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Visualization of femorotibial contact in total knee arthroplasty using X-ray fluoroscopy.

The purpose of this study was to build a visualization technique of the femorotibial contact in fixed-bearing total knee arthroplasty (TKA) using X-ray fluoroscopy, and to apply this technique to a TKA patient during dynamic motion. In vivo kinametcis of the metallic knee implant was determined using a 2D/3D registration technique, which uses computer assisted design (CAD) model of the implant to estimate the 3D pose of radiopaque metallic femoral and tibial components from a single-plane fluoroscopic image. In fixed-bearing TKA, a 3D pose of radiolucent tibial polyethylene insert can be determined from the estimated pose of the tibial component. To visualize femorotibial contact, the proximity between surfaces of femoral component and tibial insert was calculated, and mapped onto the insert surface model. For the clinical application, dynamic states of contact on the tibial insert were observed including axial rotation and unilateral loading during knee flexion, and post-cam contact of posterior stabilized TKA. The present technique provided us new information and enabled us to better understand the relationship between in vivo knee kinematics and articular shape of the implant.

Arthroplasty, Replacement, Knee↗

Toward identifying specification requirements for digital bone-anchored prosthesis design incorporating substructure fabrication: a pilot study.

PURPOSE: This paper is the first in a series that aims to identify the specification requirements for advanced digital technologies that may be used to design and fabricate complex, soft tissue facial prostheses. MATERIALS AND METHODS: Following a review of previously reported techniques, appropriate and currently available technologies were selected and applied in a pilot study. This study uses a range of optical surface scanning, computerized tomography, computer-aided design, and rapid prototyping technologies to capture, design, and fabricate a bone-anchored auricular prosthesis, including the retentive components. The techniques are assessed in terms of their effectiveness, and the results are used to identify future research and specification requirements to direct developments. RESULTS: The case study identifies that while digital technologies may be used to design implant-retained facial prostheses, many limitations need to be addressed to make the techniques clinically viable. It also identifies the need to develop a more robust specification that covers areas such as resolution, accuracy, materials, and design, against which potential technologies may be assessed. CONCLUSION: There is a need to develop a specification against which potential technologies may be assessed for their suitability in soft tissue facial prosthetics. The specification will be developed using further experimental research studies.

Biocompatible Materials↗

One-step resection and reconstruction of the mandible using computer-aided techniques--experimental and clinical results.

In patients with advanced oral cancer, a resection of the mandible continuity is often indicated. This new method presented here uses computer-aided design and manufacturing (CAD/CAM) for preoperative fabrication of individual mandibular prostheses and their corresponding resection templates in a direct fashion without the need for additional physical models. In this experimental application, a segment of a dried mandible was resected and replaced by a titanium prosthesis prefabricated by CAD/CAM. It was the aim of this investigation to verify the processing chain and its precision, i.e., the fit of an individual implant, such as this. Although this new technique offers fascinating opportunities, possible clinical drawbacks have to be taken into account.

Bone Screws↗

The correlation between selected factors which influence dental aesthetics.

This study evaluated the inter-relationship between five aesthetic factors: the form of the face, tooth and arch, maxillary anterior tooth arrangement and palatal contour. An assessment was made to determine if correlation was sufficient to recommend their use as reliable aesthetic factors for the selection of suitable tooth moulds for edentulous and partially edentulous patients. This would enable the clinician to select a tooth mould at the chairside, based on an evaluation of the individual's aesthetic factors where, for example, the maxillary incisors should have the same outline shape as the individual's face. A computer program was developed incorporating images of the factors taken from 50 Caucasian adults aged 20-31 years and assessment of correlation made by outline superimposition and classification. The objectives were to design a computer program to analyse, classify and evaluate correlation between the five factors in each case by superimposition and classification. Correlation by superimposition recorded some concurrence between forms. The findings of this study suggest that there was insufficient correlation to support Nelson's 'Aesthetic Triangle', or Williams' face form/tooth theory. The incidence of correlation by classification between anterior tooth arrangement and arch form was sufficiently high to suggest their value as an aesthetic aid.

Adult↗

[The design and implementation of a computer application for managing a register of patients diagnosed with genetic mental retardation].

INTRODUCTION: In order to conduct studies of mental retardation of a genetic origin over the GIRMOGEN network, a computerised register of cases needs to be set up. MATERIALS AND METHODS: This register requires the implementation of a computer application consisting of a series of management programs together with the actual database. The aims of this work are: a) To analyse all the infrastructural, scientific and technical conditioning factors that allow the computer application and the databases associated to the register to be designed; b) To design all the elements that go to make up the application, namely, the application engine, consisting of all the programs responsible for providing all the operative capabilities, and the database for storing all the data structures with the variables related to the research; c) Implementing all the designs that are developed; and d) Drawing up the security protocols and work procedures involved in running the application. RESULTS: The result of all this process is the Girmogen-Pro software application, which includes all the capabilities needed to enable it to fulfil the scientific goals of the study. It includes the security measures required to comply with the current laws regarding the handling of files containing personal information. Furthermore, the data structures that will constitute the registers to be used in the study were also been built. CONCLUSIONS: This process does not end with the implementation of the designs, since an ongoing assessment process is also performed with the aim of optimising the data structures that contain the variables that go to make up the register, so as to ensure it fits the scientific objectives of the study as well as possible.

Humans↗

Shape memory alloy clip for compression colonic anastomosis.

This study was setup to investigate the design and performance of a shape memory alloy clip for colonic anastomosis. The thermo-mechanical properties of the shape memory alloy material were studied and the data were used to derive a nonlinear material model. This enabled the development of computer computer aided design models and finite element analysis of the clip and tissue compression. The maximum strain of the anastomosis clip was within the recoverable range, and it exerted parallel compression of the colonic walls with a uniform pressure distribution. The design of the anastomosis clip was optimized for safe, simple, and effective use in colon surgery.

Anastomosis, Surgical↗

Developments in the trans-tibial prosthetic socket fitting process: a review of past and present research.

A revolution in trans-tibial prosthetic design began at the end of World War II with the development of new materials and a dramatic improvement in the understanding of biomechanics. Early research was based mainly on the improvement of existing prosthetic design practice. Today, research has been focused on providing a better understanding of stump/socket interface biomechanics and improving socket fit by attempting to quantify the normal/direct stresses at the interface. The purpose of this review paper is to question whether research and prosthetic education/training to date has significantly improved our understanding of what makes a good socket. Although there is no doubt that advances in socket fitting techniques have been made what is not clear is the actual extent to which these advances have improved the quality of sockets fitted. It is suggested that a new approach is needed which can overcome some of the inherent problems of designing and manufacturing a comfortable high quality socket. It is also suggested that current research and education/training in the fields of pressure/interfacial interaction measurement and Finite Element Analysis techniques have limited potential to address many of these problems. There is also little evidence that current computer aided design systems offer any significant advantages over more conventional techniques.

Amputation, Surgical↗

Shape sensing for computer aided below-knee prosthetic socket design.

Shape sensing is useful in the computer aided prosthetic fitting process for two purposes. 1. To input characteristic prosthetic shapes that have been developed over the years through the experience of prosthetists. 2. To provide an accurate and rapid measurement of the anatomical shape of the stump. This paper describes two instruments which have been built to meet these objectives.

Amputation Stumps↗

Porous scaffold design for tissue engineering.

A paradigm shift is taking place in medicine from using synthetic implants and tissue grafts to a tissue engineering approach that uses degradable porous material scaffolds integrated with biological cells or molecules to regenerate tissues. This new paradigm requires scaffolds that balance temporary mechanical function with mass transport to aid biological delivery and tissue regeneration. Little is known quantitatively about this balance as early scaffolds were not fabricated with precise porous architecture. Recent advances in both computational topology design (CTD) and solid free-form fabrication (SFF) have made it possible to create scaffolds with controlled architecture. This paper reviews the integration of CTD with SFF to build designer tissue-engineering scaffolds. It also details the mechanical properties and tissue regeneration achieved using designer scaffolds. Finally, future directions are suggested for using designer scaffolds with in vivo experimentation to optimize tissue-engineering treatments, and coupling designer scaffolds with cell printing to create designer material/biofactor hybrids.

Animals↗

Principals of design and evaluation of an information system for a department of respiratory medicine.

OBJECTIVES: To evaluate a departmental computer system. DESIGN: a. Direct comparison of the time taken to use a manual system with the time taken to use a computer system for lung function evaluation, loan of equipment and production of correspondence. b. Analysis of the accuracy of data capture before and after the introduction of the computer system. c. Analysis of the comparative running costs of the manual and computer systems. SETTING: Within a department of respiratory medicine serving a hospital of 1323 beds. MAIN OUTCOME MEASURES: a. Time taken to perform functions with the assistance of computerised methods, in comparison to the manual method used alone. b. Accuracy of data capture. c. Relative running costs. RESULTS: a. The computer system (CS) was significantly faster than the manual system (MS) for lung function evaluation (CS = 7.63 min/test, MS = 12.25 min/test), loan of equipment (CS = 0.40 min/loan, MS = 2.07 min/loan), and checking for overdue equipment (CS = 0.49 s/record, MS = 9 s/record). The production of correspondence was slightly slower with the computer (CS = 9.30 min/letter, MS = 8.54 min/letter). b. All outpatient episodes, but only 43 of 65 (66%) of in-patient episodes, were captured. Lung function and managerial report data were accurate using both manual and computerised methods. The manual system for equipment loans was inefficient, and use of the computer resulted in the recovery of 221 nebulisers. c. Development costs for 1988-1990 were high (72,178 pounds). Only 1200 pounds to 1845 pounds per year was recovered directly from staff time saved by the computer but larger savings resulted from changes in work practice (4049-4765 pounds). After 10 years the projected deficit is 10,000 pounds per annum in running costs. CONCLUSIONS: In comparison with the manual methods, the computer system has shown significant advantages which provide accurate information, with significant favourable effects on working practices. In evaluating computer systems used in clinical practice it is essential to ensure that the projected work practice benefits are achieved without unacceptable costs in staff time, inaccurate data and high financial outlay.

Computer Systems↗

[Use of VR (virtual reality) software for preoperative implantation fitting with an implantable hearing aid as an example].

PURPOSE: To prove the feasibility of a preoperative fitting test for an implantable hearing aid using a VR environment. METHODS: A high-resolution spiral CT was performed after mastoidectomy in 10 temporal bone specimens. The bony structures were segmented and merged with the Computer-Aided Design (CAD) data of the hearing aid in a VR environment. For each specimen a three-dimensional fitting test was carried out by three examiners determining the implantability of the hearing aid. The implantation simulation was compared with the real implantation procedure performed by an experienced ENT surgeon. RESULTS: The used VR system enabled real-time 3D-visualisation and manipulation of CT- and CAD-data. All objects could be independently moved in all three dimensions. The VR fitting test corresponded closely with the real implantation. The implantability of the hearing aid was properly predicted by all three examiners. CONCLUSION: Merging CT and CAD data in a virtual reality environment bears high potential for the pre-surgical determination of the fit and mountability of medical implants in complex anatomical regions.

Cochlear Implantation↗

Adapting computer data storage to user group behaviour.

We have designed several interactive computer systems for financial analysts. In early designs we treated the analysts-computer interactive dialogue at a computer terminal as being isolated from group considerations. In a later system we were forced to make extensive technical changes to take account of data storage sharing. This sharing of data storage had to operate in a way which was consistent with existing group attitudes. The relevant features of this system are described, and reviewed after more than two years of operation. We conclude that many user-computer interactive dialogues cannot be designed as if they were 'private' to a single user, but must be considered in a wider context of the way in which members of a user group interact.

Journal Article↗

A preliminary investigation into the development of 3-D printing of prosthetic sockets.

The socket is considered an element of major importance in the makeup of a prosthesis. Each socket is a tailor-made device, designed to fit the unique geometry of the patient's residual limb. The design and manufacture of a prosthetic socket traditionally has been a manual process that relies on the use of plaster of Paris casts to capture the shape of the patient's residual limb and then artisan fabrication techniques to manufacture the socket. Computer-aided design and manufacturing technologies have overcome some of the shortcomings of the traditional process, but the final manufacture of the prosthetic socket is still performed manually. Rapid prototyping (RP), a relatively new class of manufacturing technologies, creates physical models directly from three-dimensional (3-D) computer data. Previous research into the application of RP systems to the manufacture of prosthetic sockets has focused on expensive, high-end technologies that have proven too expensive. This paper investigates the use of a cheaper, low-end RP technology known as 3-D printing. Our investigation was an initial approach to using a technology that is normally associated with producing prototypes quickly, some of which could not be manufactured by alternative means. Under normal circumstances, these printed components are weak and relatively fragile. However, comfortable prosthetic sockets manufactured with 3-D printing have been used in preliminary fittings with patients.

Amputation Stumps↗

Logarithmic simulated annealing for X-ray diagnosis.

We present a new stochastic learning algorithm and first results of computational experiments on fragments of liver CT images. The algorithm is designed to compute a depth-three threshold circuit, where the first layer is calculated by an extension of the Perceptron algorithm by a special type of simulated annealing. The fragments of CT images are of size 119x119 with eight bit grey levels. From 348 positive (focal liver tumours) and 348 negative examples a number of hypotheses of the type w(1)x(1)+. . .;+w(n)x(n)>/=theta were calculated for n=14161. The threshold functions at levels two and three were determined by computational experiments. The circuit was tested on various sets of 50+50 additional positive and negative examples. For depth-three circuits, we obtained a correct classification of about 97%. The input to the algorithm is derived from the DICOM standard representation of CT images. The simulated annealing procedure employs a logarithmic cooling schedule c(k)=Gamma/ln(k+2), where Gamma is a parameter that depends on the underlying configuration space. In our experiments, the parameter Gamma is chosen according to estimations of the maximum escape depth from local minima of the associated energy landscape.

Algorithms↗

A comparison of retrieval effectiveness for three methods of indexing medical literature.

Conventional approaches to indexing medical literature include the human assignment of terms from a controlled vocabulary, such as MeSH, or the computer assignment of all words in the title and abstract as indexing terms. Human indexing suffers from inconsistency, while word-based indexing suffers from the multiple meanings of words. SAPHIRE is a computer program designed to provide indexing using controlled terms that are assigned by computer, based on their occurrence in the title and abstract. In this first evaluation of SAPHIRE, the authors compared the retrieval performance of the three indexing approaches--human-based MEDLINE with text words; machine-based SAPHIRE with text words; and text words only--for searches by measuring recall and precision for each search using a test collection of 200 abstracts. The abstracts were judged by human reviewers for relevance as applied to 12 literature queries. The results suggest that text word indexing is more effective than indexing with MeSH terms. SAPHIRE's indexing performance was slightly inferior but the program has other advantageous features.

Abstracting and Indexing↗

Teaching microcomputing to student nurses: an evaluation.

This paper describes an introductory computer course designed for student nurses facing a career in nursing in which computers will play a major part. Questionnaires were given before and after the course. The purpose of the questionnaires were (a) initially to gain information about the students' previous computing experience, motivation and expectations of the course, and (b) to enable an evaluation to be undertaken. The course content, structure and results of the questionnaires are presented; modifications made to the course following the evaluation are mentioned and finally some of the issues which need to be considered when developing a computer course for nurses are raised.

Computer User Training↗

New cysteine derivatives with antiproliferative activity on melanoma cells.

Here we describe the rational design, computer-aided virtual ligand docking and synthesis of 19 nonpeptidic compounds designed to inhibit histone deacetylases and kill melanoma cells. Compounds were derived from cysteine, fused at the S-terminus to 4-butanoyl hydroxamate, and at the N-terminus to 4-(dimethylamino)benzoic acid. The latter was extended by coupling to amines to form a small library of prospective anti-cancer compounds. Four compounds were cytotoxic at sub-micromolar concentrations against cells of a particularly aggressive human melanoma (MM96L), and nine compounds showed selectivities of >or=5:1 for killing human melanoma instead of normal human fibroblast cells. The most active compounds were shown to cause hyperacetylation of histones due to inhibition of histone deacetylases. Further refinement of these compounds may produce an anti-tumor drug suitable for treating melanoma.

Antineoplastic Agents↗

[The computer-assisted spatial reconstruction of the hip acetabulum].

Computer aided design is a useful method in presenting graphics. By 2 simple computer programs written in BASIC and running on most home computers very clear plots of the 3-dimensional (3D) structure of joints like the acetabulum can be drawn quickly. By orthogonal transformations the 3D-body may be easily regarded from every possible point of view. The surface of the acetabulum may be emphasized by an optional automatic hatching between adjacent cutting bows. Further methods of automatic data entering from given joints are discussed.

Acetabulum↗