Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “immunogenetics”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,333 records · Page 74Linked to original sources
PubMed1981

Immunogenetic studies on the resistance of mice to highly metastatic DBA/2 tumor cell variants. I. Effect of incompatibilities at H-2 or non-H-2 genes in normal and nude (nu/nu) mice.

The ability of two highly metastatic tumor lines of DBA/2 (H-2d) origin to metastasize in various allogeneic normal or nude (nu/nu) mouse strains was investigated. Normal mice differing from DBA/2 at either the major histocompatibility complex or at minor histocompatibility loci were both able to reject rather high subcutaneous inocula of these tumor cells. F1 hybrids between susceptible and resistant strains could not reject the metastatic tumors. This suggests that tumor rejection was dependent on the recognition of allogeneic histocompatibility antigens. Two mouse strains appeared to be selectively resistant to the establishment of tumor metastases but could not prevent the progressive tumor growth at a local site. One was a new variant subline of DBA/2, provisionally designated as DBA/2/HD, the other was C57B1/6 (nu/nu), an athymic 'nude' mouse of C57B1/6 background. 'Nude' mice of BALB/c or C3H background were more or less susceptible to these tumors and their metastases. These studies demonstrate that the establishment of tumor metastasis is greatly influenced by genetic factors of the host. Resistance to local tumor growth seemed to require the presence of mature T lymphocytes while resistance to metastasis formation could be established in T-cell-deficient nude mice of certain genetic backgrounds.

Animals↗
PubMed1980

Immunogenetics of nasopharyngeal carcinoma--position in 1980.

The HLA profile of 313 newly diagnosed Chinese NPC patients was compared to that of 330 normal Chinese subjects. A2 Bw46 and Aw19/B B17 were associated with increase risks of developing NPC whereas A11 was associated with a decreased risk. A2 Bw46 was confined to older onset patients whereas Aw19/B B17 was associated with NPC patients of all ages but particularly with younger patients. The Aw19/B B17 haplotypes was also associated with poor survival. A DR blank was strongly associated with NPC giving a relative risk of 26.5. In Malay NPC the HLA associations were Aw19/B B17 and A9 B18 and in Kadazan NPC, the association was with A9. Possible mechanisms of the HLA association were discussed.

Adult↗