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At least 1,351 records · Page 75Linked to original sources
PubMed1980

Incidence of hepatitis B-antigenaemia and positive alphafoetoprotein in New Zealand, Western Samoa and Tonga--(a pilot study of Polynesian liver disease).

A pilot study was carried out to determine the nature of Polynesian liver disease by a study of blood donors and liver biopsy material from natives in Samoa, Tonga and Auckland, New Zealand. The data is suggestive that the Hepatitis B carrier state and hepatoma are greater in Polynesians than in Europeans. One familial hepatoma in two Maori brothers at ages of 11 and 13 years are reported.

Adolescent↗
PubMed1981

Familial predisposition to filarial infection--not linked to HLA-A or-B locus specificities.

Two hundred and twenty-five Polynesians were selected from a larger study population for the evaluation of potential genetic influences on the susceptibility to bancroftian filariasis. Analysis showed that there was significantly familial clustering of patients with filariasis and that this clustering was most compatible with genetic transmission of disease susceptibility. The data best fit a model in which the hypothetical gene for filariasis was recessive with a frequency of 0.82 +/- 0.15 in the population and a penetrance of 0.62 +/- 0.14. The alternative hypothesis that susceptibility was environmentally (i.e., not genetically) determined was also compatible with the data but was estimated to be 1.9 times less likely to account for the observed findings than the genetic hypothesis. Extensive evaluation of HLA-A and -B locus specificities failed to detect significant linkage either between particular antigen specificities and the clinical manifestations of filariasis or between individual haplotypes (indicated by HLA markers in studies of large families) and the predisposition to filarial infection or disease.

Adolescent↗
PubMed1981

Hepatocellular carcinoma and liver pathology in tonga.

All liver histology records from Tonga during 1970-79 were reviewed, including 42 biopsy and one necropsy specimens. Primary hepatocellular carcinoma was the histological diagnosis in 13 (30 percent). The age standardised incidence rate for confirmed cases are: males 2.9 and females 1.5 per 100 000. These are unremarkable compared to some reported rates, but many of these areas have included a high percentage of unconfirmed cases. Other diagnosis included cirrhosis (14), cholangiocarcinoma (2), metastatic carcinoma (2), cholangitis (2), hepatic fibrosis (2), and actinomycosis (1). The difficulties of diagnosis and areas for further studies are discussed.

Adolescent↗
PubMed1982

Addison's disease, adrenal autoantibodies and computerised adrenal tomography.

The present study describes 53 patients with Addison's disease, who attended Auckland hospitals between 1971-1980, 32 of whom presented for the first time during this period, when the mean annual incidence of Addison's disease was 4.5 cases/million population, and the respective frequency of idiopathic (auto-immune) and tuberculous aetiologies was 92 percent and 4 percent for caucasians, but 25 percent and 63 percent for Polynesians. In addition, adrenal reserve was tested by ACTH stimulation in 20 clinically non-Addisonian patients in whom circulating adrenal antibodies had been incidentally demonstrated and present for periods of up to six years, and was normal in all cases. Such antibodies therefore lack functional disease specificity. The diagnostic value of CT adrenal scanning in illustrating the contrasting appearances between tuberculous and auto-immune adrenalitis is shown in four patients.

Addison Disease↗
PubMedDate not supplied

[A Polynesian case of sideropenic dysphagia].

This first case has been found in a polynesian woman, a casual finding of the above condition during a whole heart decompensation. Clinical, biological, endoscopic and therapeutic aspects of Plummer-Vinson syndrome are reviewed.

Deglutition Disorders↗
PubMed1983

Ethnic differences in the incidence of cleft lip and/or cleft palate in Auckland, 1960-1976.

The incidence of facial clefts among live births in the Auckland urban area has been studied for the years 1960-1976. After correction for ascertainment, the live-born incidence of non-syndromal cleft palate among Maoris was 1.867/1000, and among Europeans it was 0.643/1000. The incidences for non-syndromal cleft lip, with or without cleft palate, were 0.397/1000 for Maoris, and 1.195/1000 for Europeans. The sex ratio for cleft palate showed the usual female preponderance, although there was evidence of heterogeneity between the races. Cleft lip occurred more commonly among males. Birth rank, maternal age, and paternal age had no apparent effect on the incidences, and there were no significant secular or seasonal changes in incidence.

Cleft Lip↗
PubMed1983

Lung function in Maoris and Samoans working in New Zealand.

The lung function of 79 Maori workers was compared with that of 31 workers from Western Samoa and with 616 Europeans from the same factory. No significant difference was found in either forced expiratory volume in one second (FEV1) or in forced vital capacity (FVC) between the two Polynesian groups. The combined 110 Polynesians had a lung function which was significantly lower, by about 9%, than that of the Europeans working in the same factory. The lung function differences did not appear to be related to smoking, occupational or environmental factors. While it seems likely that the cause of the differences is a major gene effect a non-job-related social factor cannot yet be completely excluded. Charts for predicting FEV1 and FVC in male Maori and Samoan workers in New Zealand are given.

Adult↗
PubMed1983

Polynesian bronchiectasis.

Six Polynesian children aged 8-14 years with recurrent lower respiratory infections and abnormal lung mucociliary clearance were assessed for immuno-deficiency. Measurements were made in these 6 children and in 21 healthy Polynesians of serum immunoglobulins (IgG, IgM, IgA) and complement components (C3, C4), leucocyte function tests, and T and B cell populations. A further 8 Polynesian bronchiectatics were tested for sputum secretory-IgA. There was no evidence of S-IgA deficiency and 4 had high levels. There was no evidence of immunodeficiency. Nasal epithelium was obtained from 6 children using a cytology brush and ciliated epithelium was obtained in only 4. The ultrastructure was normal although few cilia were examined.

Adolescent↗
PubMed1983

Club foot in the Polynesian: an epidemiological survey.

The incidence of idiopathic club foot deformity in Polynesian peoples, including the New Zealand Maori, is higher than in other races. A study of 118 Polynesian children treated in Auckland for the condition, found no significant correlation among sex, maternal age and the presence or absence of a family history of club foot, and questions the validity of dividing index cases into two groups on the basis of family history. Previous observations of a significant predominance of right-sided deformity in unilateral Polynesian cases, were not confirmed.

Adolescent↗
PubMed1984

A survey of ESR and eosinophil count in a racially mixed population in New Zealand.

A volunteer study in a racially mixed community in New Zealand has shown marked differences between ESRS in healthy European, Maori, and Cook Island subjects. As expected, females had higher ESRs than males. In the European group the values fell close to the Westergren normal range, but the Maori group had a significant number abnormal, with Islander group showing more abnormalities. Occult bacterial or parasitic infections may explain high ESRs in Islanders, but mycobacteria and microfilaria are considered unlikely causes. Islanders have a high incidence of elevated eosinophil count, but this is not associated with high ESR, or the converse. The oral contraceptive pill causes significant elevation of ESR in European females. Further study is needed to establish causes of the abnormal ESRs detected.

Adolescent↗
PubMed1983

A cross sectional study of markers of hepatitis B infection in Niue.

To determine whether the island of Niue would be a suitable location to evaluate the efficacy of hepatitis B vaccine, the prevalence of hepatitis B infection in the adult population was studied. Sera were collected from 1147 of 1244 residents above the age of 20 years, and tested for the presence of hepatitis B surface antigen (HBsAg) and specific antibody to the surface and core antigens (anti-HBs and anti-HBc) by solid-phase radioimmunoassay (SPRIA). Hepatitis B was found to be hyperendemic; 11.9% of those tested were found to be carriers of HBsAg and an additional 84% had detectable levels of anti-HBs or anti-HBc indicative of current or past infection. In this population HBV infection appears to occur early in life as the peak prevalence of serological markers was found in young adults. The almost universal infection of the population, their high rate of compliance with the study and the relatively high birth rate indicate that Niue would be a suitable location to evaluate methods of preventing hepatitis B infection.

Adult↗