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PubMed2005

Continuity and discontinuity in the historical development of modern psychopharmacology.

In the middle of the twentieth century psychiatry underwent a transition that is often referred to as the "psychopharmacology revolution." Implicit in the term revolution is the idea that a paradigm shift occurred. Specifically, it has been argued that psychiatry abandoned the psychoanalytic paradigm in favor of a qualitatively distinct conceptual system based on brain chemistry. The validity of this view requires that psychoanalysis had the status of a paradigm. This paper presents evidence that psychoanalysis did not constitute a paradigm and that the advent of psychopharmacology was not, technically, a scientific revolution. Instead, the rise of modern psychopharmacology was the culmination of a linear growth of biological knowledge that began to develop in the nineteenth century.

History, 20th Century↗

PubMed1990

Impact of "designated smoking area" policy on nicotine vapor and particle concentrations in a modern office building.

A series of measurements of nicotine vapor and particle concentrations were carried out in a modern office building. The measurement program was designed to document the impact of the new smoking policy (e.g. smoking restricted to two specific areas) on air quality in various parts of the building. Measurements at over 30 locations examined areas where smoking was restricted, where smoking was permitted, and where an air handler shared the load of a designated smoking area. These measurements were taken at the same locations before and after the policy was implemented. The measurement results indicated that: After the policy was implemented, general employee exposure to nicotine vapor (as a surrogate for all environmental tobacco smoke) was reduced by about 98 percent on most floors. Other patterns related to spillover from designated smoking areas and changes in the designated smoking areas themselves are described in the paper. Substantial reductions in exposure to nicotine vapor were found even for those general office areas which had the highest concentrations after the policy was implemented.

Air↗

PubMedDate not supplied

Communicating to promote justice in the modern health care system.

The systemic prejudices and biases that often limit the effectiveness of health care delivery are examined. How the inherent imbalance in control between consumers and providers of health care, based on the micropolitics of sharing relevant health information, perpetuates a system of marginalization and alienation within health care delivery systems is discussed. Communication barriers that often confront many stigmatized groups of health care consumers, such as the poor, people with AIDS, minorities, the ill elderly, and women, are identified. Such prejudicial treatment is framed within a cultural ideologies model, leading to identification of communication strategies for promoting justice in the modern health care system and enhancing the quality of health care delivery.

Aged↗

PubMed2006

The modern mythology of the left-handedness of Alexander the Great.

The prevalent modern suggestion that Alexander the Great was left-handed probably derives from Michael Barsley's (1966) book, Left-handed man is a right-handed word, perhaps by mutation from as earlier story cited by Wile in 1934 from a 17th century Rabbirical exegesis, which said that Alexander discovered a country where all the inhabitants were left-handed. That itself may derive in part from the medieval Hebrew Book of Jossippon, which mentions Alexander talking of the superiority of the left hand and of how "kings stemming from the tribe of kings are left-handed".

Functional Laterality↗

PubMedDate not supplied

Vulnerability to HIV among regular male partners and the social coding of intimacy in modern societies.

Recent studies suggest that regular male partners who engage in unprotected anal intercourse (UAI) are currently at risk of HIV infection. In this paper, we try to offer a single and coherent theoretical framework to understand this profile of HIV infection. Data on transformations of intimacy in recent times, UAI and condom use between regular male partners and their correlates are reviewed. Firstly, we describe the social and historical context of modern intimate relationships. The differentiation of intimate relationships and their newfound autonomy from traditional social forces are explored to determine how they may contribute to the destabilization of intimate trajectories. Secondly, we theorize UAI as an attempt to stabilize intimate relationships and a strategy to reaffirm mutual trust, desire and intimacy between regular male partners. The impacts of such an approach to social vulnerability and HIV prevention are also discussed.

HIV Infections↗

PubMed1997

Immigration and the modern welfare state: the case of USA and Germany.

"This article presents a comparison of the inclusion of migrants into welfare programmes in the USA and in Germany. In the first part of the article a brief overview is provided of immigration categories in both countries in order to demonstrate the relevance of these administrative regulations for the opportunities of individual migrants to participate in the welfare system. In the second part we elaborate in more detail on how welfare programmes have developed as basic mechanisms to include or exclude migrants. Our findings illustrate an increasing differentiation of membership statuses parallel to the expansion of modern welfare systems. In both the USA and Germany, the territorial principle and participation in the labour market are of prime importance to the access to social rights. In both cases all migrants may profit from contributory programmes."

Americas↗

PubMedDate not supplied

Sex-determination and sex-preselection tests in India: modern techniques for femicide.

"In India during recent years techniques that were developed to detect genetic deformities in fetuses have been increasingly used mainly for determining the sex of fetuses so that female fetuses can be exterminated. This paper explores the factors underlying this practice and the related practice of preselecting the sex of offspring, examining both the widespread availability and use of sex-determination and sex-preselection techniques and the root causes of female devaluation in India. Also presented and analyzed are the responses of women's groups and the government to these uses of modern technology to carry out the ultimate abuse of women--not allowing them to be born."

Abortion, Induced↗

PubMed2006

Bi-syllabic, modern Greek word lists for use in word recognition tests.

The development of a word recognition test for Modern Greek, which is comprised of three fifty-word lists, is described herein. The development was guided by four principles: (1) use of the shortest words possible (two syllables for Greek) (2) use of highly frequent words (3) phonetic balance and (4) appropriate balance of first and second syllable stress. The lists were recorded by one male and one female native speakers. Thirty-seven native speakers of Greek listened to all words by both speakers. Across lists, the mean correct identification score was 97.9% for the female voice (95% confidence interval 96.97 to 98.84) and 96.5% (95% confidence interval 95.31 to 97.77) for the male voice. This small difference was statistically significant (p < .01) and concentrated on words with first syllable stress. In future work, these recordings can be used in adult tests of speech perception and can be modified for tests of central auditory processing.

Acoustic Stimulation↗

PubMed2006

Some problems in modern bioelectromagnetics.

One of the main problems of bioelectromagnetics - the unbelievable narrow resonance peaks at the cyclotron frequency of the alternating magnetic field - was considered. Modern electrodynamics of condensed matter clearly brings out that the reason of this phenomenon is extremely low viscosity within coherence domains of aqueous electrolytic solutions. The electrochemical model of action of combined static and alternating magnetic fields on aqueous solutions of amino acids is proposed. The possibility of arising a succession of changes in ionic forms in these processes was revealed. The dipole ions (zwitterions) together with water molecules electrostatically forming joint groups in the solution, create favorable conditions for arising mixed coherence domains there. Simultaneously with evolution of the coherent processes in these domains, the amino acid zwitterions are transforming into the usual ionic form, fit for cyclotron resonance. The development of cyclotron resonance under action of combined magnetic fields increases the ion kinetic energy, and the ions leave the domains for the incoherent component of the solution according to Del Giudice pattern (Comisso et al., 2006; Del Giudice et al., 2002), creating the peak current through the solution. Then the ions are transforming little by little into zwitterionic form again; after that, the solution becomes ready to react on exposure of magnetic fields again. The possibilities for formation of coherence domains composed of water molecules together with peptide molecules or protein ones are discussed.

Amino Acids↗

PubMed2000

Mortality and economic development over the course of modernization: an analysis of short-run fluctuations in Spain, 1850-1990.

Distributed lag models are used to explore the issue of the importance of economic factors for demographic performance over the course of the demographic and economic modernization of Spain. Mortality indicators are generated by age, sex, and cause and are assessed in terms of shifts in Gross Domestic Product. During the pre-transitional period, links between mortality and economic performance were simultaneous and rather weak but in the expected direction, declining to near 0 by the beginning of the twentieth century. Afterwards the importance of economic shifts for mortality fluctuations increased dramatically and delayed effects began to predominate, only disappearing after 1950. The paper explains the increase in the importance of economic factors and the change in the lag structure in terms of the greater economic volatility of the 1915-1950 period, the progressive implantation of more efficient public health systems and their sensitivity to economic fluctuations, and improving levels of nutrition and general health.

Economics↗

PubMed2000

Short tandem-repeat polymorphism/alu haplotype variation at the PLAT locus: implications for modern human origins.

Two dinucleotide short tandem-repeat polymorphisms (STRPs) and a polymorphic Alu element spanning a 22-kb region of the PLAT locus on chromosome 8p12-q11.2 were typed in 1,287-1,420 individuals originating from 30 geographically diverse human populations, as well as in 29 great apes. These data were analyzed as haplotypes consisting of each of the dinucleotide repeats and the flanking Alu insertion/deletion polymorphism. The global pattern of STRP/Alu haplotype variation and linkage disequilibrium (LD) is informative for the reconstruction of human evolutionary history. Sub-Saharan African populations have high levels of haplotype diversity within and between populations, relative to non-Africans, and have highly divergent patterns of LD. Non-African populations have both a subset of the haplotype diversity present in Africa and a distinct pattern of LD. The pattern of haplotype variation and LD observed at the PLAT locus suggests a recent common ancestry of non-African populations, from a small population originating in eastern Africa. These data indicate that, throughout much of modern human history, sub-Saharan Africa has maintained both a large effective population size and a high level of population substructure. Additionally, Papua New Guinean and Micronesian populations have rare haplotypes observed otherwise only in African populations, suggesting ancient gene flow from Africa into Papua New Guinea, as well as gene flow between Melanesian and Micronesian populations.

Africa South of the Sahara↗

PubMed2001

Bartonellosis (Carrión's disease) in the modern era.

Bartonellosis remains a major problem in Peru, but many contemporary aspects of this disease have not been adequately described. We examined the cases of 145 symptomatic patients in Lima, Peru, in whom bartonellosis was diagnosed from 1969 through 1992, including 68 patients in the acute (hematic) phase and 77 patients in the eruptive (verruga) phase. In modern Peru, symptomatic patients who have acute-phase bartonellosis typically present with a febrile illness and systemic symptoms caused by profound anemia; most patients respond successfully to treatment with chloramphenicol. Patients who have eruptive-phase bartonellosis most often present with cutaneous verrugas but may have less specific symptoms, such as fever and arthralgias; diagnosis can be confirmed in such patients by Western immunoblotting, and most patients appear to respond to treatment with rifampin.

Acute Disease↗

PubMed2002

Etiological diagnosis of childhood pneumonia by use of transthoracic needle aspiration and modern microbiological methods.

Childhood pneumonia is usually treated without determining its etiology. The causative organism can be isolated from specimens of blood, empyema fluid, or lung aspirate, but this is rarely done. The potential of transthoracic needle aspiration for identification of causative agents was tested with use of modern microbiological methods. Aspiration was performed for 34 children who had radiological signs compatible with community-acquired pneumonia and had alveolar consolidation. In addition to bacterial and viral cultures and viral antigen detection, nucleic acid detection for common respiratory pathogens was performed on aspirate specimens. Aspiration disclosed the etiology in 20 (59%) of 34 cases overall and in 18 (69%) of 26 patients from whom a representative specimen was obtained. Aspiration's advantages are high microbiological yield and a relatively low risk of a clinically significant adverse event. Aspiration should be used if identification of the causative agent outweighs the modest risk of the procedure.

Adolescent↗

PubMed2003

Features of evolution and expansion of modern humans, inferred from genomewide microsatellite markers.

We study data on variation in 52 worldwide populations at 377 autosomal short tandem repeat loci, to infer a demographic history of human populations. Variation at di-, tri-, and tetranucleotide repeat loci is distributed differently, although each class of markers exhibits a decrease of within-population genetic variation in the following order: sub-Saharan Africa, Eurasia, East Asia, Oceania, and America. There is a similar decrease in the frequency of private alleles. With multidimensional scaling, populations belonging to the same major geographic region cluster together, and some regions permit a finer resolution of populations. When a stepwise mutation model is used, a population tree based on TD estimates of divergence time suggests that the branches leading to the present sub-Saharan African populations of hunter-gatherers were the first to diverge from a common ancestral population (approximately 71-142 thousand years ago). The branches corresponding to sub-Saharan African farming populations and those that left Africa diverge next, with subsequent splits of branches for Eurasia, Oceania, East Asia, and America. African hunter-gatherer populations and populations of Oceania and America exhibit no statistically significant signature of growth. The features of population subdivision and growth are discussed in the context of the ancient expansion of modern humans.

Africa↗

PubMed2000

The fourfold Democritus on the stage of early modern science.

The renewed success of ancient atomism in the seventeenth century has baffled historians not only because of the lack of empirical evidence in its favor but also because of the exotic heterogeneity of the models that were proposed under its name. This essay argues that one of the more intriguing reasons for the motley appearance of early modern atomism is that Democritus, with whose name this doctrine was most commonly associated, was a figure of similar incoherence. There existed in fact no fewer than four quite different Democriti of Abdera and as many literary traditions: the atomist, the "laughing philosopher," the moralizing anatomist, and the alchemist. Around the year 1600 the doctrines of these literary figures, three of whom had no tangible connection with atomism, began to merge into further hybrid personae, some of whom possessed notable scientific potential. This essay offers the story of how these Democriti contributed to the rise of incompatible "atomisms."

Alchemy↗

PubMed2001

Curiosity, forbidden knowledge, and the reformation of natural philosophy in early modern England.

From the patristic period to the beginning of the seventeenth century curiosity was regarded as an intellectual vice. Curious individuals were considered to be proud and "puffed up," and the objects of their investigations were deemed illicit, dispute engendering, unknowable, or useless. Seventeenth-century projects for the advancement of learning had to distance themselves from curiosity and its dubious fruits or, alternatively, enhance the moral status of the curious sensibility. Francis Bacon's proposals for the instauration of knowledge were an integral part of a process by which curiosity underwent a remarkable transformation from vice to virtue over the course of the seventeenth century. The changing fortunes of this human propensity highlight the morally charged nature of early modern debates over the status of natural philosophy and the particular virtues required of its practitioners. The rehabilitation of curiosity was a crucial element in the objectification of scientific knowledge and led to a gradual shift of focus away from the moral qualities of investigators and the propriety of particular objects of knowledge to specific procedures and methods.

England↗

PubMed2001

Families made by science. Arnold Gesell and the technologies of modern child adoption.

This essay considers the effort to transform child adoption into a modern scientific enterprise during the first half of the twentieth century via a case study of Arnold Gesell (1880-1961), a Yale developmentalist well known for his studies of child growth and the applied technologies that emerged from them: normative scales promising to measure and predict development. Scientific adoption was a central aspiration for many human scientists, helping professionals, and state regulators. They aimed to reduce the numerous hazards presumed to be inherent in adopting children, especially infants, who were not one's "own." By importing insights and techniques drawn from the world of science into the practical world of family formation, scientific adoption stood for kinship by design. This case study explores one point of intersection between the history of science and the history of social welfare and social policy, simultaneously illustrating the cultural progress and power of scientific authority and the numerous obstacles to its practical realization.

Adoption↗

PubMed1999

The nutrient-toxin dosage continuum in human evolution and modern health.

Recent findings support the long-recognized principle that nutritive and toxic effects of an ingested material depend not only on its nature but very much on its quantity. The well known observation that essential nutrients can be toxic at high dosages suggests that the same reversal of effect may be true of many substances that could be beneficial but not essential at low dosages (the phenomenon of hormesis). This has been demonstrated for many well known toxins. We suggest a mathematical model that describes these dosage effects as an expected result of the evolution of human metabolic and dietary adaptations for maximizing benefits and minimizing costs of the ingestion or other intake of any substance. Evolved mechanisms for achieving benefits may be unrelated to those for reducing costs. These evolutionary considerations suggest important consequences demonstrable by experimental or epidemiological studies. They also suggest ways in which our evolved dietary adaptations may be currently maladaptive, and individual development of taste preferences poorly calibrated by early experience in modern environments. The apparent reality of hormesis raises the possibility of counterproductive effects of current dosage recommendations and limits for nutrients and pollutants. We propose that some conceptual and factual problems are urgently in need of resolution. Fundamental to evolutionary biology is the tendency for organisms to become increasingly adapted to those environments to which they are most commonly exposed (Parsons 1990).

Adaptation, Physiological↗