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At least 1,351 records · Page 75Linked to original sources
PubMed2006

Role of hyperpolarization-activated conductances in the lateral superior olive: a modeling study.

This modeling study examines the possible functional roles of two hyperpolarization-activated conductances in lateral superior olive (LSO) principal neurons. Inputs of these LSO neurons are transformed into an output, which provides a firing-rate code for a certain interaural sound intensity difference (IID) range. Recent experimental studies have found pharmacological evidence for the presence of both the Gh conductance as well as the inwardly rectifying outward GKIR conductance in the LSO. We addressed the question of how these conductances influence the dynamic range (IID versus firing rate). We used computer simulations of both a point-neuron model and a two-compartmental model to investigate this issue, and to determine the role of these conductances in setting the dynamic range of these neurons. The width of the dynamic regime, the frequency-current (f-I) function, first-spike latency, subthreshold oscillations and the interplay between the two hyperpolarization activated conductances are discussed in detail. The in vivo non-monotonic IID-firing rate function in a subpopulation of LSO neurons is in good correspondence with our simulation predictions. Two compartmental model simulation results suggest segregation of Gh and GKIR conductances on different compartments, as this spatial configuration could explain certain experimental results.

Action Potentials↗
PubMed2005

Changes in the latency of mouse inferior colliculus neuron responses depending on the position and direction of movement of spectral contrast.

Changes in the latency of mouse (Mus musculus) inferior colliculus neuron responses in the presence of wideband sound signals with spectral notches and noise bands with regularly varying central notch/band frequencies were studied. Relationships between the latency and the magnitude of the response on the one hand and the central notch/band frequency on the other were obtained (latency and spike count functions). Crossing of the margins of the excitatory areas of the responses of the frequency receptive fields of neurons by spectral notches/noise bands could lead to displacement of latency functions (and corresponding displacements in spike count functions). Direction-dependent shifts in latency and spike count functions were more characteristic of primary-like and V-shaped neurons. The most interesting feature of the directional sensitivity of inhibition-dependent neurons was the selective decrease in the latency and selective synchronization of the initial spike response (with a corresponding increase in the spike count). The dynamic properties of inhibition-dependent neurons can be explained on the basis of their selective sensitivity to the position of the spectral contrast in the frequency receptive field, which is associated with disinhibition, and by the nature of the distribution of the excitatory and inhibitory inputs. The extents of these effects depended on the spectral shape of the signals and the widths of the spectral notches.

Acoustic Stimulation↗
PubMed2005

Effects of the azimuthal position of stationary and moving sound images on the mismatch negativity phenomenon.

This report presents results obtained from studies of the phenomenon of mismatch negativity in conditions of dichotic stimulation with presentation of deviant stimuli modeling movement of a sound image towards or away from a standard stimulus and on presentation of stationary deviants located at an angle of 90 degrees to the standard. Standard stimuli were located close to the left or right ear or in the midline of the head. All deviant stimuli induced mismatch negativity. Movement of the deviant stimulus from the standard was found to induce mismatch negativity with the longest latency and smallest amplitude for all azimuthal positions of the standard stimulus. In addition, it was only in this direction of movement that there was a relationship between measures of mismatch negativity and the azimuth of the standard. It was suggested that the process of the recognition of differences between interaural delay times is significantly dependent on the nature of changes in this parameter at the moment at which the deviant stimulus is presented.

Acoustic Stimulation↗
PubMed2006

Effects of a sound source moving in a vertical plane on postural responses in humans.

The effects of moving sound sources on postural responses were studied. Sound source movement was simulated by sequential switching of loudspeakers located along an arch positioned in the sagittal plane relative to the subject. The total durations of the sound stimulus movement were 1.6, 3.2, and 4.8 sec. Signals of 1.6 and 3.2 sec led to decreases in the mean amplitude of oscillogram oscillations in the sagittal and frontal planes. Stabilogram curves averaged for all subjects for the signal of duration 4.8 sec showed that the center of gravity deviated during exposure to the sound stimulus towards the side opposite the direction of movement of the sound source.

Acoustic Stimulation↗
PubMed1989

An additive factors analysis of the effect(s) of location cues associated with auditory stimuli on stages of information processing.

The additive factors method (AFM) was used as a tool for assessing the locus (or loci) of the detrimental effect of auditory location cues in the chain of (visual) information processing. In the first experiment the location variable was factorially combined with response specificity, which is assumed to affect the response adjustment stage. A second experiment was performed in which movement amplitude, assumed to affect the response programming stage, was manipulated in addition to the location variable and a different variety of response specificity. Finally, the location variable was combined with relative S-R frequency, which is also assumed to affect the response programming stage, in a third experiment. The results of these experiments showed additive effects of the location variable with motor variables. The remaining two experiments were designed to assess the effects of location cues on response selection. In these experiments the location variable was combined with the number of response alternatives. Response speed decreased with an increase in the number of response alternatives. However, the effects of the location variable and number of response alternatives were additive. According to the additive factor logic, then, the results of experiments 1, 2 and 3 seem to indicate that the locus of interference of the location cues is not in the later response stages of the reaction process. The results of the last two experiments were interpreted to suggest that the effects of location cues and the number of response alternatives affect either different processes within the response selection stage or affect different process stages. It was concluded that the latter alternative explains most of the data currently available and that the stimulus identification stage is the most likely candidate for the locus of the location effect.

Adolescent↗
PubMed1980

Brain stem auditory evoked potentials are related to interaural time discrimination in patients with multiple sclerosis.

In a combined psychophysical-electrophysiological study on 29 patients with multiple sclerosis (MS), a compromised ability to make interaural time discriminations was nearly always found to be associated with 'abnormal' brain stem potentials evoked by clicks to at least one ear. However, no obvious relationships were found between evoked brain stem potentials and several other auditory behavioral measures such as interaural intensity discrimination, pure-tone thresholds and speech discrimination.

Adolescent↗
PubMed1987

The recruitment order of stapedius motoneurons in the acoustic reflex varies with sound laterality.

In many muscles, motor units are recruited in a fixed order with increasing strength of muscular contraction. We show that for the stapedius muscle of the cat, vastly different recruitment orders can be obtained, depending on which ear is acoustically stimulated. The data support the idea that the distribution of inputs to a motoneuron pool can be inhomogeneous and a significant factor in determining recruitment order.

Animals↗
PubMed1989

Non-N-methyl-D-aspartate receptors may mediate ipsilateral excitation at lateral superior olivary synapses.

Principal cells of the lateral superior olivary nucleus (LSO) are thought to receive a direct excitatory input from spherical bushy cells located in the ipsilateral ventral cochlear nucleus (VCN) and an indirect input from the contralateral VCN globular bushy cells via a secure synapse in the medial nucleus of the trapezoid body (MNTB). MNTB bushy cells project to the somata and proximal dendrites of LSO principal cells. LSO neurons display phasic 'chopper' temporal response patterns to ipsilateral tone-burst stimuli at characteristic frequency (CF), while binaural stimuli suppress this ipsilaterally evoked activity. This suppression is sensitive to interaural differences in intensity, phase and time, suggesting a role for these neurons in the localization of sound in space. In the present study, the nature of the neurotransmitter mediating fast ipsilateral excitation of LSO neurons was examined using iontophoretic application of excitant amino acid (EAA) agonists and antagonists. N-methyl-D-aspartate (NMDA) and quisqualate (QUIS) were used as agonists, while the selective NMDA receptor antagonist D. L-2-amino-5-phosphonovaleric acid (APV), and the non-selective receptor EAA antagonist cis-2,3-piperidine-dicarboxylic acid (PDA) were used to study ipsilaterally evoked neuronal responses. In 3 additional experiments the selective non-NMDA receptor antagonist 6,7-dinitroquinoxaline-2,3-dione (DNQX) replaced PDA. Ipsilateral, tone-evoked and spontaneous activities were generally enhanced by EAA agonists while partial blockade of tone-evoked, ipsilateral excitation was observed with EAA antagonists. Both PDA and DNQX more effectively blocked ipsilateral tone-evoked excitations and spontaneous activity than did the NMDA-receptor antagonist, APV.(ABSTRACT TRUNCATED AT 250 WORDS)

Acoustic Stimulation↗
PubMed1994

The effects of monocular enucleation on the representation of auditory space in the superior colliculus of the guinea-pig.

Multi-unit responses, to free-field auditory stimuli, in the superior colliculus were investigated in guinea-pigs following earlier removal of one eye. Enucleation resulted in disruption of the normal tuning parameter values and of the topographical precision of auditory responses in the SC both ipsilateral and contralateral to the enucleated eye. These data demonstrate that monocular enucleation prevents the normal development of the superior collicular auditory space map.

Aging↗
PubMed1984

Effects of sound frequency on behavioral and cardiac orienting in newborn and five-month-old infants.

Alert newborn and 5-month-old infants' responsivity to variations in spectral composition of a rattle sound was examined. Each child received four stimulus conditions: low-, mid-, and high-frequency bandpass-filtered rattles and an unfiltered broadband rattle. Stimuli were played through a single loudspeaker laterally positioned, and head orientation and cardiac responses to sound were recorded. Compared to other stimuli, the low-frequency sound elicited less head turning in both age groups, with this effect exaggerated in younger infants. Head orientation toward the mid-frequency, high-frequency, and broadband stimuli did not differ with age. For all conditions, latency and duration of newborns' head turning was longer than that of 5-month-olds. Newborns responded with cardiac deceleration only on trials when they failed to turn. When head turns occurred, an acceleratory cardiac response was obtained. Five-month-olds responded with reliable cardiac deceleration irrespective of head turning toward the sound. Heart rate change did not vary as a function of frequency at either age, suggesting that all stimuli were equally effective in eliciting the infant's attention.

Arousal↗
PubMed1985

The effects of sound duration on newborns' head orientation.

Two experiments assessed the importance of sound duration for eliciting head orientation responses from newborn infants. In Experiment 1, thirty infants turned with equal frequency toward 20-s continuous rattle sounds and 20-s trains of rattle segments. The duration of the rattle segments--14 and 100 ms (2/s), or 500 ms (1/s)--did not influence the likelihood of turning. Response latencies and durations proved quite similar for all stimuli. In Experiment 2, twenty-four infants heard continuous rattle sounds of four different durations: 1, 5, 10, and 20 s. They turned reliably to all stimulus durations; furthermore, the magnitude and temporal characteristics of head orientation responses did not differ for the four stimulus durations. These results suggest that the newborn's head orientation response may reflect a motor program that is initiated by auditory input and then executed in a similar fashion regardless of further stimulation.

Acoustic Stimulation↗
PubMed1988

Auditory sensitivity in school-age children.

Thresholds for octave-band noises with center frequencies of 0.4, 1, 2, 4, and 10 kHz and 1/3-octave-band noises centered at 10 and 20 kHz were obtained from children 6 to 16 years of age. Such thresholds, combined with those obtained previously for infants, preschool children, and adults, provide a detailed picture of developing auditory sensitivity between infancy and maturity. Continuing improvements in sensitivity are evident from infancy through the preschool period, well into the school years. For stimuli with center frequencies of 0.4 and 1 kHz, maximal sensitivity is achieved at about 10 years of age, compared to 8 years for stimuli of 2 and 4 kHz. For 10-kHz stimuli, there is little change beyond 4 or 5 years of age. Finally, 20-kHz stimuli yield maximal sensitivity at about 6 or 8 years of age, followed by a progressive decline to adult levels. These findings are considered in relation to auditory sensitivity in nonhuman species, to structural and functional development of the ear, and to possible changes in the efficiency of neural processing.

Adolescent↗
PubMed1991

Infants' coordination of auditory and visual depth information.

Using the preferential-looking procedure infants 5, 7, and 9 months of age were presented two videoimages side by side on separate monitors accompanied by a soundtrack that matched one of the images. Each infant was presented: (1) a stationary drum-beating toy paired with the same toy approaching and receding in depth, to assess infants' recognition both that changing sound amplitude is a property of an object that is moving in space and that constancy in amplitude is a property of a stationary object; (2) a drum-beating toy moving horizontally paired with one approaching and receding in depth, to assess infants' recognition that systematic increases and decreases in amplitude accompany object movement in a particular dimension, namely depth; and (3) two identical toys alternately approaching and receding in depth but out of phase (i.e., one approaching while the other is receding), to assess infants' recognition that increases and decreases in amplitude accompany a particular type of object movement in depth. Measures of mean duration of looking time indicated that the 5-month-olds looked reliably to the correct videoimage only for the stationary toy paired with the constant amplitude sound. The 7-month-olds recognized that changes in amplitude accompany object movement in depth but did not coordinate auditory with visual depth information as well as older infants. The 9-month-olds looked reliably to the correct videoimages in all conditions. Possible contributing factors to these developmental trends in performance are discussed.

Attention↗