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Results for “Hydroxyproline”

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PubMed1992

[New data on a second endogenous molecular form of mammalian hypothalamic LHRH, (hydroxyproline 9) LHRH].

An endogenous hydroxylated form of LHRH, (Hyp) LHRH, is able to displace LHRH bound to pituitary membrane preparations. In parallel, it stimulates release of both LH and FSH from pituitary cells in primary culture. The potency ratio of (Hyp)LHRH is approximately 1:20 and 1:5 with respect to the native decapeptide when peptidasic degradation is or is not inhibited. This correlates with a greater resistance of (Hyp) LHRH towards enzymatic degradation; in contrast to LHRH, the C-terminal (residues 6 to 10) end of (Hyp) LHRH is not degraded and generates C-terminal fragments which account for 64% of the LHRH immunoreactivity in extrahypothalamic areas as the hippocampus. Besides its weak gonadotropin releasing activity and its action or its localization in peripheral organs (placenta, gonads), a major role of the hydroxylated decapeptide may thus be to serve as a precursor of smaller active fragments on targets other than pituitary receptors.

Animals↗
PubMed1977

[Hydroxyproline content in blood and urine in ischemic heart disease].

The content of protein-bound oxyproline in blood and the total oxyproline content in urine were studied in 70 healthy individuals between the ages of 20 and 60 and in 124 patients with chronic ischemic heart disease whose ages ranged from 32 to 74. No age dependence of the protein-bound oxyproline level in blood plasma was revealed in healthy individuals. The concentration of oxyproline excreted in the urine was higher in individuals between the ages of 20 and 30 than among older individuals. In patients with chronic ischemic heart disease the level of protein-bound oxyproline in blood plasma was normal, excretion of oxyproline with the urine was increased. In patients with myocardial infarction a period of increased content of oxyproline in blood and urine was observed, the duration of which was determined by the extent and depth of infarction and the clinical course of the disease.

Adult↗
PubMed1989

[Relationship between urinary hydroxyproline creatine ratio and growth rates in boys of age 13 to 16].

A total number of 241 boys aged 13 to 16 were studied longitudinally for 8 months from April 1986 to December 1986. The linear correlation analysis showed that urinary HP/Cr was highly correlated with height growth rate (r = 0.83) and moderately with weight growth rate (r = 0.63). The multiple correlation coefficients between urinary HP/Cr and height growth rates were much bigger than those between urinary HP/Cr and weight growth rates, only the former were statistically significant. It is suggested that the urinary HP/Cr is mainly correlated with height growth rate. The multiple regression analysis was employed with urinary HP/Cr, age as independent variables and height growth rate as dependent variable. The equation is very significant, 95% confidence limit is y +/- 1.38%. It is suggested that the prediction of height growth rate is rather precise, so urinary HP/Cr is a valuable index in the evaluation of growth of children.

Adolescent↗