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At least 1,351 records · Page 75Linked to original sources
PubMed1995

Diagnostic entropy as a function of therapeutic benefit/risk ratio.

Current clinical practice is based upon 'out stubborn quest for diagnostic certainty' which in turn is considered as one of the major reasons for ever-increasing health costs. We linked a treatment-threshold concept with classic information theory to show that measurable clinical variables, such as benefit and risk of available treatments, can be used to calculate the acceptable levels of diagnostic uncertainties associated with a particular clinical situation. Our analysis shows that practising physicians should aim for diagnostic certainty only when the benefit of treatment is equal to its associated risk. In all other cases, decisions about treatment do not have to rely on maximum diagnostic certainty. Determination of acceptable levels of diagnostic uncertainty according to the concepts outlined here should lead to improvement of clinical practice and decrease healthcare costs.

Appendicitis↗
PubMed1984

Hypothetical entropy-driven mechanism for self-regulation of the size and division of primitive cells, suggesting the origin and nature of mesosomes.

It is proposed that, when a critical cell radius was reached, spontaneous invaginations caused by adhesion of adjacent nodes in membranes rippled by Brownian bombardment, became progressive due to re-orientation of self-seeking molecules. Some circumstantial bacteriological evidence is adduced; the significance of mesosomes is discussed.

Animals↗
PubMed2004

Sample entropy.

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Journal Article↗