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PubMed2006

Urinary retention can be the sole initial manifestation of acute myelitis.

Urinary retention is a frequent feature in patients with acute myelitis (AM). We here describe the result of a survey of 32 consecutive AM patients as to what extent of AM patients initially present with micturition disturbance. Among those, 3 patients (9%) were shown to have urinary retention as the initial sole manifestation, which was followed by dysesthesia of foot in 3 and leg weakness in 1; and the average interval between micturition disturbance and these second-appearing symptoms/signs was 11 days (8-15 days). Although initial presentation of urinary retention was not common, occurring in only 9% of all the AM patients, clinically it has relevance because patients who suffer urinary retention but have no obvious neurological symptoms may first see general physicians or urologists. In those patients, when obstructive disease has been excluded, AM should be considered.

Acute Disease↗
PubMed2005

Inhibitory avoidance memory retention in the elevated T-maze is impaired after perivascular manipulation of the common carotid arteries.

Perivascular manipulation promoted by the positioning of a silicone collar around the common carotid arteries causes local inflammation and has been suggested as an animal model of atherosclerosis. This manipulation induces biochemical and morphological changes that are similar to those observed in the early stage of atherosclerosis in humans. Based on evidences showing that atherosclerosis is associated with cognitive deficits in humans, we presently investigated the temporal consequences of the bilateral positioning of silicone collars around the common carotid arteries (n = 15) on inhibitory avoidance memory retention in male Wistar rats tested in the elevated T-maze. The effects of this procedure were compared to those observed in sham-operated animals (n = 15) and to those observed in animals submitted to permanent bilateral occlusion of the common carotid arteries (n = 16). Additionally we studied the effects of the pretreatment with the non-selective anti-inflammatory drug indomethacin (n = 13) or the selective COX-2 inhibitor celecoxib (n = 12) and compared the effects to those of the pretreatment with vehicle (n = 11). The results showed that the silicone collar implants induced deficits in memory retention when animals were tested 2 and 4, but not 15 or 30, days after surgery. Permanent bilateral occlusion of the common carotid arteries impaired avoidance retention up to 30 days after surgery. Pretreatment with indomethacin (2 mg/kg/day) or celecoxib (5 mg/kg/day) post surgery and up to 3 days thereafter did not prevent memory deficits caused by silicone collar implants. Our data suggest that the prostanoids that participate in the inflammatory process triggered by the placement of the silicone collar do not seem responsible for the deficit in memory retention observed during the first days after collar placement.

Animals↗
PubMed2004

Methylene blue improves brain oxidative metabolism and memory retention in rats.

Methylene blue (MB) increases mitochondrial oxygen consumption and restores memory retention in rats metabolically impaired by inhibition of cytochrome c oxidase. This study tested two related hypotheses using biochemical and behavioral techniques: (1) that low-level MB would enhance brain cytochrome c oxidation, as tested in vitro in brain homogenates and after in vivo administration to rats and (2) that corresponding low-dose MB would enhance spatial memory retention in normal rats, as tested 24 h after rats were trained in a baited holeboard maze for 5 days with daily MB posttraining injections. The biochemical in vitro studies showed an increased rate of brain cytochrome c oxidation with the low but not the high MB concentrations tested. The in vivo administration studies showed that the corresponding MB low dose (1 mg/kg) increased brain cytochrome c oxidation 24 h after intraperitoneal injection, but not after 1 or 2 h postinjection. In the behavioral studies, spatial memory retention in probe trials (percentage of visits to training-baited holes compared to total visits) was significantly better for MB-treated than saline control groups (66% vs. 31%). Together the findings suggest that low-dose MB enhances spatial memory retention in normal rats by increasing brain cytochrome c oxidase activity.

Animals↗
PubMed2006

The comparison of provisional luting agents and abutment surface roughness on the retention of provisional implant-supported crowns.

STATEMENT OF PROBLEM: In immediate implant loading, it is important to keep provisional restorations in place during early-phase healing. Current luting agents for provisional restorations may provide inadequate retention, creating a clinical challenge. PURPOSE: This study compared the retention of provisional autopolymerizing acrylic resin implant-supported single restorations with combinations of different implant abutment surface conditions and provisional luting agents. MATERIAL AND METHODS: Thirty solid titanium implant abutments (ITI), 4 mm high, were divided into 3 groups. Ten abutments were unaltered, 10 were airborne-particle abraded with 50-microm aluminum oxide, and 10 were roughened with a medium-roughness diamond rotary cutting instrument. Thirty implant analogs (ITI) were mounted in autopolymerizing acrylic resin blocks. A solid titanium implant abutment was placed in each implant analog and torqued to 35 N.cm. After fabrication of 4 provisional acrylic resin crowns for each abutment, provisional luting agents TempBond, TempBond NE, Life, and Zone were used to secure the provisional crowns to the respective abutments. All specimens were luted with one of the provisional luting agents for a given test. After ultrasonic cleaning of the abutments, another provisional crown was luted with another luting agent. All specimens were stored in 100% humidity environment for 1 day at 37 degrees C prior to testing. Each provisional acrylic resin crown was pulled from the abutment with a 500-kg load cell in a universal testing machine at a crosshead speed of 0.5 cm/minute, and tensile strength was recorded (N). Data were analyzed using analysis of variance (ANOVA) and the Scheffe test (alpha=.05). RESULTS: Tensile strength was significantly higher for Life and TempBond NE than for TempBond and Zone, regardless of the surface conditions (P=.0001). The result of the 2-way ANOVA indicated that a significant interaction existed between the provisional luting agents and surface conditions (P=.0039). TempBond NE showed significantly higher tensile strength when combined with airborne-particle-abraded surfaces compared to other combinations (P=.011). However, no difference was found in tensile strength of Life and Zone between different combinations. The tensile strength of TempBond was lower when used with the unaltered surface compared to other combinations (P=.001). CONCLUSION: Surface modification of an implant abutment by airborne-particle abrasion or diamond rotary cutting instrument did not improve retention of a provisional acrylic crown when Life or Zone was used as the luting agent. Airborne-particle abrasion may be an effective method to increase retention of a provisional acrylic crown when TempBond NE is used.

Acrylic Resins↗
PubMed2006

Urodynamic predictors of outcomes with photoselective laser vaporization prostatectomy in patients with benign prostatic hyperplasia and preoperative retention.

OBJECTIVES: To determine whether preoperative urodynamic parameters can predict the outcome in men in urinary retention and aid in counseling these men. METHODS: Forty men in urinary retention due to benign prostatic hyperplasia underwent photoselective laser vaporization prostatectomy (PVP). Preoperative urodynamic studies were used to identify the men with detrusor overactivity (DO) and impaired detrusor contractility (IDC). The International Prostate Symptom Score (IPSS), maximal flow rate, and postvoid residual urine volume were collected at 1, 3, 6, and 12 months after PVP. RESULTS: Of the 40 men, 8 (20%) had IDC and 30 had DO (75%) preoperatively. The men without preoperative DO had a significantly lower IPSS than those with preoperative DO at 1 month of follow-up. Men without preoperative IDC had a significantly lower IPSS and postvoid residual urine volume at the same point compared with men with preoperative IDC. The flow rate in men with preoperative IDC 1 and 6 months postoperatively was significantly lower than in men without preoperative IDC. CONCLUSIONS: Preoperative urodynamic parameters predict for outcome in men in urinary retention undergoing PVP. Men in urinary retention benefit from PVP with an improvement in both subjective and objective voiding function, regardless of the presence of DO or IDC. Postoperatively, patients with DO have more voiding symptoms than those without DO, and are almost twice as likely to require anticholinergics. Men without IDC have better IPSS, flow rates, and postvoid residual urine volumes compared with men with IDC. Of the 8 men with IDC, 3 required reoperation within the first year.

Humans↗
PubMed2004

Spatial memory retention is enhanced by acute and continuous estradiol replacement.

Estradiol replacement to ovariectomized female rats causes dramatic changes in hippocampal structure and function as well as in performance on hippocampally dependent tasks. Using a delayed matching-to-place version of the water maze, the present study examines the time course of estradiol-induced enhancements in memory retention as well as the effectiveness of acute and continuous patterns of replacement. One 10-microg injection of estradiol administered on each of two successive days resulted in significant improvements in memory retention that persisted for approximately 4 days following the second injection. When estradiol administration continued for 10 consecutive days, these improvements in memory retention persisted. These findings indicate that estradiol replacement can improve memory retention and that these improvements can be maintained by continuous replacement for at least 10 days.

Analysis of Variance↗
PubMed2002

Effects of histamine and opioid systems on memory retention of passive avoidance learning in rats.

The present study investigated the effect of interactions between histamine receptor agents and the opioid peptidergic system on memory retention of passive avoidance learning in rats. Post-training intracerebroventricular (i.c.v.) injections were carried out in all the experiments. Administration of histamine (20 micro g/rat) reduced, but the histamine H(1) receptor antagonist, pyrilamine (20 and 50 micro g/rat), and the histamine H(2) receptor antagonist, cimetidine (10 and 50 micro g/rat), increased memory retention in rats. The histamine receptor antagonists decreased the response induced by histamine. Morphine (1-10 micro g/rat) reduced, while pentazocine (5 and 10 micro g/rat) or the opioid receptor antagonist, naloxone (5 and 15 micro g/rat), increased memory retention. The combination of histamine with morphine showed potentiation. Effects of pyrilamine and cimetidine were attenuated by morphine. The responses to pentazocine and naloxone also were decreased by histamine. It is concluded that the histaminergic system has an interaction with opioidergic system that is involved in the memory retention process.

Animals↗
PubMed2002

Effects of alpha-adrenoceptor agonists and antagonists on histamine-induced impairment of memory retention of passive avoidance learning in rats.

The effect of alpha-adrenoceptor agents on the impairment induced by histamine was measured for memory retention of passive avoidance learning in rats. Post-training intracerebroventricular (i.c.v.) injection was carried out in all the experiments. Histamine (5, 10 and 20 microg/rat) reduced, while a histamine H(1) receptor antagonist, chlorpheniramine (0.1, 1 and 10 microg/rat), increased memory retention. The histamine H(2) receptor antagonist, ranitidine (0.1, 1, 10 and 20 microg/rat), did not elicit any response in this respect. Different doses of chlorpheniramine but not ranitidine reversed the histamine-induced impairment of memory. Clonidine and prazosin decreased, but yohimbine and phenylephrine increased, memory retention. Yohimbine decreased the inhibitory response to histamine. Phenylephrine, clonidine and prazosin did not alter the histamine effect. It is concluded that a histamine-induced impairment of memory retention through histamine H(1) receptors and an alpha(2)-adrenoceptor mechanism may be involved in the histamine response.

Adrenergic alpha-Agonists↗
PubMed2000

Effects of abutment size and luting cement type on the uniaxial retention force of implant-supported crowns.

STATEMENT OF PROBLEM: The assumption that increasing the diameter of the abutment/crown components will provide greater resistance to crown loosening forces than standard-sized components has not been reported either with clinical trials or in the laboratory. PURPOSE: This study attempted to determine what effect abutment dimension and type of luting agent have on the retention of the prosthetic crown. METHODS AND MATERIAL: Test specimens consisted of standard, wide, and "experimental" CeraOne titanium abutments and matching CeraOne gold cylinders cemented with a zinc phosphate permanent or a zinc oxide eugenol provisional cement. The mean uniaxial force (Newtons) and the load (MPa) required to dislodge the cylinder from the abutment was determined. Statistical analysis of the sample data was performed using a 2-way analysis of variance test (alpha=.05). RESULTS: Mean uniaxial resistance force (Newtons) was significantly greater for zinc phosphate cement than for zinc oxide cement (P <. 001). Abutment size was a significant factor when permanent luting cement is used (P <.001). Retention strength per unit area (MPa) of the wide abutments was lower than the standard size and "experimental" abutments. CONCLUSION: Permanent luting cement produced uniaxial retention forces approximately 3 times greater than provisional cement. The increase in surface area provided by a wide abutment did not result in an improvement in retention strength over the standard abutment.

Analysis of Variance↗
PubMed1995

Retentive ability of various denture adhesive materials: an in vitro study.

This in vitro investigation of the retentive ability of various commercially available denture adhesives was performed by measuring the adhesion and cohesion that developed between a glass surface and an acrylic resin disk surface when some liquids, adhesive materials, or both were placed between them. Student's paired t-test, repeated measures, and two-factor design analysis of variance were performed to determine the significance among mean values. The adhesive materials studied exhibited a significantly greater retentive ability than that of saliva, and their retentive ability increased significantly when they were used in combination with artificial saliva. Highly significant differences of the retentive ability among the different brands of denture adhesives were observed.

Acrylic Resins↗
PubMed1997

Influence of tooth surface roughness and type of cement on retention of complete cast crowns.

STATEMENT OF PROBLEM: Bond strength of luting cements to dentin is a critical consideration for success of cast restorations. PURPOSE OF STUDY: This study determined the relationship between surface characteristics of teeth prepared for complete cast crowns and retention of respective cemented restorations. MATERIAL AND METHODS: Ninety artificial crowns were cast for standardized complete crown tooth preparations accomplished with the use of a milling machine on extracted human teeth. Diamond, tungsten carbide finishing, and cross-cut carbide burs of similar shape were used. The crowns in each group were randomly subdivided into three subgroups of 10 for the three luting cements selected for this study: zinc phosphate cement (Fleck's), glass ionomer cement (Ketac-Cem), and adhesive resin cement (Panavia-EX). Retention was evaluated by measuring the tensile load required to dislodge the artificial crowns from tooth preparations with an Instron testing machine. RESULTS: Analysis of forces with parametric analysis of variance and Tukey's Studentized Range (HSD) disclosed a statistically significant difference for both luting cement and finishing burs (p < 0.001). A statistically significant interaction effect (p < 0.001) was also found. The greatest retention value (372.9 N) was for tooth preparations refined with carbide burs and cemented with Panavia-EX cement. However, the least retention value (201.6 N) was for tooth preparations completed with finishing burs and luted with zinc phosphate cement. CONCLUSIONS: Significant differences were found among all three cements for finishing burs. However, there was a difference only between Panavia-EX cement and the other two cements for tungsten carbide burs. For diamond rotary instruments, zinc phosphate cement was significantly different from glass ionomer and Panavia-EX cements.

Analysis of Variance↗
PubMed1999

Method for enhancing retention in complete denture bases.

STATEMENT OF PROBLEM: Physical retention of a denture depends on adhesion of a salivary film to its fitting surface and supporting tissues. Adhesion is influenced by many factors. PURPOSE: This study examined the effect of the texture of the fitting surface on denture retention. MATERIAL AND METHODS: According to the method developed, mucosal-supported palatal bases were made for 10 dentate subjects who had no obvious oral disease, history of allergy to dental materials, or palatal mucosal undercuts. A specially designed strain gauge force transducer and a pen-chart recorder were used to record forces that were needed to dislodge the bases from the palate. Forces were recorded 30 times (10/day) for each subject. Similar forces were recorded after the fitting surface of each base was uniformly air-particle abraded under 4 kg/cm2 of pressure for 1 minute with 50-microm grit alumina dust. Data were analyzed with a 2-sample Student t test and a paired t test. RESULTS: Substantial variations for all measurements were observed both between and within subjects. Notwithstanding, these variations, the mean retention of the bases significantly (P <.05) increased by more than 2-fold when the fitting surface was air-particle abraded. These force values were similar to those recorded previously for well-fitting mucosal-supported palatal bases in a separate group of dentate subjects. CONCLUSIONS: While reinforcing the importance of good adaptation of the denture to the tissues, these findings also suggest that an additional improvement in denture retention can be accomplished after the fitting surface is air-particle abraded.

Adult↗
PubMed1999

Retention of provisional crowns fabricated from two materials with the use of four temporary cements.

STATEMENT OF PROBLEM: Practitioners often choose resin materials and temporary cements with little understanding about their effect on provisional crown retention. PURPOSE: This study evaluated the retention of provisional restorations made with 2 materials and cemented with 4 temporary cements. METHODS AND MATERIAL: Recently extracted molars were prepared with a flat occlusal surface, 4-mm axial length and 20-degree angle of convergence. Specimens were distributed into equivalent groups. Provisional crowns were constructed for each preparation with polymethyl methacrylate (Temporary Bridge Resin) or bis-acrylic composite (Protemp Garant) and later cemented with Temp-Bond, Temp-Bond NE, Temrex, and an experimental calcium hydroxide temporary cement. A second group with Temrex was evaluated using half the recommended liquid. A cementing force of 2.5 kg for 5 minutes was used. After initial bench set followed by 24 hours in room temperature water, the crowns were removed with an Instron mechanical testing machine at 0.5 mm/min. A 2-factor ANOVA was used with alpha=.05 (n = 10). Mode of debonding was analyzed with a nonparametric chi-square test of association. RESULTS: Mean dislodgment stresses ranged from 670 to 1072 kPa for polymethyl methacrylate crowns and 554 to 884 kPa for those made of composite. Differences were nearly significant for the type of provisional material (P =.061) and the cross-product interaction (P =.376) was not significant, whereas there were significant differences among the cements (P =.002) and the mode of debonding (P =.0034). CONCLUSIONS: Excluding Temp-Bond to eliminate a cross-product interaction demonstrated that the polymethyl methacrylate crowns were 19.3% more retentive than the composite crowns (P =.015). There was no statistically significant difference among the 4 temporary cements when the manufacturer's mixing instructions were followed (P =.186). However, the thicker consistency Temrex was more retentive than the recommended Temrex mix and Temp-Bond.

Analysis of Variance↗
PubMed1998

Mechanisms of incontinence and retention after orthotopic neobladder diversion.

OBJECTIVES: To define the mechanism of incontinence and retention after orthotopic neobladder diversion. METHODS: The results of urodynamic and endoscopic evaluations were assessed in 19 patients (15 men and 4 women). Mean age and postoperative follow-up were 58.3 years and 19.6 months, respectively. Seventeen patients (15 men, 2 women) presented with the sole complaint of nocturnal incontinence, and 2 women presented with retention. Evaluations included voiding and continence history, pelvic examination (for women), postvoid residual, uroflowmetry, triple-lumen video-urodynamic study, and cystourethroscopy. RESULTS: Among patients with incontinence, 11 (65%) were found to have a primary failure-to-store problem as a result of either reservoir or sphincter failure. Four patients (24%) had a primary failure-to-empty problem, and 2 (11%) had features of both. The predominant etiology of voiding difficulty was the inability to relax the external urethral sphincter adequately during Valsalva's maneuver. Of the 2 women who presented with retention, one had obstructing mucosal folds at the neobladder opening and both demonstrated anterior vaginal wall prolapse on pelvic examination. CONCLUSIONS: The mechanism of incontinence and retention after orthotopic neobladder diversion can vary. Carefully performed urodynamic and endoscopic assessments can define the underlying etiology and may serve as a guide for proper treatment selection.

Adult↗
PubMed1994

The effects of pregnenolone on acquisition and retention of a food search task.

Two experiments were undertaken in which the effects of semichronic administration of the precursor steroid, pregnenolone, were examined in a food search task. In both experiments male rats were required to find a food reward in a designated hole in an arena with 16 equally spaced holes. Hormone administration began 8 days before the onset of training. Training was given on an every-other-day schedule for five sessions. Animals were deprived of food for 18 h before training or testing. Retention testing occurred 10 days after acquisition and this was followed by 2 days of training using a different hole for the reward. The two experiments differed only in the method of hormone administration. In one experiment the rats received an implanted (sc) slow release pellet containing pregnenolone before training. In the second experiment the animals received ip injections of pregnenolone sulfate before and during initial training and then had the slow release pellet implanted between acquisition and retention. Significant enhancement of retention was found during the middle trials of the retention test when the treated and control groups from the two experiments were combined. No differences were found during acquisition training in either experiment. On the first day of training the animals to find the reward in a new location, the group injected with pregnenolone sulfate and later implanted with pregnenolone slow-release pellets exhibited performance superior to that of their matched control group.

Animals↗
PubMed1986

Scopolamine effects on memory retention in mice: a model of dementia?

Scopolamine-treated normal young human subjects exhibit memory dysfunctions analogous to those observed in demented patients. The dysfunctions are reversible by physostigmine but not by d-amphetamine which suggests that the memory impairment is specifically related to reduced cholinergic transmission caused by scopolamine. Scopolamine-induced amnesia has been proposed as a model for dementia where reduced cholinergic function is the suspected cause. We report seven experiments in young adult mice which examine scopolamine's effects on memory retention and whether its amnestic effects are specifically blocked by cholinergic agonists or cholinomimetics. Young adult mice were trained to avoid footshock in a T maze and their retention tested 1 week after training. Pretraining subcutaneous injection of scopolamine improved retention scores of "undertrained" mice at a dose of 0.01 mg/kg but impaired at a dose of 0.1 mg/kg. Post-training injection showed no effect at 0.01 mg/kg, enhanced retention scores at 0.1 mg/kg, and impaired at 1.0 mg/kg. The impairment by 1.0 mg/kg was blocked by injection 45 min post-training of each of two cholinergic drugs but was also counteracted by six drugs which act upon five other neural systems (catecholamine, serotonin, glycine, GABA, and hormonal). When scopolamine was injected 40 min pretraining, and each of eight drugs was injected immediately after training, the amnestic effect of scopolamine was only partially counteracted. This suggests that scopolamine impaired acquisition, in addition to some impairment of memory processing. This was confirmed by a direct study of acquisition rates of the avoidance response; 0.1 mg/kg of scopolamine impaired acquisition. The overall results indicate that pretraining administration of scopolamine impairs learning and to some degree memory processing. Counteracting scopolamine-induced amnesia, by either pretraining or post-training drug administration, is not specific to the cholinergic system.

Animals↗
PubMed1987

The impairment of retention induced by pentylenetetrazol in mice may be mediated by a release of opioid peptides in the brain.

Pentylenetetrazol (PTZ, 45 mg/kg, ip) impaired retention of a one-trial step-through inhibitory avoidance task when injected into male Swiss mice 10 min after training, as indicated by retention performance 48 h later. The amnestic effect of PTZ was prevented by naltrexone (0.01 or 0.10 mg/kg, ip) administered after training, but prior to PTZ-treatment. On the contrary, neither naltrexone methyl bromide (0.01, 0.10, or 10.0 mg/kg, ip), a quaternarium analog of naltrexone, nor MR2266 (0.01 or 0.10 mg/kg, ip), a putative kappa opiate receptor antagonist, modified the behavioral effects of PTZ. On the other hand, the body seizures produced by PTZ were unaffected by any of the three opiate receptor antagonists that were given before the convulsant. Taken together, these results suggest that the effects of PTZ on retention are mediated, at least in part, by opioid peptides of central origin, and rules out a possible participation of opioid peptides derived from prodynorphin-precursor molecule. Administration of beta-endorphin (0.01 or 0.10 microgram/kg, ip) 10 min prior to testing attenuate the retrograde amnesia caused by PTZ. The effect of beta-endorphin was prevented by the simultaneous administration of naltrexone (0.10 mg/kg, ip) prior to testing. Naltrexone has no effect of its own upon retrieval. These results suggest that the impairment of retention induced by PTZ is probably due, at least in part, to a release of opioid peptides in the brain during the post-training period. PTZ given after training do not affect consolidation or memory storage, as mice thus treated may retrieve the learned information when they are submitted to an appropriate neurohumoral and/or hormonal state in the test session, that is, beta-endorphin injection. Therefore, the action of PTZ would be primarily at the level of the mechanism that make stored information available for late retrieval.

Animals↗
PubMed1997

Effects of selective catechol-O-methyltransferase inhibitors on single-trial passive avoidance retention in male rats.

The effects of new selective catechol-O-methyltransferase (COMT) inhibitors entacapone (mainly peripheral effect) and tolcapone (acting also in the brain) on normal and impaired cognitive functions were studied in aversively motivated inhibitory avoidance using a single-trial passive avoidance paradigm in young adult rats. Passive avoidance retention latency was shortened by either scopolamine (1.0 mg/kg) or bilateral lesions to nucleus basalis magnocellularis (NBM) caused by infusions of ethylcholine aziridinium (AF64A). Entacapone (30 mg/kg) administered once before training or before the retention test, 24 h after training, prevented the effect of scopolamine but did not alter extinction in these rats. However, entacapone (30 mg/kg) prolonged lag time when given during the extinction process to intact rats after training. Tolcapone administered once before training (10 mg/kg) counteracted the effect of scopolamine. It prolonged retention latency of the intact rats when given after training (10 mg/kg). Tolcapone (3 mg/kg) also prolonged lag time when given during extinction to rats bearing NBM lesions. The effect of scopolamine on extinction and retrieval was not prevented by tolcapone. Only entacapone improved memory storage. Collectively, the present results indicate that COMT inhibitors prolong retention latencies in a single-trial passive avoidance test assessed at several memory phases.

Animals↗