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[Risk factors for hysterectomy among Brazilian women].

A case-control study was conducted to investigate risk factors for hysterectomy among women using the public health system in Northeast Brazil. The cases were 373 women aged 30-54 years that had undergone elective hysterectomy for benign pelvic conditions. Controls were 742 women with preserved uterus selected from public health clinics. Data were collected through a review of medical records and a personal interview using a structured, pre-tested questionnaire. Unconditional multiple logistic regression was applied in the analysis. Women at greater risk for hysterectomy were those with a higher per capita family income, zero to three children, a history of medical consultation for menstrual problems, hospitalization for gynecological problems, or tubal ligation before age 30 years. Menopause and a history of stillbirth appeared as protective factors in the statistical analysis.

Adult↗

Breast cancer in Latin America and the Caribbean.

As recently as two decades ago breast cancer was not a significant public health concern in Latin America and the Caribbean (LAC). However, mortality rates from breast cancer have been increasing for at least 40 years in most LAC countries. Socioeconomic development and consequent changes in reproductive behaviors over the past 50 years are thought to have contributed to the increased risk of breast cancer. Socioeconomic development has also increased women's health awareness and therefore the demand for quality services. In industrialized countries, screening and widely available, high-quality treatment protocols are being implemented as the main strategy for breast cancer control. Studies show that out of three available screening methods (mammography, clinical breast examination, and breast self-examination), only mammography for women 50-69 years of age has been effective at reducing mortality, and has done so by an estimated 23%. While there is much controversy about the benefits and cost-effectiveness of mammography screening for women aged 40-49, some countries, including Australia, the United States of America, and four European nations, recommend that physicians assess the need for it on an individual basis. A survey that we conducted of LAC countries shows that most of their breast cancer screening policies are not justified by available scientific evidence. Moreover, as seen by relatively high mortality/incidence ratios, breast cancer cases are not being adequately managed in many LAC countries. Before further developing screening programs, these countries need to evaluate the feasibility of designing and implementing appropriate treatment guidelines and providing wide access to diagnostic and treatment services. Given the relevance of breast cancer in Latin America and the Caribbean today, it is crucial that both women and health care providers have access to up-to-date information on which to base their decisions.

Aged↗

Reproduction of species of the genus Cichla in a reservoir in southeastern Brazil.

The reproduction of two species of Cichla (Cichla cf. ocellaris and C. monoculus, commonly known in Brazil as tucunaré) introduced in the Volta Grande Reservoir, southeastern Brazil, was analyzed. The period for spawning began at the end of the dry season (September) and extended until the end of the rainy season (January). The length of the first gonad maturation (L50) and the length at which all fish are considered adults (L100) were very similar for both species and coincide with the length of fish at one year of age. The analysis of disassociated oocytes evidenced a partitioned spawning, and that C. monoculus was more prolific than C. cf. ocellaris. The low fecundity, partitioned spawning, bi-parental brood care, and supplying of food for the young are related to the way of life, habitat, and reproductive behavior of these fish.

Animals↗

Production of pheromones by artificially fed males of the tick Amblyomma maculatum (Acari: Ixodidae).

Aggregation-attachment pheromones are produced only by male ticks of the genus Amblyomma that have imbibed blood for at least 8 d from their mammalian hosts. This report demonstrates that production and release of aggregation-attachment pheromones by Amblyomma maculatum (Koch) males can be induced in vitro by using nonblood media, artificially introduced through capillary tubes, into the male ticks. The presence of these pheromones is demonstrated by using both biological observations on bovine hosts and in vitro experimentation with petri dishes. The attraction of unfed female ticks to the artificially fed males (using the petri dish method) was significantly higher (P < 0.001) than the attraction of unfed females to unfed males. Similarly, attraction and attachment were recorded on bovine hosts. Only 62.8 +/- 17.5% of the females released attached to the bovine host. Of these, 61.9 +/- 19.37% attached around artificially fed males that were placed on the bovine 24 h earlier. This percentage did not differ significantly from the 81.4 +/- 7.1% of the total that attached around males that fed naturally for 8 d. In comparison, only 33.3 +/- 21.9% of the total number of females placed on the host did so after being fed 1 d (control group). The possibility of using capillary feeding as a new tool for investigating the physiology and reproductive behavior of blood-sucking arthropods is discussed.

Animals↗

Diminishing educational differences in breast cancer mortality among Finnish women: a register-based 25-year follow-up.

OBJECTIVES: This study examined trends in breast cancer mortality by education, age, and birth cohort. METHODS: Census records of Finnish women 35 years and older were linked with death records for 1971 through 1995. RESULTS: Excess breast cancer mortality of more-educated women has declined rapidly, mainly because of increasing mortality among less-educated women and stable or decreasing mortality among more-educated 35- to 64-year-old women. During the 1990s, mortality among more-educated 50- to 64-year-old women declined particularly fast. CONCLUSIONS: The causes of declining differences by education in breast cancer mortality are difficult to verify, but they may be due in part to narrowing differences in reproductive behavior among the younger birth cohorts and to a period effect possibly associated with the introduction of breast cancer screening in the late 1980s.

Adult↗

[Risk factors of stillbirths in Fortaleza-Brazil: a case-control study].

Stillbirths are a common event in areas where reproductive health care is poorly delivered, such as the Northeast region of Brazil. This case-control study aimed to identify risk factors associated to foetal deaths occurred in a major obstetric facility of Fortaleza, 1.7 million inhabitants, Northeastern Brazil. 125 stillborn foetus over 20 weeks of gestation (cases) were compared to 250 healthy newborns (controls), in relation to socioeconomic, reproductive, behavioral and morbidity characteristics of their mothers. Crude and adjusted Odds Ratios were then calculated. After adjustment for confounders, the following characteristics of the mother remained as risk factors for stillbirths, with OR statistically significant at the 95% level: attending <5 antenatal consultations during pregnancy (OR=3.30; CI=1.92 - 5.07 ), illiterate mother (OR=3.30; CI=1.84 - 5.92 ), mother's age above 19 (OR=2.73; CI=1.42 - 5.24 ), monthly family income of 1 minimum wage or less (OR=2.12; CI=1.03 - 4.35 ) and severe illnesses or complication during pregnancy (OR=1.75; CI=1.01 - 3.03 ). Inadequate attendance to antenatal care consultations was the risk factor most strongly associated to stillbirths. Similarly, it was the condition most amenable to change in a short term, among those identified as risk factors.

English Abstract↗

Age-period-cohort analysis of female breast cancer mortality in Korea.

BACKGROUND: Although breast cancer in women remains relatively rare in Korea, its incidence and mortality figures are increasing, consistent with the increasing risk observed in successive generations of Korean women. The aim of the current study was to examine time trends of breast-cancer mortality during the period 1984-2003 in Korea, assessing the importance of the effects of age, period and birth cohort as risk factors. METHODS: Data on the annual number of deaths due to female breast cancer and on female population statistics from 1984 to 2003 were obtained from the Korean National Statistical Office. A log-linear Poisson age-period-cohort model was used to estimate age, period and cohort effects. RESULTS: The trend of breast cancer mortality was explained by an age-cohort model based on goodness of fit, even though the significance of the cohort effect was marginal (p=0.08) after adjusting for age. The risk of breast cancer death was found to increase with age after adjusting for the cohort effect, and it was different from the cross-sectional age curve. Also, breast cancer mortality increased along with the birth cohort. CONCLUSIONS: Even though the cohort effect was found to have a marginally significant effect on breast cancer mortality, it is expected to be more significant in the future given the recent on-going changes in diet and reproductive behavior shown by Korean women.

Adult↗

Electron microscopic and functional aspects of the human vomeronasal organ.

The vomeronasal organ or Jacobson's organ is essential for pheromone detection and reproductive behavior in most mammals. The purpose of this article is to describe the fine structure of the adult human vomeronasal organ in 14 specimens and to discuss functional aspects. Our studies show a duct-like invagination of the epithelium, surrounded by numerous exocrine glands with short ducts; their fine structure suggests serous secretion. In the depth of the invagination, pseudostratified columnar epithelial cells are seen, with plump processes, kinocilia, and microvilli at the apical cell membrane. There are several cell types that differ regarding their organelles and electron density; the light sensory cells exhibit neurofilaments. Underneath the typical basement membrane, in the very vascular lamina propria, numerous myelinated and unmyelinated axons are present. These morphologic findings, which are unique in the human body, suggest that a chemosensory epithelium corresponding to a vomeronasal organ may exist. Its central connections and the possible functional significance for pheromone detection are unknown. Preservation of the vomeronasal organ in endonasal surgery could become important both clinically and medicolegally, should function be demonstrated in humans.

Adolescent↗

Clinical experience with a triphasic oral contraceptive.

A triphasic combined oral contraceptive containing fluctuating amounts of ethinylestradiol and levonorgestrel was tested clinically in a multicenter trial at six hospitals in Norway. 367 women were included in the study, 3 588 cycles were studied, and the follow up period was 12 months. The one year continuation rate was 67%. Five pregnancies occurred during the study period. All of them had to be considered as patient failures. The causes for stopping medication were side effects in about 50% and the rest for personal reasons. The cycle control taking into account duration of bleeding, amount of flow, and intermenstrual bleeding was good and comparable to the low-dose monophasic combined pills. The incidence of side effects was low. One woman had an increase in systolic blood pressure to more than 140 mmHg. Thrombophlebitis was not registered. In conclusion the triphasic oral contraceptive was effective and had a good cycle control and low incidence of side effects.

Adult↗

Induced abortion. Effects of marital status, age and parity on choice of pregnancy termination.

OBJECTIVE: To study the impact of marital status, age and parity on the decision regarding pregnancy termination over time among pregnant Norwegian women. DESIGN: National surveillance data of induced abortions and births. MATERIAL: All women terminating their pregnancies (n = 174,590) as registered in the Abortion File in the Central Bureau of Statistics and all women giving birth (n = 639,551) as registered in the Medical Birth Registry of Norway between January 1, 1979 and December 31, 1990 were eligible for the study. Included in the analysis of pregnancy outcome were records with complete information on marital status, age and parity, which comprise 93.8% (n = 163,826) of all women having had an induced abortion and 99.0% (n = 633,542) of all women giving birth during the time period. OUTCOME MEASURE: The proportion of pregnancies terminated as induced abortions and the relative risk of pregnant women choosing abortion in strata of marital status, age and parity. STATISTICAL METHODS: Trend analysis of the proportion of pregnancies terminated as induced abortions in different time periods in categories of marital status, age and parity. RESULTS AND CONCLUSION: From the first three-year period 1979-81 to the last three-year period 1988-90 there was a decreasing tendency to choose abortion among unmarried pregnant women above 20 years of age and married women with two or more children. In the other strata of marital status, age and parity there were no changes over the time period, except for married women 20-24 years of age which was the only group that showed an increasing abortion tendency over the time period. The prospect of single parenthood was the strongest determinant for choosing abortion independent of age and parity. Within all age groups of married women the abortion tendency increased more with parity than age. Cohabiting women chose abortion significantly more often than married women did. However, the true estimate of choosing abortion among cohabiting women was closer to married women than to single women. In order to find out the importance of other social factors and attitudes in the decision making process regarding pregnancy outcome, adjustments must be made for marital status, age and parity.

Abortion, Induced↗

Age-period-cohort analysis of cervical cancer mortality in Taiwan, 1974-1992.

OBJECTIVES: To develop a hypothesis about the carcinogenesis of cervical cancer from a descriptive analysis. METHODS: The mortality data of cervical cancer were analyzed over the period from 1974 to 1992 among Taiwanese women using a log-linear Poisson model modified from the method of Osmond and Gardner to examine the effects of age, calendar period of death, and birth cohort on cervical cancer mortality. RESULTS: This age-period-cohort model provides a summary guide for interpretation of cancer mortality trends. According to this model, age was found to be the strongest factor predicting cervical cancer mortality. Women in 50-54 age group have 89.3-fold risk of cervical cancer compared to those in the 30-34 age group. The cohort effect is also of particular interest because the generation at greatest risk for cervical cancer is the one born between 1893 and 1938, and a dramatically declining trend is observed thereafter for 1938-1963 birth cohort. Interest has emerged about the increasing trend in recent cohorts (after 1963 birth cohort). However calendar time only has a slight effect in the APC analysis. The model also identified a possible role of female sex hormones as the age effect, promiscuous sexual activity as the period effect (promoter) and the change in reproductive behavior as the cohort effect (initiator). CONCLUSIONS: These results may help to develop a hypothesis of carcinogenesis of cervical cancer in Taiwan.

Adult↗

On the birth of an infant with sickle cell anemia.

This is the first report in the English literature of the birth of an obligate SS infant whose parents both had sickle cell anemia. The young adult SS parents of this infant and their families did not wish to prevent the birth of this child but had, in fact, many positive reasons to continue the pregnancy to term even in the face of the increased personal risk of pregnancy for this mother. This unusual circumstance initiated a re-appraisal of the realistic expectations with respect to reproduction in patients with homozygous recessive genetic disorders. No definitive studies could be found which attempted to evaluate the influence of genetic counseling on reproductive behavior in patients with sickle cell anemia. The questions raised about the 'right to reproduce' and the realistic aims of genetic counseling in adult homozygote patients have been discussed. However, no conclusions seem warranted because of the paucity of available information.

Adult↗

Long-term divergent selection for eight-week body weight in white Plymouth rock chickens.

This paper provides an overview of results from a long-term (38 generations) selection experiment. Lines were developed from individual phenotypic selection for high or low body weight at 8 wk of age. Included are data for the selected lines, sublines in which selection was relaxed, crosses of the selected lines, and sublines in which the sex-linked dw gene was introduced. Periodically (and in some cases every generation) data were obtained for unselected traits. These unselected traits included feed consumption and intake behavior, reproduction, allomorphic relationships, and metabolic, immunological, endocrine, and molecular factors. These responses have been integrated into a resource allocation paradigm.

Aging↗

Focus on adolescent pregnancy and childbearing: a bit of history and implications for the 21st century.

Early childbearing in the United States has roots in the past; is the focus of intense partisan debate at the present time; and will have demographic, social, and economic ramifications in the future. It is an extremely complex issue, for which its associated problems have no easy or simple answers. Early parenthood is viewed as a social problem that has defied public policy attempts to stem its growth. It has become the focus of concern primarily for three reasons: (1) sexual activity has increased sharply, most recently among the youngest teens; (2) out-of-wedlock childbearing has risen among all teenagers, regardless of age; and (3) the issue of welfare. A review of statistics highlights the problem and discussion focuses on means of mitigating the negative effects of early childbearing.

Adolescent↗

Created equal? The moral challenge of prenatal diagnosis.

Prenatal diagnosis, as currently practiced in close linkage with selective abortion, poses a moral challenge of many dimensions. The challenge is moral because it brings into question values that have long served as the normative basis for human reproductive behavior. A moral policy is needed to match this challenge, a policy that will promote the development of effective therapy and the emancipation of the early emerging human spirit.

Canada↗

Age at marriage and intrafamily planning in young families.

INTRODUCTION: The sociological inquiry on current problems of intrafamily planning carried out in 1995 provided opportunities for finding the effect of a number of social and demographic factors on the formation of family. OBJECTIVE: The present study has investigated the influence of the age of woman at marriage on the main indicators characterizing the reproductive behavior. MATERIAL AND METHODS: Direct individual inquiry was performed and 500 young families from the town of Plovdiv were approached. Data were analyzed by percentage distribution methods and non-parametric tests. RESULTS AND DISCUSSION: We should note here the high percentage of spouses who had not planned the number of children in their future family--33.1% of women and 34.3% of men. Paradoxically, the percentage of women that had not planned the number of children in their families increases with age. The intended number of children does not depend on the age of women at marriage. The women aged below 19 have indicated the highest number of children. The "ideal number of children" indicator has the highest value in women aged below 19 (2.25 children), but there is no statistically significant difference in the ideal number of children between the different age groups. The opinion about a "large family" is studied in spouses and relatives of the young family. With the increase of age, the number of children in the "large family" decreases in all three groups (P < 0.001). There is no difference in length of the protogenetic interval between different age groups. Intergenetic interval between the first and second birth is about three years in all three age groups. The largest interval between the second and third birth is registered in women aged above 25. About half of the women have admitted that they do not wish to have a third child. The age at last delivery is highly correlated with age at marriage (P < 0.05); the correlation is strongest in women above 25 years of age.

Adolescent↗