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Multimodal inhibition of return effects in adults with and without Down syndrome.

Data from a previous study (Welsh & Elliott, 2001) has been reanalyzed to explore inhibition of return (IOR) effects in adults with and without Down syndrome (DS). Participants were required to react and move with either the left or right hand as quickly as possible to 1 of 2 target locations based on either a visual or a verbal cue. Although persons with DS demonstrated a different pattern of information processing capabilities, they demonstrated the same magnitude of IOR across all conditions of presentation as their peers without DS. This pattern of results provides further support for the multimodal and response-based nature of IOR. Moreover, the results indicate that the inhibitory processes that underlie IOR in the average population seem to be functional in persons with DS.

Acoustic Stimulation↗

Emotional and behavioural problems in adolescents/young adults receiving treatment at a community-based psychotherapy centre for young people: a preliminary study of the correspondence among adolescent/young adult and significant other reports.

The present study examined the correspondence among adolescent/young adult and parental figure, professional, peer and partner reports, in their rating of emotional and behavioural problems of 195 young people aged between 12 and 25 years who attended a community-based psychotherapy centre. Data from young people were obtained at intake by participants completing the Youth Self Report Form and from significant others by them completing the Significant Other version of the Teacher's Report Form. Professionals rated internalizing (emotional) problems lower than peers, partners or parental figures. Externalizing (disruptive) problems were rated lowest by professionals, highest by partners with parental figures and peers in between. Agreement for internalizing problems was highest between self and professionals and lowest for partners and peers; parental figures were in between these two extremes. For externalizing problems, agreement was highest between self and friends but very low for partners. Professionals' ratings of internalizing problems showed a strong association with clinicians' assessment of global functioning and there was a strong association between partner ratings of total problems and clinicians' ratings of global functioning. The study showed the value of using a wider range of informants for assessing emotional and behavioural problems presented by young people seeking treatment than used in the assessment of pre-adolescents.

Adolescent↗

Morphofunctional parameters and adaptation capabilities of students at the beginning of the third millennium.

On the basis of comprehensive anthropometrical observation of 1st and 2nd year students from different faculties of Moscow State University (MSU) carried out in 2002-2003, functional characteristics of the cardiovascular system (systolic and diastolic blood pressure, heart rate) were investigated in 205 young men and 327 young women along with traditional morphological parameters. In comparisons of contemporary young men and women with their peers, whose characteristics were obtained in the course of investigations carried out over the period 1920-1990, secular trends towards an increase of body length and a worsening of strength indices were detected. Evaluation and comparative analysis of adaptation capabilities of students were carried out based on screening and assessment of adaptation potential using the Bayevsky method (1987). It was shown that the parameters of physical development and the level of adaptation of an organism to environmental conditions can be used as additional markers for determination of the health status of contemporary students for early prevention of some diseases, improvement of their physical status and increase of adaptation potentials.

Adaptation, Physiological↗

Bilateral optic nerve abnormalities associated with a 4-10 chromosomal translocation.

A neonate with ocular abnormalities and a chromosomal aberration is described. The patient demonstrates a typical choroidal coloboma involving the iris ciliary body and choroid of the right eye, bilateral optic pits-coloboma and a karyotype with a 4-10 chromosomal translocation. Although a random occurrence of the ocular phenomena and the chromosomal aberration cannot be ruled out, it is appealing to speculate about the possible association of the ocular colobomata and the chromosomal translocation harbored by this patient.

Choroid↗

Verapamil increases the bacteriostatic and bactericidal effects of adriamycin on Escherichia coli.

The purpose of this study was to evaluate the effect of verapamil on adriamycin-resistant and -sensitive Escherichia coli bacterial strains. Two E. coli strains: B-SR9 and K12-KL16 were incubated with adriamycin in various concentrations in the presence or absence of verapamil. Growth and killing rates were measured using optical densities and colonogenic assays. Transmembrane transport capacity was evaluated by measuring radioactively labelled leucine uptake and intracellular potassium concentrations. While adriamycin (ADR) showed both bacteriostatic and bactericidal effects upon the two bacterial strains, the K12 strain was significantly more resistant to the drug than its peer. Subtoxic concentrations of verapamil augmented these effects in both strains. Verapamil affected bacterial transmembrane transport activity and caused potassium leakage through the cell membrane. Simultaneous exposure to adriamycin and verapamil resulted in rapid, massive damage to membrane functions, indicating accelerated killing rate. The authors concluded that verapamil acts as a potentiator of adriamycin's cytotoxicity in E. coli bacteria in a manner similar to that in multidrug resistant mammalian tumour cells. This observation suggests that the mechanisms of resistance to the drug may be similar in both species.

Antibiotics, Antineoplastic↗

Communicative performance of mentally retarded adults in four conversational settings.

A sociolinguistic analysis of the communicative performances and social interactions of four mentally retarded adults was conducted. Role relationships were examined along dimensions of dominance-submission and control in various conversational settings. Audiotape recordings were made of each adult's conversation while engaged in discourse with his speech-language pathologist, peers, parents, and with a normal young child. Relational communication coding schemes involving the analysis of questions and subsequent responses were applied to the data. Results indicated that the retarded adults, though not always able to hold a dominant position in a conversation, were capable of expressing the same types of control as normal adults. The types of control expressed by each subject varied as a function of the conversational setting. Furthermore, differences existed in the types and frequencies of control expressed across subjects. These findings suggest that a sociolinguistic approach provides important information regarding the mentally retarded adult's communicative performance.

Adult↗

Early predictors of parent- and self-reported perceived global psychological difficulties among adolescents: a prospective cohort study from age 3 to age 15.

AIMS: To study predictors at age 3 and at age 12 for parent and self-reported perceived global psychological difficulties at age 15. METHOD: A representative birth cohort was prospectively followed from early childhood to age 15. Ratings of children's behavioral and emotional problems were collected at age 3 (Child Behavior Check List 2/3) and at age 12 (Child Behavior Check List 4-16, Youth Self Report). Mothers and fathers separately completed a questionnaire on their own well-being, health and mental distress when the child was 12. At the same time-point, family functioning was measured with the Family Assessment device. Outcome variables included both parent and self-reports of children's perceived psychological difficulties at age 15. RESULTS: At age 15, of the 707 children with both parent and self-reports on perceived difficulties available, 10% had more perceived difficulties than peers of the same age in parent or self-reports. There was a significant increase in perceived difficulties from age 12 to age 15 in self-reports but not in parent reports. The parent-child agreement on difficulties at both time-points was very low (proportion of agreement 0.12-0.17). At age 3, externalizing problems, especially aggressiveness, predicted parent reports of child's difficulties at 15 years of age in univariate analysis. At age 12, parent-reported child's externalizing symptoms and perceived difficulties, poor social competence in self-reports, and mothers' reports of her own poor well-being, independently predicted parents' reporting of their child's perceived difficulties at age 15. Self-reports of internalizing problems and mother's own reports of her depressiveness when the child was 12 independently predicted the 15-year old's self-reported difficulties. Furthermore, in univariate analysis, poor family functioning at age 12 predicted perceived difficulties in parent and self-reports. CONCLUSIONS: Both parent and self-reports of a child's difficulties are the outcome of an accumulation of the child's psychopathology, parental distress, and family dysfunction. The results emphasize the importance of early detection of children at risk of negative developmental pathways. In clinical practice and in prevention interventions, it is important to take into account the child's individual psychopathology, parental distress, and family dysfunction.

Adolescent↗

The effects of long-term endurance training on the immune and endocrine systems of elderly men: the role of cytokines and anabolic hormones.

BACKGROUND: A decline in immune and endocrine function occurs with aging. The main purpose of this study was to investigate the impact of long-term endurance training on the immune and endocrine system of elderly men. The possible interaction between these systems was also analysed. RESULTS: Elderly runners showed a significantly higher T cell proliferative response and IL-2 production than sedentary elderly controls. IL-2 production was similar to that in young adults. Their serum IL-6 levels were significantly lower than their sedentary peers. They also showed significantly lower IL-3 production in comparison to sedentary elderly subjects but similar to the youngs. Anabolic hormone levels did not differ between elderly groups and no clear correlation was found between hormones and cytokine levels. CONCLUSION: Highly conditioned elderly men seem to have relatively better preserved immune system than the sedentary elderly men. Long-term endurance training has the potential to decelerate the age-related decline in immune function but not the deterioration in endocrine function.

Journal Article↗

Functional measurement assessment of young children's ability to predict future behavior.

The reported experiments demonstrate that young children's ability to use previous behavioral information to predict future behavior emerges on quantitative, but not dichotomous, judgment tasks. In a first experiment, kindergartners, second graders, and fourth graders made quantitative liking judgments and predictions for peers after being presented 2 pieces of behavioral information. Children of all 3 age groups used both pieces of information in their liking judgments and predictions. In a second experiment, kindergartners were presented with 2 types of tasks; one was a quantitative prediction, comparable to the task in Experiment 1, and the second were dichotomous predictions, comparable to judgment tasks typically used in other experiments. Children's predictions were significantly more consistent with the behavioral information on the quantitative task than on either of the dichotomous tasks. These results suggest that young children believe in the ability of interpersonal behavior, but have difficulty dealing with the complexity of some prediction tasks.

Child↗

The impact of an emotional self-management skills course on psychosocial functioning and autonomic recovery to stress in middle school children.

Unmanaged emotional reactions to stress not only lead to behavior problems in young people but also create physiological conditions that inhibit learning and potentially increase the risk of disease later in life. For these reasons, the integration of emotional self-management skills training programs has become an increased priority in some schools. In this study, middle school students enrolled in a course in emotional competence skills learned techniques designed to intercept stressful responses during emotionally challenging situations. Behavioral outcomes were assessed using the Achievement Inventory Measure and autonomic function was measured by heart rate variability (HRV) analysis during and after a stressful interview. Following the program, students exhibited significant improvements in areas including stress and anger management, risky behavior, work management and focus, and relationships with family, peers and teachers. These improvements were sustained over the following six months. Students using the skills taught in the course to recover from acute emotional stress were also able to positively modulate their physiological stress responses. As compared to a control group, trained students demonstrated significantly increased HRV and more rhythmic, sine wave-like heart rhythm patterns during recovery. This response pattern reflects increased parasympathetic activity, heart rhythm coherence, and entrainment of other biological oscillatory systems to the primary heart rhythm frequency. Increased physiological coherence is associated with improved cognitive performance, emotional balance, mental clarity and health outcomes. These physiological shifts could promote the sustained psychological and behavioral improvements associated with the use of emotional management skills. It is suggested that learning emotional competence skills in childhood establishes healthier physiological response patterns which can benefit learning and long-term health. Results provide support for the integration in school curricula of courses designed to teach effective self-management skills to children.

Acute Disease↗

Physical fitness testing in children operated on for tracheoesophageal fistula.

The maximal physical activity capacity of children operated on for tracheoesophageal fistula (TEF) has not been clearly defined. Eight patients (average age, 12 years) successfully operated on for TEF at birth underwent maximal exercise stress testing on a treadmill, according to the Bruce protocol, to test physical work capacity. Heart rate (HR), oxygen consumption (VO2), and pulmonary ventilation (VE) were measured by a portable lightweight telemetric device. Nine healthy children served as controls. Exercise duration was significantly lower for TEF subjects than for controls (11.6 +/- 1.7 minutes v 15.1 +/- 2.3 minutes; P < .01). Mean HR at rest and during exercise did not differ between the groups. All children reached the maximum HR according to their age; however, for the majority of TEF patients, this occurred at an earlier stage than in the controls. No differences were seen in mean VO2 at rest and on exertion between TEF and control children. However, maximal VO2, as measured at the end of exercise, was significantly different when normalized per kilogram of body weight (VO2/kg = 52.3 +/- 5.8 v 33.3 +/- 6.6; P < .005). The physical rehabilitation of TEF children usually takes into account only respiratory and nutritional factors. However, complete assessment of their cardiac and respiratory function, at rest and on exertion, also should be performed, because this may show that some patients have reduced motor performance; evidence is now accumulating that these children can safely participate in the same physical activities of their healthy peers.

Adolescent↗

Cross-linking of presynaptic calcium channels: a mechanism of action for Lambert-Eaton myasthenic syndrome antibodies at the mouse neuromuscular junction.

Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder of neuromuscular transmission. Immunoglobulin G (IgG) autoantibodies act presynaptically to cause functional loss of Ca2+ channels by down-regulation. This in turn causes reduced release of acetylcholine in response to nerve stimulation (i.e. reduced quantal content). We show here that in vitro application of LEMS IgG for 24 h was as effective in causing reduced quantal content in mice as injecting animals with the antibody for 2 days. Furthermore, incubation with divalent (F(ab')2) fragments also significantly reduced quantal content. However, monovalent (Fab) fragments were without significant effect. No antibody or antibody fragment preparation affected spontaneous release. Whole LEMS IgG and F(ab')2 (but not Fab) fragments also inhibited K(+)-evoked 45Ca2+ flux in a small cell carcinoma cell line. These findings present functional evidence that LEMS IgG-induced down-regulation of nerve terminal Ca2+ channels arises due to antibody cross-linking of these channels.

Acetylcholine↗

Computer network home care demonstration: a randomized trial in persons living with AIDS.

PURPOSE: As Internet-based health care applications grow, it is important to determine their acceptability to ill persons and the likely outcomes resulting from their use. This randomized field investigation demonstrated the use and effects of a specialized computer network, the ComputerLink, among persons living with AIDS (PLWA). HYPOTHESIS: This study was designed to determine whether a home-based computer network designed for people with AIDS (PLWA) would be used and whether it would reduce social isolation and improve confidence and skill in decision making without causing differential decline in health status among PLWA. INTERVENTION: Wyse 30 terminals were placed in private homes, linked via a 1200 baud modem to a public access computer network. Services available to PLWA included an on-line electronic encyclopedia, public and private communication and a decision support system; all services were coordinated by a registered nurse. DESIGN: A six-month randomized trial involved 57 community-dwelling PLWA; 31 were in the experimental group. Mean age was 33, 93% were male, 61% white, 34% working, 13.5 mean years education. Six participants were lost to follow-up. RESULTS: 8449 accesses to the system were made during the study period. Mean number of access per participant was 192, the median, 129. Duration of access averaged 12 min. PLWA used two services during each session. First order hypotheses testing revealed no significant difference between experimental and control group participants. Post hoc exploration indicated that use of the system did reduce social isolation once participants levels of depression were controlled and that decision making confidence improved as a function of number of accesses. CONCLUSION: Computer networks provide feasible alternatives for the delivery of health services to home-bound individuals. Communication services were used more extensively than other services, suggesting that the primary mechanism of intervention is peer contact. Similar to other experiments, system use improves confidence, though not skill, in decision making. The Internet represents a promising pathway to reaching home-bound patients and providing them with information, communication and decision assistance.

Acquired Immunodeficiency Syndrome↗

Tumors of the spine and spinal cord.

OBJECTIVES: To provide an overview of spinal cord neoplasms with a focus on location, histology, pathophysiology, diagnosis, treatment and nursing assessment and management. DATA SOURCES: Published books and peer-reviewed articles. CONCLUSIONS: Tumors of the spine and spinal cord are rare, and they can have grave implications for the patient. The key in the management of spinal cord tumors is their timely diagnosis and treatment to preserve function. IMPLICATIONS FOR NURSING PRACTICE: A thorough nursing assessment and timely intervention can have a positive impact on the outcome of patients with tumors of the spine and spinal cord.

Humans↗

Systematic discovery of analogous enzymes in thiamin biosynthesis.

In all genome-sequencing projects completed to date, a considerable number of 'gaps' have been found in the biochemical pathways of the respective species. In many instances, missing enzymes are displaced by analogs, functionally equivalent proteins that have evolved independently and lack sequence and structural similarity. Here we fill such gaps by analyzing anticorrelating occurrences of genes across species. Our approach, applied to the thiamin biosynthesis pathway comprising approximately 15 catalytic steps, predicts seven instances in which known enzymes have been displaced by analogous proteins. So far we have verified four predictions by genetic complementation, including three proteins for which there was no previous experimental evidence of a role in the thiamin biosynthesis pathway. For one hypothetical protein, biochemical characterization confirmed the predicted thiamin phosphate synthase (ThiE) activity. The results demonstrate the ability of our computational approach to predict specific functions without taking into account sequence similarity.

Alkyl and Aryl Transferases↗

Pathogenesis of DNA repair-deficient cancers: a statistical meta-analysis of putative Real Common Target genes.

DNA mismatch repair deficiency is observed in about 15% of human colorectal, gastric, and endometrial tumors and in lower frequencies in a minority of other tumors thereby causing insertion/deletion mutations at short repetitive sequences, recognized as microsatellite instability (MSI). Evolution of tumors, including those with MSI, is a continuous process of mutation and selection favoring neoplastic growth. Mutations in microsatellite-bearing genes that promote tumor cell growth in general (Real Common Target genes) are assumed to be the driving force during MSI carcinogenesis. Thus, microsatellite mutations in these genes should occur more frequently than mutations in microsatellite genes without contribution to malignancy (ByStander genes). So far, only a few Real Common Target genes have been identified by functional studies. Thus, comprehensive analysis of microsatellite mutations will provide important clues to the understanding of MSI-driven carcinogenesis. Here, we evaluated published mutation frequencies on 194 repeat tracts in 137 genes in MSI-H colorectal, endometrial, and gastric carcinomas and propose a statistical model that aims to identify Real Common Target genes. According to our model nine genes including BAX and TGFbetaRII were identified as Real Common Targets in colorectal cancer, one gene in gastric cancer, and three genes in endometrial cancer. Microsatellite mutations in five additional genes seem to be counterselected in gastrointestinal tumors. Overall, the general applicability, the capacity to unlimited data analysis, the inclusion of mutation data generated by different groups on different sets of tumors make this model a useful tool for predicting Real Common Target genes with specificity for MSI-H tumors of different organs, guiding subsequent functional studies to the most likely targets among numerous microsatellite harboring genes.

Base Pair Mismatch↗

Selective serotonin reuptake inhibitor use in the treatment of the pediatric non-obsessive-compulsive disorder anxiety disorders.

The non-OCD (obsessive-compulsive disorder) anxiety disorders in the pediatric population- separation anxiety disorder, generalized anxiety disorder, and social phobia and others- are arguably the most common psychiatric disorders in this age group. Anxiety disorders, in addition to being common, also significantly impair the affected child at home, school, and with peers. A small developing evidence base suggests the selective serotonin reuptake inhibitors (SSRIs) are the pharmacological treatment of choice for pediatric non-OCD anxiety disorders. In clinical trials, SSRIs are often very effective in reducing symptoms and improving functioning and generally well tolerated. The U.S. Food and Drug Administration's (FDA) review of the safety of antidepressants in the pediatric population suggest a small, but significant, increased relative risk for suicidality adverse events on antidepressant versus placebo. Despite the apparent increased risk, the larger magnitude of benefit of the SSRIs for pediatric non-OCD anxiety disorders compared to depression suggests the benefit/risk ratio for anxiety disorders is more favorable than that for depression. This paper will review available studies on the treatment of non-OCD childhood anxiety disorders with antidepressants, including the SSRIs, and discuss pertinent safety issues.

Adolescent↗

Psychosocial and pharmacologic explanations of nicotine's "gateway drug" function.

Research has shown that adolescent users of tobacco are much more likely to progress to use of illicit drugs than are nonusers of tobacco. This article suggests potential psychosocial reasons for the progression based on principles of learning theory, Theory of Reasoned Action, Health Belief Model, and Cognitive Dissonance. In addition, a neuropharmacologic causal mechanism is discussed. The existence of tobacco's gateway function has important implications in the nation's efforts to reduce illicit drug use and adolescent smoking.

Adolescent↗