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PubMed1964

KORSAKOFF'S SYNDROME ASSOCIATED WITH ADRENAL VIRILISM.

Korsakoff's syndrome of obscure etiology was observed in a 34-year-old single woman with an 11-year history of hirsutism and mood swings, and previous hospitalizations for mania three years ago and depression 11 years ago.Recently the virilism had intensified with increased muscularity and coarsening of facial features. The 24-hour urinary 17-ketosteroids ranged between 14.4 mg. and 21.5 mg. and were suppressed by dexamethasone. The 17-hydroxycorticosteroid excretion was normal. These and other findings suggested a diagnosis of adrenal virilism due to adrenocortical hyperplasia. In the absence of other discernible causes it appeared that the adrenal pathology was responsible for the Korsakoff's syndrome. Both conditions responded well to glucocorticoid therapy although low doses were necessary to avoid mania.It is speculated that the encephalopathy was due to an associated adrenal insufficiency. Although hypoadrenalism is accepted as a complication of only the infant form of adrenal virilism, it is noteworthy that this patient had pathological pigmentation of her skin.

17-Hydroxycorticosteroids↗
PubMed1992

Serum free and total iodothyronine concentrations in dogs with hyperadrenocorticism.

Serum concentrations of total and free thyroxine (T4 and FT4, respectively), 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (reverse T3) were measured in 42 dogs with hyperadrenocorticism, and were compared with values determined in clinically normal dogs. Mean total T4 concentration in dogs with hyperadrenocorticism (14.3 nmol/L) was significantly (P less than 0.001) lower than the normal value (25.7 nmol/L), with 38% of the dogs having low serum T4 concentration. Although 16 (38%) of the 42 dogs with hyperadrenocorticism had a high FT4 fraction, indicative of diminished serum T4 binding, normal FT4 concentration was found in only 6 of the 16 dogs (38%) with low total T4 values. Mean serum T3 concentration in dogs with hyperadrenocorticism (0.79 nmol/L) was also significantly (P less than 0.001) lower than the normal value (1.16 nmol/L), with 39% of the dogs having T3 values below the normal range. Individual T3-to-T4 and T3-to-FT4 ratios, indices of T3 production and/or clearance, were above the normal range in 29 and 24% of dogs with hyperadrenocorticism, respectively. Mean reverse T3 concentration in dogs with hyperadrenocorticism (0.17 nmol/L) was also significantly (P less than 0.001) lower than the normal mean value (0.39 nmol/L), with 48% of the dogs having reverse T3 values below the normal range. Of the 21 dogs in which all iodothyronines were measured, 6 (29%) had undetectable values for all hormones.(ABSTRACT TRUNCATED AT 250 WORDS)

Adrenocortical Hyperfunction↗
PubMed1992

[Formal pathogenesis, average age and breed distribution in the comparison of 61 Lysodren-treated and 36 untreated cases of canine hyperadrenocorticism which were dissected in the years 1975 to 1991 at the Institute for Veterinary Pathology of the Free University of Berlin].

61 Lysodren -treated dogs with hyperadrenocorticism are compared with 36 untreated dogs with the same disease. 75.14% of the treated dogs had pituitary-dependent-hyperadrenocorticism (PDH) whereas this diagnosis was found in 63.89% of the untreated dogs. A functioning adrenocortical tumor (FAT) was found in 13.11% of the treated dogs but was evident in 22.22% of the untreated dogs. Simultaneous pituitary and adrenal Cushing's syndrome (PDH/FAT) were found in 11.48% of the treated and 8.33% of the untreated cases. Sex distribution was equal in both groups. Overall slightly more females than males were affected by the disease. Poodles (38.14%) and dachshunds (23.71%) were the mainly affected races. Race-distribution of diseased animals is compared to the overall race-distribution in a ten years statistic (1981-1990) of all necropsied animals (Walter und Schwegler, 1992). The mean age of Lysodren -treated dogs with a PDH diagnosis (10.0 years) is lower as the mean age of untreated dogs with the same diagnosis (10.3 years). Reasons for this unexpected finding are discussed.

Adrenal Cortex Neoplasms↗