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Results for “INFECTIOUS MONONUCLEOSIS”

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At least 1,351 records · Page 75Linked to original sources
PubMed1990

Comparative evaluation of two test methods (enzyme immunoassay and latex fixation) for the detection of heterophil antibodies in infectious mononucleosis.

The present study evaluated the Ventrescreen Mono enzyme immunoassay (Ventrex Laboratories) and Monolatex (Wampole Laboratories) for detection of infectious mononucleosis-specific heterophil antibodies by comparing test results on sera of 247 symptomatic patients. The purpose of this study was to compare not only the two different test systems but also the two different methods they represent for accuracy in detecting infectious mononucleosis-specific heterophil antibodies. Discrepancies in the test results of the two kits were arbitrated by determining the Epstein-Barr virus antibody profiles of the samples. The study showed that the Ventrescreen Mono enzyme immunoassay is as good as the Monolatex test for detecting heterophil antibodies. After discrepancies were resolved, the sensitivity and specificity of the Ventrescreen assay were 100 and 98%, respectively.

Adolescent↗
PubMed1996

[Serologic signs of Epstein-Barr-virus infections in various patients without infectious mononucleosis].

The authors detected Epstein-Barr virus (EBV) virus capsid (VCA) antibodies of IgM and IgG type together with EBNA and heterophil antibodies in the sera collected from 1882 unselected patients without infectious mononucleosis. Out of them IgM type antibodies were found in 123 cases and in an additional group of 30 patients heterophil antibodies were detected together with EBV specific virus markers. Altogether 153 patients were considered as cases of primary EBV infection, or reinfection. Comparing the distribution of age groups of the 1729 and the 153 patients, the author observed the increased incidence of elderly cases among patients with actual EBV infection, particularly above 60 years of age (P < 0.001). The 1729 patients were composed of 141 main diagnostic groups and the 153 patients with actual EBV infection consisted of 30 main diagnostic groups of which more than one third (53 cases) were of alcoholic liver diseases and patients of HBsAg carriers. The authors suppose, that in the cases of alcoholic liver diseases and of HBsAg carriers the suspected "immunocompromised" condition of those patients resulted the actual EBV infection, or reinfection. In other cases, like virus infection or meningitis serosa, it is suspected that the EBV can be responsible producing the symptoms.

Adult↗