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PubMed2006

Interplay of biomaterials and micro-scale technologies for advancing biomedical applications.

Micro-scale technologies have already dramatically changed our society through their use in the microelectronics and telecommunications industries. Today these engineering tools are also useful for many biological applications ranging from drug delivery to DNA sequencing, since they can be used to fabricate small features at a low cost and in a reproducible manner. The discovery and development of new biomaterials aid in the advancement of these micro-scale technologies, which in turn contribute to the engineering and generation of new, custom-designed biomaterials with desired properties. This review aims to present an overview of the merger of micro-scale technologies and biomaterials in two-dimensional (2D) surface patterning, device fabrication and three-dimensional (3D) tissue-engineering applications.

Base Sequence↗
PubMed1996

Interplay between mycoplasma surface proteins, airway cells, and the protean manifestations of mycoplasma-mediated human infections.

Adherence of mycoplasmas to specific tissue surfaces is a crucial step in the establishment of infection. Several pathogenic mycoplasmas are flask-shaped and possess specialized tips that permit a highly oriented surface parasitism of host target cells. Mycoplasma pneumoniae, which causes primary atypical pneumonia in humans, requires a network of interactive adhesins and accessory proteins to cytadhere. The adhesins must cluster at the mycoplasma tip organelle in close association with cytadherence-related accessory proteins and a naplike structure, which together appear to comprise a primitive cytoskeleton-like system. Proline-rich regions associated with these proteins play critical roles in the maintenance of the structural and functional integrity of the tip. Mycoplasma genitalium, originally isolated from the human urogenital tract of patients with nongonococcal urethritis, also colonizes airway cells along with M. pneumoniae. The molecular basis for cytadherence of these mycoplasmas is discussed in terms of the identification, cloning, and sequencing of the implicated mycoplasma genes, their common DNA and amino acid homologies and structural and functional domains, and the organizational similarities in their cytadherence-related operons. In addition, the multiorgan protean manifestations of mycoplasma infection are discussed in terms of the role that mycoplasma adhesins may play in molecular mimicry, postinfectious autoimmunity, and immune-mediated damage.

Adhesins, Bacterial↗
PubMed2003

Interplay of confinement, strain, and piezoelectric effects in the optical spectrum of GaN quantum dots.

We theoretically investigated excitonic states, energy and oscillator strength of optical transitions in GaN quantum dots characterized by different size, shape, interface, and substrate. On the basis of our multi-band model we determined that the piezoelectric field-induced red shift of the ground state transition, observed in recent experiments, can manifest itself only in strained GaN/AIN dots with the dot height larger than 3 nm. It was also established that the oscillator strength of the red-shifted transitions is small (< 0.05) and decreases fast with increasing the dot size, while the strength of ground state transitions in c-GaN/c-AIN and GaN/dielectric dots is large (approximately 0.4-0.7) and almost independent of the dot size.

Electrochemistry↗
PubMed2003

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation.

Regulated recruitment and clearance of neutrophils (PMN) is the hallmark of competent host defense and resolution of inflammation. We now report that IFN-gamma controls PMN infiltration and modulates IL-6 signaling through its soluble receptor (sIL-6R) to promote their apoptosis and clearance. Induction of peritoneal inflammation in IFN-gamma-deficient (IFN-gamma-/-) mice emphasized that the initial rate of PMN recruitment was impaired. This defect in PMN recruitment was also associated with the suppressed intraperitoneal expression of IL-1beta and IL-6. Reconstitution of IFN-gamma signaling restored the rate of PMN infiltration and IL-6 levels and was accompanied by normalization of PMN-activating CXC chemokine expression. To test whether local IL-6 signaling modulated PMN recruitment, inflammation was induced in IFN-gamma-/- and IL-6-/- mice and cytokine signaling adapted by intraperitoneal sIL-6R-IL-6 fusion protein (HYPER-IL-6) or IFN-gamma. Although HYPER-IL-6 attenuated PMN influx in IFN-gamma-/- mice, IFN-gamma had no effect on PMN infiltration in IL-6-/- mice. Examination of the leukocyte infiltrate from IFN-gamma-/-, IL-6-/-, and wild-type mice showed that apoptosis was aberrant in the absence of IFN-gamma and IL-6 as a result of impaired sIL-6R signaling. These data emphasize a pivotal role for IFN-gamma in regulating innate immunity through control of both the recruitment and clearance phases of PMN trafficking.

Animals↗
PubMed2004

The T cell cometh: interplay between adaptive immunity and cytokine networks in rheumatoid arthritis.

The etiology of autoimmunity in humans remains poorly defined, and animal models provide a unique opportunity to study potential autoimmune mechanisms. A novel model of autoimmune inflammatory arthritis results from a point mutation in the zeta-associated-protein of 70 kDa (ZAP-70), which causes abnormal thymic T cell selection and survival of autoreactive clones. Although the resulting clinical and pathologic abnormalities are clearly T cell-dependent, macrophage and fibroblast cytokines such as IL-1 and TNF-alpha are required for full expression of the disease. The studies of Hata et al. raise the intriguing possibility that traditional proinflammatory cytokine networks represent common effector mechanisms in inflammatory joint diseases such as rheumatoid arthritis. Hence, effective therapeutic interventions can target either unique etiologic pathways related to adaptive immune responses or shared terminal mechanisms.

Animals↗
PubMed2001

The interplay and etiological continuity of neuroticism, difficulties, and life events in the etiology of major and subsyndromal, first and recurrent depressive episodes in later life.

OBJECTIVE: Stressful life events, long-term difficulties, and high neuroticism are established risk factors for depression. Less is known about their role in late-life depression, how they modify or mediate one another's effects, and whether this differs between major and subsyndromal, first and recurrent episodes. METHOD: The authors used a prospective case-control design nested in a community survey of elderly subjects that included a measure of neuroticism. They compared 83 survey participants who subsequently developed a depressive episode with 83 randomly selected comparison participants. The authors determined dates of onset, history, and severity of episodes and dates of occurrence and severity of stressful life events and difficulties. RESULTS: Stressful life events did not mediate the effects of high neuroticism and difficulties at onset, possibly because of the uncontrollable nature of common stressful life events in later life. Without both high neuroticism and difficulties, stressful life events did not increase risk. High neuroticism and difficulties increased risk, even without a stressful life event. In the presence of high neuroticism and/or difficulties, the depressogenic effect of stressful life events was substantial, suggesting effect modification. The authors found no evidence to suggest etiological discontinuity between major and subsyndromal episodes. First and recurrent episodes showed a discontinuous pattern of associations. Severe stressful life events had weaker associations, but high neuroticism and mild stressful life events had stronger associations with recurrent than with first episodes. CONCLUSIONS: This study demonstrated the usefulness of a dynamic stress-vulnerability model for understanding late-life depression. Evidence was found suggesting etiological discontinuity between first and recurrent but not between major and subsyndromal episodes.

Aged↗
PubMed1995

The phenomena of Pine's "four psychologies": their contrast and interplay as exhibited in the Beatles' "white album".

Psychoanalytically informed clinicians are frequently challenged with recognizing and integrating into their work the diverse phenomena central to differing psychoanalytic theoretical frameworks. In addressing this dilemma, Pine has formulated a "multiple model" that recognizes the qualitatively different psychological phenomena and the distinct motivational forces emphasized by what he calls "the four psychologies of psychoanalysis," the psychologies of drive, ego, object relations and self. This model makes it possible to describe individual personality organizations in terms of psychological hierarchies of the phenomena of the four psychologies. Use of this model promotes a particular kind of listening stance that facilitates recognition and use of a wide variety of clinical data. The usefulness of this model is demonstrated through its application to a creative work, the Beatles' "White Album." This application shows the utility of Pine's psychological hierarchies in describing differing personality organizations, the "multiple functions" mental events can represent through serving the motives of multiple psychologies, and the frequent interactions that occur between the differing psychological phenomena. Pine's model facilitates a recognition that an important quality found in works by the Beatles is their demonstration in strikingly clear form, of the qualitatively different aspects of human experience emphasized by the four psychologies. The accessibility of Beatles music makes it a potentially valuable teaching tool for demonstrating Pine's model.

Creativity↗
PubMed1995

The analytic role: a mediating influence in the interplay of transference and countertransference.

Recognition of the analyst's subjective involvement has led to profound reconsideration of the nature of mutative process. How is it that the analyst can be personally involved in an unconscious way, yet also be an "objective" participant in the relationship? The paper proposes that the analyst's subjectivity is mediated by his or her role. The analytic role conditions how the analyst listens, experiences, and behaves, leading to interactive outcomes different from that expectable from unmodified subjectivity. The paper describes the analytic role in terms of contributions from metapsychology, clinical theory, and tactics. Each affects the function of the analyst-at-work in a different way. The analytic role, learned during training, is maintained by a combination of internalization and ongoing involvement in psychoanalytic activities. A clinical illustration demonstrates how a typical transference-countertransference enactment is influenced by the analytic role. The vignette suggests ways in which the concept of role modifies the effect of subjectivity. Three recent viewpoints--those of Renik, Ehrenberg, and Hoffman--that challenge previous theories of mutative process are discussed in terms of the analytic role. In each case, consideration of role clarifies the nature of the innovative technique or view, and seeming contradictions between it and existing clinical theory.

Adult↗
PubMed1987

Social psychiatry in Zimbabwe or the interplay of culture and psychosocial disorders.

This article describes stresses that affect the social security of patients in a developing country like Zimbabwe and the influence of those stresses on the onset of psychosocial disorder. This is demonstrated in the form of case presentations. The impact on psycho-social disorders reflects a process in which the main factors are social status; stress/support; deprivation; reference.

Adjustment Disorders↗
PubMed2003

Spontaneous skepticism: the interplay of motivation and expectation in responses to favorable and unfavorable medical diagnoses.

The quantity of processing view of motivated reasoning predicts that individuals are more likely to spontaneously question the validity of unfavorable than favorable feedback even when the objective likelihood of the feedback is equivalent. Participants were videotaped self-administering a bogus medical test revealing either a favorable or an unfavorable result. In Studies 1 and 2, unfavorable result participants required more time to accept the validity of the test result and were more likely to spontaneously recheck its validity than were favorable result participants. However, unfavorable results also were perceived as less expected than were favorable results, even though the information supplied about their objective likelihood was identical. Study 3 showed that participants evaluating another student's results perceived favorable and unfavorable outcomes as equally likely, suggesting that the subjective likelihood of positive and negative feedback is also subject to motivational influence.

Affect↗
PubMed2005

The interplay between goal intentions and implementation intentions.

Two studies tested whether action control by implementation intentions is sensitive to the activation and strength of participants' underlying goal intentions. In Study 1, participants formed implementation intentions (or did not) and their goal intentions were measured. Findings revealed a significant interaction between implementation intentions and the strength of respective goal intentions. Implementation intentions benefited the rate of goal attainment when participants had strong goal intentions but not when goal intentions were weak. Study 2 activated either a task-relevant or a neutral goal outside of participants' conscious awareness and found that implementation intentions affected performance only when the relevant goal had been activated. These findings indicate that the rate of goal attainment engendered by implementation intentions takes account of the state (strength, activation) of people's superordinate goal intentions.

Analysis of Variance↗
PubMed2006

Long ago it was meant to be: the interplay between time, construal, and fate beliefs.

Fate means that an event was meant to be, that is, predetermined by prior unseen forces. Most people believe in fate, which seems at odds with similarly pervasive beliefs that alternative past actions would have brought about different circumstances (i.e., counterfactual beliefs). Two experiments revealed that construal level accounts for the relative plausibility of fate versus counterfactual explanations. Construal was manipulated in Experiment 1, such that goal pursuits framed in abstract ("why?") as opposed to concrete ("how?") terms heightened fate but not counterfactual attributions. Extending this finding, Experiment 2 showed that fate judgments were higher for temporally distant than recent past events, an effect mediated by construal perceptions. Neither counterfactual nor luck judgments varied with temporal distance. These findings help to explain how individuals explain complicated yet meaningful life events while extending the reach of Trope and Liberman's (2003) construal-level theory.

Adult↗
PubMed2005

Nature-nurture interplay: genetically informative designs contribute to understanding the effects of trauma and interpersonal violence.

The past two decades have seen an explosion in research in the fields of violence and trauma and behavior genetics. These two fields came into direct conflict when Lisabeth Fisher DiLalla and Irving I. Gottesman outlined a fundamental conceptual limitation of trauma and violence research: that rather than being causal, the well-documented relationship between exposure to trauma or violence and later negative outcomes could be explained by gene-environment correlation. In the past decade, researchers have addressed this limitation by studying the effects of trauma and violence using genetically informative designs. This report briefly discusses the gains made from this research approach and the promising future for genetically informative trauma and violence research.

Female↗
PubMed2006

Antiphospholipid-mediated thrombosis: interplay between anticardiolipin antibodies and vascular cells.

The antiphospholipid syndrome (APS) is characterized by thrombosis or pregnancy morbidity in the presence of antiphospholipid autoantibodies (aPL). aPL are a heterogeneous family of autoantibodies with diverse cross-reactivities whose origin and role have not been fully elucidated. Many of the autoantibodies associated with APS are directed against phospholipid-binding plasma proteins, such as beta2-GPI and prothrombin, or phospholipid-protein complexes. The mechanisms by which aPL cause thrombosis are not completely understood. There is no unique mechanism able to explain all symptoms associated with the presence of aPL. Different theories have been proposed, including the effect of aPL on endothelial cells, monocytes, and platelets. aPL are able to recognize, injure, or activate cultured vascular endothelial cells. Cultured endothelial cells incubated with aPL express increased levels of cell adhesion molecules and tissue factor (TF), an effect mediated by beta2-GPI, and may promote inflammation and thrombosis. Overexpression of TF has been also shown in monocytes in vitro and ex vivo. TF is the major initiator of coagulation in vivo; thus, its dysregulation may be one of the most important contributors to thrombosis. Effects of aPL upon platelets are not completely elucidated. aPL bind anionic phospholipid but they are normally in the inner side of cell membranes. When platelets are activated by different agonists, anionic phospholipids are exposed. There is some evidence showing that activated platelets are present in aPL-positive patients. Increased levels of beta-thrombomodulin, and microvesicle formation seem to support this hypothesis. Activated platelets may contribute to thrombosis by persistent exposure of a procoagulant surface.

Antibodies, Anticardiolipin↗
PubMed2005

Considering the interplay of cultural context and service provision in intimate partner violence: the case of Haitian immigrant women.

This qualitative study explored how the cultural context of intimate partner violence affected accessibility to mainstream services for one immigrant group: Haitian women. Analysis of the data revealed two major themes. First, the nature and context of intimate partner violence in the Haitian immigrant community contribute to Haitian women's reluctance to seek services as well as their overall vulnerability to intimate partner violence. Second, mainstream services are largely inaccessible to Haitian women. The authors conclude with suggestions for overcoming cultural barriers through education, increasing cultural competency of mainstream services, and creating alternative community-based services.

Adult↗