Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “LUPUS ERYTHEMATOSUS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,351 records · Page 75Linked to original sources
PubMed1999

Rectal ulcers: a rare gastrointestinal manifestation of systemic lupus erythematosus.

A patient with systemic lupus erythematosus (SLE) developed a rectal ulcer and sepsis from colonic bacteria. At that time she had no other clinical manifestations of SLE. Histopathologic examination of the biopsies taken from the ulcer found evidence of vasculitis. Treatment with high-dose systemic steroids healed the ulcer clinically and endoscopically, but symptoms recurred when steroids were tapered. The patient was referred for surgery. This is a rare but dangerous complication of SLE and can be the only clinical manifestation of the disease.

Adult↗
PubMed1988

OKT4+ T cell deficiency and an association of immunoglobulin deficiency in systemic lupus erythematosus.

A patient with systemic lupus erythematosus and selective serum IgA and IgM deficiency also had a deficiency of OKT4+, OKT4A+, OKT4B+, and OKT4E+ T cells in circulating blood. This deficiency of helper/inducer T cell subsets in blood was associated with impaired T cell responses to phytohaemagglutinin in vitro, and an impaired ability to produce IgA and IgM by the patient's B cells. The patient's OKT4+ (CD4+) T cell deficient population suppressed IgM synthesis by normal B and T cells.

Adult↗
PubMed1990

Laminar periostitis and multiple osteonecrosis in systemic lupus erythematosus.

Bone affectation in systemic lupus erythematosus (SLE) is caused both by the disease itself and by the treatment used. We report the case of a woman diagnosed of SLE, who, in the course of her illness, develops multiple aseptic osteonecrosis (AON) and laminar periostitis, radiologically compatible with the diagnosis of hypertrophic osteoarthropathy (HOA), with no evidence of acropaquia. In this case, the patient shows all the risk factors involved in the pathogenesis of the development of ischemia in bone microcirculation.

Adult↗
PubMed1991

[Ballism in systemic lupus erythematosus].

A case of systemic lupus erythematosus (SLE) with ballism is presented. The movement disorders, as a group, account for approximately 2% of the neurological and psychiatric symptoms of central nervous system (CNS) involvement in SLE, and more than any of the other neuro-psychiatric manifestations they tend to precede the diagnosis of SLE. Ballism and other rare movement disorders are not included in the 1982 revised American Rheumatism Association criteria for SLE. Being aware of the correlation between CNS disease and more severe SLE, one should assess therapeutic intervention critically.

Adolescent↗
PubMed1993

Whole saliva in systemic lupus erythematosus patients.

Whole saliva composition and flow rate were examined in 22 patients with systemic lupus erythematosus and compared with matched healthy controls. Significantly lowered salivary flow rate was observed in patients with systemic lupus erythematosus unrelated to the subjective complaint of xerostomia. Salivary sodium, calcium, and magnesium concentrations were significantly higher in the SLE patients with systemic lupus erythematosus, whereas potassium and total protein concentrations and amylase activity did not differ significantly from the controls. Salivary IgA and IgM levels were significantly higher in the patients than in controls. IgA, IgG, IgM, C3, C4, antinuclear antibody, and anti-DNA antibody levels were measured in serum of the patients with systemic lupus erythematosus and correlated with salivary immunoglobulins. The only significant correlation between saliva and serum was found between levels of salivary IgG and serum anti-DNA antibody. The altered salivary composition might indicate a subclinical involvement of salivary glands in the patients.

Adult↗
PubMed1988

[The pathogenesis of systemic lupus erythematosus--data and considerations].

Systemic lupus erythematosus (SLE) is viewed as a prototype of generalized autoimmune disease. The causes and mechanisms of inflammatory damage to various organ systems are not known. In this article, we will try to conceive a synopsis of existing hypotheses from the literature and our own data in order to project directions for further research. The use of the methods of modern biotechnology promises further insights into details of the genetic predisposition to this disease as well as into environmental factors that lead to disordered immunoregulation and organ damage.

Autoantigens↗
PubMed2000

Circulating endothelial cells and vascular injury in systemic lupus erythematosus.

In flares of systemic lupus erythematosus (SLE), endothelial cells activated by immune stimuli are potential participants in the inflammatory processes, which contribute to injury. Elevated levels of circulating endothelial cells (CEC) may be a proxy for vascular injury, as demonstrated in patients with sickle cell anemia during acute crises. In active SLE, CEC levels in peripheral blood are elevated (vs healthy controls and correlate with plasma C3a). CEC may reflect widespread unrecognized, ongoing injury despite the absence of clinical stigmata of vasculitis in patients with SLE.

Biomarkers↗
PubMed1978

Autoimmune hemolytic anemia and periodic pure red cell aplasia in systemic lupus erythematosus.

A patient with systemic lupus erythematosus and autoimmune hemolytic anemia complicated by periodic episodes of red cell hypoplasia is described. Using a plasma clot culture system a serum inhibitor of erythropoiesis was detected. In addition, heat eluates of the red cells of this patient were capable of impairing erythroid colony formation. The possibility that the autoantibodies of acquired autoimmune hemolytic anemia might influence the proliferation and/or maturation of erythroid progenitor cells is raised by these findings.

Anemia, Aplastic↗
PubMedDate not supplied

Tophaceous gout in patients with systemic lupus erythematosus.

Coexistent gout and systemic lupus erythematosus (SLE) has been reported rarely, below the expected incidence even when adjusted for the discordance of age and sex of the affected populations. It is possible that SLE prevents expression of gout, or vice-versa. Review of the reported cases suggests that SLE is likely to be inactive and serum complement normal when gout is active. Lack of awareness of the possibility of gout and concurrent treatment with corticosteroids and nonsteroidal anti-inflammatory drugs may prevent recognition of gout in many patients with SLE.

Adult↗
PubMed2006

Non-tuberculous mycobacterial infection in patients with systemic lupus erythematosus.

OBJECTIVES: Patients with systemic lupus erythematosus (SLE) are susceptible to opportunistic infections. To examine the clinical manifestations of non-tuberculous mycobacterial (NTM) infections with those of Mycobacterium tuberculosis (MTB) infections in SLE patients. METHODS: Medical records of a cohort of 725 SLE patients were reviewed for previous NTM infections. Demographic characteristics, predisposing factors and clinical outcomes were compared with patients who had previous MTB infections (n = 39). RESULTS: Eleven (nine female and two male) cases were identified (prevalence 1.5%). The mean +/- S.D. age at the time of infection was 42.8 +/- 13.9 yrs, 9.3 +/- 5.8 yrs after the onset of SLE. The mean +/- S.D. time taken from onset of symptoms to the diagnosis of NTM infection was 5.7 +/- 7.2 months. Sites of involvement included skin and soft tissue (n = 8), chest (n = 2) and disseminated infection (n = 1). NTM infections were more likely to involve extrapulmonary sites (P = 0.006), presented in patients with longer lupus disease duration (P < 0.001), occurred in older patients (P < 0.001) and in those who had a higher cumulative dose of prednisolone (P = 0.01) than MTB infections. Using a stepwise logistic regression, disease duration was found to be the only independent predictive factor (P = 0.005) for NTM infections. Ten (25.6%) patients with MTB infections but none of the patients with NTM infections presented concomitantly at the onset of SLE (P = 0.09). There were no differences in the recurrence rate (P = 0.64) and frequency of disseminated infections (P = 0.40) between NTM and MTB infections. CONCLUSIONS: NTM infections tended to develop in SLE patients later in their disease course than MTB infections. A high index of suspicion is required for its diagnosis.

Adult↗
PubMedDate not supplied

Total hip arthroplasty for avascular necrosis of the femur in systemic lupus erythematosus.

Six patients with systemic lupus erythematosus and avascular necrosis of the femoral head were treated by total hip arthroplasty (THA). The primary indication for surgery was persistent hip pain despite conservative therapy. Postoperatively, pain was relieved with corresponding improvement in range of motion in all six patients. There were no serious complications. At follow-up ranging from 23 to 76 months after surgery there was no recurrence of hip pain. These results suggest that THA is indicated in selected SLE patients.

Adult↗
PubMed2004

Clinical mini-review: systemic lupus erythematosus and the eye.

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease, the exact etiology of which is unknown. It is characterized by the production of pathological autoantibodies which adhere to cellular surfaces or form immune complexes which deposit in tissue, leading to end-organ damage via inflammatory mechanisms including complement activation. SLE may manifest itself in any organ system. In the eye, keratoconjunctivitis sicca is the most common finding. Other ophthalmic sites of involvement include the cornea, conjunctiva, episclera, sclera, uveal tract, retina, vasculature, optic nerve, and orbit. Therapy varies based on the disease manifestation and severity.

Eye Diseases↗
PubMedDate not supplied

Pulse corticosteroid therapy for refractory thrombocytopenia in systemic lupus erythematosus.

A patient with systemic lupus erythematosus and severe thrombocytopenia was refractory to therapy with prednisone, alone or in combination with cyclophosphamide or vincristine. Intravenous pulse therapy with methylprednisolone was associated with an increased platelet count from 4,000/mm3, to 52,000/mm3, but the response was short-lived. A second course of pulse therapy was also successful, and splenectomy was safely performed. The platelet count has remained normal for 15 months after surgery, allowing prednisone to be tapered and discontinued. Intravenous pulse therapy with methylprednisolone may be a safe alternative in preparing patients with profound, refractory thrombocytopenia for splenectomy.

Adult↗
PubMed1988

Protein-losing enteropathy in systemic lupus erythematosus.

Two patients with systemic lupus erythematosus (SLE) presented with anasarca, pleural effusions and severe hypoalbuminema. Both were demonstrated to have protein-losing enteropathy, a rare complication of SLE. Other causes of gastrointestinal protein loss were excluded. There were marked similarities in both cases including circulating ANF with speckled staining, anti-(U1)RNP antibodies and low serum complement levels. Complete remission was achieved in both with prednisolone. Anti-(U1)RNP may be a marker for a subset of SLE in which protein-losing enteropathy is a major manifestation.

Adult↗
PubMed1983

Occult systemic lupus erythematosus in elderly men.

Systemic lupus erythematosus (SLE) is often not suspected in elderly men with a debilitating illness, particularly when pleuropericarditis is not prominent. Five elderly men with SLE were initially seen with a systemic illness, marked by fever, weight loss, and arthritis. The diagnosis of SLE was established after considerable delay with extensive diagnostic evaluations and was supported by the presence of DNA antibodies in four patients. Treatment with corticosteroids was effective in three patients. Early testing for DNA antibodies may be cost effective in the evaluation of the elderly patient with a debilitating illness.

Age Factors↗
PubMedDate not supplied

[The ocular manifestations in systemic lupus erythematosus].

Retinal involvement in systemic lupus erythematosus is dominated by a microangiopathy of unknown aetiology, with occlusive consequences. Although cases of severe retinal ischaemia have been recently described, from a statistic point of view, the occlusive phenomena seem to have declined over the last decades, under the influence of a better therapy and follow-up of the disease. The relatively high incidence of papilloedema and the fact that this oedema might be unilateral or asymptomatic are pointed out. The importance of ophthalmic examination in patients with SLE-like syndromes or in seronegative cases of SLE is revealed. Other ocular manifestation of the disease are reviewed.

Eye Diseases↗
PubMed1993

Involvement of the local immune response in a case of advanced cervical cancer in a patient with systemic lupus erythematosus.

Although patients with systemic lupus erythematosus (SLE) have frequently accompanying malignancies, there are few documented cases in the literature of advanced cervical cancer patients with SLE. This report describes a case of advanced cervical cancer in a 39-year-old patient with a 20-year history of SLE (FIGO stage IIIb) and evaluates the immunological response of the tumor. The clinical course of this patient with SLE, with rapid growth of cervical cancer and a poor prognosis, may suggest that T cells play a key role in the growth of cancer.

Adult↗
PubMed1987

Gout and hyperuricaemia in systemic lupus erythematosus.

Coexistent gout and systemic lupus erythematosus (SLE) have received increasing attention. An additional case is reported and published cases reviewed. Common clinical features of this group include nephritis, diuretic and corticosteroid therapy and a tendency to be older and more frequently male. Prevalence of hyperuricaemia (HU) was assessed in 38 patients with SLE. HU was found in 29% and was closely associated with renal involvement particularly proteinuria and diuretic therapy. The presentation of gout in SLE may be modified or suppressed by anti-inflammatory therapy and may be misinterpreted as SLE arthritis.

Adolescent↗