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Source monitoring by children with autism.

The term "source monitoring" refers to the ability to distinguish the origins of memories. One type of source monitoring is reality monitoring-which means distinguishing internally and externally generated memories. This experiment examined reality monitoring by children with autism (with a mean mental age of 7 years 8 months). The children said several words and listened to another person say similar words. The children were then given a surprise memory test and asked to identify which words they had said and which the other person had said. The children with autism were compared to matched groups of normal children and children with mental retardation. There were no differences between the groups and, at least for this task, there was no evidence that children with autism have a deficit in their reality monitoring abilities.

Adolescent↗

Reality monitoring of performed and imagined interactive events: developmental and contextual effects.

Age differences in reality monitoring of interactive events were examined among 4-year-olds, 8-year-olds, 12-year-olds, and adults. Participants engaged in some interactions and imagined others. Afterward, they were asked to determine whether each action was performed, imagined, or new. This memory test was repeated 1 week later. The 4-year-olds had more difficulty discriminating imagined actions than the two oldest age groups. Imagined actions were more often confused with performed ones than the reverse, though this bias was significant only for the two younger age groups. Reality monitoring decreased over time, especially for imagined items. Activities in which the participant was the agent of action were discriminated better than those in which someone else was the agent of action. Object use during the activity increased the discrimination of imagined actions, especially after the delay. Similarity among actions had no effect. Implications for child eyewitness testimony are discussed.

Adolescent↗

Understanding the cortex of crawling cells: insights from Dictyostelium.

All animal cells are believed to use the same basic molecular mechanisms for locomotion when crawling on a surface. Study of a wide range of crawling cells has tended to confirm this belief but has also led to a diversity of hypotheses for locomotion and a bewildering list of candidate effector proteins. The emergence of a powerful model system, Dictyostelium discoideum, for the study of crawling of cells makes definitive tests of hypotheses for locomotion a reality.

Journal Article↗

[Difficult asthma].

Difficult asthma is a major issue in pulmonary medicine today because of its cost for patients and society. Difficult asthma is asthma that remains uncontrolled despite optimal specialist management. The validity of the diagnosis must be reconsidered in these cases: associated or differential diagnoses may be involved in the lack of control, and it is always necessary to assess the patient's treatment adhesion. Sufficient time--at least a year--must be taken to get to know the patient and to meet the objectives set. The standard asthma therapies should be tested objectively. Severe asthma is the reality of difficult asthma that endures despite a reaffirmed diagnosis, optimal compliance and controlled comorbidities. Better knowledge is needed of the pathophysiology of these patients' asthma. Improved knowledge of these phenotypes will make it possible to develop innovative treatments. They will need to be validated in clinical research for subsequent use that is wider but more rational because targeted at phenotypes likely to benefit from them.

Administration, Oral↗

Sunscreen isn't enough.

Topical sunscreens act by absorbing or scattering UV radiation and are widely available for general public use as a consumer product. Surveys carried out in the UK find that sunscreen use is regarded as the most important, and by implication the most effective, sun protection measure. But is perception borne out by reality? Sunscreens applied at the thickness tested by manufacturers need only possess an SPF of 15 to prevent sunburn even for all day exposure in tropical sunshine. Yet behavioural studies show that high SPF (>15) sunscreens do not always prevent sunburn. That the protection achieved is often less than that expected depends upon a number of factors: application thickness and technique; type of sunscreen applied; resistance to water immersion and sand abrasion; and when, where and how often sunscreen is re-applied. These factors provide ample evidence that the numerical measure of protection indicated on the product pack is generally higher than achieved in practice. This mismatch between expectation and realisation may be one contributing factor why sunscreens have been reported to be a risk factor in melanoma.

Humans↗

The impact of the accessibility of cranial CT scans on patient evaluation and management decisions.

OBJECTIVES: Cranial CT scans are amongst the most frequently performed radiological investigations performed in most developed countries. However, these tests are relatively expensive and economic realities should compel physicians to re-evaluate the utilization of this technology. The aim of this study was to review the utilization pattern and effect on management decisions of cranial CT scanning. DESIGN: Retrospective chart review. SETTING: University-affiliated community teaching hospital. SUBJECTS: The clinical data on 451 consecutive patients undergoing cranial CT scanning in our radiology department were reviewed. Eighty-five patients were referred from outside the hospital and were subsequently excluded from further analysis. INTERVENTIONS: None. MAIN OUTCOME MEASURES: The following data was abstracted from each patient's chart: the presenting clinical syndrome, the physician ordering the scan, details of the neurological examination performed prior to scanning, the CT scan findings and the impact the CT scan findings had on management decisions. RESULTS: The largest percentage of patients were referred from the emergency department (61%). Chronic intracranial lesions were present in 77 (21%) patients. New pathological findings were found in 91 (25%) patients. The commonest new lesions were ischaemic infarcts (43%), followed by intracerebral haemorrhage (13%) and space occupying lesions (11%). Ninety-seven per cent of patients presenting with new focal neurological signs had new findings on the CT scan, compared to 28% of patients with severe headache and 27% with a history of loss of consciousness. Head trauma was the presenting problem in 139 patients. New pathological findings were diagnosed in 24 of these patients. Fifty-four patients had no signs or symptoms referable to the central nervous system. None of these patients had new findings on CT scan. In the vast majority of patients the neurological examination performed prior to CT scanning was incomplete. CT scanning was considered to have altered the management or provided a new diagnosis in 162 (44%) patients; of these patients 61 (67%) were in the group with new findings on CT scanning and 101 (37%) in the group with no new findings. CONCLUSION: In this study cranial CT scanning affected clinical management decisions in less than half of the patients. Furthermore, a careful history and neurological examination was performed in the minority of patients undergoing CT scanning. It would therefore appear that the easy accessability of CT scans largely determines the utilization of this diagnostic tool.

Brain Diseases↗

The evolution of mathematical modeling of glioma proliferation and invasion.

Gliomas are well known for their potential for aggressive proliferation as well as their diffuse invasion of the normal-appearing parenchyma peripheral to the bulk lesion. This review presents a history of the use of mathematical modeling in the study of the proliferative-invasive growth of gliomas, illustrating the progress made in understanding the in vivo dynamics of invasion and proliferation of tumor cells. Mathematical modeling is based on a sequence of observation, speculation, development of hypotheses to be tested, and comparisons between theory and reality. These mathematical investigations, iteratively compared with experimental and clinical work, demonstrate the essential relationship between experimental and theoretical approaches. Together, these efforts have extended our knowledge and insight into in vivo brain tumor growth dynamics that should enhance current diagnoses and treatments.

Animals↗

Fake abortion clinics: the threat to reproductive self-determination.

The establishment of "fake abortion clinics" poses a great threat to women's ability to make free and informed procreative decisions. Such clinics intentionally deceive pregnant women into believing that they provide a full range of women's health services when, in reality, they provide only a pregnancy test, accompanied by intense anti-abortion propaganda. Because fake abortion clinics threaten women's interests in "privacy" and decisional autonomy, state attorneys general should challenge them under deceptive business practice statutes. Successful challenges can be brought without violating anti-abortion groups' First Amendment rights.

Abortion, Legal↗

[Evaluation of the sampling plan for a Salmonella monitoring program for slaughter pigs].

In the setting of the Salmonella monitoring programme of the Federal Republic of Germany the sampling plan does not take into account prevalences occuring in reality. Hence, in most farms the testing effort will increase. This particularly applies to pig farms up to 100 fatteners, for which the proportion of animals to be tested is too high. Besides, the threshold values determing the allocation to the three quality categories, less than 20%, 20-40%, and more than 40% Salmonella positive fatteners, are also chosen too high.

Animals↗

Construction of a high-tech operating room for image-guided surgery using VR.

This project aimed to construct an operating room to implement high dimensional (3D, 4D) medical imaging and medical virtual reality techniques that would enable clinical tests for new surgical procedures. We designed and constructed such an operating room at Dai-san Hospital, the Jikei Univ. School of Medicine, Tokyo, Japan. The room was equipped with various facilities for image-guided, robot and tele- surgery. In this report, we describe an outline of our "high-tech operating room" and future plans.

Facility Design and Construction↗

Biomechanical modeling of anterior spine instrumentation in AIS.

This study is part of a larger project regarding the development of a Spine Surgery Simulator (S3), which has shown good results for posterior instrumentation surgeries. The aim was to develop a biomechanical model for the anterior instrumentation of the scoliotic spine. A biomechanical model using flexible mechanism was developed and surgical manoeuvres (instrumentation, rod installation and compression) were reproduced. Validation of the model was done by comparing the results for the instrumented part of the spine to the post-operative data (analytical Cobb angles in the frontal and sagittal planes, plane of maximum deformity, etc.). To date, surgeries of four patients operated by thoracotomy were reproduced. Preliminary results show that anterior instrumentation of the scoliotic spine can be adequately modelled using pre-operative geometric data and using mechanical properties from literature. Once validated with a larger sample of cases, the anterior instrumentation model could be implemented into S3 and used by orthopaedic surgeons to test various instrumentation strategies in virtual reality before performing the actual surgery.

Adolescent↗

[A multicenter study of the biometric parameters of Tuscan newborns].

We combined data concerning weight, length, chest's perimeter and head's circumference of newborns of 16 Tuscan hospitals on 1985, with sample of 4,215 boys and 4,119 girls, from 33.th to 42.th gestational week. These data have been statistically elaborated to obtain values of the four considered parameters and the respective standard deviation. For the distribution of the 16 hospital in the region, we think that these data are representatives of Tuscan newborn's reality. We have moreover considered whether data of Tuscan newborns, with parents proceeding from different regions, were dissimilar from those with autochthonous parents. The statistical comparison of the two reality, with "T-Student's test', is resulted not significant. We calculated then values of the four parameters with their standard deviation, for each hospital participating to the research, excluding groups with to small numerousness, i.e. 33rd, 34th, 35th and 42nd gestational week. Besides, we valued if data of each Hospital were statistically different from those related to the whole Tuscan sample. The results of this testing, performed with "T-Student's test", are illustrated in the schedules. The differences seem to be referred to local conditions, that will be object of new researches. At present, we can only emphasize that the chest's perimeter is the parameter with the larger variability, so that we will exclude this size from the next research.

Anthropometry↗

[Kleptomania: phenomenological, clinical and legal aspects].

Kleptomania is currently classified in psychiatric nomenclature as one of the impulse control disorders (DSM-IV, 1994). It is characterized by repeated failure to resist impulses to steal objects, not for personal use or monetary gain. The objects are therefore discarded, given away, or hoarded (ICD-10, 1992). This disorder is known since the early 18th century from the phenomenological and clinical viewpoints, yet is still debated with regard to therapeutic strategies and criminal liability. Although there are usually complications associated with the legal consequences of being caught and arrested, subjects continue to violate the law despite repeated arrests and convictions. In a 28-year old man suffering from kleptomania, years of psychodynamic psychotherapy were ineffective. Only when he was treated as suffering from an impulse control disorder or a variant of obsessive-compulsive disorder, was there significant improvement. The positive response to buspirone (5-HT1A) augmentation of fluvoxamine (SSRI) suggested that disturbed central serotonergic neurotransmission might play an important role in the pathogenesis of kleptomania. This concept is strengthened by the comorbidity of the syndrome with depression and by its compulsive traits. We stress that although kleptomaniacs cannot differentiate between right and wrong, testing shows that their sense of reality is intact, but they act under the influence of drives they cannot resist.

Adult↗

Physical measurements of the lumbar spine.

This article describes measurement of lumbar function. The simplest range of motion devices are compared with the progressive, more complex computerized devices for range and strength testing. The author presents his own opinion as to the place of these devices in both research and clinical practices. The economics of accurate physical testing is compared to the clinical realities of current payment systems.

Anthropometry↗

How to select aspirant laparoscopic surgical trainees: establishing concurrent validity comparing Xitact LS500 index performance scores with standardized psychomotor aptitude test battery scores.

BACKGROUND: Although a controversial topic in medical education, the selection of aspirant surgical trainees is a subject that needs to be addressed. In the view of preventing surgical trainee drop-outs and of appropriate allocation of limited resources, it is an issue critical to the profession. Traditional methods of selection are often subjective, and do not seem to correlate with skill needed for surgery. Standardized neuropsychometric test batteries may be useful in helping to select aspirant laparoscopic surgeons. Our study attempts to link surgical novices' psychometric ability test battery data with actual performance outcome on an objective, validated, and reproducible surgical laparoscopic task using virtual-reality simulation. MATERIALS AND METHODS: Thirty-three novices with no laparoscopic surgical experience participated. Each participant performed the Xitact LS500 Virtual Reality cholecystectomy clip-and-cut module 30 times. Individual learning curves were computed and patterns were assessed. Participants were examined using the aptitude test battery including the Abstract Reasoning test, the Space Relations test, the Gibson Spiral Maze test, and the Crawford Small Parts Dexterity tester. RESULTS: Over 900 virtual-reality simulation tasks were generated and assessed. Of the participants, 93.3% were able to complete the virtual-reality simulation 30 times and all elements of our aptitude test battery. The abstract reasoning test is the only test correlating significantly to Xitact test outcome. This test is highly correlated to the space relations test. Both tests have discriminative power, comparing groups of performers. CONCLUSIONS: The present study addresses the concurrent validity in aptitude testing, comparing scores of surgical novices on the Xitact LS500 laparoscopic cholecystectomy virtual-reality simulation with performance scores on a battery of standardized psychometric aptitude tests. The abstract reasoning and the space-relation test have predictive and selective value, identifying individuals who have good laparoscopic surgical virtual-reality performance. Aspiring laparoscopic surgeons who score below 25 on either test, that is, an expected 36%, would have to be further assessed using Xitact surgical task performance. The group of participants scoring above 35 on the Abstract Reasoning test and above 45 on the Space Relations test, that is, an expected 18% of the population, is unlikely to mal-perform on Xitact. The other 46% could very well benefit from Xitact simulation and assessment when the opportunity is present.

Adult↗

[The imaginary in the psychic reality. Psychotherapeutic applications].

Imagery is considered an important psychotherapeutic means in many contemporary systems, in an explicit way, or implicitely. Its function is at least double. On the one hand it detains the development of personal possibilities, for it raises an unreal barrier of transference when confronting new experiences, but on the other it amplifies life by extending it towards what Gaston Bachelard calls "a reality of superabundance". It represents the discovery of new facets in the external world but, much more important in psychotherapy, the revelation of unknown aspects of oneself. Thus, for explorative aims imagery is used in tests, interviews and even anamnesis, and for furthering the cure (insight and growth) in systems such as psychodrama, Desoille's waking dreams, sensitivity training and others. The question arises: what is the source of its effectivity? In my opinion it depends on two influences: 1) images, as symbols, constitute "intermediary objects" which permit a confrontation comparatively free of anxiety with oneself and above all to envisage new forms of behaviour. These can even be rehearsed in some psychodramatic techniques or in laboratories; 2) symbols give access to psychical areas which are forbidden to a conceptual approach. Therefore, I suggest that the conquest of one's reality results, paradoxically, from incursions in unreality.

Ego↗

[In favour of a systemic vision of liaison psychiatry].

One of the problems of consultation-liaison psychiatry is the absence of request of the patient. Indeed, the patients do not recognize their disorder and prefer to go to the emergency unit in a general hospital. Thus, we meet in the emergency unit or in medical unit (liaison psychiatry activity). This is the reason why this first meeting has to be prepared. Consultation-liaison Psychiatry proposes to provide medical staff with the competences developed by psychiatry, and the denomination: Consultation and Liaison Psychiatry, indicates the bipolarity of its practice according to whether the intervention is addressed to the patient (consultation) or to the staff (liaison). However collaboration is sometimes difficult and the psychiatrist often meets with resistance. This is the reason why psychiatrists must work on their integration in the general hospital. Indeed, the psychiatrist works in an institution which is unfamiliar and he/she must adapt and create new practices if it is going to work. It is now clearly established that consultation-liaison psychiatry is not limited to consultations with patients, but is based on collaboration with medical staff. There are various ways of studying human problems: psychoanalysis, cognitive therapy, behavioural therapy. It is also possible to focus interest on the communication between individuals. The systemic therapies are interested in the interactions more than with any other aspect of reality, and this always from a pragmatic point of view. This concept is based on a series of designs. First of all, an intervention by problem solving aims at a change: the question is to know how a problem is maintained, hic et nunc. Secondly, humans are a sum of training by tests and errors. Finally, what we call reality is only our perception of reality: the human conflicts emerge when two persons assign a different direction to a reality which is perceived jointly. The human relationship can be defined as interaction circles, which we propose to use in our practice of consultation-liaison psychiatry. The question is no longer to know why the subject has a problem but to know how to resolve it. The call for a consultation of psychiatry is often the result of an interaction between patient and staff. We propose an assessment of the consultation-liaison-psychiatry's demand so as to offer a concrete response to medical teams and patients. 1. First of all, the claimant should be known. This first question is to be asked before even meeting the patient. In the majority of cases, it is the medical staff that suffers from the situation (and wants a change). To work only on the patient, discredits the psychiatric intervention. 2. The definition of the problem is a concrete question, which we want based on the facts and not on the comments. That which requires the consultation (the patient, his/her family or the medical team) awaits concrete answers from the psychiatrist. It is important that the objectives of the intervention are defined before meeting the patient. These preliminary exchanges facilitate the consultation-liaison intervention. 3. By knowing the solutions tried before the request for psychiatric help, the psychiatrist will be able to know the measures already tried (whether they were effective or not). 4. By proposing minimal changes, it defines small but obtainable objectives, which will be as much as to increase therapeutic alliance and the tolerance of patients sometimes difficult to understand. 5. Finally, the consultation-liaison psychiatrist must know the language of his/her interlocutors. Interdisciplinary alliance is a fundamental condition for the success of the intervention: like the patients, the medical staff must feel understood to be able to cooperate. To develop this alliance and to inhibit resistance, it is important to speak the language of the claimant. The demand will progressively become interventions, more adapted, especially when the psychiatrist is recognized and appreciated by the team, like a good consultant, credible and concrete. Thus, mentally distressed patients can benefit from psychiatric care (although they do not request it). However, two phases appear essential. First, we have to define the demand and the claimant (environment, medical staff and patient) and second, we have to support the integration of the psychiatrist in the functioning of the medical unit. Our systemic vision of the consultation-liaison psychiatry proposes a pragmatic collaboration, centred on the problem. This approach allows the patient to prepare to meet the psychiatrist, and does not a priori discredit the intervention. Presented by the staff, who know the problem in concrete terms and are ready to answer it in a concrete way, this mode of intervention is only the first step of subsequent psychiatric care.

Adaptation, Psychological↗

Anosognosia in parietal lobe syndrome.

Patients with right parietal lesions often deny their paralysis (anosognosia), but do they have "tacit" knowledge of their paralysis? I devised three novel tests to explore this. First, the patients were given a choice between a bimanual task (e.g., tying shoe laces) vs a unimanual one (e.g., threading a bolt). They chose the former on 17 of 18 trials and, surprisingly, showed no frustration or learning despite repeated failed attempts. I conclude that they have no tacit knowledge of paralysis (or, if such knowledge exists, it is not available for this particular task). Second, I used a "virtual reality box" to convey the optical illusion to the patient that she was moving her paralyzed left hand up and down to the rhythm of a metronome, and yet she showed no sign of surprise. Third, I irrigated patient BM's left ear canal with cold water, a procedure that is known to shift that patient's spatial frame of reference by stimulating the vestibular system. Surprisingly, this allowed her "repressed" memory of the paralysis to come to the surface; she said she had been paralyzed continuously for several days. I suggest that the vestibular stimulation produces these remarkable effects by mimicking REM sleep. These patients also employ a whole arsenal of grossly exaggerated Freudian "defense mechanisms" to account for their paralysis. To explain this, I propose that in normal individuals the left hemisphere ordinarily deals with small, local anomalies by trying to impose consistency but, when the anomaly exceeds threshold, an interaction with the right hemisphere forces a "paradigm shift." A failure of this process, in patients with right hemisphere damage, might partially account for anosognosia. Finally, I present a new conceptual framework that may help link several psychological and neurological phenomena such as Freudian defense mechanisms, vestibular stimulation, anosognosia, memory repression, visual illusions, anterograde amnesia, REM sleep, dreaming, and humor.

Adaptation, Psychological↗