmesartan medoxomil, RNH-6270 (active metabolite of olmesartan), Benicar, angiotensin receptors, and antihypertensive agents. In addition, references from relevant articles were reviewed for additional citations. The authors independently reviewed literature identified in the searches. Studies evaluating olmesartan (i.e., abstracts, clinical trials, data on file with manufacturer) were considered for inclusion. STUDY SELECTION: All articles identified from data sources with pertinent information regarding olmesartan medoxomil were evaluated, and all information deemed relevant was included in this review. DATA SYNTHESIS: Olmesartan medoxomil is a competitively priced addition to the class of angiotensin II receptor antagonists. Monotherapy with olmesartan medoxomil in once-daily doses of 20-40 mg has produced significant reductions in systolic and diastolic blood pressure in hypertensive patients. Adverse effects have been minimal with olmesartan medoxomil, with dizziness being the only adverse effect occurring more often than with placebo in clinical trials. Additionally, animal studies indicate that olmesartan medoxomil may prove to be useful treatment for diabetic nephropathy, as well as atherosclerosis. CONCLUSIONS: Olmesartan medoxomil has a favorable safety and efficacy profile, with blood pressure-lowering effects comparable to those of other angiotensin receptor blockers (i.e., losartan, valsartan, irbesartan). At this time, formulary decisions will be driven primarily by economic issues. Theoretical benefits of olmesartan medoxomil in reducing atherogenesis and lowering angiotensin II concentrations better than the alternative agents will be determined only with more extensive research.

Angiotensin II↗
PubMed2002

Mortality and morbidity in white water rafting in New Zealand.

OBJECTIVES: This study provides the first descriptive overview of fatal and non-fatal injury associated with white water and other recreational river rafting in New Zealand. The current study sought to identify the nature and causes of hospitalisable injuries and to identify the causes of fatal injuries to white water rafters. DESIGN: The data were obtained from the New Zealand Health Information Service (NZHIS) mortality and morbidity files. Mortality data for the period from 1983 to 1995 and morbidity data from 1983-1996 were used. PARTICIPANTS: Members of the public who took part in white water and other recreational river rafting activities throughout the above periods. RESULTS: Of the 33 fatalities, over 80% were male. Almost all the fatalities involved drowning, more than a third resulting from the raft capsizing. Nearly half of the 215 hospitalisations resulted from fractures, victims spending an average of 3.3 days in hospital. The effects of submersion, and intracranial injuries were the next most common categories. CONCLUSIONS AND IMPLICATIONS: In relation to fatalities, the potentially modifiable risk factors involve improved resistance to raft capsizing, and equipment and skills required to stay afloat. In relation to injuries, the potentially modifiable risk factors relate mainly to preventing slipping and falling through the design of footwear, protective equipment, and procedures for entry and egress.

Adolescent↗
PubMed1993

Use of postal codes and addresses in the analysis of health data.

This article describes various ways of using postal codes and addresses to analyze health data. It gives examples of files that contain data suitable for coding to small areas, explains how the coding can be done efficiently using the Postal Code Conversion File (PCCF), and shows various ways of analyzing the resulting data. It also points out limitations of the data and methods, and suggests ways of avoiding or working around some of the problems frequently encountered. Examples are given of several types of analytical studies based on data coded to local area through use of postal codes and addresses. Examples are also given of simpler types of analysis not requiring recourse to the PCCF, which are based on only the first three characters of the postal code.

Abstracting and Indexing↗