Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “ANTHELMINTICS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,351 records · Page 75Linked to original sources
PubMed1979

Avermectins, new family of potent anthelmintic agents: efficacy of the B1a component.

When given to sheep as a single oral dose at 0.1 mg/kg, the B(1a) component of the avermectins caused a reduction of >95% in the numbers of Haemonchus contortus, Ostertagia circumcincta (including inhibited L(4) larvae), Trichostrongylus axei, Trichostrongylus colubriformis, Cooperia oncophora, and Oesophagostomum columbianum. When given to cattle as a single oral dose at 0.1 mg/kg, avermectin B(1a) was >95% effective in reducing the numbers of Haemonchus placei, Ostertagia ostertagi (including inhibited L(4) larvae), T. axei, T. colubriformis, C. oncophora, Cooperia punctata, Oesophagostomum radiatum, and Dictyocaulus viviparus. Avermectin B(1a) was similarly effective, with the exception of a detectable loss in activity against adult C. oncophora, when administered to cattle as a parenteral injection. Some of these ruminant parasites were fully susceptible to dosages of avermectin B(1a) at 0.025 mg/kg, e.g., D. viviparus, O. radiatum, O. ostertagi, and H. contortus. Avermectin B(1a) removed 83 to 100% of Ancylostoma caninum from dogs given a single oral dose of 0.003 to 0.005 mg/kg. The poultry nematodes Capillaria obsignata and immature Ascaridia galli were effectively removed by avermectin B(1a) at 0.05 and 0.1 mg/kg, respectively, but 0.1 mg/kg was not effective for Heterakis gallinarum. Thus, the avermectins would appear to have unprecedented potency and spectrum of biological activity.

Administration, Oral↗
PubMed1994

In vitro susceptibility of the opportunistic fungus Cryptococcus neoformans to anthelmintic benzimidazoles.

Ten benzimidazole derivatives and amphotericin B were tested in vitro against three isolates of Cryptococcus neoformans. Drug concentrations inhibiting 50% of growth (IC50s) were determined. Four derivatives, including mebendazole and albendazole, had moderately high activities (IC50 = 0.1 to 0.3 microgram/ml). Fenbendazole, however, was 10-fold more active (IC50 = 0.01 to 0.02 microgram/ml) and also 2-fold more active than amphotericin B. Ten additional clinical isolates of C. neoformans were tested against fenbendazole, mebendazole, and albendazole; similar susceptibilities were observed. Drug concentrations lethal to 90% of the cells (LC90s) were determined for two isolates. The LC90s of albendazole and mebendazole were 0.92 to 2.1 micrograms/ml, and those of fenbendazole were 0.06 to 0.07 microgram/ml; the latter are eight to ninefold lower than the LC90s of amphotericin B that were obtained. Spontaneously arising mutants displaying partial resistance to fenbendazole arose at a low frequency (5 x 10(-9).

Amphotericin B↗
PubMed1981

Anthelmintic activity of oxfendazole in pigs.

Eighty-five pigs were artificially infected with Hyostrongylus rubidus, Oesophagostomum species and Ascaris suum. On days 2, 10, 20 or 51 after infection groups of six were treated with oxfendazole premix in food at various dose rates. Subsequently the pigs were slaughtered for comparative worm counts to be made in treated and control animals. The efficacy of treatment against hyostrongylus worms of increasing age was 68, 57, 99.8 and 100 per cent after a 3 mg per kg dose, 75, 75, 99.8 and 100 per cent after a 4.5 mg per kg dose and 81, 83, 99.8 and 100 per cent after a 6 mg per kg dose. In the case of Oesophagostomum species the corresponding figures were 78, 100, 100 and 100 per cent efficacy after a 3 mg dose, 93, 100, 100 and 100 per cent after a 4.5 mg per kg dose and 91, 99, 100 and 100 per cent after a 6 mg per kg dose. Ascaris infestation established too poorly for significant results to be obtained. It is concluded that a dose rate of 4.5 mg oxfendazole per kg body-weight should give practical control of Hyostrongylus and Oesophagostomum species in pigs.

Animals↗