Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Intellectual Property”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,351 records · Page 75Linked to original sources

A scalogram analysis of behavioral strategies in severely and profoundly retarded adults.

The present study was designed to provide empirical evidence for an assumed order sequence of five behavioral strategies in 75 severely and profoundly retarded adults. A behavioral strategy was defined as a set of task-related behaviors each of which is controlled by the same stimulus properties of the materials. Four sets of tasks were used to measure four of the five strategies. Multiple presentation modes were employed to enhance the Ss' understanding of the demand characteristics of the tasks. A scalogram analysis revealed that the four sets of items met the requirements for a cumulative scale. Additional analyses were performed to identify individual items measuring a specific behavioral strategy. The obtained results indicated that most items measured one strategy although not always the one for which they were designed. The additional value of the described classification system over other, more traditional measures, is discussed.

Adolescent↗

Psychometric properties of the Beck Depression Inventory and the Zung Self Rating Depression Scale in adults with mental retardation.

The psychometric properties of the Beck Depression Inventory and the Zung Self Rating Depression Scale were examined. Both tests were administered to 120 adults with mental retardation. Results were analyzed, correlated, and examined with principle component analysis. Findings suggest that the tests have good clinical utility with these persons and that depression may be more severe in people with mental retardation. Characteristics that can be employed in building other behavioral measures of depression for persons with mental retardation were also identified. Results show that there may be a tendency for persons with mental retardation to minimize distress report, further complicating the depression diagnostic process for these persons.

Adult↗

A functional analysis of photo-object matching skills of severely retarded adolescents.

Matching-to-sample procedures were used to assess picture representation skills of severely retarded, nonverbal adolescents. Identity matching within the classes of objects and life-size, full-color photos of the objects was first used to assess visual discrimination, a necessary condition for picture representation. Picture representation was then assessed through photo-object matching tasks. Five students demonstrated visual discrimination (identity matching) within the two classes of photos and the objects. Only one student demonstrated photo-object matching. The results of the four students who failed to demonstrate photo-object matching suggested that physical properties of photos (flat, rectangular) and depth dimensions of objects may exert more control over matching than the similarities of the objects and images within the photos. An analysis of figure-ground variables was conducted to provide an empirical basis for program development in the use of pictures. In one series of tests, rectangular shape and background were removed by cutting out the figures in the photos. The edge shape of the photo and the edge shape of the image were then identical. The results suggest that photo-object matching may be facilitated by using cut-out figures rather than the complete rectangular photo.

Adolescent↗

Position paper of the American Council on Science and Health: public health concerns about environmental polychlorinated biphenyls (PCBs).

Polychlorinated biphenyls, or PCBs, were widely used in various industrial applications for their insulating and fire retardant properties. In the 1960s, PCBs were found in soil and water, and research confirmed that some PCB congeners degrade very slowly in the environment and can build up in the food chain. Two widespread poisoning episodes in Japan and Taiwan were initially attributed to the consumption of rice bran oil contaminated with PCBs. Although subsequent analysis suggested that toxic thermal degradation products of PCBs in the oil, rather than the PCBs, were responsible for the observed health effects, commercial production of PCBs in the United States was discontinued in 1979. Several regulatory and advisory agencies have categorized PCBs as animal carcinogens; however, studies of workers exposed to high doses of PCBs over long periods of time have not demonstrated an increased cancer risk. In fact, the only health effects that could be attributed to PCBs were skin and eye irritation. Recent studies of the possible effects of prenatal exposure to PCBs on neurodevelopment in infants and children have been criticized for methodological deficiencies. There is no conclusive evidence that PCB levels in the general population are causing intellectual deterioration in children exposed in utero. Some investigators have also suggested that PCBs and other chemicals in the environment can interfere with the body's endocrine system, leading to infertility, certain types of cancer, and other hormone-related disorders. Evidence for estrogenic effects of environmental PCBs remains weak and circumstantial. The following actions are recommended: development of innovative, cost-effective remediation techniques, particularly for sites that are difficult to remediate (e.g., river sediments); and scientifically based improvements to risk assessment, to reduce the considerable uncertainty associated with PCB exposure to health effects in humans.

Animals↗

The measurement properties of the Swedish version of the Assessment of Communication and Interaction Skills.

The purpose of this study was to validate the Swedish translation of the Assessment of Communication and Interaction Skills (ACIS-S) and its applicability in Sweden. The ACIS is an observational rating scale designed to capture, in detail, a person's social interactional ability, while he/she is participating in meaningful occupations. Eighteen occupational therapists trained in administering the ACIS-S, completed 157 ACIS-S assessments of 67 subjects with psychosocial and learning disabilities. Many-faceted Rasch analysis was used to analyse the data. The results supported internal, construct and person response validity of the ACIS-S, and rater validity and reliability. The scale effectively categorized subjects according to the levels of communication and interaction ability.

Adolescent↗

Differential reinforcement as treatment for behavior disorders: procedural and functional variations.

For many years, differential reinforcement has been a prevalent and preferred treatment procedure for the reduction of behavior disorders. This paper reviews the procedural variations of differential reinforcement and discusses their functional properties. It is proposed that such procedures are more likely to be successful if behavioral function is a primary consideration in prescribing treatments; furthermore, limited success noted in previous research may be due to the arbitrary relationship that often exists between reinforcers and target behaviors when behavioral function is unknown. Despite the promise of a function-based approach to differential reinforcement, several current limitations exist in the identification and manipulation of relevant variables. Thus, further research is required to elucidate the relationship between aberrant behaviors and the variables responsible for maintaining them; otherwise, successful treatment cannot be expected. Several areas for future research are discussed conceptually as extensions of current and past experimentation.

Behavior Therapy↗

The psychometric properties of the Social Training and Achievement Record: II. Reliabilities and concurrent validities.

Three studies are reported which investigated the test-retest and inter-rater reliabilities of the Social Training and Achievement Record as well as concurrent validities with intelligence. Reliabilities of total and sub-scale scores as well as individual items are reported. Test-retest reliabilities over the period of one month were good for total scores, subscale scores and individual items. Inter-rater reliabilities were more modest. At times, inter-rater reliabilities of a small proportion of items were only at chance levels. Concurrent validities with Raven's Matrices and the Weschler Adult Intelligence Scale were comparable with other measures of adaptive behaviour. The role of direct observation in the assessment of adaptive behaviour, in particular with respect to individual skills being selected for teaching, is discussed.

Activities of Daily Living↗

A Dutch version of the Psychopathology Inventory for Mentally Retarded Adults (PIMRA).

Eighty-nine mildly mentally retarded adults were assessed using the Psychopathology Inventory for Mentally Retarded Adults (PIMRA). This study reports on the psychometric properties of the PIMRA in a Dutch population, the correlation between self-report and ratings-by-others forms, and the relationship of the PIMRA to both behavior problems and subject characteristics. It was revealed that internal consistency was good for both forms on total scores but modest for most of the subscales. Furthermore, interrater reliability was low to modest. Both forms of the PIMRA showed good criterion validity. The correlation between the two forms was modest. A strong relationship was found between PIMRA scores and behavior problems, as measured using the Reiss Screen of Maladaptive Behavior. Furthermore, the relationship between PIMRA scores and subject characteristics was weak.

Adult↗

FXR1, an autosomal homolog of the fragile X mental retardation gene.

Fragile X mental retardation syndrome, the most common cause of hereditary mental retardation, is directly associated with the FMR1 gene at Xq27.3. FMR1 encodes an RNA binding protein and the syndrome results from lack of expression of FMR1 or expression of a mutant protein that is impaired in RNA binding. We found a novel gene, FXR1, that is highly homologous to FMR1 and located on chromosome 12 at 12q13. FXR1 encodes a protein which, like FMR1, contains two KH domains and is highly conserved in vertebrates. The 3' untranslated regions (3'UTRs) of the human and Xenopus laevis FXR1 mRNAs are strikingly conserved (approximately 90% identity), suggesting conservation of an important function. The KH domains of FXR1 and FMR1 are almost identical, and the two proteins have similar RNA binding properties in vitro. However, FXR1 and FMR1 have very different carboxy-termini. FXR1 and FMR1 are expressed in many tissues, and both proteins, which are cytoplasmic, can be expressed in the same cells. Interestingly, cells from a fragile X patient that do not have any detectable FMR1 express normal levels of FXR1. These findings demonstrate that FMR1 and FXR1 are members of a gene family and suggest a biological role for FXR1 that is related to that of FMR1.

Amino Acid Sequence↗

Assessing stimulus control in natural settings: an analysis of stimuli that acquire control during training.

When a learner is taught a new response, the stimuli that influence its display are often unknown. The presence or absence of these stimuli alters the probability of occurrence of the response. By identifying the stimuli influencing the probability of newly acquired responses, interventionists may program for their generalization more effectively and efficiently. This investigation describes the application of an operant methodology to assess functional relationships between responses and specific stimulus variables. Four young adults with moderate mental retardation were taught to include "please" as part of requests they made in school. Four environmental stimuli, present during training, were assessed for the controlling properties they acquired. Each of the four was assessed prior to and after training by presenting it in isolation (i.e., the other three were varied). If the presence of a single stimulus associated with training did not occasion "please," then pairs of stimuli were probed. The results revealed that single-stimulus probing occasioned responding by only 1 learner; paired-stimulus probing set the occasion for including "please" by 2 others. Control of the 4th learner's responding was lost before training was introduced, because he began including "please" in his requests during baseline. The implications of these results are discussed in terms of analyzing stimulus control and promoting stimulus generalization.

Adolescent↗

Assessing the functions of aberrant behaviors: a review of psychometric instruments.

Reviewed the psychometric properties, treatment utility, and conceptual basis of psychometric instruments used to identify the functions of aberrant behaviors in people with developmental disabilities. The instruments reviewed are the Motivational Assessment Scale (Durand & Crimmins, 1992), the Motivation Analysis Rating Scale (Weisheler, Hanson, Chamberlain, & Thompson, 1985), the Functional Analysis Interview Form (O'Neill, Horner, Albin, Storey, & Sprague, 1990), and the Functional Analysis Checklist (Van Houten & Rolider, 1991). Recurrent problems in this area include the lack of replicability of the reliability of these instruments, difficulties in summarizing the information from these assessment devices, difficulties in translating the assessment into treatment packages, strong individual differences in the functions of behavior problems, and, finally, issues relating to the concurrent validity, both across these instruments and across other assessment methods.

Adolescent↗

[Spectral analytical study on the developmental properties of EEG in children: variability of EEG in normal and mentally retarded children (author's transl)].

The present study aimed at clarifying the characteristics of variability of the resting arousal EEGs in normal and mentally retarded children. Their ages ranged from 3 to 15 years in 58 normal and from 7 to 18 in 63 retarded. The EEG was recorded monopolarly from six regions of the scalp. The data analysed by a multipurpose digital computer comprised auto-power spectra and a coefficient of variation of power at each frequency. The variability of power at peak within the theta frequency band in both groups of children showed a notably higher value as compared with other frequency bands in all regions. We discussed some of the problems of treating this variability of power as a general characteristic of theta waves or as a developmental one.

Adolescent↗

[Influence of attention on an auditory-verbal learning test in schizophrenic patients].

Schizophrenic patients are known to feature alterations in their cognitive performances, principally in executive functions, attention and memory. In this last domain, studies have shown a relatively severe and global deficit, which can be assessed in chronic and first episode patients. It seems that the memory dysfunction is independent of age and intellectual level, but does correlate with negative psychopathology and global functioning. In the study of memory dysfunction, attentional capacities, information processing and symptomatology have to be considered as determining factors. It has been shown that patients with schizophrenia perform poorly in selective attention tasks and that this deficit may interfere with learning. In the same way, the slowing of information processing contributes to a superficial and incomplete learning. The impact of symptomatology has also to be considered, as negative and depressive symptoms are linked to mnesic performances. The majority of studies bearing on working memory and schizophrenia show an alteration of performances, but studies on long term memory are more equivocal. Procedural memory seems to be preserved, while declarative memory is impaired. These results support the hypothesis that in schizophrenia, memory processes that are consciously controlled are impaired, contrary to implicit learning which may be intact. Nevertheless, studies bearing on semantic memory and episodic memory show controversial results. Still, many authors argue that schizophrenic patients have difficulties in recalling learned material, specially when a delay or a interfering task are introduced in the test. Besides, the schizophrenic subjects do not use the semantic properties of the words, as well as the control subjects, when they have to learn a words list for example. The main goal of the present study was to examine the auditory-verbal learning capacities of 31 schizophrenic patients (20 men and 11 women, 19-56 years old), compared to 27 healthy subjects (11 men and 16 women, 23-56 years old). All subjects received an evaluation including the Rey Auditory-Verbal Learning Test, used to study the progressive acquisition of 15 disyllabic words which are successively orally presented five times to the subject. About forty-five minutes after the last of the five immediate recalls, the delayed recall is assessed and a percentage of retention is also calculated. Visual reasoning and attention capacities were studied with the Progressive Matrix and the d2 encumbrance test respectively. Global psychiatric symptomatology of the patients group was assessed with the Brief Psychiatric Rating Scale. Considering the literature existing on the verbal learning capacities of schizophrenic patients, it was expected that the patients would perform poorly and learn slower than controls. The initial learning of the material, which is a critical stage for schizophrenic patients, was studied with particular attention as well as the effect of the introduction of a delay upon the recall of the words list. A secondary objective of the study was to investigate the role of visual reasoning and attention upon auditory-verbal learning process. According to published studies, it is expected that schizophrenic patients manifest some impairment in the domains of visual reasoning and attention. The question is to know whether it alters performances in the auditory-verbal learning test or not. Finally, the links between clinical characteristics of the patients, like age and illness duration, and their learning performances were explored. Statistical analysis included first a descriptive analysis of data to examine differences between the two groups. Second, ANCOVAs were used in order to control the respective impact of educational level, attention capacities and verbal reasoning capacities upon learning performances. Third, Spearman's correlations were used to detect links between clinical characteristics of the patients and learning performances. The comparisons between patients and controls confirmed that schizophrenic patients scored less in the attentional and visual reasoning tasks. They also featured a lower educational level compared to the healthy subjects. In the auditory-verbal learning test, the patients showed altered performances in the five recalls, as well as in the delayed recall and for the retention percentage. In order to control the impact of educational level, attentional and visual reasoning capacities, these parameters were introduced in the statistical analyses. Educational level did not influence memory alterations in the schizophrenic group. However, attention and, to a lesser extend, visual reasoning had an impact on the comparison of memory scores: when controlling attention, almost no significant group effect remained. Finally, the exploratory analyses of links between clinical characteristics and memory only revealed the presence of a significant negative correlation between illness duration and learning performances. Thus, the analyze of data showed that schizophrenic subjects featured poor performances in the domains of attention, verbal reasoning and auditory-verbal memory. Further analyses taking into account group differences on attention suggest that the impairment featured by schizophrenic patients in the domain of verbal memory strongly relies on an attentional deficit. These results are discussed according to the existing literature and methodological limitations. Clinical implications are also discussed.

Adult↗

An analysis of the reinforcing properties of hand mouthing.

Hand mouthing often has been described as a stereotypic response that is maintained by nonsocial (automatic) reinforcement; however, data supporting this conclusion can be found in relatively few studies. This series of studies presents an experimental analysis of conditions associated with the maintenance of hand mouthing. In Experiment 1, a functional analysis was conducted for 12 individuals who engaged in chronic hand mouthing, to determine whether the behavior is usually maintained independent of social contingencies. Results obtained for 10 subjects were consistent with an automatic reinforcement hypothesis; the remaining 2 subjects' hand mouthing was maintained by social-positive reinforcement. Based on these results, Experiment 2 was designed to identify the specific reinforcing properties of hand mouthing. Each of 4 subjects was provided with a toy that substituted for hand mouthing, and preference for a specific topography of toy manipulation (hand-toy contact or mouth-toy contact) was measured. Results indicated that hand stimulation was the predominant reinforcer for all subjects. Experiment 3 provided an extension of Experiment 2 in that the same responses were measured across a variety of toys presented to each of 5 subjects. Results again indicated that hand stimulation was the predominant reinforcer for all subjects. Implications of these results are discussed with relevance to treatment.

Adult↗

Psychometric properties of the Dyskinesia Identification System: Condensed User Scale (DISCUS)

Individuals with developmental disability (N = 400) were assessed with the Dyskinesia Identification System: Condensed User Scale (DISCUS), a 15-item tardive dyskinesia rating scale shortened from the 34-item Dyskinesia Identification System-Coldwater (DIS-Co). Interrater reliability assessments were made for 148 individuals, and 2-week stability (test-retest) assessments were made for 128 individuals. Mean DISCUS total score was 4.1 (SD = 3.5); reliability was .92, p less than .001, and stability was .40, p less than .001. Based upon this study and a larger study of 4,649 individuals with developmental disability, we recommend that clinicians carefully evaluate for tardive dyskinesia any individuals with developmental disability who have been prescribed antipsychotics for greater than 3 months and who score 6 or above on the DISCUS.

Adolescent↗

Psychometric evaluation of a self-report measure of depression for individuals with mental retardation.

The psychometric properties of the Self-Report Depression Questionnaire (SRDQ) were evaluated, extending a previous assessment of this instrument. Data from two independent studies (Esbensen, 2004; Seltzer & Krauss, 1989) were pooled to generate a sample of 192 individuals with primarily mild or moderate mental retardation. Reliability estimates of this questionnaire were good to excellent and corroborated prior findings. In addition, the measure was found to have sound validity as evidenced by convergent validity, discriminant validity, and predictive validity and by comparing individuals with and without clinical diagnoses of depression. Thus, the SRDQ appears to be a reliable and valid measure of depressive symptomatology for individuals with mild or moderate mental retardation. Screening procedures are suggested.

Adult↗

Clinical features and molecular analysis of the alpha thalassemia/mental retardation syndromes. II. Cases without detectable abnormality of the alpha globin complex.

We have identified five unrelated patients, all of north European origin, who have hemoglobin H (Hb H) disease and profound mental handicap. Surprisingly, detailed molecular analysis of the alpha globin complex is normal in these subjects. Clinically, they present with a rather uniform constellation of abnormalities, notably severe mental handicap, microcephaly, relative hypertelorism, unusual facies and genital anomalies. Hematologically, their Hb H disease has subtly but distinctly milder properties than the recognized Mendelian forms of the disease. These common features suggest that these five "nondeletion" patients have a similar underlying mutation, quite distinct from the 16p13.3 deletion associated with alpha thalassemia and mild to moderate mental retardation described in the accompanying paper. We speculate that the locus of this underlying mutation is not closely linked to the alpha globin complex and may encode a trans-acting factor involved in the normal regulation of alpha globin expression.

Adolescent↗

Development of the fear survey for adults with mental retardation.

This paper describes the development of the fear survey for adults with mental retardation (FSAMR) and provides initial evidence of its psychometric properties. The FSAMR was designed to be sensitive to the assessment needs of individuals with mental retardation. The items were developed through open-ended interviews, a review of existing measures, expert input, and pilot testing. The sample consisted of 138 adults with mental retardation (73 from institutional settings and 65 from community settings). Cronbach's alpha internal consistency coefficients were 0.97 for the scale, and above the 0.60 threshold set for the study for all but the acquiescence response set (ARS) subscale. Significant concurrent validity coefficients with anxiety measures were in the moderate range (r=0.32 and 0.40) and are comparable to other similar studies. Implications for using the FSAMR are discussed.

Adolescent↗